Title:
COMPOSITION COMPRISING ISOQUINOLINE DERIVATIVE AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF PARKINSON'S DISEASE
Document Type and Number:
WIPO Patent Application WO/2024/080708
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for the prevention or treatment of Parkinson's disease. Leading to the present invention, an isoquinoline derivative, identified through screening based on mitophagy activation, was found to exhibit an excellent effect in promoting mitophagy and proved to be a fundamental therapeutic agent for Parkinson's disease. Specifically, the isoquinoline derivative according to the present invention not only reduces mitochondrial dysfunction closely associated with Parkinson's disease in a Parkinson's disease animal model but also ameliorates motor function impairment in the Parkinson's disease animal model. Particularly, in the Parkinson's disease animal model treated with the isoquinoline derivative according to the present invention, the demise of dopaminergic neurons, a primary cause of Parkinson's disease, was effectively inhibited. Thus, the isoquinoline derivative according to the present invention is expected to be advantageously utilized as a fundamental therapeutic agent in the field of prevention, alleviation, and/or treatment of Parkinson's disease.
Inventors:
YUN JEANHO (KR)
CHO JONG HYUN (KR)
UM JEE-HYUN (KR)
SHIN DONG JIN (KR)
KIM YOUNG YEON (KR)
CHOI SE MYEONG (KR)
CHO JONG HYUN (KR)
UM JEE-HYUN (KR)
SHIN DONG JIN (KR)
KIM YOUNG YEON (KR)
CHOI SE MYEONG (KR)
Application Number:
PCT/KR2023/015548
Publication Date:
April 18, 2024
Filing Date:
October 10, 2023
Export Citation:
Assignee:
ALTMEDICAL CO LTD (KR)
UNIV DONG A RES FOUND FOR IND ACAD COOP (KR)
UNIV DONG A RES FOUND FOR IND ACAD COOP (KR)
International Classes:
A61K31/4745; A23L33/10; A61P25/16
Domestic Patent References:
| WO2016015634A1 | 2016-02-04 | |||
| WO2011006000A1 | 2011-01-13 |
Foreign References:
| KR20210000682A | 2021-01-05 | |||
| US20100150895A1 | 2010-06-17 |
Other References:
KOLLA RAJASEKHAR: "Antioxidant Berberine-Derivative Inhibits Multifaceted Amyloid Toxicity ", ISCIENCE, ELSEVIER, vol. 2, 24 April 2020 (2020-04-24), XP093158163, DOI: 10.1016/j.sci.2020.101005
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
Download PDF: