Title:
FLAVONOID COMPOUNDS, GENES ASSOCIATED WITH BIOSYNTHESIS THEREOF AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/082757
Kind Code:
A1
Abstract:
Provided are the use of chlorflavonin and derivatives thereof, in particular the use thereof in inhibiting the growth of microorganisms and inhibiting the growth of plants. Also provided are genes associated with the synthesis of flavone and new flavonoid compounds. The genes associated with the synthesis of flavone in a target strain are subjected to genetic operation, so that new flavonoid compounds can be obtained, and the flavonoid compounds have a good antibacterial effect. In addition, also provided is a resistance gene cfoL, which can confer microorganisms resistance to chlorflavonin, so that the resistance gene cfoL can be used as a screening label for genetic transformation operation in microorganisms.
Inventors:
LV XUEFENG (CN)
HUANG XUENIAN (CN)
ZHANG WEI (CN)
ZHANG XUAN (CN)
ZHOU YU (CN)
GUO QING (CN)
HUANG XUENIAN (CN)
ZHANG WEI (CN)
ZHANG XUAN (CN)
ZHOU YU (CN)
GUO QING (CN)
Application Number:
PCT/CN2023/109563
Publication Date:
April 25, 2024
Filing Date:
July 27, 2023
Export Citation:
Assignee:
QINGDAO INST BIOENERGY & BIOPROCESS TECH CAS (CN)
International Classes:
C12P7/26; C07D311/32; C12N1/21; C12N9/02; C12P17/06; C12R1/00
Foreign References:
| JPH01135574A | 1989-05-29 | |||
| CN113322288A | 2021-08-31 | |||
| CN114854703A | 2022-08-05 | |||
| CN107164253A | 2017-09-15 | |||
| CN101948794A | 2011-01-19 |
Other References:
SHUZO WATANABE: "CJ-19,784, a New Antifungal Agent from a Fungus, Acanthostigmella sp", THE JOURNAL OF ANTIBIOTICS, NATURE PUBLISHING GROUP UK / JAPAN ANTIBIOTICS RESEARCH ASSOCIATION, UK / JP, vol. 54, no. 12, 31 December 2001 (2001-12-31), UK / JP, pages 1031 - 1035, XP093161855, ISSN: 0021-8820, DOI: /10.7164/antibiotics.54.1031
RICHARDS M: "Chlorflavonin, a new antifungal antibiotic (Communications to the editors)", THE JOURNAL OF ANTIBIOTICS, NATURE PUBLISHING GROUP UK / JAPAN ANTIBIOTICS RESEARCH ASSOCIATION, UK / JP, vol. 22, no. 8, 1 August 1969 (1969-08-01), UK / JP, pages 388 - 389, XP009554043, ISSN: 0021-8820
FUNAYAMA S, ET AL.: "CYTOCIDAL AND ANTIMICROBIAL ACTIVITIES OF FLAVONOIDS", JOURNAL OF NATURAL MEDICINES, JAPANESE SOCIETY OF PHARMACOGNOSY, TOKYO., JP, vol. 49, no. 03, 1 January 1995 (1995-01-01), JP , pages 322 - 328, XP009072301, ISSN: 1340-3443
MONIKA STOMPOR , BARBARA ZAROWSKA: "Antimicrobial Activity of Xanthohumol and Its Selected Structural Analogues", MOLECULES, vol. 21, no. 5, 11 May 2016 (2016-05-11), pages 1 - 10, XP055683543, DOI: 10.3390/molecules21050608
TALEB-CONTINI S H, ET AL.: "ANTIMICROBIAL ACTIVITY OF FLAVONOIDS AND STEROIDS ISOLATED FROM TWO CHROMOLAENA SPECIES", REVISTA BRASILEIRA DE CIENCIAS FARMACEUTICAS - BRAZILIAN JOURNALOF PHARMACEUTICAL SCIENCES, FACULDADE DE CIENCIAS FARMACEUTICAS, SAO PAULO,, BR, vol. 39, no. 04, 1 October 2003 (2003-10-01), BR , pages 403 - 408, XP009053550, ISSN: 1516-9332
