Title:
DIAZO COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/208233
Kind Code:
A1
Abstract:
Provided are a diazo compound, a preparation method therefor, and a use thereof. The diazo compound has a structure as shown in formula (I), wherein R1 represents H, an alkyl, a halogen, an alkoxy or an alkylamino; and R2 represents an aryl. On the basis of using the diazo compound as a derivatization reagent, after derivatization treatment, the mass spectrometry response of a small molecule carboxylic acid can be clearly enhanced, the detection sensitivity is improved, and therefore the detection accuracy is improved. Moreover, the derivatized small molecule carboxylic acid does not need to be provided with a special chromatographic column and does not need to be provided with a special mobile phase, the optimal separation effect can be achieved in a shorter time with a lower cost, high-throughput sample detection is better facilitated, and the detection accuracy is improved. In particular, on the basis of using the diazo compound as a derivatization reagent, the beneficial effects of in-situ derivative cell samples can be effectively achieved.
Inventors:
CHEN ZHIXING (CN)
QUAN LI (CN)
LI CONG (CN)
CHENG KUNLUN (CN)
ZHAO QIJIN (CN)
QUAN LI (CN)
LI CONG (CN)
CHENG KUNLUN (CN)
ZHAO QIJIN (CN)
Application Number:
PCT/CN2023/091869
Publication Date:
November 02, 2023
Filing Date:
April 28, 2023
Export Citation:
Assignee:
UNIV BEIJING (CN)
International Classes:
C07D215/14; C07C245/18; G01N30/06; G01N30/72; G01N30/86
Foreign References:
| CN109298115A | 2019-02-01 | |||
| CN113156027A | 2021-07-23 | |||
| CN108931603A | 2018-12-04 | |||
| CN109358134A | 2019-02-19 | |||
| CN111574476A | 2020-08-25 | |||
| CN112326848A | 2021-02-05 | |||
| CN107607638A | 2018-01-19 | |||
| US20200158702A1 | 2020-05-21 |
Attorney, Agent or Firm:
KANGXIN PARTNERS , P.C. (CN)
Download PDF: