Title:
AGENT FOR PREVENTING OR AMELIORATING NEUROPATHY
Document Type and Number:
WIPO Patent Application WO/2024/090549
Kind Code:
A1
Abstract:
Provided is an agent for preventing or ameliorating neuropathy caused by decreased nerve function due to nerve damage or diabetic neuropathy. The agent for preventing or ameliorating neuropathy is obtained by combining one or more lactone compounds represented by formulae (1a) and (1b) and one or more substances from among hydroxybenzoic acid compounds represented by formula (2) and salts thereof. (In the formulas, R1 represents a hydrogen atom or a hydroxy group and R2 represents a hydrogen atom or a methyl group).
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Inventors:
MOTOHASHI HIROAKI (JP)
SUGITA SATOSHI (JP)
MINEGISHI YOSHIHIKO (JP)
NOJI SAYAKA (JP)
SAITO KEITA (JP)
KAWASAKI AKIKO (JP)
SUGITA SATOSHI (JP)
MINEGISHI YOSHIHIKO (JP)
NOJI SAYAKA (JP)
SAITO KEITA (JP)
KAWASAKI AKIKO (JP)
Application Number:
PCT/JP2023/038861
Publication Date:
May 02, 2024
Filing Date:
October 27, 2023
Export Citation:
Assignee:
KAO CORP (JP)
International Classes:
A61K31/192; A23L33/10; A61K31/365; A61K31/366; A61P21/02; A61P25/00; A61P25/02; A61P25/04; A61P43/00
Foreign References:
| JPH1171271A | 1999-03-16 | |||
| JP2022171558A | 2022-11-11 |
Other References:
JAYASINGH CHELLAMMAL HANISH SINGH: "Cognitive effects of vanillic acid against streptozotocin-induced neurodegeneration in mice", PHARMACEUTICAL BIOLOGY, SWETS AND ZEITLINGER, LISSE,, NL, vol. 53, no. 5, 4 May 2015 (2015-05-04), NL , pages 630 - 636, XP093165731, ISSN: 1388-0209, DOI: 10.3109/13880209.2014.935866
KHAN HEENA; GREWAL AMARJOT KAUR; KUMAR MANISH; SINGH THAKUR GURJEET: "Pharmacological Postconditioning by Protocatechuic Acid Attenuates Brain Injury in Ischemia–Reperfusion (I/R) Mice Model: Implications of Nuclear Factor Erythroid-2-Related Factor Pathway", NEUROSCIENCE, NEW YORK, NY, US, vol. 491, 18 March 2022 (2022-03-18), US , pages 23 - 31, XP087058375, ISSN: 0306-4522, DOI: 10.1016/j.neuroscience.2022.03.016
HONG-XIA CHANG: "Protocatechuic acid as an inhibitor of the JNK/CXCL1/CXCR2 pathway relieves neuropathic pain in CCI rats", BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES, ASSOCIATION OF BASIC MEDICAL SCIENCES OF FBIH, SARAJEVO , BOSNIA, vol. 22, no. 2, 23 November 2021 (2021-11-23), Sarajevo , Bosnia , pages 217 - 228, XP093165733, ISSN: 1512-8601, DOI: 10.17305/bjbms.2021.5928
JUNXI DAI: "Ficus carica L. Attenuates Denervated Skeletal Muscle Atrophy via PPARα/NF-κB Pathway", FRONTIERS IN PHYSIOLOGY, FRONTIERS RESEARCH FOUNDATION, CH, vol. 11, 3 December 2020 (2020-12-03), CH , pages 580223, XP093165735, ISSN: 1664-042X, DOI: 10.3389/fphys.2020.580223
KHAN HEENA; GREWAL AMARJOT KAUR; KUMAR MANISH; SINGH THAKUR GURJEET: "Pharmacological Postconditioning by Protocatechuic Acid Attenuates Brain Injury in Ischemia–Reperfusion (I/R) Mice Model: Implications of Nuclear Factor Erythroid-2-Related Factor Pathway", NEUROSCIENCE, NEW YORK, NY, US, vol. 491, 18 March 2022 (2022-03-18), US , pages 23 - 31, XP087058375, ISSN: 0306-4522, DOI: 10.1016/j.neuroscience.2022.03.016
HONG-XIA CHANG: "Protocatechuic acid as an inhibitor of the JNK/CXCL1/CXCR2 pathway relieves neuropathic pain in CCI rats", BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES, ASSOCIATION OF BASIC MEDICAL SCIENCES OF FBIH, SARAJEVO , BOSNIA, vol. 22, no. 2, 23 November 2021 (2021-11-23), Sarajevo , Bosnia , pages 217 - 228, XP093165733, ISSN: 1512-8601, DOI: 10.17305/bjbms.2021.5928
JUNXI DAI: "Ficus carica L. Attenuates Denervated Skeletal Muscle Atrophy via PPARα/NF-κB Pathway", FRONTIERS IN PHYSIOLOGY, FRONTIERS RESEARCH FOUNDATION, CH, vol. 11, 3 December 2020 (2020-12-03), CH , pages 580223, XP093165735, ISSN: 1664-042X, DOI: 10.3389/fphys.2020.580223
Attorney, Agent or Firm:
ARUGA PATENT OFFICE (JP)
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