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Title:
COMPOSITION FOR PROMOTING ANGIOGENESIS COMPRISING THYMOSIN BETA-4 FUSION PROTEINS
Document Type and Number:
WIPO Patent Application WO/2023/096330
Kind Code:
A1
Abstract:
The present invention relates to a composition which is for promoting angiogenesis and comprises thymosin β-4 fusion proteins. The thymosin β-4 fusion proteins according to an aspect of the present invention can very effectively pass through cell membranes to induce angiogenesis as well as inhibit apoptosis, and can induce wound healing, and thus can be effectively used as a therapeutic agent for the regeneration of blood vessels or other damaged tissues or the treatment of ischemic diseases or diabetic foot ulcers.

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Inventors:
KIM JUNG SEOK (KR)
BAEK BYEONG HA (KR)
YUN SEOK HWAN (KR)
Application Number:
PCT/KR2022/018574
Publication Date:
June 01, 2023
Filing Date:
November 23, 2022
Export Citation:
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Assignee:
UNION KOREA LIFE SCIENCES INC (KR)
International Classes:
A61K38/00; A61K38/22; A61K47/64; A61P17/00; A61P41/00; A61P43/00
Foreign References:
KR20160107818A2016-09-19
US20090169538A12009-07-02
KR20140120018A2014-10-13
Other References:
LV SHUMIN, CAI HONGWEN, XU YIFEI, DAI JIN, RONG XIQING, ZHENG LANZHI: "Thymosin‑β4 induces angiogenesis in critical limb ischemia mice via regulating Notch/NF‑κB pathway", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, SPANDIDOS PUBLICATIONS, GR, vol. 46, 1 January 2020 (2020-01-01), GR , pages 1347 - 1358, XP093069204, ISSN: 1107-3756, DOI: 10.3892/ijmm.2020.4701
DIETZ, G.P.H. BADHR, M.: "Delivery of bioactive molecules into the cell: the Trojan horse approach", MOLECULAR AND CELLULAR NEUROSCIENCES., SAN DIEGO, US, vol. 27, no. 2, 1 October 2004 (2004-10-01), US , pages 85 - 131, XP004599335, ISSN: 1044-7431, DOI: 10.1016/j.mcn.2004.03.005
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
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