Title:
ANTI-RCP ANTIBODY AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2024/078288
Kind Code:
A1
Abstract:
Disclosed in the present invention are an anti-RCP antibody and a preparation method therefor. The anti-RCP antibody comprises a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises a heavy chain complementarity determining region HCDR1 consisting of an amino acid sequence as shown in SEQ ID NO: 1, a heavy chain complementarity determining region HCDR2 consisting of an amino acid sequence as shown in SEQ ID NO: 2, and a heavy chain complementarity determining region HCDR3 consisting of an amino acid sequence as shown in SEQ ID NO: 3; and the light chain variable region comprises a light chain complementarity determining region LCDR1 consisting of an amino acid sequence as shown in SEQ ID NO: 4, a light chain complementarity determining region LCDR2 consisting of an amino acid sequence as shown in SEQ ID NO: 5, and a light chain complementarity determining region LCDR3 consisting of an amino acid sequence as shown in SEQ ID NO: 6. The anti-RCP antibody provided in the present invention has a biological function and can weaken the phagocytosis function of macrophages. The RCP antibody in the present invention can be used for constructing lupus-like mice.
Inventors:
YE JUNNA (CN)
ZHOU ZHUOCHAO (CN)
YOU YIJUN (CN)
SUN YUE (CN)
WANG FAN (CN)
YANG CHENGDE (CN)
ZHOU ZHUOCHAO (CN)
YOU YIJUN (CN)
SUN YUE (CN)
WANG FAN (CN)
YANG CHENGDE (CN)
Application Number:
PCT/CN2023/120276
Publication Date:
April 18, 2024
Filing Date:
September 21, 2023
Export Citation:
Assignee:
RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE (CN)
International Classes:
C07K16/40; C12N15/13
Domestic Patent References:
| WO2016077526A1 | 2016-05-19 |
Foreign References:
| CN116102652A | 2023-05-12 |
Other References:
JIN, M. ; GOLDENRING, J.R.: "The Rab11-FIP1/RCP gene codes for multiple protein transcripts related to the plasma membrane recycling system", BIOCHIMICA ET BIOPHYSICA ACTA . GENE STRUCTURE AND EXPRESSION., ELSEVIER, AMSTERDAM., NL, vol. 1759, no. 6, 1 June 2006 (2006-06-01), NL , pages 281 - 295, XP027896517, ISSN: 0167-4781
CHI HIN WONG ET AL.: "CircRTN4 promotes pancreatic cancer progression through a novel CircRNA-miRNAlncRNA pathway and stabilizing epithelialmesenchymal transition protein", MOLECULAR CANCER, vol. 21, no. 10, 4 January 2022 (2022-01-04), XP093157882, ISSN: 1476-4598
CHI HIN WONG ET AL.: "CircRTN4 promotes pancreatic cancer progression through a novel CircRNA-miRNAlncRNA pathway and stabilizing epithelialmesenchymal transition protein", MOLECULAR CANCER, vol. 21, no. 10, 4 January 2022 (2022-01-04), XP093157882, ISSN: 1476-4598
Attorney, Agent or Firm:
SHANGHAI HANGSOME INTELLECTUAL PROPERTY LTD (CN)
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