Title:
DEGRADABLE LIPOSOME FOR ACTIVE MOLECULE DELIVERY AND NANOCOMPOSITE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/165595
Kind Code:
A1
Abstract:
The present invention relates to a liposome for forming a nanodrug carrier. The liposome can form a nanocomposite that selectively and efficiently delivers a pharmaceutically active molecule, and reduce or minimize treatment-associated toxicity. The present invention also relates to a nanocomplex comprising the liposome and a pharmaceutically active molecule, and a pharmaceutical composition comprising the nanocomplex.
Inventors:
WANG MING (CN)
CAI WEIQI (CN)
CAI WEIQI (CN)
Application Number:
PCT/CN2023/079515
Publication Date:
September 07, 2023
Filing Date:
March 03, 2023
Export Citation:
Assignee:
BEIJING CARRIUS BIO LTD (CN)
International Classes:
A61K47/18; A61K9/127; C07C319/22; C07C323/12
Foreign References:
| CN110101665A | 2019-08-09 | |||
| US20140308304A1 | 2014-10-16 |
Other References:
CHANG JIN, CAI WEIQI, LIANG CHUNJING, TANG QIAO, CHEN XIANGHAN, JIANG YING, MAO LANQUN, WANG MING: "Enzyme-Instructed Activation of Pro-protein Therapeutics In Vivo", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 141, no. 45, 13 November 2019 (2019-11-13), pages 18136 - 18141, XP093089456, ISSN: 0002-7863, DOI: 10.1021/jacs.9b08669
LIANG CHUNJING, CHANG JIN, JIANG YING, LIU JI, MAO LANQUN, WANG MING: "Selective RNA interference and gene silencing using reactive oxygen species-responsive lipid nanoparticles", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 55, no. 56, 9 July 2019 (2019-07-09), UK , pages 8170 - 8173, XP093089457, ISSN: 1359-7345, DOI: 10.1039/C9CC04517A
LIANG CHUNJING, CHANG JIN, JIANG YING, LIU JI, MAO LANQUN, WANG MING: "Selective RNA interference and gene silencing using reactive oxygen species-responsive lipid nanoparticles", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 55, no. 56, 9 July 2019 (2019-07-09), UK , pages 8170 - 8173, XP093089457, ISSN: 1359-7345, DOI: 10.1039/C9CC04517A
Attorney, Agent or Firm:
WU , FENG & ZHANG (CN)
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