Title:
COMPOSITIONS AND METHODS FOR TREATING CANCER
Document Type and Number:
WIPO Patent Application WO/2023/107842
Kind Code:
A3
Abstract:
This disclosure is based, at least in part, on unexpected discoveries that a novel composition of a leukotoxin (LtxA) polypeptide isolated from Aggregatibatier actin omycetcmcomitans can retain stability and biological activities for an extended period of time even after the composition, is subject to a process of lyophilization, storage, reconstitution, and/or further storage, or under an accelerated condition, and that a particular range of dosage of the LtxA polypeptide and administration regimen can provide high efficacy and low toxicity in treating cancer in a patient in need thereof.
Inventors:
KACHLANY SCOTT C (US)
Application Number:
PCT/US2022/080670
Publication Date:
May 10, 2024
Filing Date:
November 30, 2022
Export Citation:
Assignee:
UNIV RUTGERS (US)
International Classes:
C07K14/285; A61P35/00; C07K14/195; C07K14/36
Attorney, Agent or Firm:
BUTCH III, Peter J. et al. (US)
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