CONJUGATE OF FINASTERIDE WITH PEPTIDE

WIPO Patent Application WO/2017/159922

A1

The present invention relates to a composition for preventing hair loss and, more specifically, to a compound having a structure in which finasteride and a peptide are linked through a covalent bond and a pharmaceutical composition or a cosmetic composition for preventing hair loss or promoting hair growth comprising the same. The compound of the present invention having a structure in which finasteride and a peptide are linked through a covalent bond is excellent in physiological activities such as hair loss improvement, hair growth promotion, cell growth promotion, etc., is excellent in stability in water and skin permeation, and thus can be effectively used as a composition for preventing hair loss and promoting hair growth.

CHUNG YONG JI (KR)
KIM EUN MI (KR)

PCT/KR2016/005405

September 21, 2017

May 20, 2016

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CAREGEN CO LTD (KR)

C07K19/00; A61K8/63; A61K31/56; A61Q7/00; A61Q19/00; C07J73/00; C07K7/06; C07K7/08

US20120289471A1	2012-11-15
JPH1059829A	1998-03-03
US20150118292A1	2015-04-30
KR20140041437A	2014-04-04
KR20100085407A	2010-07-29
KR20080077762A	2008-08-26
KR20120120912A	2012-11-02
KR20100085407A	2010-07-29
KR20090010832A	2009-01-30
KR20110023991A	2011-03-09

EUNJU RYU ET AL., THE JOURNAL OF KOREAN SOCIETY OF DESIGN CULTURE, vol. 18, no. 2, 2012, pages 89 - 100
MERRIFIELD, J. AMER. CHEM. SOC., vol. 85, 1963, pages 2149 - 54
STEWART ET AL.: "Solid Phase Peptide Synthesis", vol. 111, 1984, PIERCE CHEM. CO.
"Remington's Pharmaceutical Sciences", 1995
RIZZINO ET AL., CANCER RES., vol. 48, 1988, pages 4266
See also references of EP 3431505A4

BAE, KIM & LEE IP GROUP (KR)

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