Title:
ANTIBODY AND CHIMERIC ANTIGEN RECEPTORS TARGETING GCC AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/067762
Kind Code:
A1
Abstract:
Provided are anti-GCC single domain antibodies (e. g., VHH domain antibodies), and chimeric antigen receptors (CARs) that bind to GCC comprising same in an extracellular antigen binding domain, a transmembrane domain, and an intracellular signaling domain. Immune cells transduced with the disclosed CAR constructs and/or a chimeric receptor can be used for cancer immunotherapy.
Inventors:
FAN XIAOHU (CN)
XU PANGLIAN (CN)
ZHUANG QIUCHUAN (CN)
WEI MIN (CN)
TANG JIANGJING (CN)
ZHENG CHENCHEN (CN)
FANG XU (CN)
XU PANGLIAN (CN)
ZHUANG QIUCHUAN (CN)
WEI MIN (CN)
TANG JIANGJING (CN)
ZHENG CHENCHEN (CN)
FANG XU (CN)
Application Number:
PCT/CN2023/122401
Publication Date:
April 04, 2024
Filing Date:
September 28, 2023
Export Citation:
Assignee:
NANJING LEGEND BIOTECH CO LTD (CN)
LEGEND BIOTECH IRELAND LTD (IE)
LEGEND BIOTECH IRELAND LTD (IE)
International Classes:
C07K16/40; A61K39/00; A61P35/00; C12N5/10; C12N15/10; C12N15/62; C12N15/867
Domestic Patent References:
| WO2022123307A1 | 2022-06-16 | |||
| WO2022123316A1 | 2022-06-16 |
Foreign References:
| CN108949789A | 2018-12-07 | |||
| CN112795584A | 2021-05-14 | |||
| US20130287783A1 | 2013-10-31 | |||
| US20130315923A1 | 2013-11-28 | |||
| US20110110936A1 | 2011-05-12 |
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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