1. This invention is about the discovery of a new novel antibiotic of maximum effectiveness that can ever be obtained by simpler than usual Chemical synthesis and modification methods, namely“Flavocilin”.

2. Flavocilin will overcome all the possible and potential antibiotic resistance problems and mechanisms as per stated mechnaisms of action and its unqiue and basic structure will be the strongest antibiotic ever used in Medicine, according to claim 1.

3. Flavocilin will consist of a flavonoid as R group attached to basic penicilin structure, according to claim 2.

4. Flavocilin can simply be obtained/synthesized in a Chemistry laboratory as following moderate detail synthesis methods (Other synthetic methods can also be developed besides this and grams and scales yet need to be determined by expert Organic/synthetic Chemists in field): Any basic flavonoid or a flavone solution is firstly extracted from a herbal tea by using any one of dichloromethane, diethyl ether, chloroform or ethyl acetate as a solvent. There are more than one way of extraction and many of these methods are available from many different public resources. The flavonoid extract is then isolated from the rest of the tea and H₂S0₄ is added to the isolated flavonoid solution to produce lone paired Oxygens (as Flavonoids contain Oxygen around Cyclic carbons). The solution is then reacted with a readily available penicilin powder so that the formed lone pairs around Oxygen(s) in flavonoid attack the carbon attached to NH, O and R groups of Penicilin. This will result in double bond brokage and newly formed bond with the flavonoid due to an SN reaction. Since Penicilin contains Sulphur atom and methyls, an acid or other acidic compounds such as Sulphuric acid is likely to be resulted from this reaction, but such formed acids can easily be removed with the addition of a base to the solution resulting in salt formation that can be extracted and isolated later on so that it is gotten rid as it is unwanted. Finally, identification methods such as High Performance Liquid Chromatography (HPLC) and Carbon NMR must be used to analyze the solution to ensure the finally obtained sample contains Flavocilin and to ensure its structure represents the Flavocilin structure as identified in figure 2 of drwaings part of the invention. Once this is ensured, the very final step of the process is to purify the sample with purification methods to obtain 99% Flavocilin. Alternative synthetic routes or pathways at any stage is also possible.

received by the International Bureau on 2nd June 2019 (02.06.2019)

1. This invention is about the discovery of a new novel antibiotic of maximum effectiveness that can ever be obtained by simpler than usual Chemical synthesis and modification methods, namely“Flavocilin’’ . The patent protection is sought for both“FlavocillhT’ compound and also for the methodologies defined in this application as well as its Medicinal use on humans as a new antibiotic, after relevant tests confirm on what types of bacteria it will be effective, if on any, to back the claims in these application.

2. Flavocilin will overcome all the possible and potential antibiotic resistance problems and mechanisms as per stated mechnaisms of action and its unqiue and basic structure will be the strongest antibiotic ever used in Medicine, according to claim 1. Due to the modification of Penicillin R group, it is expected that the bacterial resistance that happens to Penicillin, will not happen in case of Flavocillin compounds, because of the detailed reasons provided in the additional document to back these claims. The same document contains full detail synthetic methodologies as a possible strategy of obtaining Flavocillin compounds.

3. Flavocilin will consist of a flavonoid as R group attached to basic penicilin structure, according to claim 2. There are many different types of Flavonoids, and the purpose of this application, provided with the amended claims, is to seek patent protection for any type of Flavonoids that can be derived as“Flavocillin”, whether the general structure or its derivatives are being obtained, and also for the methodologies and synthesis and for its testing on microorganisms or on humans.

4. Flavocilin can simply be obtained/synthesized in a Chemistry laboratory as following moderate detail synthesis methods (Other synthetic methods can also be developed besides this and grams and scales yet need to be determined by expert Organic/synthetic Chemists in field): Any basic flavonoid or a flavone solution is firstly extracted from a herbal tea by using any one of dichloromethane, diethyl ether, chloroform or ethyl acetate as a solvent. There are more than one way of extraction and many of these methods are available from many different public resources. The flavonoid extract is then isolated from the rest of the tea and H2S04 is added to the isolated flavonoid solution to produce lone paired Oxygens (as Flavonoids contain Oxygen around Cyclic carbons). The solution is then reacted with a readily available penicilin powder so that the formed lone pairs around Oxygen(s) in flavonoid attack the carbon attached to NH, O and R groups of Penicilin. This will result in double bond brokage and newly formed bond with the flavonoid due to an SN reaction. Since Penicilin contains Sulphur atom and methyls, an acid or other acidic compounds such as Sulphuric acid is likely to be resulted from this reaction, but such formed acids can easily be removed with the addition of a base to the solution resulting in salt formation that can be extracted and isolated later on so that it is gotten rid as it is unwanted. Finally, identification methods such as High Performance Liquid Chromatography (HPLC) and Carbon NMR must be used to analyze the solution to ensure the finally obtained sample contains Flavocilin and to ensure its structure represents the Flavocilin structure as identified in figure 2 of drwaings part of the invention. Once this is ensured, the very final step of the process is to purify the sample with purification methods to obtain 99% Flavocilin. Alternative synthetic routes or pathways at any stage is also possible. And one of these in detail synthetic methodologies have been developed, in the form of widely accepted Chemical procedures and methods, and they have been presented in the amended application.