Title:
AMMONIUM OXALATE DERIVATIVE, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PHARMACEUTICAL USE OF SAME
Document Type and Number:
WIPO Patent Application WO/2024/067708
Kind Code:
A1
Abstract:
Provided are an ammonium oxalate compound represented by formula (I) or a pharmaceutically acceptable salt, an ester, an optical isomer, a tautomer, a stereoisomer, a polymorph, a solvate, a N-oxide, an isotopically labeled compound, a metabolite, a chelate, a complex, a clathrate or a prodrug thereof, and a pharmaceutical composition comprising the compound. Also provided are use of the compound as a hypoxia-inducible factor 2α (HIF-2α) inhibitor and use of the compound in the preparation of a drug for treating diseases related to hypoxia-inducible factor 2α.
Inventors:
LIU ZHIGUO (CN)
WU JIE (CN)
YE YANGLIANG (CN)
WANG HAO (CN)
WU JIE (CN)
YE YANGLIANG (CN)
WANG HAO (CN)
Application Number:
PCT/CN2023/122073
Publication Date:
April 04, 2024
Filing Date:
September 27, 2023
Export Citation:
Assignee:
SUZHOU ALPHAMA BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07D209/54; A61K31/397; A61K31/403; A61K31/438; A61P3/04; A61P3/06; A61P19/02; A61P35/00; C07D205/04; C07D207/04; C07D221/20
Domestic Patent References:
| WO2022099144A1 | 2022-05-12 | |||
| WO2007145835A2 | 2007-12-21 |
Foreign References:
| CN114901652A | 2022-08-12 | |||
| CN114948953A | 2022-08-30 | |||
| CN107072207A | 2017-08-18 | |||
| CN103319468A | 2013-09-25 | |||
| CN101765596A | 2010-06-30 | |||
| CN108570048A | 2018-09-25 |
Attorney, Agent or Firm:
FIWIS INTELLECTUAL PROPERTY LAW FIRM (CN)
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