Title:
COMPOUND, EXTRACELLULAR VESICLE STAINING AGENT, AND FLUORESCENT STAINING METHOD FOR EXTRACELLULAR VESICLES
Document Type and Number:
WIPO Patent Application WO/2024/053316
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel compound, which binds to extracellular vesicles and enables size measurement by liquid chromatography, etc., an extracellular vesicle staining agent and a fluorescent staining method for extracellular vesicles. The problem can be solved by a compound represented by formula (1). [In formula (1), R1 represents H, a C1-C6 alkyl group, a hydroxy group, an amino group, or a carboxy group. R2 represents H, a C1-C18 alkyl group, a C1-C18 alkoxy group, NO2, or N(CH3)2. R3 and R4 each independently represent H or CH3. However, R3 and R4 may be bonded to each other to form a ring, in which case R3 and R4 are CH2. a represents 0 or 1, and b represents 1, 2 or 3. Z represents a linker in which 0 to 12 chain molecules, each chain molecule comprising an element selected from the group consisting of C, O and N, are bonded together, and the chain molecules may contain a cyclic structure or a branched chain.]
Inventors:
TAKEMORI HIROSHI (JP)
FURUTA KYOJI (JP)
MORITA YOKO (JP)
HAMAMOTO AKIE (JP)
FURUTA KYOJI (JP)
MORITA YOKO (JP)
HAMAMOTO AKIE (JP)
Application Number:
PCT/JP2023/028846
Publication Date:
March 14, 2024
Filing Date:
August 08, 2023
Export Citation:
Assignee:
NATIONAL UNIV CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (JP)
International Classes:
C07D271/12; C07D413/12; G01N33/48
Domestic Patent References:
| WO2022163446A1 | 2022-08-04 |
Other References:
YAMAGUCHI, TAKAO ET AL.: "Turn-ON fluorescent affinity labeling using a small bifunctional O-nitrobenzoxadiazole unit", CHEMICAL SCIENCE, vol. 5, no. 3, 2014, pages 1021 - 1029, XP093079913, DOI: 10.1039/ C3SC52704B
Attorney, Agent or Firm:
MATSUMOTO Seiji (JP)
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