Acid dyes, process for the production thereof and their use

The present invention relates to the technical field of dyestuffs for dyeing and printing of hydroxyl- and/or carboxamido-containing material.

Acid dyes with bridging groups are known from prior art and can be used as colorants in different applications, see for example GB 1 ,331 ,445, DE 34 16 327, US 3,979,378, US 5,543,259, US 2009/207287 A1 , WO2010/000780 and CN 101337925 A. Acid dyes with pyridine couplers are known from the prior art and can be used as colorants in different applications, see for example US 3,959,250, US 5,468,848 and WO 2007/045825. However, in the context of the dyeing and printing of hydroxyl- and/or carboxamido- containing material the known dyes have a number of technical disadvantages, which require improvement. One such disadvantage is, that many of them are comprising heavy metals such as Cu, Cr or Ni. Such heavy metals are critical from a toxicological as well as an environmental point of view and shall thus be excluded.

Surprisingly, it has now been found that the dyes of the formula (I) as described below show highly advantageous properties over the known dyes. These include high tinctorial strength with high brilliancy as well as high fastness properties such as wash, contact and light fastness on the materials mentioned above, on blends containing them as well as on microfibres. Most importantly, dyes of formula (I) are substantially heavy metal free and provide dyeings that are levelled. Metals may only be present as counter ions and are selected from the groups of alkali and earth alkali metals, which do not have such effects as heavy metals. The present invention refers to dye(s) of formula (I)

(Ma) or formula II b,

(lib) Y ² is formula Ilia

(Ilia)

or formula Illb,

(Illb)

R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ and R ⁸ independent of each other is hydrogen, alkyi, alkoxy, halogen, trifluoromethyl or SO3M,

- whereby at least two of them are SO3M, R ⁹ , R ¹⁰ , R ^{1 1} , R ¹² , R ¹³ , R ¹⁴ , R ¹⁵ , R ¹⁶ independent of each other is hydrogen, alkyi, substituted alkyi, alkyi interrupted by one or two heteroatoms selected from the group consisting of oxygen and sulphur, alkoxy, substituted alkoxy, halogen, trifluoromethyl, cycloalkyl, heterocycloalkyl, cyano, acyloxy, alkylcarbonyl, acylamino, alkylsulfonyl- amino, amino, monoalkyl-amino, monocycloalkyl-amino, dialkyl-amino, di(cyclo)alkyl- amino, alkylthio, alkylsulfonyl, alkoxycarbonyl, carbamoyl, sulfamoyi, ureido, -SO3M or alkylureido,

R ¹⁷ and R ²⁰ independent of each other is hydrogen, alkyi, alkenyl, cycloalkyl, trifluoromethyl, aryl, heteroaryl, heterocycloalkyl, carbamoyl, N-monocycloalkyl-carba- moyl, N-monoalkyl-carbamoyl, N,N-dicycloalkyl-carbamoyl, Ν,Ν-dialkyl-carbamoyl, N- monoaryl-carbamoyl, Ν,Ν-diaryl-carbamoyl, N-monocycloalkyl-N-monoarylcarbamoyl, N-monoalkyl-N-monoarylcarbamoyl, sulfamoyi, N-monocycloalkyl-sulfamoyl, N- monoalkyl-sulfamoyl, Ν,Ν-dicycloalkyl-sulfamoyl, Ν,Ν-dialkyl-sulfamoyl, N-monoaryl- sulfamoyl, Ν,Ν-diaryl-sulfamoyl, N-monocycloalkyl-N-nnonoarylsulfannoyl, N- monoalkyl-N-nnonoaryl-sulfannoyl, amino, N-acylamino, N-thioacylamino, ureido, alkylureido, phenylureido, N-monoalkylamino, Ν,Ν-dialkyl-amino, N-arylamino, N,N- diarylamino, N-alkyl-N-aryl-amino, N-monocycloalkylamino, Ν,Ν-dicycloalkylamino, N- alkyl-N-cycloalkyl-amino, N-aryl-N-cycloalkyl-amino, N-heteroarylamino, N- heterocycloalkylamino, hydroxyalkylsulfonylalkyl

or

alkyi interrupted by one or more heteroatoms selected from the group consisting of oxygen and sulphur

or

alkyi substituted by one or more substituents selected from the group consisting of hydroxy, aryl, cycloalkyl, alkoxy, thioalkoxy, amino, N-monoalkyl-amino, N,N-dialkyl- amino, N-monoaryl-amino, Ν,Ν-diaryl-amino, N-alkyl-N-aryl-amino, N-monocycloalkyl- amino, Ν,Ν-dicycloalkyl-amino, N-monoalkyl-monocycloalkyl-amino, N,N-monoaryl- monocycloalkyl-amino, N-acylamino, N-alkylsulfonyl-amino, ureido, alkylureido, phenylureido, halogen, cyano, COOM, nitro, acyl, thioacyl, alkylsulfonyl, aryloyl, trifluoromethyl, heteroaryl, heterocycloalkyl, alkoxycarbonyl, alkoxythiocarbonyl, acyloxy, aryloyloxy, carbamoyl, N-monocycloalkyl-carbamoyl, N-monoalkyl- carbamoyl, N,N-dicycloalkyl-carbamoyl, Ν,Ν-dialkyl-carbamoyl, N-monoaryl- carbamoyl, Ν,Ν-diaryl-carbamoyl, N-monocycloalkyl-N-monoarylcarbamoyl, N- monoalkyl-N-monoaryl-carbamoyl, sulfamoyl, N-monocycloalkyl-sulfamoyl, N- monoalkyl-sulfamoyl, N,N-dicycloalkyl-sulfamoyl, Ν,Ν-dialkyl-sulfamoyl, N-monoaryl- sulfamoyl, Ν,Ν-diaryl-sulfamoyl, N-monocycloalkyl-N-monoarylsulfamoyl, N- monoalkyl-N-monoarylsulfamoyl and SO3M,

or

alkyi interrupted by one or more heteroatoms selected from the group consisting of oxygen and sulphur and substituted by one or more substituents selected from the group consisting of hydroxy, aryl, cycloalkyl, alkoxy, thioalkoxy, amino, N-monoalkyl- amino, Ν,Ν-dialkyl-amino, N-monoaryl-amino, Ν,Ν-diaryl-amino, N-alkyl-N-aryl-amino, N-monocycloalkyl-amino, Ν,Ν-dicycloalkyl-amino, N-monoalkyl-monocycloalkyl- amino, Ν,Ν-monoaryl-monocycloalkyl-amino, N-acylamino, N-alkylsulfonyl-amino, ureido, alkylureido, phenylureido, halogen, cyano, COOM, nitro, acyl, thioacyl, alkylsulfonyl, aryloyl, trifluoromethyl, heteroaryl, heterocycloalkyl, alkoxycarbonyl, alkoxythiocarbonyl, acyloxy, aryloyloxy, carbamoyl, N-monocycloalkyl-carbamoyl, N- monoalkyl-carbamoyl, N,N-dicycloalkyl-carbamoyl, Ν,Ν-dialkyl-carbamoyl, N- monoaryl-carbamoyl, Ν,Ν-diaryl-carbamoyl, N-monocycloalkyl-N-monoarylcarbamoyl, N-monoalkyl-N-monoaryl-carbamoyl, sulfamoyl, N-monocycloalkyl-sulfamoyl, N- monoalkyl-sulfamoyl, N,N-dicycloalkyl-sulfamoyl, Ν,Ν-dialkyl-sulfamoyl, N-monoaryl- sulfamoyl, Ν,Ν-diaryl-sulfamoyl, N-monocycloalkyl-N-monoarylsulfamoyl, N- monoalkyl-N-monoarylsulfamoyl and SO3M,

R ¹⁸ and R ²¹ independent of each other is cyano, carbamoyl, substituted carbamoyl, alkoxycarbonyl, trifluoromethyl, carbonyltrifluoromethyl, alkylsulfonyl, halogen, alkylsulfonic acid or SO3M,

R ¹⁹ and R ²² independent of each other is hydrogen, alkyl, cycloalkyl, trifluoromethyl, alkoxy, cyano, carbamoyl, alkoxycarbonyl, COOM, amino, hydroxyl, monocycloalkyl- amino, monoalkyl-amino, di(cyclo)alkyl-amino, dialkyl-amino, monoaryl-amino, diaryl- amino, monocycloalkylmonoarylamino, monoalkyl monoaryl amino, alkylthio, arylthio or

is alkyl substituted by one or more substituents selected from the group consisting of hydroxy, cycloalkyl, heteroaryl, heterocycloalkyl, aryl, aryloxy, alkoxy, alkylthio, arylthio, halogen, cyano, COOM, alkoxycarbonyl, acyloxy, carbamoyl, nitro, amino, acylamino, arylcarbonylamino, alkylsulfonylamino, arylsulfonylamino, ureido, alkyl- ureido and phenylureido,

R ²³ and R ²⁹ independent of each other is hydrogen, alkyl, cycloalkyl, trifluoromethyl, alkoxy, cyano, carbamoyl, alkoxycarbonyl, COOM, amino, hydroxyl, monocycloalkyl- amino, monoalkyl-amino, di(cyclo)alkyl-amino, dialkyl-amino, monoaryl-amino, diaryl- amino, monocycloalkylmonoarylamino, monoalkyl monoaryl amino, alkylthio, arylthio or

is alkyl substituted by one or more substituents selected from the group consisting of hydroxy, cycloalkyl, heteroaryl, heterocycloalkyl, aryl, aryloxy, alkoxy, alkylthio, arylthio, halogen, cyano, COOM, alkoxycarbonyl, acyloxy, carbamoyl, nitro, amino, acylamino, arylcarbonylamino, alkylsulfonylamino, arylsulfonylamino, ureido, alkyl- ureido and phenylureido, R ²⁴ and R ³⁰ independent of each other is cyano, carbamoyl, substituted carbamoyl, alkoxycarbonyl, trifluoromethyl, carbonyltrifluoromethyl or halogen,

R ²⁵ , R ²⁶ , R ²⁷ , R ²⁸ , R ³¹ , R ³² , R ³³ and R ³⁴ independent of each other is hydrogen, alkyi, hydroxyalkyl, alkoxy, alkenyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, carbamoyl, alkylureido, phenylureido, hydroxyakylsulfonylalkyl, aminoalkyl, amino-hydroxy-alkyl, alkoxyalkylaminoalkyl, thioalkoxyalkyl-aminoalkyl, aminoalkyloxyalkyl, amino- alkylthioxyalkyl, cycloalkylalkyl, aryloxyalkyl, arylthioxyalkyl, heteroarylalkyl, heterocycloalkylalkyl

or

alkyi interrupted by one or more heteroatoms selected from the group consisting of oxygen and sulfur

or

alkyi substituted by one or more substituents selected from the group consisting of hydroxy, aryl, cycloalkyl, alkoxy, thioalkoxy, amino, N-monoalkyl-amino, N,N-dialkyl- amino, N-monoaryl-amino, Ν,Ν-diaryl-amino, N-alkyl-N-aryl-amino, N-monocycloalkyl- amino, Ν,Ν-dicycloalkyl-amino, N-monoalkyl-monocycloalkyl-amino, N,N-monoaryl- monocycloalkyl-amino, N-acylamino, N-alkylsulfonyl-amino, ureido, alkylureido, phenyilureido, halogen, cyano, COOM, nitro, acyl, thioacyl, alkylsulfonyl, aryloyl, trifluoromethyl, heteroaryl, heterocycloalkyl, alkoxycarbonyl, alkoxythiocarbonyl, acyl- oxy, aryloyloxy, carbamoyl, N-monocycloalkyl-carbamoyl, N-monoalkyl-carbamoyl, N,N-dicycloalkyl-carbamoyl, Ν,Ν-dialkyl-carbamoyl, N-monoaryl-carbamoyl, N,N-di- aryl -carbamoyl, N-monocycloalkyl-N-monoarylcarbamoyl, N-monoalkyl-N-monoaryl- carbamoyl, sulfamoyl, N-monocycloalkyl-sulfamoyl, N-monoalkyl-sulfamoyl, N,N- dicycloalkyl-sulfamoyl, Ν,Ν-dialkyl-sulfamoyl, N-monoaryl-sulfamoyl, N,N-diaryl- sulfamoyl, N-monocycloalkyl-N-monoarylsulfamoyl, N-monoalkyl-N-monoarylsulfamo- yl and SO ₃ M

or

alkyi interrupted by one or more heteroatoms selected from the group consisting of oxygen and sulfur and substituted by one or more substituents selected from the group consisting of hydroxy, aryl, cycloalkyl, alkoxy, thioalkoxy, amino, N-monoalkyl-amino, Ν,Ν-dialkyl-amino, N-monoaryl-amino, Ν,Ν-diaryl-amino, N-alkyl-N-aryl-amino, N- monocycloalkyl-amino, Ν,Ν-dicycloalkyl-amino, N-monoalkyl-monocycloalkyl-amino, Ν,Ν-monoaryl-monocycloalkyl-amino, N-acylamino, N-alkylsulfonyl-amino, ureido, alkylureido, phenyilureido, halogen, cyano, COOM, nitro, acyl, thioacyl, alkylsulfonyl, aryloyl, thfluoromethyl, heteroaryl, heterocycloalkyl, alkoxycarbonyl, alkoxythiocarbonyl, acyloxy, aryloyloxy, carbamoyl, N-monocycloalkyl-carbamoyl, N- monoalkyl-carbamoyl, N,N-dicycloalkyl-carbamoyl, Ν,Ν-dialkyl-carbamoyl, N- monoaryl-carbamoyl, Ν,Ν-diaryl-carbamoyl, N-monocycloalkyl-N-monoarylcarbamoyl, N-monoalkyl-N-monoaryl-carbamoyl, sulfamoyl, N-monocycloalkyl-sulfamoyl, N- monoalkyl-sulfamoyl, N,N-dicycloalkyl-sulfamoyl, Ν,Ν-dialkyl-sulfamoyl, N-monoaryl- sulfamoyl, Ν,Ν-diaryl-sulfamoyl, N-monocycloalkyl-N-monoarylsulfamoyl, N- monoalkyl-N-monoarylsulfamoyl and SO3M,

M is hydrogen, an alkali metal, ammonium, one equivalent of an alkali earth metal or a monovalent organic cation, the dyes of formula (I) have two to six sulfonic acid groups and whereby the bonds with unfixed attachment points on the pyridine couplers mean that the amino rests bearing the substituents R ²⁵ , R ²⁶ , R ²⁷ and R ²⁸ , respectively can be positioned ortho or para to R ²⁴ , meaning that when the amino rest bearing the substituents R ²⁵ and R ²⁶ is positioned ortho to R ²⁴ , the amino rest bearing the substituents R ²⁷ to R ²⁸ is positioned para to R ²⁴ , and vice versa;

and

the same applies to the amino rests bearing the substituents R ³¹ , R ³² , R ³³ to R ³⁴ , respectively that can be positioned ortho or para to R ³⁰ , meaning that when the amino rest bearing the substituents R ³¹ and R ³² is positioned ortho to R ³⁰ , the amino rest bearing the substituents R ³³ to R ³⁴ is positioned para to R ³⁰ , and vice versa.

This invention refers to all tautomeric and geometric isomers of the dyes of formula (I).

Alkyl groups appearing in this invention may be straight-chain or branched and are (Ci Ci2)-alkyl groups, preferably (Ci-C8)-alkyl groups, for example n-butyl, isobutyl, n pentyl, isopentyl, n-hexyl, 2-ethylhexyl, sec-butyl, tert-butyl and methylbutyl. The same applies to alkoxy groups which accordingly are preferably (Ci-C8)-alkoxy, for example methoxy and ethoxy, to thioalkoxy groups, which are preferably (Ci-Cs)- thioalkoxy, for example -SCH3 or -SC2H5. Cycloalkyl groups are preferably (C3-C8)-cycloalkyl and especially preferably cyclopentyl and cyclohexyl. The term cycloalkyl comprises for the purpose of the present invention substituted cycloalkyl groups and unsaturated cycloalkyl groups as well. A preferred group of this type is cyclopentenyl. Preferred substituents are alkyl, hydroxyalkyl, halogen, hydroxyl, alkoxy, acyl, cyano, nitro, amino, monoalkylamino, dialkylamino, mono(hydroxyalkyl)amino, bis-(hydroxyalkyl)amino, monoalkyl-mono- (hydroxyalkyl)amino, carbamoyl, sulfamoyl, acylamino, ureido, aminosulfonylamino, alkoxycarbonyl and acyloxy.

Alkenyl groups may be straight-chain or branched and are preferably (C2-C6)-g roups for example vinyl and allyl. The term alkenyl comprises for the purpose of the present invention alkynyl groups as well, for example ethynyl and propargyl.

Aryl groups appearing in this invention are preferably phenyl or naphthyl. The terms phenyl and naphthyl comprise unsubstituted as well as substituted phenyl and naphthyl. Preferred substituents are alkyl, cycloalkyl, heterocycloalkyl, hydroxyalkyl, halogen, hydroxyl, alkoxy, alkylthio, acyl, nitro, cyano, amino, monoalkylamino, dialkylamino, mono(hydroxyalkyl)amino, bis (hydroxyalkyl)amino, monoalkyl-mono- (hydroxyalkyl)amino, carbamoyl, sulfamoyl, acylamino, ureido, aminosulfonylamino, alkoxycarbonyl and acyloxy.

Heteroaryl groups appearing in this invention are preferably pyridine, pyrimidine, pyridazine, pyrazine, pyrrole, imidazole, pyrazole, 1 ,2,4-thiadiazole, 1 ,2,4-triazole, tetrazole, thiophene, thiazole, isothiazole, benzothiazole, benzoisothiazole, 1 ,3,4- thiadiazole, furane, oxazole, benzoxazole or isoxazole. The terms heteroayl comprises the above groups in unsubstituted as well as in substituted form. Preferred substituents are alkyl, hydroxyalkyl, halogen, hydroxyl, alkoxy, alkylthio, acyl, nitro, cyano, amino, monoalkylamino, dialkylamino, mono(hydroxyalkyl)amino, bis (hydroxyalkyl)amino, monoalkyl-mono(hydroxyalkyl)amino, carbamoyl, sulfamoyl, acylamino, ureido, aminosulfonylamino, alkoxycarbonyl and acyloxy. Heterocycloalkyi groups are preferably pyrrolidine, piperidine, morpholine, tetrahydrofuran or piperazine. The terms heterocycloalkyi comprises the above groups in unsubstituted as well as in substituted form. Preferred substituents are alkyl, hydroxyalkyl, halogen, hydroxyl, alkoxy, alkylthio, acyl, nitro, cyano, amino, monoalkylamino, dialkylamino, mono(hydroxyalkyl)amino, bis (hydroxyalkyl)amino, monoalkyl-mono(hydroxyalkyl)amino, carbamoyl, sulfamoyl, acylamino, amino- carbonylamino, aminosulfonylamino, alkoxycarbonyl and acyloxy. Halogen is preferably chlorine, bromine or fluorine.

M is preferably hydrogen, lithium, sodium, potassium or mono-, di-, tri- or tetra-(Ci-C ₄ )- alkylammonium. There exist some groups of preferred dyes. In one group of preferred dyes Y ¹ is a group of formula (I la) and Y ² is a group of formula (Ilia). In another preferred group of dyes Y ¹ is a group of formula (Mb) and Y ² is a group of formula (1Mb). Also dyes wherein Y ¹ is a group of formula (I la) and Y ² is a group of formula (1Mb) or the other way round forms a preferred embodiment of the present invention.

