Title:
DEVELOPMENT AND USE OF BROAD-SPECTRUM VACCINE FOR H5N8 AVIAN INFLUENZA
Document Type and Number:
WIPO Patent Application WO/2023/207717
Kind Code:
A1
Abstract:
Provided are development and use of a broad-spectrum vaccine for H5N8 avian influenza, and particularly, provided are preparation methods for a recombinant protein vaccine, an inactivated vaccine and a nucleic acid vaccine, and use thereof. Experiments show that the prepared recombinant protein vaccine, inactivated vaccine and nucleic acid vaccine can effectively prevent infection with avian influenza virus.
Inventors:
WANG GUIQIN (CN)
ZHOU BAOLUO (CN)
WANG HAIKUN (CN)
CHANG XIAOYAN (CN)
LIU DONGPING (CN)
REN HUANHUAN (CN)
ZHOU BAOLUO (CN)
WANG HAIKUN (CN)
CHANG XIAOYAN (CN)
LIU DONGPING (CN)
REN HUANHUAN (CN)
Application Number:
PCT/CN2023/089267
Publication Date:
November 02, 2023
Filing Date:
April 19, 2023
Export Citation:
Assignee:
NANJING ADVANCED ACAD OF LIFE AND HEALTH (CN)
INST PASTEUR SHANGHAI CAS (CN)
INST PASTEUR SHANGHAI CAS (CN)
International Classes:
C12N7/01; A61K39/145; A61P31/16; C07K19/00; C12N15/11; C12N15/44; C12N15/85
Domestic Patent References:
| WO2020093984A1 | 2020-05-14 |
Foreign References:
| CN113913395A | 2022-01-11 | |||
| CN113913394A | 2022-01-11 | |||
| CN113150083A | 2021-07-23 | |||
| CN113603754A | 2021-11-05 |
Other References:
CUENO MARNI E., SHIOTSU HAYATO, NAKANO KARIN, SUGIYAMA EMIKO, KIKUTA MARI, USUI RIKUYA, OYA RIKU, IMAI KENICHI: "Structural significance of residues 158–160 in the H3N2 hemagglutnin globular head: A computational study with implications in viral evolution and infection", JOURNAL OF MOLECULAR GRAPHICS AND MODELLING, ELSEVIER SCIENCE, NEW YORK, NY, US, vol. 89, 1 June 2019 (2019-06-01), US , pages 33 - 40, XP093102782, ISSN: 1093-3263, DOI: 10.1016/j.jmgm.2019.02.007
SEALY JOSHUA E., HOWARD WENDY A., MOLESTI ELEONORA, IQBAL MUNIR, TEMPERTON NIGEL J., BANKS JILL, SLOMKA MAREK J., BARCLAY WENDY S.: "Amino acid substitutions in the H5N1 avian influenza haemagglutinin alter pH of fusion and receptor binding to promote a highly pathogenic phenotype in chickens", JOURNAL OF GENERAL VIROLOGY, SOCIETY FOR GENERAL MICROBIOLOGY, vol. 102, no. 11, 2 November 2021 (2021-11-02), XP093102785, ISSN: 0022-1317, DOI: 10.1099/jgv.0.001672
SEALY JOSHUA E., HOWARD WENDY A., MOLESTI ELEONORA, IQBAL MUNIR, TEMPERTON NIGEL J., BANKS JILL, SLOMKA MAREK J., BARCLAY WENDY S.: "Amino acid substitutions in the H5N1 avian influenza haemagglutinin alter pH of fusion and receptor binding to promote a highly pathogenic phenotype in chickens", JOURNAL OF GENERAL VIROLOGY, SOCIETY FOR GENERAL MICROBIOLOGY, vol. 102, no. 11, 2 November 2021 (2021-11-02), XP093102785, ISSN: 0022-1317, DOI: 10.1099/jgv.0.001672
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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