Title:
CUCURBITACIN B DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/169372
Kind Code:
A1
Abstract:
A cucurbitacin B derivative, a preparation method therefor and a use thereof. The structure of the compound is shown in formula I. The cucurbitacin B derivative is easy to synthesize, has good anti-tumor and anti-inflammatory activity, and can be used for preparing anti-tumor and anti-inflammatory drugs.
Inventors:
NAN FAJUN (CN)
LI JINGYA (CN)
ZHUO NING (CN)
CAO LEI (CN)
SUN XINYU (CN)
MA JIE (CN)
KONG XIANGRONG (CN)
LI JINGYA (CN)
ZHUO NING (CN)
CAO LEI (CN)
SUN XINYU (CN)
MA JIE (CN)
KONG XIANGRONG (CN)
Application Number:
PCT/CN2023/079902
Publication Date:
September 14, 2023
Filing Date:
March 06, 2023
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
C07J9/00; A61K31/575; A61P29/00; A61P35/00
Domestic Patent References:
WO2002078617A2 | 2002-10-10 | |||
WO2009024103A2 | 2009-02-26 |
Foreign References:
CN102659888A | 2012-09-12 | |||
CN103360452A | 2013-10-23 | |||
US20190144492A1 | 2019-05-16 |
Other References:
ZHUO, NING: "Design and Synthesis of Intestinal-restricted TGR5 Agonists Based on Pentacyclic Triterpene Skeleton and Diversified Transformation of Cucurbitacin B", CHINA DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, MEDICINE & PUBLIC HEALTH, no. 02, 15 February 2023 (2023-02-15)
Attorney, Agent or Firm:
XU & PARTNERS , LLC. (CN)
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