Title:
CITRATE SALT OF CYCLIN-DEPENDENT KINASE (CDK4/6) INHIBITOR, CRYSTAL FORM THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/067085
Kind Code:
A1
Abstract:
The present invention relates to a citrate salt of a compound of formula (I). The present invention also relates to a crystal form A, a crystal form B, a crystal form C, and a crystal form D of the citrate salt of the compound of formula (I). The present invention also relates to a pharmaceutical composition comprising at least one of the citrate salt of the compound of formula (I) of the present invention, and the crystal form A, the crystal form B, the crystal form C, and the crystal form D of the citrate salt of the compound of formula (I) of the present invention. The present invention also relates to use of the citrate salt of the present invention, the crystal form A, the crystal form B, the crystal form C, and the crystal form D of the citrate salt of the present invention, and the pharmaceutical composition of the present invention in the preparation of a drug for treating, preventing or ameliorating abnormal cell proliferation. The present invention also relates to use of the citrate salt of the present invention, the crystal form A, the crystal form B, the crystal form C, and the crystal form D of the citrate salt of the present invention, and the pharmaceutical composition of the present invention, optionally in combination with a second therapeutic agent, in the preparation of a drug for treating, preventing or ameliorating abnormal cell proliferation.
Inventors:
WANG KEXIN (CN)
PENG YUHUI (CN)
ZHU QIAOYOU (CN)
HUANG WENSHU (CN)
LIU JIUZHI (CN)
JIN MEIXIA (CN)
YU JIANGTIAN (CN)
ZHU SHUANG (CN)
PENG YUHUI (CN)
ZHU QIAOYOU (CN)
HUANG WENSHU (CN)
LIU JIUZHI (CN)
JIN MEIXIA (CN)
YU JIANGTIAN (CN)
ZHU SHUANG (CN)
Application Number:
PCT/CN2023/118429
Publication Date:
April 04, 2024
Filing Date:
September 13, 2023
Export Citation:
Assignee:
AVANC PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D495/04; A61K31/519; A61P35/00; C07C51/43; C07C59/265
Foreign References:
| CN109153686A | 2019-01-04 | |||
| CN106795179A | 2017-05-31 |
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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