Title:
ANTICOAGULATION AND ANTICALCIFICATION BIOLOGICAL MATERIAL, AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/213516
Kind Code:
A1
Abstract:
An anticoagulation and anticalcification biological material, and a preparation method therefor. The preparation method comprises the following steps: introducing, on biological tissue, an active group capable of causing polymerization reaction, and then carrying out free radical copolymerization with zwitterions. By introducing, in biological tissue, an active group capable of causing free radical polymerization and enabling free radical copolymerization with a zwitterionic monomer, collagen in the biological tissue is cross-linked at multiple sites by means of a polymer, thereby achieving sufficient cross-linking within and between collagen fibers, improving the stability of the biological tissue, and prolonging the service life of the biological tissue. Moreover, zwitterions are introduced to the surface of the biological tissue, so that the anticoagulation performance can be improved, in situ endothelialization of a biological valve can be promoted, and calcium element deposition is further prevented.
Inventors:
WANG YUNBING (CN)
YANG FAN (CN)
GUO GAOYANG (CN)
YANG FAN (CN)
GUO GAOYANG (CN)
Application Number:
PCT/CN2021/089448
Publication Date:
October 28, 2021
Filing Date:
April 23, 2021
Export Citation:
Assignee:
VENUS MEDTECH HANGZHOU INC (CN)
International Classes:
A61L27/36; A61L27/24; A61L33/00; C08F220/36; C08F220/60; C08F230/02; C08F289/00
Foreign References:
| CN111481743A | 2020-08-04 | |||
| CN109820625A | 2019-05-31 | |||
| CN101128225A | 2008-02-20 | |||
| CN107617126A | 2018-01-23 |
Other References:
GUO GAOYANG, JIN LINHE, JIN WANYU, CHEN LIANG, LEI YANG, WANG YUNBING: "Radical polymerization-crosslinking method for improving extracellular matrix stability in bioprosthetic heart valves with reduced potential for calcification and inflammatory response", ACTA BIOMATERIALIA, ELSEVIER, AMSTERDAM, NL, vol. 82, 1 December 2018 (2018-12-01), AMSTERDAM, NL, pages 44 - 55, XP055839486, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.10.017
WEI-HSUAN KUO, MENG-JIY WANG, HSIU-WEN CHIEN, TA-CHIN WEI, CHIAPYNG LEE, WEI-BOR TSAI: "Surface Modification with Poly(sulfobetaine methacrylate- co -acrylic acid) To Reduce Fibrinogen Adsorption, Platelet Adhesion, and Plasma Coagulation", BIOMACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 12, no. 12, 12 December 2011 (2011-12-12), US , pages 4348 - 4356, XP055315720, ISSN: 1525-7797, DOI: 10.1021/bm2013185
WEI-HSUAN KUO, MENG-JIY WANG, HSIU-WEN CHIEN, TA-CHIN WEI, CHIAPYNG LEE, WEI-BOR TSAI: "Surface Modification with Poly(sulfobetaine methacrylate- co -acrylic acid) To Reduce Fibrinogen Adsorption, Platelet Adhesion, and Plasma Coagulation", BIOMACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 12, no. 12, 12 December 2011 (2011-12-12), US , pages 4348 - 4356, XP055315720, ISSN: 1525-7797, DOI: 10.1021/bm2013185
Attorney, Agent or Firm:
SHINY INTELLECTUAL PROPERTY FIRM (CN)
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