Title:
CA-4 ANTITUMOUR DRUG, SYNTHESIS METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/020016
Kind Code:
A1
Abstract:
Disclosed are a CA-4 antitumour drug, a synthesis method and the use thereof. The CA-4 antitumour drug introduces an alkoxy group or a fluorine-containing alkoxy group at the 4' position of a natural product, i.e., combretastatin, and carries out functional chemical modification at the 3' position thereof. The CA-4 antitumour drug of the present invention has an inhibitory ability for the two targets of tubulin and aryl sulfatase and can be used for antitumour therapy.
Inventors:
WU FANHONG (CN)
HUANG LEILEI (CN)
HUANG JINWEN (CN)
LI YINGZI (CN)
XIE DA (CN)
HU MEICHEN (CN)
HUANG LEILEI (CN)
HUANG JINWEN (CN)
LI YINGZI (CN)
XIE DA (CN)
HU MEICHEN (CN)
Application Number:
PCT/CN2018/096836
Publication Date:
January 31, 2019
Filing Date:
July 24, 2018
Export Citation:
Assignee:
SHANGHAI HUALI BIOMEDICAL CO LTD (CN)
International Classes:
C07C307/02; A61P3/10; A61P9/00; A61P17/10; A61P27/02; A61P27/06; A61P31/04; A61P31/10; A61P31/18; A61P35/00; A61P37/06; C07C303/34
Foreign References:
| CN107382796A | 2017-11-24 | |||
| CN1907989A | 2007-02-07 | |||
| CN101885738A | 2010-11-17 | |||
| CN107021980A | 2017-08-08 |
Attorney, Agent or Firm:
SHANGHAI SSH INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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