Title:
BENZOIC ESTER COMPOUND
Document Type and Number:
WIPO Patent Application WO/2020/045326
Kind Code:
A1
Abstract:
The present invention provides a benzoic ester compound having an enteropeptidase inhibitory activity and a use of the compound as a medicine for the treatment or prevention of obesity, diabetes, etc. The compound is represented by formula (I) (wherein the symbols are as defined in the description). The compound or a salt thereof has an enteropeptidase inhibitory activity and is useful as a medicine for the treatment or prevention of obesity, diabetes, etc.
Inventors:
HARA RYOMA (JP)
ASANO KOHEI (JP)
NIIDA AYUMU (JP)
KASAI SHIZUO (JP)
MAEKAWA TSUYOSHI (JP)
ASANO KOHEI (JP)
NIIDA AYUMU (JP)
KASAI SHIZUO (JP)
MAEKAWA TSUYOSHI (JP)
Application Number:
PCT/JP2019/033215
Publication Date:
March 05, 2020
Filing Date:
August 26, 2019
Export Citation:
Assignee:
SCOHIA PHARMA INC (JP)
International Classes:
C07C279/18; A61K31/235; A61P3/04; A61P3/10; A61P43/00; C07C257/18
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Foreign References:
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Other References:
MASASHI MATSUSHIMA , NAOHISA YAHAGI, MASAO ICHINOSE, KAZUMASA MIKI, MASAO OMATA , HIDESHI INOUE , TAKAYUKI TAKAHASHI ,KENJI TAKAHA: "Inhibition of enteropeptidase by antitrypsin drugs", BIOMEDICAL RESEARCH, vol. 22, no. 5, 31 October 2001 (2001-10-31), Sapporo Japan , pages 257 - 260, XP055683897, ISSN: 0388-6107, DOI: 10.2220/biomedres.22.257
YASHIRO HIROAKI, HAMAGAMI KENICHI, HIYOSHI HIDEYUKI, SUGAMA JUN, TSUCHIMORI KAZUE, YAMAGUCHI FUMINARI, MORITOH YUSUKE, SASAKI MINO: "SCO‐792, an enteropeptidase inhibitor, improves disease status of diabetes and obesity in mice", DIABETES, OBESITY AND METABOLISM, vol. 21, no. 10, 30 May 2019 (2019-05-30), pages 2228 - 2239, XP009523627, ISSN: 1463-1326, DOI: 10.1111/dom.13799
MASAKO SASAKI ,IKUO MIYAHISA ,SACHIKO ITONO ,HIROAKI YASHIRO ,HIDEYUKI HIYOSHI , KAZUE TSUCHIMORI .KEN‐ICHI HAMAGAMI ,YUSUKE MORIT: "Discovery and characterization of a small‐molecule enteropeptidase inhibitor, SCO‐792", PHARMACOLOGY RESEARCH & PERSPECTIVES, vol. 7, no. 5, 4 September 2019 (2019-09-04), GB, pages 1 - 11, XP055683905, ISSN: 2052-1707, DOI: 10.1002/prp2.517
L. F. TIETZETH. EICHER: "Modern Organic Synthesis in the Laboratory: A Collection of Standard Experimental Procedures", vol. I-VII, 1989, KAGAKU-DOJIN PUBLISHING COMPANY, INC.
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE
P.J. KOCIENSKI: "Protecting Groups", 2004, THIEME MEDICAL PUBLISHERS
"Diagnosis and Classification of Diabetes Mellitus", 1999, WORLD HEALTH ORGANIZATION, article "World Health Organization: Definition, Diagnosis and Classification of Diabetes Mellitus and Its Complications"
"National Cholesterol Education Program: Executive Summary of the Third Report of National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adults Treatment Panel III", THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, vol. 285, 2001, pages 2486 - 2497
See also references of EP 3650440A4
YASHIRO HIROAKI, HAMAGAMI KENICHI, HIYOSHI HIDEYUKI, SUGAMA JUN, TSUCHIMORI KAZUE, YAMAGUCHI FUMINARI, MORITOH YUSUKE, SASAKI MINO: "SCO‐792, an enteropeptidase inhibitor, improves disease status of diabetes and obesity in mice", DIABETES, OBESITY AND METABOLISM, vol. 21, no. 10, 30 May 2019 (2019-05-30), pages 2228 - 2239, XP009523627, ISSN: 1463-1326, DOI: 10.1111/dom.13799
MASAKO SASAKI ,IKUO MIYAHISA ,SACHIKO ITONO ,HIROAKI YASHIRO ,HIDEYUKI HIYOSHI , KAZUE TSUCHIMORI .KEN‐ICHI HAMAGAMI ,YUSUKE MORIT: "Discovery and characterization of a small‐molecule enteropeptidase inhibitor, SCO‐792", PHARMACOLOGY RESEARCH & PERSPECTIVES, vol. 7, no. 5, 4 September 2019 (2019-09-04), GB, pages 1 - 11, XP055683905, ISSN: 2052-1707, DOI: 10.1002/prp2.517
L. F. TIETZETH. EICHER: "Modern Organic Synthesis in the Laboratory: A Collection of Standard Experimental Procedures", vol. I-VII, 1989, KAGAKU-DOJIN PUBLISHING COMPANY, INC.
THEODORA W. GREENEPETER G. M. WUTS: "Protective Groups in Organic Synthesis", 2007, WILEY-INTERSCIENCE
P.J. KOCIENSKI: "Protecting Groups", 2004, THIEME MEDICAL PUBLISHERS
"Diagnosis and Classification of Diabetes Mellitus", 1999, WORLD HEALTH ORGANIZATION, article "World Health Organization: Definition, Diagnosis and Classification of Diabetes Mellitus and Its Complications"
"National Cholesterol Education Program: Executive Summary of the Third Report of National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adults Treatment Panel III", THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, vol. 285, 2001, pages 2486 - 2497
See also references of EP 3650440A4
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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