Accordingly dye(s) of formula (1 )

(Ilia) R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ and R ⁸ independent of each other is hydrogen, alkyi, alkoxy, halogen, trifluoromethyl or SO3M, whereby at least two of them are SO3M,

R ⁹ , R ¹⁰ , R ^{1 1} , R ¹² , R ¹³ , R ¹⁴ , R ¹⁵ , R ¹⁶ independent of each other is hydrogen, alkyi, substituted alkyi, alkyi interrupted by one or two heteroatoms selected from the group consisting of oxygen and sulphur, alkoxy, substituted alkoxy, halogen, trifluoromethyl, cycloalkyl, heterocycloalkyl, cyano, acyloxy, alkylcarbonyl, acylamino, alkylsulfonyl- amino, amino, monoalkyl-amino, monocycloalkyl-amino, dialkyl-amino, di(cyclo)alkyl- amino, alkylthio, alkylsulfonyl, alkoxycarbonyl, carbamoyl, sulfamoyi, ureido, -SO3M or alkylureido,

R ¹⁷ and R ²⁰ independent of each other is hydrogen, alkyi, alkenyl, cycloalkyl, trifluoromethyl, aryl, heteroaryl, heterocycloalkyl, carbamoyl, N-monocycloalkyl-carba- moyl, N-monoalkyl-carbamoyl, N,N-dicycloalkyl-carbamoyl, Ν,Ν-dialkyl-carbamoyl, N- monoaryl-carbamoyl, Ν,Ν-diaryl-carbamoyl, N-monocycloalkyl-N-monoarylcarbamoyl, N-monoalkyl-N-monoarylcarbamoyl, sulfamoyi, N-monocycloalkyl-sulfamoyl, N- monoalkyl-sulfamoyl, N,N-dicycloalkyl-sulfamoyl, Ν,Ν-dialkyl-sulfamoyl, N-monoaryl- sulfamoyl, Ν,Ν-diaryl-sulfamoyl, N-monocycloalkyl-N-monoarylsulfamoyl, N- monoalkyl-N-monoaryl-sulfamoyl, amino, N-acylamino, N-thioacylamino, ureido, alkylureido, phenylureido, N-monoalkylamino, Ν,Ν-dialkyl-amino, N-arylamino, N,N- diarylamino, N-alkyl-N-aryl-amino, N-monocycloalkylamino, Ν,Ν-dicycloalkylamino, N- alkyl-N-cycloalkyl-amino, N-aryl-N-cycloalkyl-amino, N-heteroarylamino, N- heterocycloalkylamino, hydroxyalkylsulfonylalkyl

or

alkyi interrupted by one or more heteroatoms selected from the group consisting of oxygen and sulphur

or

alkyi substituted by one or more substituents selected from the group consisting of hydroxy, aryl, cycloalkyl, alkoxy, thioalkoxy, amino, N-monoalkyl-amino, N,N-dialkyl- amino, N-monoaryl-amino, Ν,Ν-diaryl-amino, N-alkyl-N-aryl-amino, N-monocycloalkylamino, Ν,Ν-dicycloalkyl-amino, N-monoalkyl-monocycloalkyl-amino, N,N-monoaryl- monocycloalkyl-amino, N-acylamino, N-alkylsulfonyl-amino, ureido, alkylureido, phenylureido, halogen, cyano, COOM, nitro, acyl, thioacyl, alkylsulfonyl, aryloyl, trifluoromethyl, heteroaryl, heterocycloalkyl, alkoxycarbonyl, alkoxythiocarbonyl, acyloxy, aryloyloxy, carbamoyl, N-monocycloalkyl-carbamoyl, N-monoalkyl- carbamoyl, N,N-dicycloalkyl-carbamoyl, Ν,Ν-dialkyl-carbamoyl, N-monoaryl- carbamoyl, Ν,Ν-diaryl-carbamoyl, N-monocycloalkyl-N-monoarylcarbamoyl, N- monoalkyl-N-monoaryl-carbamoyl, sulfamoyl, N-monocycloalkyl-sulfamoyl, N- monoalkyl-sulfamoyl, N,N-dicycloalkyl-sulfamoyl, Ν,Ν-dialkyl-sulfamoyl, N-monoaryl- sulfamoyl, Ν,Ν-diaryl-sulfamoyl, N-monocycloalkyl-N-monoarylsulfamoyl, N- monoalkyl-N-monoarylsulfamoyl and SO3M,

or

alkyl interrupted by one or more heteroatoms selected from the group consisting of oxygen and sulphur and substituted by one or more substituents selected from the group consisting of hydroxy, aryl, cycloalkyl, alkoxy, thioalkoxy, amino, N-monoalkyl- amino, Ν,Ν-dialkyl-amino, N-monoaryl-amino, Ν,Ν-diaryl-amino, N-alkyl-N-aryl-amino, N-monocycloalkyl-amino, Ν,Ν-dicycloalkyl-amino, N-monoalkyl-monocycloalkyl- amino, Ν,Ν-monoaryl-monocycloalkyl-amino, N-acylamino, N-alkylsulfonyl-amino, ureido, alkylureido, phenylureido, halogen, cyano, COOM, nitro, acyl, thioacyl, alkylsulfonyl, aryloyl, trifluoromethyl, heteroaryl, heterocycloalkyl, alkoxycarbonyl, alkoxythiocarbonyl, acyloxy, aryloyloxy, carbamoyl, N-monocycloalkyl-carbamoyl, N- monoalkyl-carbamoyl, N,N-dicycloalkyl-carbamoyl, Ν,Ν-dialkyl-carbamoyl, N- monoaryl-carbamoyl, Ν,Ν-diaryl-carbamoyl, N-monocycloalkyl-N-monoarylcarbamoyl, N-monoalkyl-N-monoaryl-carbamoyl, sulfamoyl, N-monocycloalkyl-sulfamoyl, N- monoalkyl-sulfamoyl, N,N-dicycloalkyl-sulfamoyl, Ν,Ν-dialkyl-sulfamoyl, N-monoaryl- sulfamoyl, Ν,Ν-diaryl-sulfamoyl, N-monocycloalkyl-N-monoarylsulfamoyl, N- monoalkyl-N-monoarylsulfamoyl and SO3M, R ¹⁸ and R ²¹ independent of each other is cyano, carbamoyl, alkoxycarbonyl, trifluoromethyl, carbonyltrifluoromethyl, alkylsulfonyl, halogen, alkylsulfonic acid or SOsM,

R ¹⁹ and R ²² independent of each other is hydrogen, alkyl, cycloalkyl, trifluoromethyl, alkoxy, cyano, carbamoyl, alkoxycarbonyl, COOM, amino, hydroxyl, monocycloalkyl- amino, monoalkyl-amino, di(cyclo)alkyl-amino, dialkyl-amino, monoaryl-amino, diaryl- amino, monocycloalkylmonoarylamino, monoalkyl monoaryl amino, alkylthio, arylthio or is alkyl substituted by one or more substituents selected from the group consisting of hydroxy, cycloalkyl, heteroaryl, heterocycloalkyl, aryl, aryloxy, alkoxy, alkylthio, arylthio, halogen, cyano, COOM, alkoxycarbonyl, acyloxy, carbamoyl, nitro, amino, acylamino, arylcarbonylamino, alkylsulfonylamino, arylsulfonylamino, ureido, alkyl- ureido and phenylureido,

M is hydrogen, an alkali metal, ammonium, one equivalent of an alkali earth metal or a monovalent organic cation

and

the dyes of formula (1 ) have two to six sulfonic acid groups form one preferred embodiment of the present invention.

Particularly preferred dyes of the present invention are those of formula (1 a)

(1 a)

wherein

R ^{1 a} , R ^2a , R ^3a , R ^4a , R ^5a , R ^6a , R ^7a and R ^8a independent of each other is hydrogen, alkyl, alkoxy, halogen, trifluoromethyl or SO3M whereby at least two of them are SO3M, R ^9a , R ^10a , R ^13a and R ^14a independently of one another are hydrogen, (Ci-C )-alkyl, (Ci- C ₄ )-alkoxy, halogen, trifluoromethyl, -SO3M or (Ci-C ₄ )-acylamino,

R ^17a and R ^20a independent of each other is hydrogen, alkyl, alkenyl, cycloalkyl, trifluoromethyl, aryl, heteroaryl, heterocycloalkyl, carbamoyl, sulfamoyl, amino, N- acylamino, ureido, alkylureido, phenylureido, N-monoalkylamino, N,N-dialkyl-amino, N-arylamino, Ν,Ν-diarylamino, N-alkyl-N-aryl-amino, N-monocycloalkylamino, N,N- dicycloalkylamino, N-alkyl-N-cycloalkyl-amino, N-aryl-N-cycloalkyl-amino, hydroxyl- alkylsulfonylalkyl

or

alkyl interrupted by one or more heteroatoms selected from the group consisting of oxygen and sulphur

or

alkyl substituted by one or more substituents selected from the group consisting of hydroxy, aryl, cycloalkyl, alkoxy, amino, N-monoalkyl-amino, Ν,Ν-dialkyl-amino, N- monoaryl-amino, Ν,Ν-diaryl-amino, N-alkyl-N-aryl-amino, N-monocycloalkyl-amino, Ν,Ν-dicycloalkyl-amino, N-monoalkyl-monocycloalkyl-amino, N,N-monoaryl-mono- cycloalkyl-amino, N-acylamino, N-alkylsulfonyl-amino, ureido, alkylureido, phenyl- ureido, halogen, cyano, COOM, nitro, acyl, alkylsulfonyl, aryloyl, trifluoromethyl, heteroaryl, heterocycloalkyl, alkoxycarbonyl, acyloxy, aryloyloxy, carbamoyl, sulfamoyl and SOsM

or

alkyl interrupted by one or more heteroatoms selected from the group consisting of oxygen and sulphur and substituted by one or more substituents selected from the group consisting of hydroxy, aryl, cycloalkyl, alkoxy, amino, N-monoalkyl-amino, N,N- dialkyl-amino, N-monoaryl-amino, Ν,Ν-diaryl-amino, N-alkyl-N-aryl-amino, N- monocycloalkyl-amino, Ν,Ν-dicycloalkyl-amino, N-monoalkyl-monocycloalkyl-amino, Ν,Ν-monoaryl-monocycloalkyl-amino, N-acylamino, N-alkylsulfonyl-amino, ureido, alkylureido, phenylureido, halogen, cyano, COOM, nitro, acyl, alkylsulfonyl, aryloyl, trifluoromethyl, heteroaryl, heterocycloalkyl, alkoxycarbonyl, acyloxy, aryloyloxy, carbamoyl, sulfamoyl and SO3M,

R ^18a and R ^{21 a} independent of each other is cyano, carbamoyl or alkoxycarbonyl,

R ^19a and R ^22a independent of each other is unsubstituted, linear or branched (Ci-C ₄ ) alkyl, unsubstiuted (C5-C7) cycloalkyl or substituted (C5-C7) cycloalkyl with one or more substituents such as methyl, ethyl, isobutyl, sec-butyl, tert-butyl and methylbutyl and

M is hydrogen, an alkali metal, ammonium, one equivalent of an alkali earth metal or a monovalent organic cation. In especially preferred dyes of formula (1 a)

R ^{1 a} , R ^3a , R ^4a , R ^5a , R ^6a and R ^8a independent from each other is SO ₃ M, hydrogen, alkyl, alkoxy or halogen, - whereby at least two of them are SO3M,

R ^2a and R ^7a is hydrogen,

R ^9a , R ^10a , R ^13a and R ^14a independent of each other is hydrogen, methyl, halogen, - SO3M or acetylamino,

R ^17a and R ^20a independent of each other is methyl, ethyl, butyl, n-propyl, n-butyl, n- pentyl, n-hexyl, cyclobutyl, cyclopentyl, cyclohexyl, 2-methylcyclohexyl, 3- methylcyclohexyl, isopropyl, sec-butyl, 2-methylbutyl, 1 -ethylpropyl, 1 ,2-dimethyl- propyl, tert-butyl, 3-methylbutyl, pentene-2-yl, 2-ethylhexyl, 2,2-dimethylpropyl, phenyl, benzyl, allyl, 2-methoxyethyl, 3-methoxypropyl, 2-cyanoethyl, 2-(methylthio)ethyl, 2- fluoroethyl, 2-chloroethyl, 3-chloropropyl, tetrahydrofurfuryl, 2-furan-2-yl-ethyl, 6- hydroxy-1 -[2-(2-hydroxyethylsulfanyl)-ethyl], 2-(2-tertbutylsulfanylethanesulfonyl)- ethyl, 2-(ethylsulfonyl)ethanol, 3-(4-hydroxybutoxy)propyl, 2-(2-hydroxyethoxy)ethyl, 3-lsopropoxy propyl or 3-ethoxypropyl,

R ^18a and R ^{21 a} independent of each other is cyano or carbamoyl,

R ^19a and R ^22a is methyl

and

M is hydrogen, sodium, potassium, lithium or ammonium.

Examples of preferred dyes of the formula (1 a) are the compounds of the formulae (1 a ¹ to 1 a ¹²⁴⁹ ) as shown in Table 1 , whereby R ^2a and R ^7a is hydrogen: Table 1

Struct _R 1a _R 3a _R 4a _R 5a _R 6a _R 8a R ^9a / R ^13a _R 10a| _R 14a _R 18a/ _R 21a _R 19a/ _R 22a R ^17a / ure _R 20a

