Title:
ANTIOXIDANT BM-ZNPP FOR TREATING RECTAL CANCER, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/115647
Kind Code:
A1
Abstract:
A preparation method for an antioxidant BM-ZnPP for treating rectal cancer, comprising: S1) reacting 1,1'-carbonyldiimidazole with 4-(carboxymethyl)phenylboronic acid pinacol ester to obtain a boronated phenyl-substituted imidazole compound; S2) carrying out a conjugation reaction on the boronated phenyl-substituted imidazole compound obtained in step S1) and maltodextrin, and then performing precipitation in cold water to obtain boron-containing maltodextrin; S3) subjecting the boron-containing maltodextrin obtained in step S2) to extraction and drying to obtain BM; and S4) mixing a solution of BM and a solution of ZnPP, and emulsifying the resulting mixture by using a double emulsion method to obtain BM-ZnPP nanoparticles. The BM-ZnPP nanoparticles have significant in-vivo anti-colorectal cancer activity and can be used as potential drugs for treating colorectal cancer.
Inventors:
DAI WENXIN (CN)
XU LANG (CN)
CHEN RONG (CN)
XU YANG (CN)
FANG FANG (CN)
XU LANG (CN)
CHEN RONG (CN)
XU YANG (CN)
FANG FANG (CN)
Application Number:
PCT/CN2022/070239
Publication Date:
June 29, 2023
Filing Date:
January 05, 2022
Export Citation:
Assignee:
HAINAN HUIYUANTANG PHARMACEUTICAL CO LTD (CN)
DAI WENXIN (CN)
DAI WENXIN (CN)
International Classes:
A61K9/14; A61K31/409; A61K33/30; A61K47/36; A61P35/00; C08B30/18
Foreign References:
| KR101963327B1 | 2019-03-28 | |||
| CN112618727A | 2021-04-09 |
Other References:
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JUNG EUNKYEONG, LEE JEONGHUN, LEE YEONGJONG, SEON SEMEE, PARK MIRAN, SONG CHULGYU, LEE DONGWON: "Tumor-Targeting H 2 O 2 -Responsive Photosensitizing Nanoparticles with Antiangiogenic and Immunogenic Activities for Maximizing Anticancer Efficacy of Phototherapy", ACS APPLIED BIO MATERIALS, AMERICAN CHEMICAL SOCIETY, US, vol. 4, no. 5, 17 May 2021 (2021-05-17), US , pages 4450 - 4461, XP093073707, ISSN: 2576-6422, DOI: 10.1021/acsabm.1c00210
JUNG EUNKYEONG, KANG CHANGSUN, LEE JEONGHUN, YOO DONGHYUCK, HWANG DO WON, KIM DOHYUN, PARK SEONG-CHEOL, LIM SANG KYOO, SONG CHULGY: "Molecularly Engineered Theranostic Nanoparticles for Thrombosed Vessels: H 2 O 2 -Activatable Contrast-Enhanced Photoacoustic Imaging and Antithrombotic Therapy", ACS NANO, AMERICAN CHEMICAL SOCIETY, US, vol. 12, no. 1, 23 January 2018 (2018-01-23), US , pages 392 - 401, XP093058389, ISSN: 1936-0851, DOI: 10.1021/acsnano.7b06560
CHENG CHUN-CHIA, GUAN SIAO-SYUN, YANG HAO-JHIH, CHANG CHUN-CHAO, LUO TSAI-YUEH, CHANG JUNGSHAN, HO AI-SHENG: "Blocking heme oxygenase-1 by zinc protoporphyrin reduces tumor hypoxia-mediated VEGF release and inhibits tumor angiogenesis as a potential therapeutic agent against colorectal cancer", JOURNAL OF BIOMEDICAL SCIENCE, vol. 23, no. 18, 1 December 2016 (2016-12-01), XP093073703, DOI: 10.1186/s12929-016-0219-6
LASCHKE MATTHIAS W.; VORSTERMAN VAN OIJEN ANTONIA E.; KÖRBEL CHRISTINA; SCHEUER CLAUDIA; MENGER MICHAEL D. : "4-Hydroxybenzyl alcohol: A novel inhibitor of tumor angiogenesis and growth", LIFE SCIENCE, PERGAMON PRESS, OXFORD, GB, vol. 93, no. 1, 3 June 2013 (2013-06-03), GB , pages 44 - 50, XP028574291, ISSN: 0024-3205, DOI: 10.1016/j.lfs.2013.05.022
KANG KYOUNG, MAENG YOUNG, ZHANG RUI, YANG YOUNG, PIAO MEI, KIM KI, KIM GI, KIM YOUNG, KOH YOUNG, KANG HEE, HYUN CHANG, CHANG WEON,: "Involvement of heme oxygenase-1 in Korean colon cancer", TUMOR BIOLOGY, KARGER, BASEL, CH, vol. 33, no. 4, 3 February 2012 (2012-02-03), CH , pages 1031 - 1038, XP009547232, ISSN: 1010-4283, DOI: 10.1007/s13277-012-0336-0
JUNG EUNKYEONG, LEE JEONGHUN, LEE YEONGJONG, SEON SEMEE, PARK MIRAN, SONG CHULGYU, LEE DONGWON: "Tumor-Targeting H 2 O 2 -Responsive Photosensitizing Nanoparticles with Antiangiogenic and Immunogenic Activities for Maximizing Anticancer Efficacy of Phototherapy", ACS APPLIED BIO MATERIALS, AMERICAN CHEMICAL SOCIETY, US, vol. 4, no. 5, 17 May 2021 (2021-05-17), US , pages 4450 - 4461, XP093073707, ISSN: 2576-6422, DOI: 10.1021/acsabm.1c00210
JUNG EUNKYEONG, KANG CHANGSUN, LEE JEONGHUN, YOO DONGHYUCK, HWANG DO WON, KIM DOHYUN, PARK SEONG-CHEOL, LIM SANG KYOO, SONG CHULGY: "Molecularly Engineered Theranostic Nanoparticles for Thrombosed Vessels: H 2 O 2 -Activatable Contrast-Enhanced Photoacoustic Imaging and Antithrombotic Therapy", ACS NANO, AMERICAN CHEMICAL SOCIETY, US, vol. 12, no. 1, 23 January 2018 (2018-01-23), US , pages 392 - 401, XP093058389, ISSN: 1936-0851, DOI: 10.1021/acsnano.7b06560
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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