Title:
CONDENSED AZINES FOR TREATING CANCER
Document Type and Number:
WIPO Patent Application WO/2024/078513
Kind Code:
A1
Abstract:
The present disclose includes, among other things, compounds that treat or lessen the severity of a disorder, pharmaceutical compositions and methods of making and using the same.
Inventors:
YANG DUN (CN)
LV GANG (CN)
LI CHAO (CN)
SUN YIN (CN)
LI JINHUA (CN)
SHI QIONG (CN)
YANG CHENGLU (CN)
LI HONGMEI (CN)
LONG YAN (CN)
ZHANG JING (CN)
ALLEN THADDEUS (US)
LIU HONG (US)
ZHANG SHENQIU (GB)
NIMISHETTI NAGANNA (IN)
ANANTOJU KISHORE KUMAR (IN)
JUPELLI RAJESH (IN)
DHAYALAN MANIKANDAN (IN)
REDDY MALLU CHENNA (IN)
LV GANG (CN)
LI CHAO (CN)
SUN YIN (CN)
LI JINHUA (CN)
SHI QIONG (CN)
YANG CHENGLU (CN)
LI HONGMEI (CN)
LONG YAN (CN)
ZHANG JING (CN)
ALLEN THADDEUS (US)
LIU HONG (US)
ZHANG SHENQIU (GB)
NIMISHETTI NAGANNA (IN)
ANANTOJU KISHORE KUMAR (IN)
JUPELLI RAJESH (IN)
DHAYALAN MANIKANDAN (IN)
REDDY MALLU CHENNA (IN)
Application Number:
PCT/CN2023/123870
Publication Date:
April 18, 2024
Filing Date:
October 10, 2023
Export Citation:
Assignee:
CHENGDU ANTICANCER BIOSCIENCE LTD (CN)
International Classes:
C07D215/44; A61K31/47; A61P35/00; C07D231/12; C07D233/61; C07D401/04; C07D401/12; C07D405/12; C07D405/14; C07D409/12; C07D413/12
Domestic Patent References:
| WO2021026101A1 | 2021-02-11 |
Foreign References:
| US20180086747A1 | 2018-03-29 |
Other References:
ASSADIESKANDAR AMIR ET AL: "Rigidification Dramatically Improves Inhibitor Selectivity for RAF Kinases", ACS MEDICINAL CHEMISTRY LETTERS, vol. 10, no. 7, 4 June 2019 (2019-06-04), US, pages 1074 - 1080, XP093118624, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.9b00194
GAY MARION ET AL: "New phenylaniline derivatives as modulators of amyloid protein precursor metabolism", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 26, no. 8, 1 May 2018 (2018-05-01), AMSTERDAM, NL, pages 2151 - 2164, XP093118630, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2018.03.016
S. M. BERGE ET AL.: "describe pharmaceutically acceptable salts in detail", J. PHARMACEUTICAL SCIENCES, vol. 66, 1977, pages 1 - 19
CARREIRAKVAEMO: "Classics in Stereoselective Synthesis", 2009, WILEY-VCH
LI JYAN ZLI HSHI QHUANG LNIMISHETTI NALLEN TDYANG DZHANG J: "A high-content screen for anti-mitosis and polyploidy-induction identifies an unknown activity of two benzophenanthridine alkaloids from Corydalis longicalcarata", PHYTOCHEMISTRY LETTERS, vol. 41, 2021, pages 180 - 185
ZHANG JZHANG SSHI QALLEN TDYOU FYANG D: "The anti-apoptotic proteins Bcl-2 and Bcl-xL suppress Beclin 1 /Atg6-mediated lethal autophagy in polyploid cells", EXP CELL RES, vol. 394, no. 1, 2020, pages 112112, XP086248602, DOI: 10.1016/j.yexcr.2020.112112
ZHANG JZHANG SSHI QALLEN TDYOU FYANG D: "A high-content screen identifies the vulnerability of MYC-overexpressing cells to dimethylfasudil", PLOS ONE, vol. 16, no. 3, 2021, pages 0248355
GAY MARION ET AL: "New phenylaniline derivatives as modulators of amyloid protein precursor metabolism", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 26, no. 8, 1 May 2018 (2018-05-01), AMSTERDAM, NL, pages 2151 - 2164, XP093118630, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2018.03.016
S. M. BERGE ET AL.: "describe pharmaceutically acceptable salts in detail", J. PHARMACEUTICAL SCIENCES, vol. 66, 1977, pages 1 - 19
CARREIRAKVAEMO: "Classics in Stereoselective Synthesis", 2009, WILEY-VCH
LI JYAN ZLI HSHI QHUANG LNIMISHETTI NALLEN TDYANG DZHANG J: "A high-content screen for anti-mitosis and polyploidy-induction identifies an unknown activity of two benzophenanthridine alkaloids from Corydalis longicalcarata", PHYTOCHEMISTRY LETTERS, vol. 41, 2021, pages 180 - 185
ZHANG JZHANG SSHI QALLEN TDYOU FYANG D: "The anti-apoptotic proteins Bcl-2 and Bcl-xL suppress Beclin 1 /Atg6-mediated lethal autophagy in polyploid cells", EXP CELL RES, vol. 394, no. 1, 2020, pages 112112, XP086248602, DOI: 10.1016/j.yexcr.2020.112112
ZHANG JZHANG SSHI QALLEN TDYOU FYANG D: "A high-content screen identifies the vulnerability of MYC-overexpressing cells to dimethylfasudil", PLOS ONE, vol. 16, no. 3, 2021, pages 0248355
Attorney, Agent or Firm:
LIU , SHEN & ASSOCIATES (CN)
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