1a ¹ H SOsH H H SOsH H Methyl Methyl CN Methyl Methyl

1a ² H H SOsH SOsH H H

1a ³ Methyl H SOsH SOsH H Methyl

1a ⁴ OMe H SOsH SOsH H OMe

1a ⁵ F H SOsH SOsH H F

1a ⁶ CFs H SOsH SOsH H CFs

1a ⁷ H SOsH H H SOsH H Methyl Methyl CN Methyl Ethyl

1a ⁸ H H SOsH SOsH H H

1a ⁹ Methyl H SOsH SOsH H Methyl

1a ¹⁰ OMe H SOsH SOsH H OMe

1a ¹¹ F H SOsH SOsH H F

1a ¹² CFs H SOsH SOsH H CFs

1a ¹³ H SOsH H H SOsH H Methyl Methyl CN Methyl Propyl

1a ¹⁴ H H SOsH SOsH H H

1a ¹⁵ Methyl H SOsH SOsH H Methyl

1a ¹⁶ OMe H SOsH SOsH H OMe

1a ¹⁷ F H SOsH SOsH H F

1a ¹⁸ CFs H SOsH SOsH H CFs

1a ¹⁹ H SOsH H H SOsH H Methyl Methyl CN Methyl Butyl

1a ²⁰ H H SOsH SOsH H H

1a ²¹ Methyl H SOsH SOsH H Methyl

1a ²² OMe H SOsH SOsH H OMe

1a ²³ F H SOsH SOsH H F

1a ²⁴ CFs H SOsH SOsH H CFs

1a ²⁵ H SOsH H H SOsH H Methyl Methyl CN Methyl Pentyl

1a ²⁶ H H SOsH SOsH H H

1a ²⁷ Methyl H SOsH SOsH H Methyl

1a ²⁸ OMe H SOsH SOsH H OMe

1a ²⁹ F H SOsH SOsH H F

1a ³⁰ CFs H SOsH SOsH H CFs

1a ³¹ H SOsH H H SOsH H Methyl Methyl CN Methyl Hexyl

1a ³² H H SOsH SOsH H H

1a ³³ Methyl H SOsH SOsH H Methyl

1a ³⁴ OMe H SOsH SOsH H OMe

1a ³⁵ F H SOsH SOsH H F

1a ³⁶ CFs H SOsH SOsH H CFs

1a ³⁷ H SOsH H H SOsH H Methyl Methyl CN Methyl Cyclobutyl

1a ³⁸ H H SOsH SOsH H H

1a ³⁹ Methyl H SOsH SOsH H Methyl

1a ⁴⁰ OMe H SOsH SOsH H OMe

1a ⁴¹ F H SOsH SOsH H F

1a ⁴² CFs H SOsH SOsH H CFs

1a ⁴³ H SOsH H H SOsH H Methyl Methyl CN Methyl Cyclopentyl

1a ⁴⁴ H H SOsH SOsH H H

1a ⁴⁵ Methyl H SOsH SOsH H Methyl

1a ⁴⁶ OMe H SOsH SOsH H OMe

1a ⁴⁷ F H SOsH SOsH H F

1a ⁴⁸ CFs H SOsH SOsH H CFs

1a ⁴⁹ H SOsH H H SOsH H Methyl Methyl CN Methyl Cyclohexyl

1a ⁵⁰ H H SOsH SOsH H H

1a ⁵¹ Methyl H SOsH SOsH H Methyl

1a ⁵² OMe H SOsH SOsH H OMe

1a ⁵³ F H SOsH SOsH H F

1a ⁵⁴ CFs H SOsH SOsH H CFs

1a ⁵⁵ H SOsH H H SOsH H Methyl Methyl CN Methyl 2-Methylcyclohexyl

1a ⁵⁶ H H SOsH SOsH H H

1a ⁵⁷ Methyl H SOsH SOsH H Methyl

1a ⁵⁸ OMe H SOsH SOsH H OMe

1a ⁵⁹ F H SOsH SOsH H F

1a ⁶⁰ CFs H SOsH SOsH H CFs

1a ⁶¹ H SOsH H H SOsH H Methyl Methyl CN Methyl 3-Methylcyclohexyl

1a ⁶² H H SOsH SOsH H H

1a ⁶³ Methyl H SOsH SOsH H Methyl

1a ⁶⁴ OMe H SOsH SOsH H OMe

1a ⁶⁵ F H SOsH SOsH H F

1a ⁶⁶ CFs H SOsH SOsH H CFs

1a ⁶⁷ H SOsH H H SOsH H Methyl Methyl CN Methyl Isopropyl

1a ⁶⁸ H H SOsH SOsH H H

1a ⁶⁹ Methyl H SOsH SOsH H Methyl

1a ⁷⁰ OMe H SOsH SOsH H OMe

1a ⁷¹ F H SOsH SOsH H F

1a ⁷² CFs H SOsH SOsH H CFs

1a ⁷³ H SOsH H H SOsH H Methyl Methyl CN Methyl Sec-butyl

1a ⁷⁴ H H SOsH SOsH H H

1a ⁷⁵ Methyl H SOsH SOsH H Methyl

1a ⁷⁶ OMe H SOsH SOsH H OMe

1a ⁷⁷ F H SOsH SOsH H F

1a ⁷⁸ CFs H SOsH SOsH H CFs

1a ⁷⁹ H SOsH H H SOsH H Methyl Methyl CN Methyl 2-Methylbutyl

1a ⁸⁰ H H SOsH SOsH H H

1a ⁸¹ Methyl H SOsH SOsH H Methyl

1a ⁸² OMe H SOsH SOsH H OMe

1a ⁸³ F H SOsH SOsH H F

1a ⁸⁴ CFs H SOsH SOsH H CFs

1a ⁸⁵ H SOsH H H SOsH H Methyl Methyl CN Methyl 1-Ethylpropyl

1a ⁸⁶ H H SOsH SOsH H H

1a ⁸⁷ Methyl H SOsH SOsH H Methyl

1a ⁸⁸ OMe H SOsH SOsH H OMe

1a ⁸⁹ F H SOsH SOsH H F

1a ⁹⁰ CFs H SOsH SOsH H CFs

1a ⁹¹ H SOsH H H SOsH H Methyl Methyl CN Methyl 1,2-

1a ⁹² H H SOsH SOsH H H Dimethylpropy

1a ⁹³ Methyl H SOsH SOsH H Methyl

1a ⁹⁴ OMe H SOsH SOsH H OMe

1a ⁹⁵ F H SOsH SOsH H F

1a ⁹⁶ CFs H SOsH SOsH H CFs

1a ⁹⁷ H SOsH H H SOsH H Methyl Methyl CN Methyl Tert-butyl

1a ⁹⁸ H H SOsH SOsH H H

1a" Methyl H SOsH SOsH H Methyl

_{1 a} ioo OMe H SOsH SOsH H OMe

_{1 g} 101 F H SOsH SOsH H F

_{1 g} 102 CFs H SOsH SOsH H CFs

_{1 g} 103 H SOsH H H SOsH H Methyl Methyl CN Methyl 3-Methylbutyl

_{1 g} 104 H H SOsH SOsH H H

_{1 a} 105 Methyl H SOsH SOsH H Methyl

_{1 a} 106 OMe H SOsH SOsH H OMe

_{1 a} 107 F H SOsH SOsH H F

_{1 a} 108 CFs H SOsH SOsH H CFs

_{1 a} 109 H SOsH H H SOsH H Methyl Methyl CN Methyl Pentan-2-yl

_{1 g} 110 H H SOsH SOsH H H

_{1 a} 111 Methyl H SOsH SOsH H Methyl

1a ¹¹² OMe H SOsH SOsH H OMe

_{1 g} 113 F H SOsH SOsH H F

_{1 a} 114 CFs H SOsH SOsH H CFs

_{1 a} 115 H SOsH H H SOsH H Methyl Methyl CN Methyl 2-Ethylhexyl

_{1 a} 116 H H SOsH SOsH H H

1a ¹¹⁷ Methyl H SOsH SOsH H Methyl

_{1 a} 118 OMe H SOsH SOsH H OMe

_{1 a} 119 F H SOsH SOsH H F

_{1 a} 120 CFs H SOsH SOsH H CFs

1a ¹²¹ H SOsH H H SOsH H Methyl Methyl CN Methyl 2,2-

1a ¹²² H H SOsH SOsH H H Dimethylpropyl

_{1 g} 123 Methyl H SOsH SOsH H Methyl

1a ¹²⁴ OMe H SOsH SOsH H OMe

_{1 a} 125 F H SOsH SOsH H F

_{1 a} 126 CFs H SOsH SOsH H CFs

1a ¹²⁷ H SOsH H H SOsH H Methyl Methyl CN Methyl Phenyl

_{1 a} 128 H H SOsH SOsH H H

_{1 g} 129 Methyl H SOsH SOsH H Methyl

_{1 a} 130 OMe H SOsH SOsH H OMe

_{1 g} 131 F H SOsH SOsH H F

_{1 g} 132 CFs H SOsH SOsH H CFs

_{1 g} 133 H SOsH H H SOsH H Methyl Methyl CN Methyl Benzyl

_{1 g} 134 H H SOsH SOsH H H

_{1 g} 135 Methyl H SOsH SOsH H Methyl

_{1 g} 136 OMe H SOsH SOsH H OMe

_{1 g} 137 F H SOsH SOsH H F

_{1 g} 138 CFs H SOsH SOsH H CFs

_{1 g} 139 H SOsH H H SOsH H Methyl F CN Methyl Methyl

_{1 g} 140 H H SOsH SOsH H H

_{1 g} 141 Methyl H SOsH SOsH H Methyl

1a ¹⁴² OMe H SOsH SOsH H OMe

_{1 g} 143 CFs H SOsH SOsH H CFs

_{1 g} 144 H SOsH H H SOsH H Methyl F CN Methyl Ethyl

_{1 g} 145 H H SOsH SOsH H H

_{1 g} 146 Methyl H SOsH SOsH H Methyl

1a ¹⁴⁷ OMe H SOsH SOsH H OMe

_{1 g} 148 H SOsH H H SOsH H Methyl F CN Methyl Propyl

_{1 g} 149 H H SOsH SOsH H H

_{1 g} 150 Methyl H SOsH SOsH H Methyl

_{1 g} 151 OMe H SOsH SOsH H OMe

_{1 g} 152 H SOsH H H SOsH H Methyl F CN Methyl Butyl

_{1 g} 153 H H SOsH SOsH H H

_{1 g} 154 Methyl H SOsH SOsH H Methyl

_{1 g} 155 OMe H SOsH SOsH H OMe

_{1 a} 156 H SOsH H H SOsH H Methyl F CN Methyl Pentyl

_{1 g} 157 H H SOsH SOsH H H

_{1 g} 158 Methyl H SOsH SOsH H Methyl

_{1 g} 159 OMe H SOsH SOsH H OMe

_{1 g} 160 H SOsH H H SOsH H Methyl F CN Methyl Hexyl

_{1 g} 161 H H SOsH SOsH H H

_{1 g} 162 Methyl H SOsH SOsH H Methyl

_{1 g} 163 OMe H SOsH SOsH H OMe

_{1 g} 164 H SOsH H H SOsH H Methyl F CN Methyl Cyclobuty

_{1 g} 165 H H SOsH SOsH H H I

_{1 g} 166 Methyl H SOsH SOsH H Methyl

_{1 g} 167 OMe H SOsH SOsH H OMe

_{1 g} 168 H SOsH H H SOsH H Methyl F CN Methyl Cyclopent

_{1 g} 169 H H SOsH SOsH H H yi

_{1 g} 170 Methyl H SOsH SOsH H Methyl

1a ¹⁷¹ OMe H SOsH SOsH H OMe

1a ¹⁷² H SOsH H H SOsH H Methyl F CN Methyl Cyclohex

_{1 a} 173 H H SOsH SOsH H H yi

1a ¹⁷⁴ Methyl H SOsH SOsH H Methyl

_{1 g} 175 OMe H SOsH SOsH H OMe

_{1 a} 176 H SOsH H H SOsH H Methyl F CN Methyl 2-Methyl-

1a ¹⁷⁷ H H SOsH SOsH H H cyclo-

_{1 g} 178 Methyl H SOsH SOsH H Methyl hexyl

_{1 a} 179 OMe H SOsH SOsH H OMe

_{1 g} 180 H SOsH H H SOsH H Methyl F CN Methyl 3-Methyl-

_{1 g} 181 H H SOsH SOsH H H cyclo-

_{1 g} 182 Methyl H SOsH SOsH H Methyl hexyl

_{1 g} 183 OMe H SOsH SOsH H OMe

_{1 g} 184 H SOsH H H SOsH H Methyl F CN Methyl Isopropyl

_{1 a} 185 H H SOsH SOsH H H

_{1 a} 186 Methyl H SOsH SOsH H Methyl

_{1 g} 187 OMe H SOsH SOsH H OMe

_{1 g} 188 H SOsH H H SOsH H Methyl F CN Methyl Sec-butyl

_{1 g} 189 H H SOsH SOsH H H

_{1 g} 190 Methyl H SOsH SOsH H Methyl

_{1 g} 191 OMe H SOsH SOsH H OMe

_{1 g} 192 H SOsH H H SOsH H Methyl F CN Methyl 2-Methylbutyl

_{1 g} 193 H H SOsH SOsH H H

_{1 g} 194 Methyl H SOsH SOsH H Methyl

_{1 g} 195 OMe H SOsH SOsH H OMe

_{1 g} 196 H SOsH H H SOsH H F CN Methyl 1-Ethylpropyl

_{1 g} 197 H H SOsH SOsH H H Methyl

_{1 g} 198 Methyl H SOsH SOsH H Methyl

_{1 g} 199 OMe H SOsH SOsH H OMe

_{1 g} 200 H SOsH H H SOsH H Methyl F CN Methyl 1 ,2-Dimethyl-

_{1 g} 201 H H SOsH SOsH H H propyl

_{1 g} 202 Methyl H SOsH SOsH H Methyl

_{1 g} 203 OMe H SOsH SOsH H OMe

_{1 a} 204 H SOsH H H SOsH H Methyl F CN Methyl Tert-butyl

_{1 a} 205 H H SOsH SOsH H H

_{1 a} 206 Methyl H SOsH SOsH H Methyl

_{1 a} 207 OMe H SOsH SOsH H OMe

_{1 a} 208 H SOsH H H SOsH H Methyl F CN Methyl 3-Methylbutyl

_{1 a} 209 H H SOsH SOsH H H

_{1 a} 210 Methyl H SOsH SOsH H Methyl

1a ²¹¹ OMe H SOsH SOsH H OMe

1a ²¹² H SOsH H H SOsH H Methyl F CN Methyl Pentan-2-yl

_{1 a} 213 H H SOsH SOsH H H

1a ²¹⁴ Methyl H SOsH SOsH H Methyl

_{1 a} 215 OMe H SOsH SOsH H OMe

_{1 g} 216 F H SOsH SOsH H F

1a ²¹⁷ CF ₃ H SOsH SOsH H CFs

_{1 a} 218 H SOsH H H SOsH H Methyl F CN Methyl 2-Ethylhexyl

_{1 g} 219 H H SOsH SOsH H H

_{1 a} 220 Methyl H SOsH SOsH H Methyl

1a ²²¹ OMe H SOsH SOsH H OMe

_{1 a} 222 H SOsH H H SOsH H Methyl F CN Methyl 2,2-Dimethyl-

_{1 a} 223 H H SOsH SOsH H H propyl

1a ²²⁴ Methyl H SOsH SOsH H Methyl

_{1 a} 225 OMe H SOsH SOsH H OMe

_{1 a} 226 H SOsH H H SOsH H Methyl F CN Methyl Phenyl

1a ²²⁷ H H SOsH SOsH H H

_{1 a} 228 Methyl H SOsH SOsH H Methyl

_{1 g} 229 OMe H SOsH SOsH H OMe

_{1 a} 230 F H SOsH SOsH H F

_{1 a} 231 CF ₃ H SOsH SOsH H CFs

_{1 a} 232 H SOsH H H SOsH H Methyl F CN Methyl Benzyl

_{1 g} 233 H H SOsH SOsH H H

_{1 g} 234 Methyl H SOsH SOsH H Methyl

_{1 a} 235 OMe H SOsH SOsH H OMe

_{1 g} 236 F H SOsH SOsH H F

_{1 g} 237 CF ₃ H SOsH SOsH H CFs

_{1 a} 238 H SOsH H H SOsH H NHCOCHs OMe CN Methyl Methyl

_{1 a} 239 H H SOsH SOsH H H

_{1 a} 240 Methyl H SOsH SOsH H Methyl

1a ²⁴¹ OMe H SOsH SOsH H OMe

1a ²⁴² F H SOsH SOsH H F

1a ²⁴³ CFs H SOsH SOsH H CFs

1a ²⁴⁴ H SOsH H H SOsH H NHCOCHs OMe CN Methyl Ethyl

_{1 a} 245 H H SOsH SOsH H H

_{1 g} 246 Methyl H SOsH SOsH H Methyl

1a ²⁴⁷ OMe H SOsH SOsH H OMe

_{1 a} 248 F H SOsH SOsH H F

_{1 g} 249 CFs H SOsH SOsH H CFs

_{1 a} 250 H SOsH H H SOsH H NHCOCHs OMe OMe Methyl Propyl

_{1 a} 251 H H SOsH SOsH H H

_{1 a} 252 Methyl H SOsH SOsH H Methyl

_{1 a} 253 OMe H SOsH SOsH H OMe

_{1 a} 254 F H SOsH SOsH H F

_{1 a} 255 CFs H SOsH SOsH H CFs

_{1 a} 256 H SOsH H H SOsH H NHCOCHs OMe CN Methyl Butyl

_{1 a} 257 H H SOsH SOsH H H

_{1 a} 258 Methyl H SOsH SOsH H Methyl

_{1 a} 259 OMe H SOsH SOsH H OMe

_{1 a} 260 F H SOsH SOsH H F

_{1 g} 261 CFs H SOsH SOsH H CFs

_{1 g} 262 H SOsH H H SOsH H NHCOCHs OMe CN Methyl Pentyl

_{1 a} 263 H H SOsH SOsH H H

_{1 g} 264 Methyl H SOsH SOsH H Methyl

_{1 a} 265 OMe H SOsH SOsH H OMe

_{1 g} 266 F H SOsH SOsH H F

_{1 g} 267 CFs H SOsH SOsH H CFs

_{1 a} 268 H SOsH H H SOsH H NHCOCHs OMe CN Methyl Hexyl

_{1 g} 269 H H SOsH SOsH H H

_{1 a} 270 Methyl H SOsH SOsH H Methyl

1a ²⁷¹ OMe H SOsH SOsH H OMe

1a ²⁷² F H SOsH SOsH H F

_{1 a} 273 CFs H SOsH SOsH H CFs

1a ²⁷⁴ H SOsH H H SOsH H NHCOCHs OMe CN Methyl Cyclobutyl

_{1 a} 275 H H SOsH SOsH H H

_{1 g} 276 Methyl H SOsH SOsH H Methyl

1a ²⁷⁷ OMe H SOsH SOsH H OMe

1a ²⁷⁸ F H SOsH SOsH H F

1a ²⁷⁹ CFs H SOsH SOsH H CFs

1a ²⁸⁰ H SOsH H H SOsH H NHCOCHs OMe CN Methyl Cyclopentyl

1a ²⁸¹ H H SOsH SOsH H H

1a ²⁸² Methyl H SOsH SOsH H Methyl

1a ²⁸³ OMe H SOsH SOsH H OMe

1a ²⁸⁴ F H SOsH SOsH H F

1a ²⁸⁵ CFs H SOsH SOsH H CFs

1a ²⁸⁶ H SOsH H H SOsH H NHCOCHs OMe CN Methyl Cyclohexyl

1a ²⁸⁷ H H SOsH SOsH H H

1a ²⁸⁸ Methyl H SOsH SOsH H Methyl

1a ²⁸⁹ OMe H SOsH SOsH H OMe

1a ²⁹⁰ F H SOsH SOsH H F

1a ²⁹¹ CFs H SOsH SOsH H CFs

_{1 a} 292 H SOsH H H SOsH H NHCOCHs OMe CN Methyl 2-Methyl-

_{1 a} 293 H H SOsH SOsH H H cyclohexyl

_{1 a} 294 Methyl H SOsH SOsH H Methyl

_{1 a} 295 OMe H SOsH SOsH H OMe

_{1 g} 296 F H SOsH SOsH H F

_{1 g} 297 CF ₃ H SOsH SOsH H CFs

_{1 a} 298 H SOsH H H SOsH H NHCOCHs OMe CN Methyl 3-Methyl-

_{1 g} 299 H H SOsH SOsH H H cyclohexyl

1a ³⁰⁰ Methyl H SOsH SOsH H Methyl

_{1 a} 301 OMe H SOsH SOsH H OMe

_{1 a} 302 F H SOsH SOsH H F

1a ³⁰³ CFs H SOsH SOsH H CFs

_{1 a} 304 H SOsH H H SOsH H NHCOCHs OMe CN Methyl Isopropyl

1 a ³⁰⁵ H H SOsH SOsH H H

1a ³⁰⁶ Methyl H SOsH SOsH H Methyl

_{1 a} 307 OMe H SOsH SOsH H OMe

1a ³⁰⁸ F H SOsH SOsH H F

1a ³⁰⁹ CFs H SOsH SOsH H CFs

_{1 a} 310 H SOsH H H SOsH H NHCOCHs OMe CN Methyl Sec-butyl

_{1 g} 311 H H SOsH SOsH H H

_{1 a} 312 Methyl H SOsH SOsH H Methyl

_{1 g} 313 OMe H SOsH SOsH H OMe

_{1 g} 314 F H SOsH SOsH H F

_{1 a} 315 CF ₃ H SOsH SOsH H CFs

_{1 g} 316 H SOsH H H SOsH H NHCOCHs OMe CN Methyl 2-Methylbutyl

_{1 g} 317 H H SOsH SOsH H H

_{1 g} 318 Methyl H SOsH SOsH H Methyl

1a ³¹⁹ OMe H SOsH SOsH H OMe

_{1 a} 320 F H SOsH SOsH H F

_{1 g} 321 CFs H SOsH SOsH H CFs

_{1 a} 322 H SOsH H H SOsH H NHCOCHs OMe CN Methyl 1-Ethylpropyl

_{1 a} 323 H H SOsH SOsH H H

_{1 g} 324 Methyl H SOsH SOsH H Methyl

_{1 a} 325 OMe H SOsH SOsH H OMe

_{1 g} 326 F H SOsH SOsH H F

_{1 g} 327 CFs H SOsH SOsH H CFs

_{1 a} 328 H SOsH H H SOsH H NHCOCHs OMe CN Methyl 1 ,2-Dimethyl-

_{1 a} 329 H H SOsH SOsH H H propyl

