AMINE SOLVATE OF SODIUM-GLUCOSE LINKED TRANSPORTER INHIBITOR, AND PREPARATION METHOD AND APPLICATION THEREOF

Title:

AMINE SOLVATE OF SODIUM-GLUCOSE LINKED TRANSPORTER INHIBITOR, AND PREPARATION METHOD AND APPLICATION THEREOF

Document Type and Number:

WIPO Patent Application WO/2017/190568

Kind Code:

A1

Abstract:

Disclosed are an amine solvate of a sodium-glucose linked transporter (SGLT) inhibitor, and a preparation method and application thereof. The SGLT inhibitor is (1S,2S,3S,4R,5S)-5-(3-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-4-ethylbenzyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol. Further provided is a crystalline compound of the amine solvate, a pharmaceutical composition comprising the amine solvate, and an application of the amine solvate in preparing an SGLT-inhibiting pharmaceutical product.

Inventors:

ZHANG LEI (CN)
WANG YUAN (CN)

Application Number:

PCT/CN2017/078309

Publication Date:

November 09, 2017

Filing Date:

March 27, 2017

Export Citation:

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Assignee:

YOUNGENE THERAPEUTICS CO LTD (CN)

International Classes:

C07H9/04; A61K31/7048; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P9/12; A61P13/12; A61P25/00; A61P27/02; C07H1/00

Domestic Patent References:

WO2015032272A1	2015-03-12
WO2015027963A1	2015-03-05

Foreign References:

CN101056853A	2007-10-17
CN104513283A	2015-04-15

Other References: