ALPROSTADIL COUPLED NITRIC OXIDE DONOR MEDICINE AND USE THEREOF

Title:

ALPROSTADIL COUPLED NITRIC OXIDE DONOR MEDICINE AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2024/082470

Kind Code:

A1

Abstract:

Provided are an alprostadil coupled nitric oxide donor compound or a pharmaceutically acceptable salt thereof. The medicine is decomposed into two active ingredients, namely alprostadil and nitric oxide, in vivo, the pharmacological action is exerted in two ways respectively, and the therapeutic effect is achieved. The medicine can significantly enhance the acting strength of the medicine, and overcome the defects of weak continuous action, insufficient activity and the like caused by large vascular irritation and short half-life period of alprostadil.

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Inventors:

LU ZHUOMIN (CN)
WANG TIANYU (CN)
LI JINHUI (CN)
TAN FENGGUI (CN)
HUANG XIAMENG (CN)
JIANG SHENG (CN)
WANG TING (CN)

Application Number:

PCT/CN2023/072259

Publication Date:

April 25, 2024

Filing Date:

January 16, 2023

Export Citation:

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Assignee:

GUANGZHOU KEMROCMED CO LTD (CN)
GUANGZHOU KEMROCMED BIOTECH CO LTD (CN)

International Classes:

C07D413/12; A61K31/5575; A61P9/10; A61P9/14; C07C405/00

Foreign References:

CN109988089A	2019-07-09
US20090088366A1	2009-04-02
CN114025768A	2022-02-08
US5625083A	1997-04-29
CN113943266A	2022-01-18
CN104470510A	2015-03-25

Other References:

SERKOV I. V. ET AL.: "1,3-Dinitrates of Cyclooxygenase Metabolites of Endocannabinoid 2-Arachidonoylglycerol. Synthesis and Properties", RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, vol. 35, no. 2, 2009-12-31, pages 225 - 232, XP055776327, DOI: 10.1134/S1068162009020113

Attorney, Agent or Firm:

BEIJING JUNYOU INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)

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