1a ³³⁰ Methyl H SOsH SOsH H Methyl

_{1 a} 331 OMe H SOsH SOsH H OMe

_{1 a} 332 F H SOsH SOsH H F

1a ³³³ CF ₃ H SOsH SOsH H CFs

_{1 g} 334 H SOsH H H SOsH H NHCOCHs OMe CN Methyl Tert-butyl

1 a ³³⁵ H H SOsH SOsH H H

1a ³³⁶ Methyl H SOsH SOsH H Methyl

_{1 a} 337 OMe H SOsH SOsH H OMe

1a ³³⁸ F H SOsH SOsH H F

1a ³³⁹ CFs H SOsH SOsH H CFs

_{1 a} 340 H SOsH H H SOsH H NHCOCHs OMe CN Methyl 3-Methylbutyl

_{1 g} 341 H H SOsH SOsH H H

_{1 g} 342 Methyl H SOsH SOsH H Methyl

_{1 g} 343 OMe H SOsH SOsH H OMe

_{1 g} 344 F H SOsH SOsH H F

_{1 a} 345 CFs H SOsH SOsH H CFs

_{1 a} 346 H SOsH H H SOsH H NHCOCHs OMe CN Methyl Pentan-2-yl

_{1 g} 347 H H SOsH SOsH H H

_{1 a} 348 Methyl H SOsH SOsH H Methyl

_{1 a} 349 OMe H SOsH SOsH H OMe

1 a ³⁵⁰ F H SOsH SOsH H F

_{1 a} 351 CF ₃ H SOsH SOsH H CFs

_{1 a} 352 H SOsH H H SOsH H NHCOCHs OMe CN Methyl 2-Ethylhexyl

1 a ³⁵³ H H SOsH SOsH H H

_{1 a} 354 Methyl H SOsH SOsH H Methyl

1 a ³⁵⁵ OMe H SOsH SOsH H OMe

1 a ³⁵⁶ F H SOsH SOsH H F

_{1 a} 357 CF ₃ H SOsH SOsH H CFs

1 a ³⁵⁸ H SOsH H H SOsH H NHCOCHs OMe CN Methyl 2,2-Di-

1 a ³⁵⁹ H H SOsH SOsH H H methyl propyl

1a ³⁶⁰ Methyl H SOsH SOsH H Methyl

_{1 g} 361 OMe H SOsH SOsH H OMe

_{1 g} 362 F H SOsH SOsH H F

1a ³⁶³ H SOsH H H SOsH H NHCOCHs OMe CN Methyl Phenyl

_{1 a} 364 H H SOsH SOsH H H

1 a ³⁶⁵ Methyl H SOsH SOsH H Methyl

1a ³⁶⁶ OMe H SOsH SOsH H OMe

1a ³⁶⁷ F H SOsH SOsH H F

1a ³⁶⁸ CFs H SOsH SOsH H CFs

1a ³⁶⁹ H SOsH H H SOsH H NHCOCHs OMe CN Methyl Benzyl

1a ³⁷⁰ H H SOsH SOsH H H

1a ³⁷¹ Methyl H SOsH SOsH H Methyl

1a ³⁷² OMe H SOsH SOsH H OMe

1a ³⁷³ F H SOsH SOsH H F

1a ³⁷⁴ CFs H SOsH SOsH H CFs

1a ³⁷⁵ H SOsH H H SOsH H Methyl Methyl CONH ₂ Methyl Methyl

1a ³⁷⁶ H H SOsH SOsH H H

1a ³⁷⁷ Methyl H SOsH SOsH H Methyl

1a ³⁷⁸ OMe H SOsH SOsH H OMe

1a ³⁷⁹ F H SOsH SOsH H F

1a ³⁸⁰ CFs H SOsH SOsH H CFs

_{1 g} 381 H SOsH H H SOsH H Methyl Methyl CONH ₂ Methyl Ethyl

_{1 a} 382 H H SOsH SOsH H H

1a ³⁸³ Methyl H SOsH SOsH H Methyl

_{1 a} 384 OMe H SOsH SOsH H OMe

1 a ³⁸⁵ F H SOsH SOsH H F

1a ³⁸⁶ CFs H SOsH SOsH H CFs

1a ³⁸⁷ H SOsH H H SOsH H Methyl Methyl CONH2 Methyl Propyl

1a ³⁸⁸ H H SOsH SOsH H H

1a ³⁸⁹ Methyl H SOsH SOsH H Methyl

1a ³⁹⁰ OMe H SOsH SOsH H OMe

1a ³⁹¹ F H SOsH SOsH H F

CFs H SOsH SOsH H CFs

1a ³⁹²

1a ³⁹³ H SOsH H H SOsH H Methyl Methyl CONH2 Methyl Butyl

1a ³⁹⁴ H H SOsH SOsH H H

1 a ³⁹⁵ Methyl H SOsH SOsH H Methyl

1a ³⁹⁶ OMe H SOsH SOsH H OMe

1a ³⁹⁷ F H SOsH SOsH H F

1a ³⁹⁸ CFs H SOsH SOsH H CFs

1a ³⁹⁹ H SOsH H H SOsH H Methyl Methyl CONH ₂ Methyl Pentyl

_{1 a} 400 H H SOsH SOsH H H

_{1 g} 401 Methyl H SOsH SOsH H Methyl

_{1 a} 402 OMe H SOsH SOsH H OMe

_{1 a} 403 F H SOsH SOsH H F

_{1 a} 404

CFs H SOsH SOsH H CFs

_{1 a} 405 H SOsH H H SOsH H Methyl Methyl CONH2 Methyl Hexyl

_{1 a} 406 H H SOsH SOsH H H

_{1 a} 407 Methyl H SOsH SOsH H Methyl

_{1 a} 408 OMe H SOsH SOsH H OMe

_{1 a} 409 F H SOsH SOsH H F

_{1 a} 410

CFs H SOsH SOsH H CFs

_{1 g} 411 H SOsH H H SOsH H Methyl Methyl CONH2 Methyl Cyclobutyl

1a ⁴¹² H H SOsH SOsH H H

_{1 a} 413 Methyl H SOsH SOsH H Methyl

_{1 g} 414 OMe H SOsH SOsH H OMe

_{1 a} 415 F H SOsH SOsH H F

_{1 g} 416

CFs H SOsH SOsH H CFs

1a ⁴¹⁷ H SOsH H H SOsH H Methyl Methyl CONH2 Methyl Cyclopentyl

_{1 a} 418 H H SOsH SOsH H H

1a ⁴¹⁹ Methyl H SOsH SOsH H Methyl

1a ⁴²⁰ OMe H SOsH SOsH H OMe

1a ⁴²¹ F H SOsH SOsH H F

1a ⁴²² CF ₃ H SOsH SOsH H CFs

_{1 a} 423 H SOsH H H SOsH H Methyl Methyl CONH2 Methyl Cyclohexyl

1a ⁴²⁴ H H SOsH SOsH H H

1a ⁴²⁵ Methyl H SOsH SOsH H Methyl

1a ⁴²⁶ OMe H SOsH SOsH H OMe

1a ⁴²⁷ F H SOsH SOsH H F

_{1 a} 428

CFs H SOsH SOsH H CFs

_{1 a} 429 H SOsH H H SOsH H Methyl Methyl CONH2 Methyl 2-Methyl-

_{1 g} 430 H H SOsH SOsH H H cyclohexyl

_{1 g} 431 Methyl H SOsH SOsH H Methyl

_{1 g} 432 OMe H SOsH SOsH H OMe

_{1 g} 433 F H SOsH SOsH H F

_{1 g} 434

CFs H SOsH SOsH H CFs

_{1 a} 435 H SOsH H H SOsH H Methyl Methyl CONH2 Methyl 3-Methyl-

_{1 a} 436 H H SOsH SOsH H H cyclohexyl

_{1 g} 437 Methyl H SOsH SOsH H Methyl

_{1 a} 438 OMe H SOsH SOsH H OMe

_{1 g} 439 F H SOsH SOsH H F

_{1 a} 440

CF ₃ H SOsH SOsH H CFs

_{1 g} 441 H SOsH H H SOsH H Methyl Methyl CONH2 Methyl Isopropyl

_{1 g} 442 H H SOsH SOsH H H

_{1 g} 443 Methyl H SOsH SOsH H Methyl

_{1 g} 444 OMe H SOsH SOsH H OMe

_{1 a} 445 F H SOsH SOsH H F

_{1 g} 446

CFs H SOsH SOsH H CFs

_{1 g} 447 H SOsH H H SOsH H Methyl Methyl CONH2 Methyl Sec-butyl

_{1 a} 448 H H SOsH SOsH H H

_{1 g} 449 Methyl H SOsH SOsH H Methyl

_{1 a} 450 OMe H SOsH SOsH H OMe

_{1 a} 451 F H SOsH SOsH H F

_{1 a} 452

CFs H SOsH SOsH H CFs

_{1 a} 453 H SOsH H H SOsH H Methyl Methyl CONH2 Methyl 2-Methylbutyl

_{1 a} 454 H H SOsH SOsH H H

_{1 a} 455 Methyl H SOsH SOsH H Methyl

_{1 a} 456 OMe H SOsH SOsH H OMe

_{1 a} 457 F H SOsH SOsH H F

_{1 a} 458

CFs H SOsH SOsH H CFs

_{1 a} 459 H SOsH H H SOsH H Methyl Methyl CONH2 Methyl 1-Ethylpropyl

_{1 a} 460 H H SOsH SOsH H H

_{1 g} 461 Methyl H SOsH SOsH H Methyl

_{1 g} 462 OMe H SOsH SOsH H OMe

_{1 a} 463 F H SOsH SOsH H F

_{1 g} 464 CFs H SOsH SOsH H CFs

_{1 a} 465 H SOsH H H SOsH H Methyl Methyl CONH2 Methyl 1 ,2-Dimethyl-

_{1 g} 466 H H SOsH SOsH H H propyl

_{1 g} 467 Methyl H SOsH SOsH H Methyl

_{1 a} 468 OMe H SOsH SOsH H OMe

_{1 g} 469 F H SOsH SOsH H F

_{1 a} 470

CFs H SOsH SOsH H CFs

1a ⁴⁷¹ H SOsH H H SOsH H Methyl Methyl CONH ₂ Methyl Tert-butyl

1a ⁴⁷² H H SOsH SOsH H H

1a ⁴⁷³ Methyl H SOsH SOsH H Methyl

1a ⁴⁷⁴ OMe H SOsH SOsH H OMe

1a ⁴⁷⁵ F H SOsH SOsH H F

1a ⁴⁷⁶ CFs H SOsH SOsH H CFs

1a ⁴⁷⁷ H SOsH H H SOsH H Methyl Methyl CONH2 Methyl 3-Methylbutyl

1a ⁴⁷⁸ H H SOsH SOsH H H

1a ⁴⁷⁹ Methyl H SOsH SOsH H Methyl

1a ⁴⁸⁰ OMe H SOsH SOsH H OMe

1a ⁴⁸¹ F H SOsH SOsH H F

1a ⁴⁸² CFs H SOsH SOsH H CFs

1a ⁴⁸³ H SOsH H H SOsH H Methyl Methyl CONH2 Methyl Pentan-2-yl

1a ⁴⁸⁴ H H SOsH SOsH H H

1a ⁴⁸⁵ Methyl H SOsH SOsH H Methyl

1a ⁴⁸⁶ OMe H SOsH SOsH H OMe

1a ⁴⁸⁷ F H SOsH SOsH H F

1a ⁴⁸⁸ CFs H SOsH SOsH H CFs

_{1 a} 489 H SOsH H H SOsH H Methyl Methyl CONH ₂ Methyl 2-Ethylhexyl

_{1 a} 490 H H SOsH SOsH H H

1a ⁴⁹¹ Methyl H SOsH SOsH H Methyl

_{1 a} 492 OMe H SOsH SOsH H OMe

_{1 a} 493 F H SOsH SOsH H F

_{1 g} 494

CFs H SOsH SOsH H CFs

_{1 a} 495 H SOsH H H SOsH H Methyl Methyl CONH2 Methyl 2,2-

_{1 g} 496 H H SOsH SOsH H H Dimethyl-

_{1 g} 497 Methyl H SOsH SOsH H Methyl propyl

_{1 a} 498 OMe H SOsH SOsH H OMe

_{1 g} 499 F H SOsH SOsH H F

1 a ⁵⁰⁰ CFs H SOsH SOsH H CFs

1a ⁵⁰¹ H SOsH H H SOsH H Methyl Methyl CONH2 Methyl Phenyl

1a ⁵⁰² H H SOsH SOsH H H

1 a ⁵⁰³ Methyl H SOsH SOsH H Methyl

1a ⁵⁰⁴ OMe H SOsH SOsH H OMe

1 a ⁵⁰⁵ F H SOsH SOsH H F

1 a ⁵⁰⁶ CFs H SOsH SOsH H CFs

1a ⁵⁰⁷ H SOsH H H SOsH H Methyl Methyl CONH ₂ Methyl Benzyl

1 a ⁵⁰⁸ H H SOsH SOsH H H

1 a ⁵⁰⁹ Methyl H SOsH SOsH H Methyl

1a ⁵¹⁰ OMe H SOsH SOsH H OMe

1a ⁵¹¹ F H SOsH SOsH H F

1a ⁵¹² CFs H SOsH SOsH H CFs

1a ⁵¹³ H SOsH H H SOsH H Methyl F CONH2 Methyl Methyl

1a ⁵¹⁴ H H SOsH SOsH H H

1a ⁵¹⁵ Methyl H SOsH SOsH H Methyl

1a ⁵¹⁶ OMe H SOsH SOsH H OMe

1a ⁵¹⁷ H SOsH H H SOsH H Methyl F CONH2 Methyl Ethyl

1a ⁵¹⁸ H H SOsH SOsH H H

1a ⁵¹⁹ Methyl H SOsH SOsH H Methyl

1a ⁵²⁰ OMe H SOsH SOsH H OMe

1a ⁵²¹ H SOsH H H SOsH H Methyl F CONH2 Methyl Propyl

1a ⁵²² H H SOsH SOsH H H

1a ⁵²³ Methyl H SOsH SOsH H Methyl

1a ⁵²⁴ OMe H SOsH SOsH H OMe

1 a ⁵²⁵ H SOsH H H SOsH H Methyl F CONH ₂ Methyl Butyl

1 a ⁵²⁶ H H SOsH SOsH H H

1 a ⁵²⁷ Methyl H SOsH SOsH H Methyl

1 a ⁵²⁸ OMe H SOsH SOsH H OMe

1 a ⁵²⁹ H SOsH H H SOsH H Methyl F CONH2 Methyl Pentyl

1 a ⁵³⁰ H H SOsH SOsH H H

1 a ⁵³¹ Methyl H SOsH SOsH H Methyl

1 a ⁵³² OMe H SOsH SOsH H OMe

1 a ⁵³³ H SOsH H H SOsH H Methyl F CONH2 Methyl Hexyl

1 a ⁵³⁴ H H SOsH SOsH H H

1 a ⁵³⁵ Methyl H SOsH SOsH H Methyl

1 a ⁵³⁶ OMe H SOsH SOsH H OMe

1 a ⁵³⁷ H SOsH H H SOsH H Methyl F CONH2 Methyl Cyclobutyl

1 a ⁵³⁸ H H SOsH SOsH H H

1 a ⁵³⁹ Methyl H SOsH SOsH H Methyl

1 a ⁵⁴⁰ OMe H SOsH SOsH H OMe

1a ⁵⁴¹ H SOsH H H SOsH H Methyl F CONH ₂ Methyl Cyclopentyl

1a ⁵⁴² H H SOsH SOsH H H

1a ⁵⁴³ Methyl H SOsH SOsH H Methyl

1a ⁵⁴⁴ OMe H SOsH SOsH H OMe

1a ⁵⁴⁵ H SOsH H H SOsH H Methyl F CONH2 Methyl Cyclohexyl

1a ⁵⁴⁶ H H SOsH SOsH H H

1a ⁵⁴⁷ Methyl H SOsH SOsH H Methyl

1a ⁵⁴⁸ OMe H SOsH SOsH H OMe

1a ⁵⁴⁹ H SOsH H H SOsH H Methyl F CONH2 Methyl 2-Methyl-

1 a ⁵⁵⁰ H H SOsH SOsH H H cyclohexyl

1a ⁵⁵¹ Methyl H SOsH SOsH H Methyl

1a ⁵⁵² OMe H SOsH SOsH H OMe

1 a ⁵⁵³ H SOsH H H SOsH H Methyl F CONH2 Methyl 3-Methyl-

1a ⁵⁵⁴ H H SOsH SOsH H H cyclohexyl

1 a ⁵⁵⁵ Methyl H SOsH SOsH H Methyl

1 a ⁵⁵⁶ OMe H SOsH SOsH H OMe

1a ⁵⁵⁷ H SOsH H H SOsH H Methyl F CONH ₂ Methyl Isopropyl

1a ⁵⁵⁸ H H SOsH SOsH H H

1a ⁵⁵⁹ Methyl H SOsH SOsH H Methyl

1a ⁵⁶⁰ OMe H SOsH SOsH H OMe

1a ⁵⁶¹ H SOsH H H SOsH H Methyl F CONH2 Methyl Sec-butyl

1a ⁵⁶² H H SOsH SOsH H H

1a ⁵⁶³ Methyl H SOsH SOsH H Methyl

1a ⁵⁶⁴ OMe H SOsH SOsH H OMe

1 a ⁵⁶⁵ H SOsH H H SOsH H Methyl F CONH ₂ Methyl 2-Methylbutyl

1 a ⁵⁶⁶ H H SOsH SOsH H H

1a ⁵⁶⁷ Methyl H SOsH SOsH H Methyl

1 a ⁵⁶⁸ OMe H SOsH SOsH H OMe

1 a ⁵⁶⁹ H SOsH H H SOsH H Methyl F CONH2 Methyl 1-Ethylpropyl

1a ⁵⁷⁰ H H SOsH SOsH H H

1a ⁵⁷¹ Methyl H SOsH SOsH H Methyl

1a ⁵⁷² OMe H SOsH SOsH H OMe

1a ⁵⁷³ H SOsH H H SOsH H Methyl F CONH2 Methyl 1 ,2-Dimethyl-

1a ⁵⁷⁴ H H SOsH SOsH H H propyl

1a ⁵⁷⁵ Methyl H SOsH SOsH H Methyl

1a ⁵⁷⁶ OMe H SOsH SOsH H OMe

1a ⁵⁷⁷ H SOsH H H SOsH H Methyl F CONH2 Methyl Tert-butyl

1a ⁵⁷⁸ H H SOsH SOsH H H

1a ⁵⁷⁹ Methyl H SOsH SOsH H Methyl

1 a ⁵⁸⁰ OMe H SOsH SOsH H OMe

1 a ⁵⁸¹ H SOsH H H SOsH H Methyl F CONH ₂ Methyl 3-Methylbutyl

1 a ⁵⁸² H H SOsH SOsH H H

1 a ⁵⁸³ Methyl H SOsH SOsH H Methyl

1 a ⁵⁸⁴ OMe H SOsH SOsH H OMe

1 a ⁵⁸⁵ H SOsH H H SOsH H Methyl F CONH2 Methyl Pentan-2-yl

1 a ⁵⁸⁶ H H SOsH SOsH H H

1 a ⁵⁸⁷ Methyl H SOsH SOsH H Methyl

1 a ⁵⁸⁸ OMe H SOsH SOsH H OMe

1 a ⁵⁸⁹ H SOsH H H SOsH H Methyl F CONH2 Methyl 2-Ethylhexyl

1 a ⁵⁹⁰ H H SOsH SOsH H H

1 a ⁵⁹¹ Methyl H SOsH SOsH H Methyl

1 a ⁵⁹² OMe H SOsH SOsH H OMe

1 a ⁵⁹³ F H SOsH SOsH H F

1 a ⁵⁹⁴ CF ₃ H SOsH SOsH H CFs

1 a ⁵⁹⁵ H SOsH H H SOsH H Methyl F CONH2 Methyl 2,2-Dimethyl-

1 a ⁵⁹⁶ H H SOsH SOsH H H propyl

1 a ⁵⁹⁷ Methyl H SOsH SOsH H Methyl

1 a ⁵⁹⁸ OMe H SOsH SOsH H OMe

1 a ⁵⁹⁹ H SOsH H H SOsH H Methyl F CONH2 Methyl Phenyl

1 a ⁶⁰⁰ H H SOsH SOsH H H

1 a ⁶⁰¹ Methyl H SOsH SOsH H Methyl

1 a ⁶⁰⁵ H SOsH H H SOsH H Methyl F CONH ₂ Methyl Benzyl

1a ⁶⁰⁶ H H SOsH SOsH H H

1a ⁶⁰⁷ Methyl H SOsH SOsH H Methyl

1a ⁶⁰⁸ OMe H SOsH SOsH H OMe

1a ⁶⁰⁹ F H SOsH SOsH H F

1a ⁶¹⁰ CFs H SOsH SOsH H CFs

1a ⁶¹¹ H SOsH H H SOsH H NHCOCHs OMe CONH2 Methyl Methyl

1a ⁶¹² H H SOsH SOsH H H

1a ⁶¹³ Methyl H SOsH SOsH H Methyl

1a ⁶¹⁴ OMe H SOsH SOsH H OMe

1a ⁶¹⁵ F H SOsH SOsH H F

1a ⁶¹⁶ CFs H SOsH SOsH H CFs

1a ⁶¹⁷ H SOsH H H SOsH H NHCOCHs OMe CONH2 Methyl Ethyl

1a ⁶¹⁸ H H SOsH SOsH H H

1a ⁶¹⁹ Methyl H SOsH SOsH H Methyl

1a ⁶²⁰ OMe H SOsH SOsH H OMe

1a ⁶²¹ F H SOsH SOsH H F

1a ⁶²² CFs H SOsH SOsH H CFs

_{1 a} 623 H SOsH H H SOsH H NHCOCHs OMe CONH ₂ Methyl Propyl

_{1 a} 624 H H SOsH SOsH H H

_{1 a} 625 Methyl H SOsH SOsH H Methyl

_{1 a} 626 OMe H SOsH SOsH H OMe

_{1 g} 627 F H SOsH SOsH H F

_{1 a} 628 CF ₃ H SOsH SOsH H CFs

_{1 g} 629 H SOsH H H SOsH H NHCOCHs OMe CONH2 Methyl Butyl

1a ⁶³⁰ H H SOsH SOsH H H

_{1 a} 631 Methyl H SOsH SOsH H Methyl

_{1 a} 632 OMe H SOsH SOsH H OMe

1a ⁶³³ F H SOsH SOsH H F

_{1 a} 634 CFs H SOsH SOsH H CFs

1 a ⁶³⁵ H SOsH H H SOsH H NHCOCHs OMe CONH2 Methyl Pentyl

1a ⁶³⁶ H H SOsH SOsH H H

_{1 g} 637 Methyl H SOsH SOsH H Methyl

1a ⁶³⁸ OMe H SOsH SOsH H OMe

1a ⁶³⁹ F H SOsH SOsH H F

_{1 a} 640 CFs H SOsH SOsH H CFs

1a ⁶⁴¹ H SOsH H H SOsH H NHCOCHs OMe CONH ₂ Methyl Hexyl

_{1 a} 642 H H SOsH SOsH H H

_{1 a} 643 Methyl H SOsH SOsH H Methyl

_{1 a} 644 OMe H SOsH SOsH H OMe

_{1 a} 645 F H SOsH SOsH H F

_{1 g} 646

CFs H SOsH SOsH H CFs

_{1 g} 647 H SOsH H H SOsH H NHCOCHs OMe CONH2 Methyl Cyclobutyl

_{1 a} 648 H H SOsH SOsH H H

_{1 g} 649 Methyl H SOsH SOsH H Methyl

1 a ⁶⁵⁰ OMe H SOsH SOsH H OMe

_{1 a} 651 F H SOsH SOsH H F

_{1 a} 652

CFs H SOsH SOsH H CFs

1 a ⁶⁵³ H SOsH H H SOsH H NHCOCHs OMe CONH2 Methyl Cyclo-

_{1 a} 654 H H SOsH SOsH H H pentyl

1 a ⁶⁵⁵ Methyl H SOsH SOsH H Methyl

1 a ⁶⁵⁶ OMe H SOsH SOsH H OMe

_{1 a} 657 F H SOsH SOsH H F

1 a ⁶⁵⁸ CFs H SOsH SOsH H CFs

1 a ⁶⁵⁹ H SOsH H H SOsH H NHCOCHs OMe CONH ₂ Methyl Cyclo-

1a ⁶⁶⁰ H H SOsH SOsH H H hexyl

1a ⁶⁶¹ Methyl H SOsH SOsH H Methyl

1a ⁶⁶² OMe H SOsH SOsH H OMe

1a ⁶⁶³ F H SOsH SOsH H F

1a ⁶⁶⁴ CFs H SOsH SOsH H CFs

1 a ⁶⁶⁵ H SOsH H H SOsH H NHCOCHs OMe CONH2 Methyl 2-

1a ⁶⁶⁶ H H SOsH SOsH H H Methyl-

1a ⁶⁶⁷ Methyl H SOsH SOsH H Methyl cyclohex

1a ⁶⁶⁸ OMe H SOsH SOsH H OMe yi

1a ⁶⁶⁹ F H SOsH SOsH H F

1a ⁶⁷⁰ CFs H SOsH SOsH H CFs

1a ⁶⁷¹ H SOsH H H SOsH H NHCOCHs OMe CONH2 Methyl 3-

1a ⁶⁷² H H SOsH SOsH H H Methyl-

1a ⁶⁷³ Methyl H SOsH SOsH H Methyl cyclo-

1a ⁶⁷⁴ OMe H SOsH SOsH H OMe hexyl

1a ⁶⁷⁵ F H SOsH SOsH H F

1a ⁶⁷⁶ CFs H SOsH SOsH H CFs

_{1 g} 677 H SOsH H H SOsH H NHCOCHs OMe CONH ₂ Methyl Isopro

_{1 a} 678 H H SOsH SOsH H H

_{1 g} 679 Methyl H SOsH SOsH H Methyl

1a ⁶⁸⁰ OMe H SOsH SOsH H OMe

_{1 a} 681 F H SOsH SOsH H F

_{1 a} 682 CFs H SOsH SOsH H CFs

1a ⁶⁸³ H SOsH H H SOsH H NHCOCHs OMe CONH2 Methyl Sec-

_{1 a} 684 H H SOsH SOsH H H butyl

1 a ⁶⁸⁵ Methyl H SOsH SOsH H Methyl

1a ⁶⁸⁶ OMe H SOsH SOsH H OMe

_{1 g} 687 F H SOsH SOsH H F

1a ⁶⁸⁸ CFs H SOsH SOsH H CFs

1a ⁶⁸⁹ H SOsH H H SOsH H NHCOCHs OMe CONH2 Methyl 2-

1a ⁶⁹⁰ H H SOsH SOsH H H Methyl

_{1 g} 691 Methyl H SOsH SOsH H Methyl butyl

_{1 g} 692 OMe H SOsH SOsH H OMe

1a ⁶⁹³ F H SOsH SOsH H F

_{1 g} 694 CFs H SOsH SOsH H CFs

1 a ⁶⁹⁵ H SOsH H H SOsH H NHCOCH OMe CONH ₂ Methyl 1-Ethy

1 a ⁶⁹⁶ H H SOsH SOsH H H 3 propyl

1a ⁶⁹⁷ Methyl H SOsH SOsH H Methyl

1 a ⁶⁹⁸ OMe H SOsH SOsH H OMe

1 a ⁶⁹⁹ F H SOsH SOsH H F

_{1 a} 700 CFs H SOsH SOsH H CFs

1a ⁷⁰¹ H SOsH H H SOsH H NHCOCH OMe CONH2 Methyl 1,2-Di-

1a ⁷⁰² H H SOsH SOsH H H 3 methyl

1a ⁷⁰³ Methyl H SOsH SOsH H Methyl propyl

1a ⁷⁰⁴ OMe H SOsH SOsH H OMe

1a ⁷⁰⁵ F H SOsH SOsH H F

1a ⁷⁰⁶ CFs H SOsH SOsH H CFs

1a ⁷⁰⁷ H SOsH H H SOsH H NHCOCH OMe CONH2 Methyl Tert-b

1a ⁷⁰⁸ H H SOsH SOsH H H 3

1a ⁷⁰⁹ Methyl H SOsH SOsH H Methyl

1a ⁷¹⁰ OMe H SOsH SOsH H OMe

1a ⁷¹¹ F H SOsH SOsH H F

1a ⁷¹² CFs H SOsH SOsH H CFs

_{1 a} 713 H SOsH H H SOsH H NHCOCH OMe CONH ₂ Methyl 3-Met

1a ⁷¹⁴ H H SOsH SOsH H H 3 butyl

1a ⁷¹⁵ Methyl H SOsH SOsH H Methyl

1a ⁷¹⁶ OMe H SOsH SOsH H OMe

1a ⁷¹⁷ F H SOsH SOsH H F

1a ⁷¹⁸ CFs H SOsH SOsH H CFs

1a ⁷¹⁹ H SOsH H H SOsH H NHCOCH OMe CONH2 Methyl Penta

_{1 a} 720 H H SOsH SOsH H H 3 yi

1a ⁷²¹ Methyl H SOsH SOsH H Methyl

1a ⁷²² OMe H SOsH SOsH H OMe

1a ⁷²³ F H SOsH SOsH H F

1a ⁷²⁴ CFs H SOsH SOsH H CFs

1a ⁷²⁵ H SOsH H H SOsH H NHCOCH OMe CONH2 Methyl 2-Ethy

1a ⁷²⁶ H H SOsH SOsH H H 3 hexyl

1a ⁷²⁷ Methyl H SOsH SOsH H Methyl

1a ⁷²⁸ OMe H SOsH SOsH H OMe

1a ⁷²⁹ F H SOsH SOsH H F

1a ⁷³⁰ CFs H SOsH SOsH H CFs

_{1 a} 731 H SOsH H H SOsH H NHCOCH OMe CONH ₂ Methyl 2,2-Di

1a ⁷³² H H SOsH SOsH H H 3 methyl

1a ⁷³³ Methyl H SOsH SOsH H Methyl propyl

1a ⁷³⁴ OMe H SOsH SOsH H OMe

1a ⁷³⁵ F H SOsH SOsH H F

H SOsH H H SOsH H NHCOCH OMe CN Methyl Phenyl

1a ⁷³⁶

3

1a ⁷³⁷ H H SOsH SOsH H H

1a ⁷³⁸ Methyl H SOsH SOsH H Methyl

1a ⁷³⁹ OMe H SOsH SOsH H OMe

1a ⁷⁴⁰ F H SOsH SOsH H F

1a ⁷⁴¹ CF ₃ H SOsH SOsH H CFs

H SOsH H H SOsH H NHCOCH OMe CN enzyl

1a ⁷⁴² Methyl B

3

1a ⁷⁴³ H H SOsH SOsH H H

1a ⁷⁴⁴ Methyl H SOsH SOsH H Methyl

1a ⁷⁴⁵ OMe H SOsH SOsH H OMe

1a ⁷⁴⁶ F H SOsH SOsH H F

1a ⁷⁴⁷ CFs H SOsH SOsH H CFs

_{1 a} 748 H SOsH H H SOsH H Methyl Methyl CN Methyl Allyl

_{1 a} 749 H H SOsH SOsH H H

_{1 g} 750 Methyl H SOsH SOsH H Methyl

1a ⁷⁵¹ OMe H SOsH SOsH H OMe

_{1 a} 752 F H SOsH SOsH H F

_{1 a} 753 CFs H SOsH SOsH H CFs

1a ⁷⁵⁴ H SOsH H H SOsH H Methyl Methyl CN Methyl 2-

_{1 a} 755 H H SOsH SOsH H H Metho

1a ⁷⁵⁶ Methyl H SOsH SOsH H Methyl ethyl

1a ⁷⁵⁷ OMe H SOsH SOsH H OMe

_{1 a} 758 F H SOsH SOsH H F

1a ⁷⁵⁹ CFs H SOsH SOsH H CFs

_{1 a} 760 H SOsH H H SOsH H Methyl Methyl CN Methyl 3-

1a ⁷⁶¹ H H SOsH SOsH H H Metho

1a ⁷⁶² Methyl H SOsH SOsH H Methyl propyl

1a ⁷⁶³ OMe H SOsH SOsH H OMe

1a ⁷⁶⁴ F H SOsH SOsH H F

_{1 a} 765 CFs H SOsH SOsH H CFs

_{1 a} 766 H SOsH H H SOsH H Methyl Methyl CN Methyl 2-Cya

1a ⁷⁶⁷ H H SOsH SOsH H H ethyl

1a ⁷⁶⁸ Methyl H SOsH SOsH H Methyl

1a ⁷⁶⁹ OMe H SOsH SOsH H OMe

1a ⁷⁷⁰ F H SOsH SOsH H F

1a ⁷⁷¹ CFs H SOsH SOsH H CFs

1a ⁷⁷² H SOsH H H SOsH H Methyl Methyl CN Methyl 2-

1a ⁷⁷³ H H SOsH SOsH H H (Meth

1a ⁷⁷⁴ Methyl H SOsH SOsH H Methyl thio)et

1a ⁷⁷⁵ OMe H SOsH SOsH H OMe

1a ⁷⁷⁶ F H SOsH SOsH H F

1a ⁷⁷⁷ CFs H SOsH SOsH H CFs

1a ⁷⁷⁸ H SOsH H H SOsH H Methyl Methyl CN Methyl 2-Fluo

1a ⁷⁷⁹ H H SOsH SOsH H H ethyl

1a ⁷⁸⁰ Methyl H SOsH SOsH H Methyl

1a ⁷⁸¹ OMe H SOsH SOsH H OMe

1a ⁷⁸² F H SOsH SOsH H F

1a ⁷⁸³ CFs H SOsH SOsH H CFs

_{1 a} 784 H SOsH H H SOsH H Methyl Methyl CN Methyl 2-Chlo

1a ⁷⁸⁵ H H SOsH SOsH H H ethyl

1a ⁷⁸⁶ Methyl H SOsH SOsH H Methyl

1a ⁷⁸⁷ OMe H SOsH SOsH H OMe

1a ⁷⁸⁸ F H SOsH SOsH H F

_{1 a} 789 CFs H SOsH SOsH H CFs

1a ⁷⁹⁰ H SOsH H H SOsH H Methyl Methyl CN Methyl 3-Chlo

1a ⁷⁹¹ H H SOsH SOsH H H propyl

1a ⁷⁹² Methyl H SOsH SOsH H Methyl

1a ⁷⁹³ OMe H SOsH SOsH H OMe

1a ⁷⁹⁴ F H SOsH SOsH H F

1a ⁷⁹⁵ CFs H SOsH SOsH H CFs

_{1 a} 796 H SOsH H H SOsH H Methyl Methyl CN Methyl Tetra-

1a ⁷⁹⁷ H H SOsH SOsH H H hydro-

1a ⁷⁹⁸ Methyl H SOsH SOsH H Methyl furfuryl

1a ⁷⁹⁹ OMe H SOsH SOsH H OMe

1 a ⁸⁰⁰ F H SOsH SOsH H F

_{1 a} 801 CFs H SOsH SOsH H CFs

_{1 a} 802 H SOsH H H SOsH H Methyl Methyl CN Methyl 2-Fura

_{1 a} 803 H H SOsH SOsH H H 2-yl-et

1a ⁸⁰⁴ Methyl H SOsH SOsH H Methyl

1a ⁸⁰⁵ OMe H SOsH SOsH H OMe

1a ⁸⁰⁶ F H SOsH SOsH H F

_{1 a} 807 CF ₃ H SOsH SOsH H CFs

1a ⁸⁰⁸ H SOsH H H SOsH H Methyl Methyl CN Methyl 2-(2-

1a ⁸⁰⁹ H H SOsH SOsH H H Hydro

1a ⁸¹⁰ Methyl H SOsH SOsH H Methyl ethyls

1a ⁸¹¹ OMe H SOsH SOsH H OMe fanyl)-

_{1 a} 812 F H SOsH SOsH H F ethyl

_{1 a} 813 CF ₃ H SOsH SOsH H CFs

_{1 a} 814 H SOsH H H SOsH H Methyl Methyl CN Methyl 2-(2-te

_{1 a} 815 H H SOsH SOsH H H Butyls

1a ⁸¹⁶ Methyl H SOsH SOsH H Methyl fanyl-

_{1 a} 817 OMe H SOsH SOsH H OMe ethan

1a ⁸¹⁸ F H SOsH SOsH H F sulfon

_{1 a} 819 CFs H SOsH SOsH H CFs ethyl

_{1 a} 820 H SOsH H H SOsH H Methyl Methyl CN Methyl 3-(4-

_{1 a} 821 H H SOsH SOsH H H Hydro

_{1 a} 822 Methyl H SOsH SOsH H Methyl butoxy

_{1 a} 823 OMe H SOsH SOsH H OMe propyl

1a ⁸²⁴ F H SOsH SOsH H F

_{1 a} 825 CFs H SOsH SOsH H CFs

1a ⁸²⁶ H S03H H H S03H H Methyl Methyl CN Methyl 2-(2-

_{1 a} 827 H H S03H S03H H H Hydro

_{1 a} 828 Methyl H S03H S03H H Methyl ethoxy

_{1 a} 829 OMe H S03H S03H H OMe ethyl

1 a ⁸³⁰ F H S03H S03H H F

1a ⁸³¹ CF3 H S03H S03H H CF3

_{1 a} 832 H SOsH H H SOsH H Methyl Methyl CN Methyl 3-lso-

1 a ⁸³³ H H SOsH SOsH H H propo

1a ⁸³⁴ Methyl H SOsH SOsH H Methyl propyl

1 a ⁸³⁵ OMe H SOsH SOsH H OMe

1 a ⁸³⁶ F H SOsH SOsH H F

_{1 a} 837 CFs H SOsH SOsH H CFs

1 a ⁸³⁸ H SOsH H H SO3H H Methyl F CN Methyl Allyl

1 a ⁸³⁹ H H SO3H SOsH H H

1a ⁸⁴⁰ Methyl H SO3H SOsH H Methyl

1a ⁸⁴¹ OMe H SO3H SOsH H OMe

1a ⁸⁴² H SOsH H H SOsH H Methyl F CN Methyl 2-

_{1 a} 843 H H SO3H SO3H H H Metho

1a ⁸⁴⁴ Methyl H SOsH SOsH H Methyl ethyl

1a ⁸⁴⁵ OMe H SOsH SOsH H OMe

1a ⁸⁴⁶ H SOsH H H SOsH H Methyl F CN Methyl 3-

1a ⁸⁴⁷ H H SOsH SOsH H H Metho

1a ⁸⁴⁸ Methyl H SOsH SOsH H Methyl propyl

1a ⁸⁴⁹ OMe H SOsH SOsH H OMe

1 a ⁸⁵⁰ H SOsH H H SO3H H Methyl F CN Methyl 2-Cya

_{1 a} 851 H H SOsH SOsH H H ethyl

_{1 a} 852 Methyl H SOsH SOsH H Methyl

1 a ⁸⁵³ OMe H SOsH SOsH H OMe

_{1 a} 854 H SOsH H H SO3H H Methyl F CN Methyl 2-

1 a ⁸⁵⁵ H H SO3H SOsH H H (Methy

1 a ⁸⁵⁶ Methyl H SO3H SO3H H Methyl thio)et

1 a ⁸⁵⁷ OMe H SO3H SOsH H OMe

1 a ⁸⁵⁸ H SOsH H H SO3H H Methyl F CN Methyl 2-Fluo

1 a ⁸⁵⁹ H H SO3H SO3H H H ethyl

1 a ⁸⁶⁰ Methyl H SO3H SOsH H Methyl

1 a ⁸⁶¹ OMe H SO3H SOsH H OMe

1 a ⁸⁶² H SOsH H H SOsH H Methyl F CN Methyl 2-Chlo

1 a ⁸⁶³ H H SOsH SO3H H H ethyl

_{1 a} 864 Methyl H SO3H SOsH H Methyl

1 a ⁸⁶⁵ OMe H SO3H SOsH H OMe

1 a ⁸⁶⁶ H SOsH H H SOsH H Methyl F CN Methyl 3-Chlo

1 a ⁸⁶⁷ H H SO3H SOsH H H propyl

1 a ⁸⁶⁸ Methyl H SO3H SO3H H Methyl

1 a ⁸⁶⁹ OMe H SO3H SOsH H OMe

_{1 a} 870 H SOsH H H SO3H H Methyl F CN Methyl Tetrah

_{1 a} 871 H H SO3H SOsH H H ofurfur

_{1 a} 872 Methyl H SO3H SO3H H Methyl

_{1 a} 873 OMe H SO3H SO3H H OMe

_{1 a} 874 H SOsH H H SO3H H Methyl F CN Methyl 2-Fura

_{1 a} 875 H H SO3H SO3H H H 2-yl-et

_{1 a} 876 Methyl H SOsH SOsH H Methyl

_{1 a} 877 OMe H SOsH SOsH H OMe

_{1 a} 878 H S0 ₃ H H H SO3H H Methyl F CN Methyl 2-(2-

_{1 a} 879 H H SO3H SO3H H H Hydro

_{1 a} 880 Methyl H SO3H SO3H H Methyl ethyls

_{1 a} 881 OMe H SO3H SO3H H OMe nyl)-et

_{1 a} 882 H SO3H H H SO3H H Methyl F CN Methyl 2-(2-te

_{1 a} 883 H H SO3H SO3H H H Butyls

1a ⁸⁸⁴ Methyl H SO3H SO3H H Methyl nyl-

OMe H SO3H SO3H H OMe ethan

_{1 a} 885 Ifonyl)- ethyl

_{1 a} 886 H SO3H H H SO3H H Methyl F CN Methyl 3-(4-

_{1 a} 887 H H SO3H SO3H H H Hydro

_{1 a} 888 Methyl H SO3H SOsH H Methyl butoxy

OMe H SO3H SO3H H OMe propyl

1a ⁸⁸⁹

_{1 a} 890 H SO3H H H SO3H H Methyl F CN Methyl 2-(2-

_{1 a} 891 H H SO3H SO3H H H Hydro

_{1 a} 892 Methyl H SO3H SO3H H Methyl ethoxy

_{1 a} 893 OMe H SO3H SO3H H OMe ethyl

_{1 a} 894 H SOsH H H SOsH H Methyl F CN Methyl 3-lso-

1 a ⁸⁹⁵ H H SOsH SOsH H H propo

1a ⁸⁹⁶ Methyl H SOsH SOsH H Methyl propyl

1a ⁸⁹⁷ OMe H SOsH SOsH H OMe

1a ⁸⁹⁸ F H SOsH SOsH H F

1a ⁸⁹⁹ CFs H SOsH SOsH H CFs

1a ⁹⁰⁰ H SO3H H H SO3H H Methyl F CN Methyl 3-

1a ⁹⁰¹ H H SO3H SO3H H H Ethox

1a ⁹⁰² Methyl H SO3H SO3H H Methyl propyl

1a ⁹⁰³ OMe H SO3H SO3H H OMe

1a ⁹⁰⁴ F H SO3H SO3H H F

1 a ⁹⁰⁵ CF3 H SO3H SO3H H CF3

H SOsH H H SOsH H NHCOCH OMe CN Methyl Ally I

1a ⁹⁰⁶

3

1a ⁹⁰⁷ H H SOsH SOsH H H

1a ⁹⁰⁸ Methyl H SOsH SOsH H Methyl

1a ⁹⁰⁹ OMe H SOsH SOsH H OMe

1a ⁹¹⁰ F H SOsH SOsH H F

1a ⁹¹¹ CFs H SOsH SOsH H CFs

_{1 a} 912 H SOsH H H SOsH H NHCOCHs OMe CN Methyl 2-

_{1 a} 913 H H SOsH SOsH H H Meth

1a ⁹¹⁴ Methyl H SOsH SOsH H Methyl ethyl

_{1 a} 915 OMe H SOsH SOsH H OMe

_{1 g} 916 F H SOsH SOsH H F

_{1 g} 917 CFs H SOsH SOsH H CFs

1a ⁹¹⁸ H SOsH H H SOsH H NHCOCHs OMe CN Methyl 3-

1a ⁹¹⁹ H H SOsH SOsH H H Meth

_{1 g} 920 Methyl H SOsH SOsH H Methyl propyl

1a ⁹²¹ OMe H SOsH SOsH H OMe

_{1 g} 922 F H SOsH SOsH H F

_{1 g} 923 CFs H SOsH SOsH H CFs

_{1 g} 924 H SOsH H H SOsH H NHCOCHs OMe CN Methyl 2-

_{1 a} 925 H H SOsH SOsH H H Cyan

_{1 g} 926 Methyl H SOsH SOsH H Methyl ethyl

_{1 g} 927 OMe H SOsH SOsH H OMe

_{1 a} 928 F H SOsH SOsH H F

_{1 g} 929 CFs H SOsH SOsH H CFs

1a ⁹³⁰ H SOsH H H SOsH H NHCOCHs OMe CN Methyl 2-

_{1 a} 931 H H SOsH SOsH H H (Methy

_{1 a} 932 Methyl H SOsH SOsH H Methyl thio)et

1a ⁹³³ OMe H SOsH SOsH H OMe

1a ⁹³⁴ F H SOsH SOsH H F

1 a ⁹³⁵ CFs H SOsH SOsH H CFs

1a ⁹³⁶ H SOsH H H SOsH H NHCOCHs OMe CN Methyl 2-Fluo

1a ⁹³⁷ H H SOsH SOsH H H ethyl

1a ⁹³⁸ Methyl H SOsH SOsH H Methyl

1a ⁹³⁹ OMe H SOsH SOsH H OMe

1a ⁹⁴⁰ F H SOsH SOsH H F

1a ⁹⁴¹ CFs H SOsH SOsH H CFs

1a ⁹⁴² H SOsH H H SOsH H NHCOCHs OMe CN Methyl 2-

1a ⁹⁴³ H H SOsH SOsH H H Chloro

1a ⁹⁴⁴ Methyl H SOsH SOsH H Methyl ethyl

1a ⁹⁴⁵ OMe H SOsH SOsH H OMe

1a ⁹⁴⁶ F H SOsH SOsH H F

1a ⁹⁴⁷ CFs H SOsH SOsH H CFs

_{1 a} 948 H SOsH H H SOsH H NHCOCHs OMe CN Methyl 3-

_{1 a} 949 H H SOsH SOsH H H Chlor

1 a ⁹⁵⁰ Methyl H SOsH SOsH H Methyl propyl

_{1 a} 951 OMe H SOsH SOsH H OMe

_{1 a} 952 F H SOsH SOsH H F

1 a ⁹⁵³ CFs H SOsH SOsH H CFs

_{1 a} 954 H SOsH H H SOsH H NHCOCHs OMe CN Methyl Tetra-

1 a ⁹⁵⁵ H H SOsH SOsH H H hydro

1 a ⁹⁵⁶ Methyl H SOsH SOsH H Methyl furfur

_{1 a} 957 OMe H SOsH SOsH H OMe

1 a ⁹⁵⁸ F H SOsH SOsH H F

1 a ⁹⁵⁹ CFs H SOsH SOsH H CFs

1 a ⁹⁶⁰ H SOsH H H SOsH H NHCOCHs OMe CN Methyl 2-

_{1 g} 961 H H SOsH SOsH H H Furan

_{1 g} 962 Methyl H SOsH SOsH H Methyl 2-yl-

1 a ⁹⁶³ OMe H SOsH SOsH H OMe ethyl

_{1 g} 964 F H SOsH SOsH H F

1 a ⁹⁶⁵ CFs H SOsH SOsH H CFs

1 a ⁹⁶⁶ H SOsH H H SOsH H NHCOCHs OMe CN Methyl 2-(2-

_{1 a} 967 H H SOsH SOsH H H Hydroxy-

1 a ⁹⁶⁸ Methyl H SOsH SOsH H Methyl ethylsulf

1 a ⁹⁶⁹ OMe H SOsH SOsH H OMe )-ethyl

1a ⁹⁷⁰ F H SOsH SOsH H F

_{1 a} 971 CFs H SOsH SOsH H CFs

_{1 a} 972 H SOsH H H SOsH H NHCOCHs OMe CN Methyl 2-(2-tert-

_{1 a} 973 H H SOsH SOsH H H Butylsulf

_{1 a} 974 Methyl H SOsH SOsH H Methyl l-ethanes

_{1 g} 975 OMe H SOsH SOsH H OMe lfonyl)-et

_{1 a} 976 F H SOsH SOsH H F

_{1 g} 977 CFs H SOsH SOsH H CFs

_{1 a} 978 H SOsH H H SOsH H NHCOCHs OMe CN Methyl 3-(4-

1a ⁹⁷⁹ H H SOsH SOsH H H Hydroxy

1 a ⁹⁸⁰ Methyl H SOsH SOsH H Methyl butoxy)

