Title:
COMPOSITION FOR PREVENTING OR TREATING MELAS SYNDROME, CONTAINING ISOPQUINOLINE DERIVATIVE AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2024/085618
Kind Code:
A1
Abstract:
The present invention relates to: a pharmaceutical composition for preventing or treating Melas syndrome; and the like, and has been completed by identifying that an isopquinoline derivative, discovered through mitophagy activity-based screening, exhibits an excellent mitophagy promotion effect, and thus can be used as a fundamental therapeutic agent for Melas syndrome. Particularly, an isopquinoline derivative according to the present invention promotes mitophagy activity and remarkably alleviates mitochondria dysfunction in Melas syndrome cell models and in cells derived from Melas syndrome patients. Therefore, the isopquinoline derivative is expected to be effectively used, in the field of prevention, alleviation and treatment of the disease, as a fundamental therapeutic agent capable of inhibiting the cause of Melas syndrome.
Inventors:
YUN JEANHO (KR)
CHO JONG HYUN (KR)
JUNG HYE LIM (KR)
CHOI SE MYEONG (KR)
CHO JONG HYUN (KR)
JUNG HYE LIM (KR)
CHOI SE MYEONG (KR)
Application Number:
PCT/KR2023/016082
Publication Date:
April 25, 2024
Filing Date:
October 17, 2023
Export Citation:
Assignee:
ALTMEDICAL CO LTD (KR)
UNIV DONG A RES FOUND FOR IND ACAD COOP (KR)
UNIV DONG A RES FOUND FOR IND ACAD COOP (KR)
International Classes:
A61K31/4745; A23L33/10; A61P43/00
Domestic Patent References:
| WO2016015634A1 | 2016-02-04 | |||
| WO2020177744A1 | 2020-09-10 | |||
| WO2022225108A1 | 2022-10-27 |
Foreign References:
| KR20210000682A | 2021-01-05 |
Other References:
TAJIRI MISATO, YAMADA RYO, HOTSUMI MAYUMI, MAKABE KOKI, KONNO HIROYUKI: "The total synthesis of berberine and selected analogues, and their evaluation as amyloid beta aggregation inhibitors", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 215, 1 April 2021 (2021-04-01), AMSTERDAM, NL , pages 113289, XP093106222, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2021.113289
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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