Title:
ANTIOXIDANT COMPOSITION AND USE THEREOF IN NUCLEIC ACID DETECTION
Document Type and Number:
WIPO Patent Application WO/2024/050820
Kind Code:
A1
Abstract:
An antioxidant composition and the use thereof in nucleic acid detection. The present invention relates to an antioxidant composition, a reagent containing the composition, a kit containing the composition or reagent, the use of the composition or reagent as a nucleic acid protection agent in nucleic acid detection, and a method for detecting a nucleic acid. The antioxidant composition contains: a saponin compound, which is selected from one or more of notoginsenoside R1, ginsenoside Rg1, ginsenoside Rd, ginsenoside Rb2, ginsenoside Rb3, ginsenoside Rc, ginsenoside Rf and ginsenoside Re; glycyrrhizic acid, or a salt of glycyrrhizic acid, or a hydrate of a salt of glycyrrhizic acid; and adenosine 5'-monophosphate or a salt thereof, or carnosine.
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Inventors:
ZHANG ZHEN (CN)
JIA MAN (CN)
MENG YIXIN (CN)
WANG JINGJING (CN)
LI CHANGYING (CN)
WANG YAMENG (CN)
XU YINGYING (CN)
LIN JIETAO (CN)
XU CHONGJUN (CN)
JIA MAN (CN)
MENG YIXIN (CN)
WANG JINGJING (CN)
LI CHANGYING (CN)
WANG YAMENG (CN)
XU YINGYING (CN)
LIN JIETAO (CN)
XU CHONGJUN (CN)
Application Number:
PCT/CN2022/118131
Publication Date:
March 14, 2024
Filing Date:
September 09, 2022
Export Citation:
Assignee:
MGI TECH CO LTD (CN)
International Classes:
C12Q1/68; C09K15/00; C09K15/04; C09K23/56; C12Q1/6869
Domestic Patent References:
| WO2006064199A1 | 2006-06-22 |
Foreign References:
| CN101443025A | 2009-05-27 | |||
| CN112423726A | 2021-02-26 | |||
| US20140328952A1 | 2014-11-06 | |||
| CN113795595A | 2021-12-14 | |||
| CN110121563A | 2019-08-13 | |||
| CN109196113A | 2019-01-11 |
Other References:
CHEN BO,XU DE-PING: "Structure and Antioxidation Studies of Alcohol Soluble Components in Royal Jelly", FOOD AND FERMENTATION INDUSTRIES, vol. 38, no. 7, 31 December 2012 (2012-12-31), pages 124 - 127, XP009553183, ISSN: 0253-990X, DOI: 10.13995/j.cnki.11-1802/ts.2012.07.001
SONG ZHIBIN, ZHANG DANSHEN, WANG HUI, ZHU CHENGLIN: "In Vitro Antioxidant Capacity of Panax Notoginseng Saponins R1 And Effect Thereof on Serum-Deprived Neuronal Cells", ZHONGGUO YAOLIXUE YU DULIXUE ZAZHI - CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY, ZHONGGUO YAOLI XUCHUI, BEIJING, CN, vol. 26, no. 3, 30 June 2012 (2012-06-30), CN , pages 417 - 418, XP009553168, ISSN: 1000-3002
GAO YUN-TAO, ZHANG WEN-BIN ,YANG LI-RONG ,WANG XUE-MEI ,YANG YI-LIN: "Effects of Panax notoginseng Saponins on Antioxidation and Preventing DNA Damage Caused by Hydroxyl Radical", ZHONGYAOCAI - JOURNAL OF CHINESE MEDICINAL MATERIALS, GUOJIA YIYAO GUANLIJU, CN, vol. 31, no. 9, 25 September 2008 (2008-09-25), CN , pages 1399 - 1401, XP093056401, ISSN: 1001-4454, DOI: 10.13863/j.issn1001-4454.2008.09.036
HAIKUAN WANG, XINGHUAI ZHAO, YAN JIANG: "Isolation and the radical scavenging activity of the effective ingredient from licorice", FOOD AND MACHINERY, vol. 21, no. 3, 25 August 2000 (2000-08-25), pages 23 - 24, XP093147367
黄进 等 (HUANG, JIN ET AL.): "肌肽对DNA氧化损伤的作用及其机制 (Effect of Carnosine on DNA Oxidative Damage And The Mechanism Thereof)", 动物生理生化第八次学术会议论文摘要汇编 (NON-OFFICIAL TRANSLATION: COMPENDIUM OF ABSTRACTS FROM THE 8TH SYMPOSIUM ON ANIMAL PHYSIOLOGY AND BIOCHEMISTRY), 31 August 2004 (2004-08-31), pages 140 - 141
SONG ZHIBIN, ZHANG DANSHEN, WANG HUI, ZHU CHENGLIN: "In Vitro Antioxidant Capacity of Panax Notoginseng Saponins R1 And Effect Thereof on Serum-Deprived Neuronal Cells", ZHONGGUO YAOLIXUE YU DULIXUE ZAZHI - CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY, ZHONGGUO YAOLI XUCHUI, BEIJING, CN, vol. 26, no. 3, 30 June 2012 (2012-06-30), CN , pages 417 - 418, XP009553168, ISSN: 1000-3002
GAO YUN-TAO, ZHANG WEN-BIN ,YANG LI-RONG ,WANG XUE-MEI ,YANG YI-LIN: "Effects of Panax notoginseng Saponins on Antioxidation and Preventing DNA Damage Caused by Hydroxyl Radical", ZHONGYAOCAI - JOURNAL OF CHINESE MEDICINAL MATERIALS, GUOJIA YIYAO GUANLIJU, CN, vol. 31, no. 9, 25 September 2008 (2008-09-25), CN , pages 1399 - 1401, XP093056401, ISSN: 1001-4454, DOI: 10.13863/j.issn1001-4454.2008.09.036
HAIKUAN WANG, XINGHUAI ZHAO, YAN JIANG: "Isolation and the radical scavenging activity of the effective ingredient from licorice", FOOD AND MACHINERY, vol. 21, no. 3, 25 August 2000 (2000-08-25), pages 23 - 24, XP093147367
黄进 等 (HUANG, JIN ET AL.): "肌肽对DNA氧化损伤的作用及其机制 (Effect of Carnosine on DNA Oxidative Damage And The Mechanism Thereof)", 动物生理生化第八次学术会议论文摘要汇编 (NON-OFFICIAL TRANSLATION: COMPENDIUM OF ABSTRACTS FROM THE 8TH SYMPOSIUM ON ANIMAL PHYSIOLOGY AND BIOCHEMISTRY), 31 August 2004 (2004-08-31), pages 140 - 141
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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