_{1 a} 981 OMe H SOsH SOsH H OMe propyl

_{1 g} 982 F H SOsH SOsH H F

1 a ⁹⁸³ CFs H SOsH SOsH H CFs

_{1 a} 984 H SOsH H H SOsH H NHCOCH OMe CN Methyl 2-(2-

1 a ⁹⁸⁵ H H SOsH SOsH H H 3 Hydroxy

1a ⁹⁸⁶ Methyl H SOsH SOsH H Methyl ethoxy)e

1a ⁹⁸⁷ OMe H SOsH SOsH H OMe yi

1a ⁹⁸⁸ F H SOsH SOsH H F

1a ⁹⁸⁹ CFs H SOsH SOsH H CFs

1a ⁹⁹⁰ H SOsH H H SOsH H NHCOCH OMe CN Methyl 3-lso-

1a ⁹⁹¹ H H SO3H SO3H H H 3 propoxy-

1a ⁹⁹² Methyl H SO3H SO3H H Methyl propyl

1a ⁹⁹³ OMe H SO3H SO3H H OMe

1a ⁹⁹⁴ F H SO3H SO3H H F

1 a ⁹⁹⁵ CFs H SO3H SO3H H CFs

1a ⁹⁹⁶ H SOsH H H SOsH H Me Me CONH Methyl Ally I

1a ⁹⁹⁷ H H SOsH SOsH H H 2

1a ⁹⁹⁸ Methyl H SOsH SOsH H Methyl

1a ⁹⁹⁹ OMe H SOsH SOsH H OMe

IglOOO F H SOsH SOsH H F

1a ¹⁰⁰¹ CFs H SOsH SOsH H CFs

_1a 1002 H SOsH H H SOsH H Me Me CONH ₂ Methyl 2-

1 g1003 H H SOsH SOsH H H Metho

1a ¹⁰⁰⁴ Methyl H SOsH SOsH H Methyl ethyl

-| g1005 OMe H SOsH SOsH H OMe

1 g1006 F H SOsH SOsH H F

_{1 a} 1007 CFs H SOsH SOsH H CFs

1 g1008 H SOsH H H SOsH H Methyl Methyl CONH2 Methyl 3-

-| g1009 H H SOsH SOsH H H Metho

_{1 a} 1010 Methyl H SOsH SOsH H Methyl propyl

_{1 a} 1011 OMe H SOsH SOsH H OMe

_{1 a} 1012 F H SOsH SOsH H F

_{1 a} 1013 CFs H SOsH SOsH H CFs

_{1 a} 1014 H SOsH H H SOsH H Methyl Methyl CONH2 Methyl 2-Cya

_{1 a} 1015 H H SOsH SOsH H H ethyl

_{1 a} 1016 Methyl H SOsH SOsH H Methyl

_{1 a} 1017 OMe H SOsH SOsH H OMe

_{1 a} 1018 F H SOsH SOsH H F

_{1 a} 1019 CFs H SOsH SOsH H CFs

_1a 1020 H SOsH H H SOsH H Methyl Methyl CONH2 Methyl 2-

_{1 g} 1021 H H SOsH SOsH H H (Meth

_1a 1022 Methyl H SOsH SOsH H Methyl thio)et

_{1 a} 1023 OMe H SOsH SOsH H OMe

_{1 a} 1024 F H SOsH SOsH H F

_{1 a} 1025 CF ₃ H SOsH SOsH H CFs

_{1 a} 1026 H SOsH H H SOsH H Methyl Methyl CONH2 Methyl 2-Fluo

_{1 a} 1027 H H SOsH SOsH H H ethyl

_{1 a} 1028 Methyl H SOsH SOsH H Methyl

_{1 a} 1029 OMe H SOsH SOsH H OMe

-|g1030 F H SOsH SOsH H F

_{1 a} 1031 CFs H SOsH SOsH H CFs

_{1 a} 1032 H SOsH H H SOsH H Methyl Methyl CONH2 Methyl 2-Chlo

-|g1033 H H SOsH SOsH H H ethyl

_{1 a} 1034 Methyl H SOsH SOsH H Methyl

1 g1035 OMe H SOsH SOsH H OMe

-|g1036 F H SOsH SOsH H F

_{1 a} 1037 CFs H SOsH SOsH H CFs

■\ g1056 H SOsH H H SOsH H Methyl Methyl CONH ₂ Methyl 2-(2-

_{1 a} 1057 H H SOsH SOsH H H Hydro

-| g1058 Methyl H SOsH SOsH H Methyl ethyls

-| g1059 OMe H SOsH SOsH H OMe nyl)-et

1 g1060 F H SOsH SOsH H F

_{1 a} 1061 CFs H SOsH SOsH H CFs

_{1 a} 1062 H SOsH H H SOsH H Methyl Methyl CONH2 Methyl 2-(2-te

-| g1063 H H SOsH SOsH H H Butyls

_{1 a} 1064 Methyl H SOsH SOsH H Methyl nyl-

-| g1065 OMe H SOsH SOsH H OMe ethan

1 g1066 F H SOsH SOsH H F Ifonyl)-

_{1 a} 1067 CFs H SOsH SOsH H CFs ethyl

1 g1068 H SOsH H H SOsH H Methyl Methyl CONH2 Methyl 3-(4-

-| g1069 H H SOsH SOsH H H Hydro

_{1 a} 1070 Methyl H SOsH SOsH H Methyl butoxy

_{1 a} 1071 OMe H SOsH SOsH H OMe propyl

_{1 a} 1072 F H SOsH SOsH H F

_{1 a} 1073 CFs H SOsH SOsH H CFs

_{1 a} 1074 H SOsH H H SOsH H Methyl Methyl CONH ₂ Methyl 2-(2-

_{1 a} 1075 H H SOsH SOsH H H Hydro

_{1 a} 1076 Methyl H SOsH SOsH H Methyl ethoxy

_{1 a} 1077 OMe H SOsH SOsH H OMe ethyl

_{1 a} 1078 F H SOsH SOsH H F

_{1 a} 1079 CFs H SOsH SOsH H CFs

1 g1080 H SOsH H H SOsH H Methyl Methyl CONH2 Methyl 3-lso-

_{1 a} 1081 H H SOsH SOsH H H propo

_{1 a} 1082 Methyl H SOsH SOsH H Methyl propyl

-| _g 1083 OMe H SOsH SOsH H OMe

_{1 a} 1084 F H SOsH SOsH H F

1 g1085 CF ₃ H SOsH SOsH H CFs

■\ g1086 H S03H H H S03H H Methyl Methyl CONH2 Methyl 3-Etho

_{1 a} 1087 H H S03H S03H H H propyl

-| g1088 Methyl H S03H S03H H Methyl

-| g1089 OMe H S03H S03H H OMe

1 g1090 F H S03H S03H H F

_{1 a} 1091 CF3 H S03H S03H H CF3

_{1 a} 1092 H SOsH H H SOsH H Methyl F CONH2 Methyl Ally I

-|g1093 H H SOsH SOsH H H

_{1 a} 1094 Methyl H SOsH SOsH H Methyl

1 g1095 OMe H SOsH SOsH H OMe

-|g1096 H SOsH H H SOsH H Methyl F CONH2 Methyl 2-Methoxy

_{1 a} 1097 H H SOsH SOsH H H ethyl

-|g1098 Methyl H SOsH SOsH H Methyl

-|g1099 OMe H SOsH SOsH H OMe

_{1 a} 1100 H SOsH H H SOsH H Methyl F CONH2 Methyl 3-Methoxy

_{1 g} 1101 H H SOsH SOsH H H propyl

_{1 a} 1102 Methyl H SOsH SOsH H Methyl

_{1 g} 1103 OMe H SOsH SOsH H OMe

_{1 a} 1104 H SOsH H H SOsH H Methyl F CONH2 Methyl 2-Cyanoet

_{1 g} 1105 H H SOsH SOsH H H

_{1 a} 1106 V H SOsH SOsH H Methyl

_{1 g} 1107 OMe H SOsH SOsH H OMe

_{1 a} 1108 H SOsH H H SOsH H Methyl F CONH2 Methyl 2-(Methyl-

_{1 a} 1109 H H SOsH SOsH H H thio)ethyl

_{1 a} 1110 Methyl H SOsH SOsH H Methyl

_{1 a} 1111 OMe H SOsH SOsH H OMe

_{1 a} 1112 H SOsH H H SOsH H Methyl F CONH2 Methyl 2-Fluoroet

_{1 a} 1113 H H SOsH SOsH H H

_{1 a} 1114 Methyl H SOsH SOsH H Methyl

_{1 a} 1115 OMe H SOsH SOsH H OMe

_{1 a} 1116 H SOsH H H SOsH H Methyl F CONH2 Methyl 2-Chloroet

_{1 g} 1117 H H SOsH SOsH H H

_{1 a} 1118 Methyl H SOsH SOsH H Methyl

_{1 g} 1119 OMe H SOsH SOsH H OMe

_{1 g} 1120 H SOsH H H SOsH H Methyl F CONH2 Methyl 3-Chloro-

_{1 g} 1121 H H SOsH SOsH H H propyl

_{1 g} 1122 Methyl H SOsH SOsH H Methyl

_{1 g} 1123 OMe H SOsH SOsH H OMe

_{1 g} 1124 H SOsH H H SOsH H Methyl F CONH2 Methyl Tetrahydr

_{1 g} 1125 H H SOsH SOsH H H furfuryl

_{1 g} 1126 Methyl H SOsH SOsH H Methyl

_{1 g} 1127 OMe H SOsH SOsH H OMe

_{1 a} 1128 H SOsH H H SOsH H Methyl F CONH2 Methyl 2-Furan-2

_{1 g} 1129 H H SOsH SOsH H H ethyl

_{1 g} 1130 Methyl H SOsH SOsH H Methyl

_{1 g} 1131 OMe H SOsH SOsH H OMe

_{1 a} 1132 H SOsH H H SOsH H Methyl F CONH2 Methyl 2-(2-

_{1 a} 1133 H H SOsH SOsH H H Hydroxy

_{1 g} 1134 Methyl H SOsH SOsH H Methyl ethyl-

OMe H SOsH SOsH H OMe sulfanyl)

_{1 g} 1135

ethyl

_{1 g} 1136 H SOsH H H SOsH H Methyl F CONH2 Methyl 2-(2-tert-

_{1 g} 1137 H H SOsH SOsH H H Butylsulf

_{1 a} 1138 Methyl H SOsH SOsH H Methyl yl-ethan

OMe H SOsH SOsH H OMe sulfonyl)

_{1 g} 1139

ethyl

_{1 g} 1140 H SOsH H H SOsH H Methyl F CONH2 Methyl 3-(4-

_{1 g} 1141 H H SOsH SOsH H H Hydroxy

_{1 g} 1142 Methyl H SOsH SOsH H Methyl butoxy)

OMe H SOsH SOsH H OMe propyl

_{1 g} 1143

_{1 a} 1144 H SOsH H H SOsH H Methyl F CONH2 Methyl 2-(2-

_{1 g} 1145 H H SOsH SOsH H H Hydroxy

_{1 g} 1146 Methyl H SOsH SOsH H Methyl ethoxy)e

_{1 g} 1147 OMe H SOsH SOsH H OMe yi

_{1 a} 1148 H SOsH H H SOsH H Methyl F CONH2 Methyl 3-lso-

_{1 g} 1149 H H SOsH SOsH H H propo

_{1 a} 1150 Methyl H SOsH SOsH H Methyl propyl

_{1 g} 1151 OMe H SOsH SOsH H OMe

_{1 g} 1152 F H SOsH SOsH H F

_{1 g} 1153 CFs H SOsH SOsH H CFs

_{1 g} 1154 H SO3H H H SO3H H Methyl F CONH2 Methyl 3-Etho

_{1 a} 1155 H H SO3H SO3H H H propyl

_{1 g} 1156 Methyl H SO3H SO3H H Methyl

_{1 g} 1157 OMe H SO3H SO3H H OMe

_{1 a} 1158 F H SO3H SO3H H F

_{1 g} 1159 CF3 H SO3H SO3H H CF3

_{1 g} 1160 H SOsH H H SOsH H NHCOCHs OMe CONH2 Methyl Ally I

_{1 g} 1161 H H SOsH SOsH H H

_{1 g} 1162 Methyl H SOsH SOsH H Methyl

_{1 g} 1163 OMe H SOsH SOsH H OMe

_{1 g} 1164 F H SOsH SOsH H F

_{1 g} 1165 CFs H SOsH SOsH H CFs

_{1 a} 1166 H SOsH H H SOsH H NHCOCHs OMe CONH2 Methyl 2-

_{1 a} 1167 H H SOsH SOsH H H Metho

_{1 a} 1168 Methyl H SOsH SOsH H Methyl ethyl

_{1 g} 1169 OMe H SOsH SOsH H OMe

_{1 g} 1170 F H SOsH SOsH H F

_{1 g} 1171 CFs H SOsH SOsH H CFs

_{1 g} 1172 H SOsH H H SOsH H NHCOCHs OMe CONH2 Methyl 3-

_{1 g} 1173 H H SOsH SOsH H H Metho

_{1 g} 1174 Methyl H SOsH SOsH H Methyl propyl

_{1 g} 1175 OMe H SOsH SOsH H OMe

_{1 g} 1176 F H SOsH SOsH H F

_{1 g} 1177 CFs H SOsH SOsH H CFs

_{1 g} 1178 H SOsH H H SOsH H NHCOCHs OMe CONH2 Methyl 2-Cya

_{1 a} 1179 H H SOsH SOsH H H ethyl

_{1 a} 1180 Methyl H SOsH SOsH H Methyl

_{1 g} 1181 OMe H SOsH SOsH H OMe

_{1 a} 1182 F H SOsH SOsH H F

_{1 a} 1183 CFs H SOsH SOsH H CFs

_{1 a} 1184 H SOsH H H SOsH H NHCOCHs OMe CONH2 Methyl 2-

_{1 a} 1185 H H SOsH SOsH H H (Meth

_{1 a} 1186 Methyl H SOsH SOsH H Methyl thio)et

_{1 g} 1187 OMe H SOsH SOsH H OMe

_{1 a} 1188 F H SOsH SOsH H F

_{1 g} 1189 CFs H SOsH SOsH H CFs

_{1 g} 1190 H SOsH H H SOsH H NHCOCHs OMe CONH2 Methyl 2-Fluo

_{1 g} 1191 H H SOsH SOsH H H ethyl

_{1 g} 1192 Methyl H SOsH SOsH H Methyl

_{1 g} 1193 OMe H SOsH SOsH H OMe

_{1 g} 1194 F H SOsH SOsH H F

_{1 g} 1195 CFs H SOsH SOsH H CFs

_{1 g} 1196 H SOsH H H SOsH H NHCOCHs OMe CONH2 Methyl 2-Chlo

_{1 g} 1197 H H SOsH SOsH H H ethyl

_{1 g} 1198 Methyl H SOsH SOsH H Methyl

_{1 g} 1199 OMe H SOsH SOsH H OMe

_1g 1200 F H SOsH SOsH H F

_{1 g} 1201 CFs H SOsH SOsH H CFs

H SOsH H H SOsH H NHCOCH OMe

_1a 1202 CONH ₂ Methyl 3-Chl

3 propyl

_{1 a} 1203 H H SOsH SOsH H H

_{1 a} 1204 Methyl H SOsH SOsH H Methyl

_{1 a} 1205 OMe H SOsH SOsH H OMe

_{1 a} 1206 F H SOsH SOsH H F

_{1 a} 1207 CFs H SOsH SOsH H CFs

H SOsH H H SOsH H NHCOCH OMe CONH2

_{1 a} 1208 Methyl Tetra-

3 hydro

_{1 a} 1209 H H SOsH SOsH H H furfur

_{1 g} 1210 Methyl H SOsH SOsH H Methyl

_{1 g} 1211 OMe H SOsH SOsH H OMe

_{1 g} 1212 F H SOsH SOsH H F

_{1 g} 1213 CFs H SOsH SOsH H CFs

_{1 g} 1214 H SOsH H H SOsH H NHCOCH OMe CONH2 Methyl 2-Fur

_{1 g} 1215 H H SOsH SOsH H H 3 2-yl-et

_{1 g} 1216 Methyl H SOsH SOsH H Methyl

_{1 g} 1217 OMe H SOsH SOsH H OMe

_{1 g} 1218 F H SOsH SOsH H F

_{1 g} 1219 CFs H SOsH SOsH H CFs

_{1 a} 1238 H SOsH H H SOsH H NHCOCH OMe CONH2 Methyl 3-lso-

_{1 a} 1239 H H SOsH SOsH H H 3 propo

_{1 a} 1240 Methyl H SOsH SOsH H Methyl propyl

_{1 g} 1241 OMe H SOsH SOsH H OMe

_{1 g} 1242 F H SOsH SOsH H F

_{1 a} 1243 CFs H SOsH SOsH H CF ₃

_{1 g} 1244 H SOsH H H SOsH H NHCOCH OMe CONH2 Methyl 3-Eth

_{1 a} 1245 H H SOsH SOsH H H 3 propyl

_{1 g} 1246 Methyl H SOsH SOsH H Methyl

_{1 g} 1247 OMe H SOsH SOsH H OMe

_{1 a} 1248 F H SOsH SOsH H F

_{1 g} 1249 CF3 H SOsH SOsH H CF3

Further preferred dyes of the present invention are those of formula (1 b)

wherein

R ^{1 b} , R ^2b , R ^3b , R ^4b , R ^5b , R ^6b , R ^7b and R ^8b independent of each other is hydrogen, alkyi, alkoxy, halogen, trifluoromethyl or SO3M whereby at least two of them are SO3M,

R ^9b , R ^10b , R ^13b and R ^14b independent of each other is hydrogen, (Ci-C )-alkyl, (C1-C4)- alkoxy, halogen, trifluoromethyl, -SO3M or (Ci-C ₄ )-acylamino,

R ^17b and R ^20b independent of each other is hydrogen, alkyi, alkenyl, cycloalkyl, trifluoromethyl, aryl, heteroaryl, heterocycloalkyl, carbamoyl, sulfamoyl, amino, N- acylamino, ureido, alkylureido, phenylureido, N-monoalkylamino, N,N-dialkyl-amino, N-arylamino, Ν,Ν-diarylamino, N-alkyl-N-aryl-amino, N-monocycloalkylamino, N,N- dicycloalkylamino, N-alkyl-N-cycloalkyl-amino, N-aryl-N-cycloalkyl-amino, hydroxyl- alkylsulfonylalkyl

or

alkyi interrupted by one or more heteroatoms selected from the group consisting of oxygen and sulphur

or

alkyi substituted by one or more substituents selected from the group consisting of hydroxy, aryl, cycloalkyl, alkoxy, amino, N-monoalkyl-amino, Ν,Ν-dialkyl-amino, N- monoaryl-amino, Ν,Ν-diaryl-amino, N-alkyl-N-aryl-amino, N-monocycloalkyl-amino, Ν,Ν-dicycloalkyl-amino, N-monoalkyl-monocycloalkyl-amino, N,N-monoaryl-mono- cycloalkyl-amino, N-acylamino, N-alkylsulfonyl-amino, ureido, alkylureido, phenyl- ureido, halogen, cyano, COOM, nitro, acyl, alkylsulfonyl, aryloyl, trifluoromethyl, heteroaryl, heterocycloalkyi, alkoxycarbonyl, acyloxy, aryloyloxy, carbamoyl, sulfamoyl and SOsM

or

alkyl interrupted by one or more heteroatoms selected from the group consisting of oxygen and sulphur and substituted by one or more substituents selected from the group consisting of hydroxy, aryl, cycloalkyl, alkoxy, amino, N-monoalkyl-amino, N,N- dialkyl-amino, N-monoaryl-amino, Ν,Ν-diaryl-amino, N-alkyl-N-aryl-amino, N- monocycloalkyl-amino, Ν,Ν-dicycloalkyl-amino, N-monoalkyl-monocycloalkyl-amino, Ν,Ν-monoaryl-monocycloalkyl-amino, N-acylamino, N-alkylsulfonyl-amino, ureido, alkylureido, phenylureido, halogen, cyano, COOM, nitro, acyl, alkylsulfonyl, aryloyl, trifluoromethyl, heteroaryl, heterocycloalkyi, alkoxycarbonyl, acyloxy, aryloyloxy, carbamoyl, sulfamoyl and SO3M,

R ^18b and R ^{21 b} independent of each other is cyano, carbamoyl or alkoxycarbonyl,

R ^19b and R ^22b independent of each other is unsubstituted, linear or branched (Ci-C ₄ ) alkyl, unsubstiuted (C5-C7) cycloalkyl or substituted (C5-C7) cycloalkyl with one or more substituents such as methyl, ethyl, isobutyl, sec-butyl, tert-butyl and methylbutyl, and

M is hydrogen, an alkali metal, ammonium, one equivalent of an alkali earth metal or a monovalent organic cation. In especially preferred dyes of formula (1 b)

R ^{1 b} , R ^3b , R ^4b , R ^5b , R ^6b and R ^8b independent of each other is SO ₃ M, hydrogen, alkyl, alkoxy or halogen, - whereby at least two of them are SO3M, R ^2b and R ^7b is hydrogen,

R ^9b , R ^10b , R ^13b and R ^14b independent of each other is hydrogen, methyl, halogen, - SO3M or acetylamino, R ^17b and R ^20b independent of each other is methyl, ethyl, butyl, n-propyl, n-butyl, n- pentyl, n-hexyl, cyclobutyl, cyclopentyl, cyclohexyl, 2-methylcyclohexyl, 3- methylcyclohexyl, isopropyl, sec-butyl, 2-methylbutyl, 1 -ethylpropyl, 1 ,2-dimethyl- propyl, tert-butyl, 3-methylbutyl, pentene-2-yl, 2-ethylhexyl, 2,2-dimethylpropyl, phenyl, benzyl, allyl, 2-methoxyethyl, 3-methoxypropyl, 2-cyanoethyl, 2-(methylthio)ethyl, 2- fluoroethyl, 2-chloroethyl, 3-chloropropyl, tetrahydrofurfuryl, 2-furan-2-yl-ethyl, 6- hydroxy-1 -[2-(2-hydroxyethylsulfanyl)-ethyl], 2-(2-tertbutylsulfanylethanesulfonyl)- ethyl, 2-(ethylsulfonyl)ethanol, 3-(4-hydroxybutoxy)propyl, 2-(2-hydroxyethoxy)ethyl, 3-lsopropoxy propyl or 3-ethoxypropyl,

R ^18b and R ^{21 b} independent of each other is cyano or carbamoyl,

R ^19b and R ^22b is methyl,

and

M is hydrogen, sodium, potassium, lithium or ammonium.

