Title:
COMPOSITION FOR TREATMENT OF KELOID SYSTEMIC SCLEROSIS THROUGH MITOCHONDRIAL TRANSPLANTATION
Document Type and Number:
WIPO Patent Application WO/2024/091036
Kind Code:
A1
Abstract:
The present invention relates to a composition for treatment of mitochondrial transplantation for immunomodulation and fibrosis control in multiple sclerosis. The present invention confirmed that, when muscle-derived mitochondria are transplanted into an animal model with multiple sclerosis, disease activity of multiple sclerosis is decreased, mitochondrial dysfunction is ameliorated, and autoimmune-related immune cells are controlled. Also, it was confirmed that, in the animal model with multiple sclerosis, mitochondrial transplantation increases a variety of intestinal bacterial flora, increases the phylum Firmicutes which are beneficial bacteria, decreases the phylum Bacterodites which are harmful bacteria, and increases, at the level of the genus, the genera Akkermansia and Romboutsia, thereby regulating the homeostasis of the intestinal bacterial flora. It was confirmed that mitochondrial transplantation reduces the expression of inflammatory fibrosis factors in keloid patient-derived fibroblasts. Also, it was confirmed that, even in cells where fibrosis is accelerated due to IL-17, mitochondrial transplantation reduces the expression of inflammatory fibrosis factors and induces autophage-activating factors, thereby ameliorating keloids. Also, it was confirmed that, in a keloid patient-derived avatar animal model, mitochondrial transplantation inhibits fibrosis of new tissue. Also, it was confirmed that, in vimentin-immunized systemic sclerosis, mitochondrial transplantation inhibits the expression of autoantibodies and inhibits tissue fibrosis.
Inventors:
CHO MI LA (KR)
LEE JUNG-HO (KR)
LEE SEON YEONG (KR)
LEE CHAE-RIM (KR)
LEE A RAM (KR)
CHOI JEONG WON (KR)
JEON SU BEEN (KR)
LEE JUNG-HO (KR)
LEE SEON YEONG (KR)
LEE CHAE-RIM (KR)
LEE A RAM (KR)
CHOI JEONG WON (KR)
JEON SU BEEN (KR)
Application Number:
PCT/KR2023/016783
Publication Date:
May 02, 2024
Filing Date:
October 26, 2023
Export Citation:
Assignee:
CATHOLIC UNIV KOREA IND ACADEMIC COOPERATION FOUNDATION (KR)
International Classes:
A61K35/34; A23L33/10; A61K35/28; A61P17/02; A61P37/00; A61P43/00
Attorney, Agent or Firm:
WIE, Byoung Gap (KR)
Download PDF: