Title:
CEFOPERAZONE MAGNESIUM COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/228007
Kind Code:
A1
Abstract:
The present invention relates to a cefoperazone magnesium compound, a preparation method therefor and an application thereof. A synergistic effect can be achieved by combining cefoperazone with magnesium; cefoperazone can inhibit the synthesis of pathogenic bacterium cell walls, has a strong effect on gram-negative bacteria, and significantly inhibits the synthesis of bacterial cell walls after being combined with magnesium elements; the use effect is remarkably enhanced. In the present invention, the cefoperazone magnesium compound is generated by reacting cefoperazone acid with magnesium ions, thereby improving the stability of a cefoperazone drug, and also providing a choice for patients who are clinically unsuitable for sodium salt. The cefoperazone magnesium compound in the present invention is a magnesium-containing antibiotic, has an antibacterial treatment effect and a magnesium supplement effect, has benefits to some inflammations, and has a synergistic effect. The preparation method for the cefoperazone magnesium is simple to operate, does not use organic solvents, does not generate toxic and harmful substances, has high product purity and is convenient for industrial production.
Inventors:
LIU CUIZHE (CN)
LIU JINXIA (CN)
ZHANG SHUFENG (CN)
MAO XIAOXIA (CN)
JIN PENG (CN)
BAI HONGHONG (CN)
YANG LUKUN (CN)
LIU JINXIA (CN)
ZHANG SHUFENG (CN)
MAO XIAOXIA (CN)
JIN PENG (CN)
BAI HONGHONG (CN)
YANG LUKUN (CN)
Application Number:
PCT/CN2021/092553
Publication Date:
November 18, 2021
Filing Date:
May 10, 2021
Export Citation:
Assignee:
CHENGDE MEDICAL COLLEGE (CN)
International Classes:
C07D501/36; A61K33/06; A61P29/00; A61P31/04; C07D501/04; C07D501/12
Foreign References:
| GB2028655A | 1980-03-12 | |||
| CN104327099A | 2015-02-04 | |||
| CN101007811A | 2007-08-01 | |||
| CN101012235A | 2007-08-08 | |||
| CN104610281A | 2015-05-13 |
Other References:
SONG YIN, SU YUQINGXU YAN: "Research on Synthesis of Cefoperazone Sodium by Solvent Method", vol. 8, no. 2, 15 April 1995 (1995-04-15), pages 86 - 88, XP055867421, ISSN: 1006-2882, DOI: 10.14035/j.cnki.hljyy.1995.02.015
YUAN HAILONG, LI XIANYI, WANG JINGGUO, QU JIAWEI, HAN CHANGZHENG: "Stability of Cefoperazone Sodium in Peritoneal Dialysis Solution", CHINESE JOURNAL OF HOSPITAL PHARMACY, ZHONGGUO YAO XUEHUI WUHAN FENHUI, WUHAN, CN, vol. 15, no. 2, 28 February 1995 (1995-02-28), CN , XP055867426, ISSN: 1001-5213
YUAN HAILONG, LI XIANYI, WANG JINGGUO, QU JIAWEI, HAN CHANGZHENG: "Stability of Cefoperazone Sodium in Peritoneal Dialysis Solution", CHINESE JOURNAL OF HOSPITAL PHARMACY, ZHONGGUO YAO XUEHUI WUHAN FENHUI, WUHAN, CN, vol. 15, no. 2, 28 February 1995 (1995-02-28), CN , XP055867426, ISSN: 1001-5213
Attorney, Agent or Firm:
BEIJING IP PATENT AGENCY CO. LTD (CN)
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