Examples of preferred dyes of the formula (1 b) are the compounds of the formul to 1 b ¹⁷⁰ ) as shown in Table 2, whereby R ^2b and R ^7b is hydrogen:

Table 2:

Structure _R 1b _R 3b _R 4b _R 5b _R 6b _R 8b _R 9b/ _R 13b _R 10b/ _R 14b _R 18b _{/ R} 21b _R 19b _R 22b _R 17b/ _R

R21 ^b R22 ^b

H SOsH H H SOsH H 6-SOsH H CONH2 Methyl Methy

1b ¹

H H SOsH SOsH H H

1b ²

Methyl H SOsH SOsH H Methyl

1b ³

OMe H SOsH SOsH H OMe

1b ⁴

F H SOsH SOsH H F

1b ⁵

H SOsH H H SOsH H 6-SOsH H

1b ⁶ CONH2 Methyl Ethyl

H H SOsH SOsH H H

Methyl H SOsH SOsH H Methyl

1b ⁸

1b ⁹ OMe H SOsH SOsH H OMe

_{1 b} io F H SOsH SOsH H F

H SOsH H H SOsH H 6-SOsH H

1b ¹¹ CONH2 Methyl

Propy

H H SOsH SOsH H H

1b ¹²

Methyl H SOsH SOsH H Methyl

1b ¹³

OMe H SOsH SOsH H OMe

1b ¹⁴

1b ¹⁵ F H SOsH SOsH H F

_{1 b} 16 H SOsH H H SOsH H 6-SOsH H CONH2 Methyl Butyl

H H SOsH SOsH H H

1b ¹⁷

_{1 b} 18 Methyl H SOsH SOsH H Methyl

_{1 b} 59 OMe H SOsH SOsH H OMe

F H SOsH SOsH H

1b ⁶⁰ F

_{1 b} 61 H S0 ₃ H H H SO3H H 6-SO3H H CN Methyl Methy

_{1 b} 62 H H SO3H SOsH H H

_{1 b} 63 Methyl H SOsH SOsH H Methyl

_{1 b} 64 OMe H SOsH SOsH H OMe

_{1 b} 65 F H SOsH SOsH H F

H SOsH H H SOsH

1b ⁶⁶ H 6-SO3H H CN Methyl Ethyl

_{1 b} 67 H H SOsH SOsH H H

_{1 b} 68 Methyl H SO3H SO3H H Methyl

_{1 b} 69 OMe H SO3H SO3H H OMe

_{1 b} 70 F H SO3H SOsH H F

H SOsH H H SOsH

1b ⁷¹ H 6-SOsH H CN Methyl Propyl

H H SOsH SOsH H H

1b ⁷²

Methyl H SOsH SOsH H Methyl

1b ⁷³

OMe H SOsH SOsH H

1b ⁷⁴ OMe

F H SO3H SO3H H F

1b ⁷⁵

H SOsH H H SOsH

1b ⁷⁶ H 6-SO3H H CN Methyl Butyl

H H SOsH SOsH H H

1b ⁷⁷

_{1 b} 78 Methyl H SO3H SOsH H Methyl

_{1 b} 79 OMe H SOsH SOsH H OMe

_{1 b} 80 F H SOsH SOsH H F

_{1 b} 81 H SOsH H H SOsH H 6-SO3H H CN Methyl Penty

_{1 b} 82 H H SOsH SOsH H H

_{1 b} 83 Methyl H SOsH SOsH H Methyl

_{1 b} 84 OMe H SOsH SOsH H OMe

_{1 b} 85 F H SOsH SOsH H F

_{1 b} 86 H SOsH H H SOsH H 7-SOsH H CONH2 Methyl Cyclohe

_{1 b} 87 H H SOsH SOsH H H

_{1 b} 88 Methyl H SO3H SOsH H Methyl

_{1 b} 89 OMe H SOsH SOsH H OMe

_{1 b} 90 F H SOsH SOsH H F

_{1 b} 91 H SOsH H H SOsH H 7-SOsH H CONH2 Methyl Hexyl

_{1 b} 92 H H SOsH SOsH H H

_{1 b} 93 Methyl H SOsH SOsH H Methyl

_{1 b} 94 OMe H SOsH SOsH H OMe

_{1 b} 95 F H SOsH SOsH H F

_{1 b} 96 H SOsH H H SOsH H 7-SOsH H CONH2 Methyl Methy

_{1 b} 97 H H SOsH SOsH H H

_{1 b} 98 Methyl H SOsH SOsH H Methyl

Another referred embodiment are dye(s) of formula (2) and mixtures thereof

(2) wherein

R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ and R ⁸ independent of each other is hydrogen, alkyl, alkoxy, halogen, trifluoromethyl or SO3M, whereby at least two of them are SO3M,

R ⁹ , R ¹⁰ , R ¹³ , R ¹⁴ independent of each other is hydrogen, alkyl, substituted alkyl, alkyl chain interrupted by one or two heteroatoms, alkoxy, substituted alkoxy, halogen, trifluoromethyl, cycloalkyi, heterocycloalkyi, cyano, acyloxy, alkylcarbonyl, acylamino, alkylsulfonylamino, amino, monoalkyl-amino, monocycloalkyl-amino, dialkyl-amino, di(cyclo)alkyl-amino, alkylthio, alkylsulfonyl, alkoxycarbonyl, carbamoyl, sulfamoyl, ureido,alkylureido or SO3M,

R ²⁴ and R ³⁰ independent of each other is cyano, carbamoyl, substituted carbamoyl, alkoxycarbonyl, trifluoromethyl, carbonyltrifluoromethyl or halogen, R ²³ and R ²⁹ independent of each other is hydrogen, alkyi, cycloalkyl, trifluoromethyl, alkoxy, cyano, carbamoyl, alkoxycarbonyl, COOM, amino, hydroxyl, monocycloalkyl- amino, monoalkyl-amino, di(cyclo)alkyl-amino, dialkyl-amino, monoaryl-amino, diaryl- amino, monocycloalkylmonoarylamino, monoalkyl monoaryl amino, alkylthio, arylthio or

is alkyi substituted by one or more substituents selected from the group consisting of hydroxy, cycloalkyl, heteroaryl, heterocycloalkyl, aryl, aryloxy, alkoxy, alkylthio, arylthio, halogen, cyano, COOM, alkoxycarbonyl, acyloxy, carbamoyl, nitro, amino, acylamino, arylcarbonylamino, alkylsulfonylamino, arylsulfonylamino, ureido, alkyl- ureido and phenylureido,

R ²⁵ , R ²⁶ , R ²⁷ , R ²⁸ , R ³¹ , R ³² , R ³³ and R ³⁴ independent of each other is hydrogen, alkyi, hydroxyalkyl, alkoxy, alkenyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, carbamoyl, alkylureido, phenylureido, hydroxyalkylsulfonylalkyl, aminoalkyl, amino-hydroxy-alkyl, alkoxyalkylaminoalkyl, thioalkoxyalkyl-aminoalkyl, aminoalkyloxyalkyl, amino- alkylthioxyalkyl, cycloalkylalkyl, aryloxyalkyl, arylthioxyalkyl, heteroarylalkyl, heterocycloalkylalkyl

or

alkyi interrupted by one or more heteroatoms selected from the group consisting of oxygen and sulfur

or

alkyi substituted by one or more substituents selected from the group consisting of hydroxy, aryl, cycloalkyl, alkoxy, thioalkoxy, amino, N-monoalkyl-amino, N,N-dialkyl- amino, N-monoaryl-amino, Ν,Ν-diaryl-amino, N-alkyl-N-aryl-amino, N-monocycloalkyl- amino, Ν,Ν-dicycloalkyl-amino, N-monoalkyl-monocycloalkyl-amino, N,N-monoaryl- monocycloalkyl-amino, N-acylamino, N-alkylsulfonyl-amino, ureido, alkylureido, phenylureido, halogen, cyano, COOM, nitro, acyl, thioacyl, alkylsulfonyl, aryloyl, trifluoromethyl, heteroaryl, heterocycloalkyl, alkoxycarbonyl, alkoxythiocarbonyl, acyloxy, aryloyloxy, carbamoyl, N-monocycloalkyl-carbamoyl, N-monoalkyl-carbamoyl, N,N-dicycloalkyl-carbamoyl, Ν,Ν-dialkyl-carbamoyl, N-monoaryl-carbamoyl, N,N-di- aryl-carbamoyl, N-monocycloalkyl-N-monoarylcarbamoyl, N-monoalkyl-N-monoaryl- carbamoyl, sulfamoyl, N-monocycloalkyl-sulfamoyl, N-monoalkyl-sulfamoyl, N,N- dicycloalkyl-sulfamoyl, Ν,Ν-dialkyl-sulfamoyl, N-monoaryl-sulfamoyl, N,N-diaryl- sulfamoyl, N-monocycloalkyl-N-monoarylsulfamoyl, N-monoalkyl-N-monoarylsulfamo- yl and SO ₃ M or

alkyl interrupted by one or more heteroatoms selected from the group consisting of oxygen and sulfur and substituted by one or more substituents selected from the group consisting of hydroxy, aryl, cycloalkyl, alkoxy, thioalkoxy, amino, N-monoalkyl-amino, Ν,Ν-dialkyl-amino, N-monoaryl-amino, Ν,Ν-diaryl-amino, N-alkyl-N-aryl-amino, N- monocycloalkyl-amino, Ν,Ν-dicycloalkyl-amino, N-monoalkyl-monocycloalkyl-amino, Ν,Ν-monoaryl-monocycloalkyl-amino, N-acylamino, N-alkylsulfonyl-amino, ureido, alkylureido, phenylureido, halogen, cyano, COOM, nitro, acyl, thioacyl, alkylsulfonyl, aryloyl, trifluoromethyl, heteroaryl, heterocycloalkyl, alkoxycarbonyl, alkoxythiocarbonyl, acyloxy, aryloyloxy, carbamoyl, N-monocycloalkyl-carbamoyl, N- monoalkyl-carbamoyl, N,N-dicycloalkyl-carbamoyl, Ν,Ν-dialkyl-carbamoyl, N- monoaryl-carbamoyl, Ν,Ν-diaryl-carbamoyl, N-monocycloalkyl-N-monoarylcarbamoyl, N-monoalkyl-N-monoaryl-carbamoyl, sulfamoyl, N-monocycloalkyl-sulfamoyl, N- monoalkyl-sulfamoyl, N,N-dicycloalkyl-sulfamoyl, Ν,Ν-dialkyl-sulfamoyl, N-monoaryl- sulfamoyl, Ν,Ν-diaryl-sulfamoyl, N-monocycloalkyl-N-monoarylsulfamoyl, N- monoalkyl-N-monoarylsulfamoyl and SO3M,

M is hydrogen, an alkali metal, ammonium, one equivalent of an alkali earth metal or a monovalent organic cation, the dyes of formula (2) have two to six sulfonic acid groups,

and

whereby the bonds with unfixed attachment points on the pyridine couplers mean that the amino rests bearing the substituents R ²⁵ , R ²⁶ , R ²⁷ and R ²⁸ , respectively can be positioned ortho or para to R ²⁴ , meaning that when the amino rest bearing the substituents R ²²⁵ and R ²⁶ is positioned ortho to R ²⁴ , the amino rest bearing the substituents R ²⁷ to R ²⁸ is positioned para to R ²⁴ , and vice versa;

and

the same applies to the amino rests bearing the substituents R ³¹ , R ³² , R ³³ and R ³⁴ , respectively that can be positioned ortho or para to R ³⁰ , meaning that when the amino rest bearing the substituents R ³¹ and R ³² is positioned ortho to R ³⁰ , the amino rest bearing the substituents R ³³ to R ³⁴ is positioned para to R ³⁰ , and vice versa.

Particularly preferred embodiments of the present invention are the dyes of formula (2a) and mixtures thereof

(2a) wherein R ^{1 a} , R ^2a , R ^3a , R ^4a , R ^5a , R ^6a , R ^7a and R ^8a independent of each other is hydrogen, alkyl, alkoxy, halogen, trifluoromethyl or SO3M, - whereby at least two of them are SO3M,

R ^9a , R ^10a , R ^{1 3a} and R ^14a independent of each other is hydrogen, (Ci -C )-alkyl, (C1 -C4)- alkoxy, halogen, trifluoromethyl(Ci -C ₄ )-acylamino or SO3M,

R ^23a and R ^29a independent of each other is unsubstituted, linear or branched (Ci -C ₄ )- alkyl, unsubstituted (Cs-CzJ-cycloalkyl or substituted (Cs-CzJ-cycloalkyl with one or more substituents preferably selected from the group consisting of methyl, ethyl, isobutyl, sec-butyl, tert-butyl and methylbutyl,

R ^24a and R ^30a independent of each other is cyano, carbamoyl or alkoxycarbonyl, _R 25 _{3j R} 26a _R 27 _{3j R} 28 _{3j R} 3i _{3j R} 32 _{3j R} 33a _{a nd R} 34a independent of each other is hydrogen, alkyi, hydroxyalkyl, alkoxy, alkenyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, carbamoyl, alkylureido, phenylureido, hydroxyalkylsulfonylalkyl, aminoalkyl, amino- hydroxy-alkyl, alkoxyalkylaminoalkyl, thioalkoxyalkyl-aminoalkyl, aminoalkyloxyalkyl, aminoalkylthioxyalkyl, cycloalkylalkyl, aryloxyalkyl, arylthioxyalkyl, heteroarylalkyl, heterocycloalkylalkyl

or

alkyi interrupted by one or more heteroatoms selected from the group consisting of oxygen and sulfur

or

alkyi substituted by one or more substituents selected from the group consisting of hydroxy, aryl, cycloalkyl, alkoxy, amino, N-monoalkyl-amino, Ν,Ν-dialkyl-amino, N- monoaryl-amino, Ν,Ν-diaryl-amino, N-alkyl-N-aryl-amino, N-monocycloalkyl-amino, Ν,Ν-dicycloalkyl-amino, N-monoalkyl-monocycloalkyl-amino, N,N-monoaryl-mono- cycloalkyl-amino, N-acylamino, N-alkylsulfonyl-amino, ureido, alkylureido, phenylureido, halogen, cyano, COOM, nitro, acyl, alkylsulfonyl, aryloyl, trifluoromethyl, heteroaryl, heterocycloalkyl, alkoxycarbonyl, acyloxy, aryloyloxy, carbamoyl, sulfamoyl and SOsM

or

alkyi interrupted by one or more heteroatoms selected from the group consisting of oxygen and sulfur and substituted by one or more substituents selected from the group consisting of hydroxy, aryl, cycloalkyl, alkoxy, amino, N-monoalkyl-amino, N,N-dialkyl- amino, N-monoaryl-amino, Ν,Ν-diaryl-amino, N-alkyl-N-aryl-amino, N-monocycloalkyl- amino, Ν,Ν-dicycloalkyl-amino, N-monoalkyl-monocycloalkyl-amino, N,N-monoaryl- monocycloalkyl-amino, N-acylamino, N-alkylsulfonyl-amino, ureido, alkylureido, phenylureido, halogen, cyano, COOM, nitro, acyl, alkylsulfonyl, aryloyl, trifluoromethyl, heteroaryl, heterocycloalkyl, alkoxycarbonyl, acyloxy, aryloyloxy, carbamoyl, sulfamoyl and SOsM

and

M is hydrogen, an alkali metal, ammonium, one equivalent of an alkali earth metal or a monovalent organic cation.

In especially preferred dyes of formula (2a) R ^{1 a} , R ^3a , R ^4a , R ^5a , R ^6a and R ^8a independent of each other is SO ₃ M, hydrogen, alkyl, alkoxy or halogen, - whereby at least two of them are SO3M,

R ^2a and R ^7a is hydrogen,

R ^9a , R ^10a , R ^13a and R ^14a independent of each other is hydrogen, methyl, halogen, SO3M or acetylamino,

R ^23a and R ^29a is methyl,

R ^24a and R ^30a independent of each other is cyano or carbamoyl,

_R 25 _{3j R} 26a _R 27 _{3j R} 28 _{3j R} 3i _{3j R} 32 _{3j R} 33a _{a nd R} 34a independent of each other is hydrogen, methyl, ethyl, n-propyl, n-butyl, n-pentyl, n-hexyl, cyclobutyl, cyclopentyl, cyclohexyl, 2-methylcyclohexyl, 3-methylcyclohexyl, isopropyl, sec-butyl, 2-methylbutyl, 1 - ethylpropyl, 1 ,2-dimethylpropyl, tert-butyl, 3-methylbutyl, pentan-2-yl, 2-ethylhexyl, 2,2-dimethylpropyl, phenyl, benzyl, 2-hydroxyethyl, allyl, 2-methoxyethyl, 3-methoxy- propyl, 2-cyanoethyl, 2-(methylthio)ethyl, 2-fluoroethyl, 2-chloroethyl, 3-chloropropyl, 2-(2-hydroxyethylsulfanyl)-ethyl, 2-(2-tertbutylsulfanylethanesulfonyl)-ethyl, 2-(2- hydroxyethoxy)propyl, 2-(2-hydroxy ethoxy)ethyl, 3-(4-hydroxybutoxy)propyl, 2-(2- hydroxyethanesulfonyl)-ethyl, 3-(2-phenoxy-ethoxy)-propyl, 3-isopropoxy-propyl, 3- ethoxy-propyl, 3-ethoxybutyl

or

(C ₂ -C ₆ )-alkyl substituted by COOM or by SO ₃ M

and

M is hydrogen, sodium, potassium, lithium or ammonium.

