Title:
AGGREGATION-INDUCED EMISSION MG-RHO FLUORESCENT DYE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/065501
Kind Code:
A1
Abstract:
Provided are an aggregation-induced emission MG-Rho fluorescent dye, and a preparation method therefor and the use thereof. The synthetic route comprises: subjecting potassium carbonate, MG-B and Br-Rho to a reaction to generate a crude product A, then dissolving the crude product A in a solvent, adding tetrachloro-p-benzoquinone, reacting same to obtain a crude product B, and purifying the crude product B to obtain an aggregation-induced emission MG-Rho fluorescent dye. Due to the fact that there are two quaternary ammonium salt groups in the structure of the aggregation-induced emission MG-Rho fluorescent dye, the molecules have excellent water solubility and can be successfully applied to the ultrafast, wash-free and low-phototoxicity imaging of living cells, which will greatly assist in biological research related to living cells.
Inventors:
ZHANG PENGFEI (CN)
LUO YUAN (CN)
CAI LINTAO (CN)
LUO YUAN (CN)
CAI LINTAO (CN)
Application Number:
PCT/CN2021/138008
Publication Date:
April 27, 2023
Filing Date:
December 14, 2021
Export Citation:
Assignee:
SHENZHEN INST ADV TECH (CN)
International Classes:
C07D311/90; C09B11/28; C09K11/06; G01N21/64
Foreign References:
| CN105199713A | 2015-12-30 |
Other References:
QI QINGKAI, HUANG LU, YANG RUNQING, LI JIN, QIAO QINGLONG, XU BIN, TIAN WENJING, LIU XIAOGANG, XU ZHAOCHAO: "Rhodamine-naphthalimide demonstrated a distinct aggregation-induced emission mechanism: elimination of dark-states via dimer interactions (EDDI)", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 55, no. 10, 29 January 2019 (2019-01-29), UK , pages 1446 - 1449, XP093058510, ISSN: 1359-7345, DOI: 10.1039/C8CC09212E
LIU XUEDAN, MA CHUNRAN, LI AISEN, XU WEIQING, MA ZHIYONG, JIA XINRU: "Schiff base-bridged TPE-rhodamine dyad: facile synthesis, distinct response to shearing and hydrostatic pressure, and sequential multicolored acidichromism", JOURNAL OF MATERIALS CHEMISTRY C, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 7, no. 27, 11 July 2019 (2019-07-11), GB , pages 8398 - 8403, XP093058511, ISSN: 2050-7526, DOI: 10.1039/C9TC02113B
TATSUMI YUTO, FUJINAGA NORIKO, KASUNO MEGUMI, MORIMOTO MASAKAZU, YOKOJIMA SATOSHI, NAKAMURA SHINICHIRO, UCHIDA KINGO: "A photo- and halochromic multicolor switching system consisting of diarylethene and malachite green moieties", NEW JOURNAL OF CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 38, no. 12, 1 December 2014 (2014-12-01), GB , pages 5706 - 5714, XP093058512, ISSN: 1144-0546, DOI: 10.1039/C4NJ00434E
LIU XUEDAN, MA CHUNRAN, LI AISEN, XU WEIQING, MA ZHIYONG, JIA XINRU: "Schiff base-bridged TPE-rhodamine dyad: facile synthesis, distinct response to shearing and hydrostatic pressure, and sequential multicolored acidichromism", JOURNAL OF MATERIALS CHEMISTRY C, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 7, no. 27, 11 July 2019 (2019-07-11), GB , pages 8398 - 8403, XP093058511, ISSN: 2050-7526, DOI: 10.1039/C9TC02113B
TATSUMI YUTO, FUJINAGA NORIKO, KASUNO MEGUMI, MORIMOTO MASAKAZU, YOKOJIMA SATOSHI, NAKAMURA SHINICHIRO, UCHIDA KINGO: "A photo- and halochromic multicolor switching system consisting of diarylethene and malachite green moieties", NEW JOURNAL OF CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 38, no. 12, 1 December 2014 (2014-12-01), GB , pages 5706 - 5714, XP093058512, ISSN: 1144-0546, DOI: 10.1039/C4NJ00434E
Attorney, Agent or Firm:
BEIJING ZHONG XUN TONG DA INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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