Title:
CALCIUM CHANNEL BLOCKER AND SCREENING METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/104159
Kind Code:
A1
Abstract:
The present invention relates to compounds as calcium channel blocker, a composition comprising thereof, use of said compounds and a method for treating diseases or disorders associated with calcium ion channel using said compounds. The present invention also relates to an in vitro screening method of calcium channel blocker compounds.
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Inventors:
XIE MINGQI (CN)
WANG HUI (CH)
FUSSENEGGER MARTIN (CH)
WANG HUI (CH)
FUSSENEGGER MARTIN (CH)
Application Number:
PCT/CN2022/137596
Publication Date:
June 15, 2023
Filing Date:
December 08, 2022
Export Citation:
Assignee:
XIE MINGQI (CN)
WANG HUI (CH)
WANG HUI (CH)
International Classes:
C07C13/38; A61K31/015; A61K31/05; A61P9/00; A61P25/00; C07C35/27; C07C39/02; C07C39/11
Foreign References:
| JP2008081472A | 2008-04-10 | |||
| US20080248040A1 | 2008-10-09 |
Other References:
YUJI IMAIZUMI, KAZUHO SAKAMOTO, AKI YAMADA, AYA HOTTA, SUSUMU OHYA, KATSUHIKO MURAKI, MASANOBU UCHIYAMA AND TOMOHIKO OHWADA: "Molecular basis of pimarane compounds as novel activators of large-conductance Ca<2+>-activated K<+> channel [alpha]-subunit", MOLECULAR PHARMACOLOGY, AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, US, vol. 62, no. 4, 1 October 2002 (2002-10-01), US , pages 836 - 846, XP002497289, ISSN: 0026-895X, DOI: 10.1124/mol.62.4.836
DAWSON RM, GODFREY IM, HOGG RW, KNOX JR: "Synthetic Routes to Some Isotopically Labeled Intermediates for Diterpenoid Biosynthesis", AUSTRALIAN JOURNAL OF CHEMISTRY, C S I R O PUBLISHING, AU, vol. 42, no. 4, 1 January 1989 (1989-01-01), AU , pages 561 - 579, XP093071749, ISSN: 0004-9425, DOI: 10.1071/CH9890561
JIANG SU-ZHEN, MI SUI-QING, WANG NING-SHENG: "A Review on Cardiovascular Pharmacological Actions of Gingerol", LISHIZHEN MEDICINE AND MATERIA MEDICA RESEARCH., vol. 18, no. 1, 1 January 2007 (2007-01-01), pages 219 - 221, XP093071750
DAWSON RM, GODFREY IM, HOGG RW, KNOX JR: "Synthetic Routes to Some Isotopically Labeled Intermediates for Diterpenoid Biosynthesis", AUSTRALIAN JOURNAL OF CHEMISTRY, C S I R O PUBLISHING, AU, vol. 42, no. 4, 1 January 1989 (1989-01-01), AU , pages 561 - 579, XP093071749, ISSN: 0004-9425, DOI: 10.1071/CH9890561
JIANG SU-ZHEN, MI SUI-QING, WANG NING-SHENG: "A Review on Cardiovascular Pharmacological Actions of Gingerol", LISHIZHEN MEDICINE AND MATERIA MEDICA RESEARCH., vol. 18, no. 1, 1 January 2007 (2007-01-01), pages 219 - 221, XP093071750
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (CN)
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