Title:
AMINOAZOLE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2017/099237
Kind Code:
A1
Abstract:
A compound represented by formula (I) and having a property of modulating the activity of an androgen receptor, or a pharmaceutically acceptable salt of the compound. X represents S or O; Z represents (Ra)n-A-(CR13R14)0-1-(CR11R12)0-1-; A represents an aryl group or a heteroaryl group; R1 represents an alkyl group, a cycloalkyl group, an alkenyl group, an alkynyl group, an alkoxyalkyl group, an aryl group, an arylalkyl group, a heterocyclic group or a heterocyclic alkyl group; R2 represents a hydrogen atom, a halogen atom, an alkyl group, a cycloalkyl group or a phenyl group; R3 represents a hydrogen atom, a halogen atom, an alkyl group, a cycloalkyl group, an alkoxyalkyl group, an alkenyl group, an alkynyl group, a cycloalkenyl group, an aryl group, an arylalkyl group, a heterocyclic group, a heterocyclic alkyl group, an acyl group, a cycloalkylcarbonyl group, a benzoyl group, a spiroalkyl group, an adamantyl group, a silyl group or R31R32NCO-; and R4 and R5 independently represent a hydrogen atom, a halogen atom, an alkyl group, a phenyl group or a cycloalkyl group.
Inventors:
HOSODA SHINNOSUKE (JP)
UNOKI GEN (JP)
WATANABE HIDEKAZU (JP)
SASAKI KOSUKE (JP)
SHIBATA JUN (JP)
YOKOYAMA EMI (JP)
HORIE KYOHEI (JP)
TAKAGI KENICHIRO (JP)
UNOKI GEN (JP)
WATANABE HIDEKAZU (JP)
SASAKI KOSUKE (JP)
SHIBATA JUN (JP)
YOKOYAMA EMI (JP)
HORIE KYOHEI (JP)
TAKAGI KENICHIRO (JP)
Application Number:
PCT/JP2016/086784
Publication Date:
June 15, 2017
Filing Date:
December 09, 2016
Export Citation:
Assignee:
TEIJIN PHARMA LTD (JP)
International Classes:
C07D263/48; A61K31/421; A61K31/422; A61K31/4245; A61K31/426; A61K31/427; A61K31/428; A61K31/433; A61K31/4439; A61K31/454; A61K31/4709; A61K31/4725; A61K31/497; A61K31/498; A61K31/501; A61K31/5377; A61P21/00; A61P21/04; A61P43/00; C07C335/12; C07C335/18; C07D249/08; C07D277/56; C07D277/82; C07D413/12; C07D417/12
Domestic Patent References:
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| WO1999000359A1 | 1999-01-07 | |||
| WO1999000373A1 | 1999-01-07 | |||
| WO1998015530A1 | 1998-04-16 | |||
| WO2010012793A1 | 2010-02-04 | |||
| WO2006114274A1 | 2006-11-02 | |||
| WO2014017093A1 | 2014-01-30 |
Foreign References:
| JPH0680653A | 1994-03-22 | |||
| JP2005537333A | 2005-12-08 | |||
| JP2007302617A | 2007-11-22 | |||
| JPH0940607A | 1997-02-10 | |||
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| JP2009513563A | 2009-04-02 |
Other References:
MARUGAN JUAN J. ET AL.: "Evaluation of 2- thioxo-2,3,5,6,7,8-hexahydropyrimido[4,5-d] pyrimidin-4(1H)-one analogues as GAA activators", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, no. 5, 2010, pages 1880 - 1897, XP026976508
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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