ANNA BERIM: "A Set of Regioselective O -Methyltransferases Gives Rise to the Complex Pattern of Methoxylated Flavones in Sweet Basil ", COMPREHENSIVE SEQUENCE ANALYSIS OF 24,783 BARLEY FULL-LENGTH CDNAS DERIVED FROM 12 CLONE LIBRARIES., vol. 160, no. 2, 1 October 2012 (2012-10-01), pages 1052 - 1069, XP093161857, ISSN: 1532-2548, DOI: 10.1104/pp.112.204164
DATABASE REGISTRY 16 November 1983 (1983-11-16), "**PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** Chemical Name: 4H-1-Benzopyran-4-one, 5,6-dihydroxy-2-(2-hydroxyphenyl)-7-methoxy- (CA INDEX NAME) OTHER CA INDEX NAMES: 5,6-Dihydroxy-2-(2-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one Molecular Formula: C16 H12 O6 Source of Registration: CA 1 REFER", XP093162101
RICHARDS M: "Chlorflavonin, a new antifungal antibiotic (Communications to the editors)", THE JOURNAL OF ANTIBIOTICS, NATURE PUBLISHING GROUP UK / JAPAN ANTIBIOTICS RESEARCH ASSOCIATION, UK / JP, vol. 22, no. 8, 1 August 1969 (1969-08-01), UK / JP, pages 388 - 389, XP009554043, ISSN: 0021-8820
FUNAYAMA S, ET AL.: "CYTOCIDAL AND ANTIMICROBIAL ACTIVITIES OF FLAVONOIDS", JOURNAL OF NATURAL MEDICINES, JAPANESE SOCIETY OF PHARMACOGNOSY, TOKYO., JP, vol. 49, no. 03, 1 January 1995 (1995-01-01), JP , pages 322 - 328, XP009072301, ISSN: 1340-3443
MONIKA STOMPOR , BARBARA ZAROWSKA: "Antimicrobial Activity of Xanthohumol and Its Selected Structural Analogues", MOLECULES, vol. 21, no. 5, 11 May 2016 (2016-05-11), pages 1 - 10, XP055683543, DOI: 10.3390/molecules21050608
TALEB-CONTINI S H, ET AL.: "ANTIMICROBIAL ACTIVITY OF FLAVONOIDS AND STEROIDS ISOLATED FROM TWO CHROMOLAENA SPECIES", REVISTA BRASILEIRA DE CIENCIAS FARMACEUTICAS - BRAZILIAN JOURNALOF PHARMACEUTICAL SCIENCES, FACULDADE DE CIENCIAS FARMACEUTICAS, SAO PAULO,, BR, vol. 39, no. 04, 1 October 2003 (2003-10-01), BR , pages 403 - 408, XP009053550, ISSN: 1516-9332
ANNA BERIM: "A Set of Regioselective O -Methyltransferases Gives Rise to the Complex Pattern of Methoxylated Flavones in Sweet Basil ", COMPREHENSIVE SEQUENCE ANALYSIS OF 24,783 BARLEY FULL-LENGTH CDNAS DERIVED FROM 12 CLONE LIBRARIES., vol. 160, no. 2, 1 October 2012 (2012-10-01), pages 1052 - 1069, XP093161857, ISSN: 1532-2548, DOI: 10.1104/pp.112.204164
DATABASE REGISTRY 16 November 1983 (1983-11-16), "**PROPERTY DATA AVAILABLE IN THE 'PROP' FORMAT** Chemical Name: 4H-1-Benzopyran-4-one, 5,6-dihydroxy-2-(2-hydroxyphenyl)-7-methoxy- (CA INDEX NAME) OTHER CA INDEX NAMES: 5,6-Dihydroxy-2-(2-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one Molecular Formula: C16 H12 O6 Source of Registration: CA 1 REFER", XP093162101
Attorney, Agent or Firm:
BEIJING BEVON INTELLECTUAL PROPERTY AGENCY (CN)
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