Title:
CRYSTAL FORMS OF KUDING SAPONIN A COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/011512
Kind Code:
A1
Abstract:
The present invention provides crystal forms of the compound Kuding saponin A, and a pharmaceutical composition and a use thereof. The crystal forms comprise crystal forms A, B, C, D, E, G, J, K and L. Characteristic peaks in the X-ray powder diffraction (XRPD) pattern of each crystal form are as described in the application. The crystal forms of the present invention are stable under suitable conditions, especially crystal forms A, C and J. The crystal forms of the present invention can be used to prepare a pharmaceutical composition for treating pulmonary disease.
Inventors:
MA MING (CN)
Application Number:
PCT/CN2022/109901
Publication Date:
February 09, 2023
Filing Date:
August 03, 2022
Export Citation:
Assignee:
SHANGHAI KE PHARMACEUTICAL CO LTD (CN)
International Classes:
C07J71/00; A61K31/7048; A61P11/00; A61P11/06; A61P11/08; A61P29/00
Foreign References:
| CN101775061A | 2010-07-14 | |||
| CN104402965A | 2015-03-11 | |||
| CN112370462A | 2021-02-19 | |||
| CN106456657A | 2017-02-22 | |||
| CN112755036A | 2021-05-07 |
Other References:
FAN, CHUNLIN: "Triterpenoid Saponins from the Leaves of Ilex Llatifolia", CHINESE PHARMACEUTICAL JOURNAL, vol. 45, no. 16, 22 August 2010 (2010-08-22), XP093033111
TU PENGFEI ET AL.: "Research on chemical components of Ilex kudingcha C. J. Tseng and its effect in reducing blood lipids", THE 25TH CHINESE CHEMICAL SOCIETY CONGRESS, 2006
"Pharmacopoeia of the People 's Republic of China", 2020, article "General Requirement 9103-Guidelines for Hygroscopicity"
TU PENGFEI ET AL.: "Research on chemical components of Ilex kudingcha C. J. Tseng and its effect in reducing blood lipids", THE 25TH CHINESE CHEMICAL SOCIETY CONGRESS, 2006
"Pharmacopoeia of the People 's Republic of China", 2020, article "General Requirement 9103-Guidelines for Hygroscopicity"
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
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