CARRIER FOR PROTEIN, AND PROTEIN INTRODUCTION METHOD

Title:

CARRIER FOR PROTEIN, AND PROTEIN INTRODUCTION METHOD

Document Type and Number:

WIPO Patent Application WO/2024/071180

Kind Code:

A1

Abstract:

Provided is a novel carrier for introducing a protein such as a Cas protein into cells.　A carrier for a protein according to the present invention is characterized by containing vesicles of the fruit of the Malpighiaceae plant, wherein an object to be held is a protein or a nucleic acid encoding the protein. The Malpighiaceae plant is, for example, the Malpighia sp. plant. A carrier for a protein according to the present invention can be used as, for example, a genome editing tool.

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Inventors:

KURODA MASAHIKO (JP)
UMEZU TOMOHIRO (JP)

Application Number:

PCT/JP2023/035106

Publication Date:

April 04, 2024

Filing Date:

September 27, 2023

Export Citation:

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Assignee:

UNIV TOKYO MEDICAL (JP)

International Classes:

C12N15/87; C07K17/02; C12N15/09

Domestic Patent References:

WO2021006222A1	2021-01-14
WO2020214542A1	2020-10-22

Other References:

TOMOHIRO UMEZU: "Acerola exosome-like nanovesicles to systemically deliver nucleic acid medicine via oral administration", MOLECULAR THERAPY- METHODS & CLINICAL DEVELOPMENT, NATURE PUBLISHING GROUP, GB, vol. 21, 1 June 2021 (2021-06-01), GB , pages 199 - 208, XP093157262, ISSN: 2329-0501, DOI: 10.1016/j.omtm.2021.03.006
LUIZA GARAEVA: "Delivery of functional exogenous proteins by plant-derived vesicles to human cells in vitro", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 11, no. 1, 1 January 2021 (2021-01-01), US , XP093157265, ISSN: 2045-2322, DOI: 10.1038/s41598-021-85833-y
YURY SHKRYL: "Plant Exosomal Vesicles: Perspective Information Nanocarriers in Biomedicine", APPLIED SCIENCES, MDPI SWITZERLAND, vol. 12, no. 16, 18 August 2022 (2022-08-18), pages 8262, XP093157267, ISSN: 2076-3417, DOI: 10.3390/app12168262

Attorney, Agent or Firm:

NAKAYAMA Yumi (JP)

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