Examples of preferred dyes of formula (2a) are the compounds of formulae (2a ¹ to 2a ²⁵⁹⁴ ) and mixtures thereof (Table 3): hereby R ^{1 a} , R ^2a , R ^7a ,and R ^8a are hydrogen Table 3

2a ²⁷ SOsH H H SOsH 2-Methyl

Methyl Methyl CN 2-Methyl butyl H H

2a ²⁸ H SOsH SOsH H butyl

2a ²⁹ SOsH H H SOsH

Methyl Methyl CN 1 -Ethyl propyl H 1 -Ethyl propyl H

2a ³⁰ H SOsH SOsH H

2a ³¹ SOsH H H SOsH 1 ,2-Dimethyl 1 ,2-Dimethyl

Methyl Methyl CN H H

2a ³² H SOsH SOsH H propyl propyl

2a ³³ SOsH H H SOsH

Methyl Methyl CN Tert-butyl H Tert-butyl H

2a ³⁴ H SOsH SOsH H

2a ³⁵ SOsH H H SOsH

Methyl Methyl CN 3-Methyl butyl H 3-Methyl butyl H

2a ³⁶ H SOsH SOsH H

2a ³⁷ SOsH H H SOsH

Methyl Methyl CN Pentan-2-yl H Pentan-2-yl H

2a ³⁸ H SOsH SOsH H

2a ³⁹ SOsH H H SOsH

Methyl Methyl CN 2-Ethylhexyl H 2-Ethylhexyl H

2a ⁴⁰ H SOsH SOsH H

2a ⁴¹ SOsH H H SOsH 2,2-Dimethyl 2,2-Dimethyl

Methyl Methyl CN H H

2a ⁴² H SOsH SOsH H propyl propyl

2a ⁴³ SOsH H H SOsH

Methyl Methyl CN Phenyl H Phenyl H

2a ⁴⁴ H SOsH SOsH H

2a ⁴⁵ SOsH H H SOsH

Methyl Methyl CN Benzyl H Benzyl H

2a ⁴⁶ H SOsH SOsH H

2a ⁴⁷ SOsH H H SOsH NHCOC

OMe CN Methyl H Methyl H

2a ⁴⁸ H SOsH SOsH H Hs

2a ⁴⁹ SOsH H H SOsH NHCOC

OMe CN Ethyl H Ethyl H

2a ⁵⁰ H SOsH SOsH H Hs

2a ⁵¹ SOsH H H SOsH NHCOC

OMe CN Propyl H Propyl H

2a ⁵² H SOsH SOsH H Hs

2a ⁵³ SOsH H H SOsH NHCOC

OMe CN Butyl H Butyl H

2a ⁵⁴ H SOsH SOsH H Hs

2a ⁵⁵ SOsH H H SOsH NHCOC

OMe CN Pentyl H Pentyl H

2a ⁵⁶ H SOsH SOsH H Hs

2a ⁵⁷ SOsH H H SOsH NHCOC

OMe CN Hexyl H Hexyl H

2a ⁵⁸ H SOsH SOsH H Hs

2a ⁵⁹ SOsH H H SOsH NHCOC

OMe CN Cyclobutyl H Cyclobutyl H

2a ⁶⁰ H SOsH SOsH H Hs

2a ⁶¹ SOsH H H SOsH NHCOC

OMe CN Cyclopentyl H Cyclopentyl H

2a ⁶² H SOsH SOsH H Hs

2a ⁶³ SOsH H H SOsH NHCOC

OMe CN Cyclohexyl H Cyclohexyl H

2a ⁶⁴ H SOsH SOsH H Hs

2a ⁶⁵ SOsH H H SOsH NHCOC 2-Methyl 2-Methyl

OMe CN H H

2a ⁶⁶ H SOsH SOsH H Hs cyclohexyl cyclohexyl

2a ⁶⁷ SOsH H H SOsH NHCOC 3-Methyl 3-Methyl

OMe CN H H

2a ⁶⁸ H SOsH SOsH H Hs cyclohexyl cyclohexyl

2a ⁶⁹ SOsH H H SOsH NHCOC

OMe CN Isopropyl H Isopropyl H

2a ⁷⁰ H SOsH SOsH H Hs

2a ⁷¹ SOsH H H SOsH NHCOC

OMe CN Sec-butyl H Sec-butyl H

2a ⁷² H SOsH SOsH H Hs

2a ⁷³ SOsH H H SOsH NHCOC 2-Methyl

OMe CN 2-Methyl butyl H H

2a ⁷⁴ H SOsH SOsH H Hs butyl

2a ⁷⁵ SOsH H H SOsH NHCOC

OMe CN 1 -Ethyl propyl H 1 -Ethyl propyl H

2a ⁷⁶ H SOsH SOsH H Hs

2a ⁷⁷ SOsH H H SOsH NHCOC 1 ,2-Dimethyl 1 ,2-Dimethyl

OMe CN H H

2a ⁷⁸ H SOsH SOsH H Hs propyl propyl

2a ⁷⁹ SOsH H H SOsH NHCOC

OMe CN Tert-butyl H Tert-butyl H

2a ⁸⁰ H SOsH SOsH H Hs

2a ⁸¹ SOsH H H SOsH NHCOC

OMe CN 3-Methyl butyl H 3-Methyl butyl H

2a ⁸² H SOsH SOsH H Hs

2a ⁸³ SOsH H H SOsH NHCOC

OMe CN Pentan-2-yl H Pentan-2-yl H

2a ⁸⁴ H SOsH SOsH H Hs

2a ⁸⁵ SOsH H H SOsH H

NHCOC

H SOsH SOsH H OMe CN 2-Ethylhexyl H 2-Ethylhexyl

2a ⁸⁶ Hs

2a ⁸⁷ SOsH H H SOsH NHCOC 2,2-Dimethyl 2,2-Dimethyl

OMe CN H H

2a ⁸⁸ H SOsH SOsH H Hs propyl propyl

2a ⁸⁹ SOsH H H SOsH NHCOC

OMe CN Phenyl H Phenyl H

2a ⁹⁰ H SOsH SOsH H Hs

2a ⁹¹ SOsH H H SOsH NHCOC

OMe CN Benzyl H Benzyl H

2a ⁹² H SOsH SOsH H Hs

2a ⁹³ SOsH H H SOsH

Methyl Methyl CONH ₂ Methyl H Methyl H

2a ⁹⁴ H SOsH SOsH H

2a ⁹⁵ SOsH H H SOsH

Methyl Methyl CONH2 Ethyl H Ethyl H

2a ⁹⁶ H SOsH SOsH H

2a ⁹⁷ SOsH H H SOsH

Methyl Methyl CONH2 Propyl H Propyl H

2a ⁹⁸ H SOsH SOsH H

2a" SOsH H H SOsH

_2a ioo Methyl Methyl CONH2 Butyl H Butyl H

H SOsH SOsH H

_2a 101 SOsH H H SOsH

_2a 102 Methyl Methyl CONH2 Pentyl H Pentyl H

H SOsH SOsH H

_2a 103 SOsH H H SOsH

_2a 104 Methyl Methyl CONH2 Hexyl H Hexyl H

H SOsH SOsH H

_2a 105 SOsH H H SOsH

_2a 106 Methyl Methyl CONH2 Cyclobutyl H Cyclobutyl H

H SOsH SOsH H

_2a 107 SOsH H H SOsH

_2a 108 Methyl Methyl CONH2 Cyclopentyl H Cyclopentyl H

H SOsH SOsH H

_2a 109 SOsH H H SOsH

_2a 110 Methyl Methyl CONH2 Cyclohexyl H Cyclohexyl H

H SOsH SOsH H

_2a 111 SOsH H H SOsH 2-Methyl 2-Methyl

Methyl Methyl CONH2 H H

2a ¹¹² H SOsH SOsH H cyclohexyl cyclohexyl

_2a 1 13 SOsH H H SOsH 3-Methyl 3-Methyl

_2g 1 14 Methyl Methyl CONH2 H H

H SOsH SOsH H cyclohexyl cyclohexyl

_2a 1 15 SOsH H H SOsH H

_2g 1 16 H SOsH SOsH H Methyl Methyl CONH2 Isopropyl H Isopropyl

2a ¹¹⁷ SOsH H H SOsH

_2a 118 Methyl Methyl CONH ₂ Sec-butyl H Sec-butyl H

H SOsH SOsH H

_2a 119 SOsH H H SOsH 2-Methyl

_2a 120 Methyl Methyl CONH2 2-Methyl butyl H H

H SOsH SOsH H butyl

2a ¹²¹ SOsH H H SOsH

Methyl Methyl CONH2 1 -Ethyl propyl H 1 -Ethyl propyl H

2a ¹²² H SOsH SOsH H

_2a 123 SOsH H H SOsH 1 ,2-Dimethyl 1 ,2-Dimethyl

Methyl Methyl CONH2 H H

2a ¹²⁴ H SOsH SOsH H propyl propyl

_2a 125 SOsH H H SOsH

_2g 126 Methyl Methyl CONH2 Tert-butyl H Tert-butyl H

H SOsH SOsH H

2a ¹²⁷ SOsH H H SOsH

_2a 128 Methyl Methyl CONH2 3-Methyl butyl H 3-Methyl butyl H

H SOsH SOsH H

_2g 129 SOsH H H SOsH

_2a 130 Methyl Methyl CONH2 Pentan-2-yl H Pentan-2-yl H

H SOsH SOsH H

_2a 131 SOsH H H SOsH

_2a 132 Methyl Methyl CONH2 2-Ethylhexyl H 2-Ethylhexyl H

H SOsH SOsH H

_2g 133 SOsH H H SOsH 2,2-Dimethyl 2,2-Dimethyl

_2g 134 Methyl Methyl CONH2 H H

H SOsH SOsH H propyl propyl

_2a 135 SOsH H H SOsH

_2g 136 Methyl Methyl CONH2 Phenyl H Phenyl H

H SOsH SOsH H

_2g 137 SOsH H H SOsH

_2a 138 Methyl Methyl CONH2 Benzyl H Benzyl H

H SOsH SOsH H

_2g 139 SOsH H H SOsH NHCOC

_2a 140 OMe CONH2 Methyl H Methyl H

H SOsH SOsH H Hs

_2g 141 SOsH H H SOsH NHCOC

OMe CONH2 Ethyl H Ethyl H

2a ¹⁴² H SOsH SOsH H Hs

_2g 143 SOsH H H SOsH NHCOC

_2g 144 OMe CONH2 Propyl H Propyl H

H SOsH SOsH H Hs

_2a 145 SOsH H H SOsH H

NHCOC

_2g 146 H SOsH SOsH H OMe CONH2 Butyl H Butyl

Hs

2a ¹⁴⁷ SOsH H H SOsH NHCOC

_2a 148 OMe CONH ₂ Pentyl H Pentyl H

H SOsH SOsH H Hs

_2a 149 SOsH H H SOsH NHCOC

_2a 150 OMe CONH2 Hexyl H Hexyl H

H SOsH SOsH H Hs

_2a 151 SOsH H H SOsH NHCOC

_2a 152 OMe CONH2 Cyclobutyl H Cyclobutyl H

H SOsH SOsH H Hs

_2a 153 SOsH H H SOsH NHCOC

_2a 154 OMe CONH2 Cyclopentyl H Cyclopentyl H

H SOsH SOsH H Hs

_2a 155 SOsH H H SOsH NHCOC

_2a 156 OMe CONH2 Cyclohexyl H Cyclohexyl H

H SOsH SOsH H Hs

_2a 157 SOsH H H SOsH NHCOC 2-Methyl 2-Methyl

_2a 158 OMe CONH2 H H

H SOsH SOsH H Hs cyclohexyl cyclohexyl

_2a 159 SOsH H H SOsH NHCOC 3-Methyl 3-Methyl

_2a 160 OMe CONH2 H H

H SOsH SOsH H Hs cyclohexyl cyclohexyl

_2g 161 SOsH H H SOsH NHCOC

_2g 162 OMe CONH2 Isopropyl H Isopropyl H

H SOsH SOsH H Hs

_2a 163 SOsH H H SOsH NHCOC

_2g 164 OMe CONH2 Sec-butyl H Sec-butyl H

H SOsH SOsH H Hs

_2a 165 SOsH H H SOsH NHCOC

_2g 166 OMe CONH2 2-Methyl butyl H 2-Methyl butyl H

H SOsH SOsH H Hs

_2g 167 SOsH H H SOsH NHCOC

_2a 168 OMe CONH2 1 -Ethyl propyl H 1 -Ethyl propyl H

H SOsH SOsH H Hs

_2g 169 SOsH H H SOsH NHCOC 1 ,2-Dimethyl 1 ,2-Dimethyl

_2a 170 OMe CONH2 H H

H SOsH SOsH H Hs propyl propyl

2a ¹⁷¹ SOsH H H SOsH NHCOC

OMe CONH2 Tert-butyl H Tert-butyl H

2a ¹⁷² H SOsH SOsH H Hs

_2a 173 SOsH H H SOsH NHCOC

OMe CONH2 3-Methyl butyl H 3-Methyl butyl H

2a ¹⁷⁴ H SOsH SOsH H Hs

_2a 175 SOsH H H SOsH NHCOC

_2g 176 OMe CONH2 Pentan-2-yl H Pentan-2-yl H

H SOsH SOsH H Hs

2a ¹⁷⁷ SOsH H H SOsH NHCOC

_2g 178 OMe CONH2 2-Ethylhexyl H 2-Ethylhexyl H

H SOsH SOsH H H ₃

_2g 179 SOsH H H SOsH NHCOC 2,2-Dimethyl 2,2-Dimethyl

_2a 180 OMe CONH2 H H

H SOsH SOsH H H ₃ propyl propyl

_2a 181 SOsH H H SOsH NHCOC

_2a 182 OMe CONH2 Phenyl H Phenyl H

H SOsH SOsH H H ₃

_2a 183 SOsH H H SOsH NHCOC

_2g 184 OMe CONH2 Benzyl H Benzyl H

H SOsH SOsH H H ₃

_2a 185 SOsH H H SOsH Ally I Ally I

_2g 186 Methyl Methyl CN H H

H SOsH SOsH H

_2g 187 SOsH H H SOsH 2-Methoxy ethyl Butyl

_2g 188 Methyl Methyl CN H H

H SOsH SOsH H

_2g 189 SOsH H H SOsH 3-Methoxy

_2a 190 Methyl Methyl CN 3-Methoxy propyl H H

H SOsH SOsH H propyl

_2g 191 SOsH H H SOsH Butyl

_2g 192 Methyl Methyl CN 3-Methoxy propyl H H

H SOsH SOsH H

_2a 193 SOsH H H SOsH 2-Methyl

_2g 194 Methyl Methyl CN H Sec-butyl H

H SOsH SOsH H thioethyl

_2a 195 SOsH H H SOsH 2-Methyl 2-

_2g 196 Methyl Methyl CN H H

H SOsH SOsH H thioethyl Hydroxyethyl

_2g 197 SOsH H H SOsH 2-

_2g 198 Methyl CN Butyl Butyl H

H SOsH SOsH H Methyl Hydroxyethyl

_2g 199 SOsH H H SOsH 2-

_2a 200 Methyl Methyl CN Isopropyl Isopropyl H

H SOsH SOsH H Hydroxyethyl

_2a 201 SOsH H H SOsH 2-Fluoro ethyl Butyl

_2a 202 Methyl Methyl CN H H

H SOsH SOsH H

_2a 203 SOsH H H SOsH 2-Chloro ethyl 2-Ethylhexyl

_2a 204 Methyl Methyl CN H H

H SOsH SOsH H

_2a 205 SOsH H H SOsH H

3-Chloro propyl 2-Ethylhexyl

_2a 206 H SOsH SOsH H Methyl Methyl CN H

2a ²⁰⁷ SOsH H H SOsH 2-(2-Hydroxy-

Butyl

H SOsH SOsH H Methyl Methyl CN ethyl sulfanyl)- H H

2a ²⁰⁸

ethyl]

2a ²⁰⁹ SOsH H H SOsH 2-(2-tert-Butyl

H SOsH SOsH H Methyl Methyl CN sulfanyl- ethane H Butyl H

2a ²¹⁰

sulfonyl)-ethyl

2a ²¹¹ SOsH H H SOsH 2-(2-Hydroxy

Methyl Methyl CN H Butyl H

2a ²¹² H SOsH SOsH H ethoxy propyl

2a ²¹³ SO3H H H SO3H 2-(2-Hydroxy

Methyl Methyl CN H Butyl H

2a ²¹⁴ H SO3H SO3H H ethoxy)ethyl

2a ²¹⁵ SOsH H H SOsH 2-(2-Hydroxy-

H SOsH SOsH H Methyl Methyl CN ethanesulf onyl)- H Butyl H

2a ²¹⁶

ethyl

2a ²¹⁷ SOsH H H SOsH 3-(4-

H SOsH SOsH H Methyl Methyl CN H H Hydroxybutoxy H

2a ²¹⁸

)-propyl

2a ²¹⁹ SOsH H H SOsH 2-(2-Hydroxy

Methyl Methyl CN H H H

2a ²²⁰ H SOsH SOsH H ethoxy)ethyl

2a ²²¹ SOsH H H SOsH 3-(4-Hydroxy

Methyl Methyl CN H H H

2a ²²² H SOsH SOsH H butoxy)-propyl

2a ²²³ SOsH H H SOsH 2-(2-Hydroxy

Methyl Methyl CN H H H

2a ²²⁴ H SOsH SOsH H ethoxy)ethyl

2a ²²⁵ SOsH H H SOsH Phenyl 2-(2-Hydroxy

Methyl Methyl CN H H

2a ²²⁶ H SOsH SOsH H ethoxy)ethyl

2a ²²⁷ SOsH H H SOsH 3-(2-Phenoxy- H

Methyl Methyl CN H H

2a ²²⁸ H SOsH SOsH H ethoxy)-propyl

2a ²²⁹ SOsH H H SOsH 3-lsopropoxy- 3-lsopropoxy-

Methyl Methyl CN H H

2a ²³⁰ H SOsH SOsH H propyl propyl

2a ²³¹ SOsH H H SOsH

H

2a ²³² H SOsH SOsH H 3-lsopropoxy-

Methyl Methyl CN H H

propyl

2a ²³³ SOsH H H SOsH 3-lsopropoxy-

Methyl Methyl CN H Phenyl H

2a ²³⁴ H SOsH SOsH H propyl

2a ²³⁵ SOsH H H SOsH 3-Ethoxy-

Methyl Methyl CN 3-Ethoxy-propyl H H

2a ²³⁶ H SOsH SOsH H propyl

2a ²³⁷ SOsH H H SOsH

Methyl Methyl CN 3-Ethoxy-propyl H H H

2a ²³⁸ H SOsH SOsH H

2a ²³⁹ SOsH H H SOsH

Methyl Methyl CN 3-Ethoxy-propyl H Phenyl H

2a ²⁴⁰ H SOsH SOsH H

2a ²⁴¹ SOsH H H SOsH

Methyl Methyl CN 3-Ethoxybutyl H 3-Ethoxy butyl H

2a ²⁴² H SOsH SOsH H

2a ²⁴³ SOsH H H SOsH

Methyl Methyl CN 3-Ethoxybutyl H H H

2a ²⁴⁴ H SOsH SOsH H

2a ²⁴⁵ SOsH H H SOsH

Methyl Methyl CN 3-Ethoxybutyl H Phenyl H

2a ²⁴⁶ H SOsH SOsH H

2a ²⁴⁷ SOsH H H SOsH 4-(2-Hydroxy

H SOsH SOsH H Methyl Methyl CN ethane sulfonyl)- H H H

2a ²⁴⁸

phenyl

2a ²⁴⁹ SOsH H H SOsH NHCOC Ally I Ally I

OMe CN H H

2a ²⁵⁰ H SOsH SOsH H Hs

2a ²⁵¹ SOsH H H SOsH NHCOC 2-Methoxy ethyl Butyl

OMe CN H H

2a ²⁵² H SOsH SOsH H Hs

2a ²⁵³ SOsH H H SOsH NHCOC Butyl

OMe CN 3-Methoxy propyl H H

2a ²⁵⁴ H SOsH SOsH H Hs

2a ²⁵⁵ SOsH H H SOsH NHCOC 2-Methyl

OMe CN H Sec-butyl H

2a ²⁵⁶ H SOsH SOsH H Hs thioethyl

2a ²⁵⁷ SOsH H H SOsH NHCOC 2-Methyl 2-

OMe CN H H

2a ²⁵⁸ H SOsH SOsH H Hs thioethyl Hydroxyethyl

2a ²⁵⁹ SOsH H H SOsH NHCOC 2-

OMe CN Butyl Butyl H

2a ²⁶⁰ H SOsH SOsH H Hs Hydroxyethyl

2a ²⁶¹ SOsH H H SOsH NHCOC 2-

OMe CN Isopropyl Isopropyl H

2a ²⁶² H SOsH SOsH H Hs Hydroxyethyl

2a ²⁶³ SOsH H H SOsH NHCOC 2-Fluoro ethyl Butyl

OMe CN H H

2a ²⁶⁴ H SOsH SOsH H Hs

2a ²⁶⁵ SOsH H H SOsH NHCOC 2-Chloro ethyl 2-Ethylhexyl

OMe CN H H

2a ²⁶⁶ H SOsH SOsH H Hs

2a ²⁶⁷ SOsH H H SOsH NHCOC 3-Chloro propyl 2-Ethylhexyl

OMe CN H H

2a ²⁶⁸ H SOsH SOsH H Hs

2a ²⁶⁹ SOsH H H SOsH 2-(2-Hydroxy-

NHCOC

H SOsH SOsH H OMe CN ethyl sulfanyl)- H Butyl H

2a ²⁷⁰ Hs

ethyl

2a ²⁷¹ SOsH H H SOsH 2-(2-tert-Butyl

NHCOC

H SOsH SOsH H OMe CN sulfanyl- ethane H Butyl H

2a ²⁷² Hs

sulfonyl)-ethyl

2a ²⁷³ SOsH H H SOsH NHCOC 2-(2-Hydroxy

OMe CN H Butyl H

2a ²⁷⁴ H SOsH SOsH H Hs ethoxyjpropyl

2a ²⁷⁵ SO3H H H SO3H NHCOC 2-(2-Hydroxy

OMe CN H Butyl H

2a ²⁷⁶ H SO3H SO3H H Hs ethoxy)ethyl

2a ²⁷⁷ SOsH H H SOsH NHCOC 2-(Ethyl sulfonyl)

OMe CN H Butyl H

2a ²⁷⁸ H SOsH SOsH H Hs ethanol

2a ²⁷⁹ SOsH H H SOsH NHCOC H 3-(4-Hydroxy

OMe CN H H

2a ²⁸⁰ H SOsH SOsH H Hs butoxyjpropyl

2a ²⁸¹ SOsH H H SOsH NHCOC 2-(2-Hydroxy

OMe CN H H H

2a ²⁸² H SOsH SOsH H Hs ethoxy)ethyl

2a ²⁸³ SOsH H H SOsH NHCOC 3-(4-Hydroxy

OMe CN H H H

2a ²⁸⁴ H SOsH SOsH H Hs butoxyjpropyl

2a ²⁸⁵ SOsH H H SOsH NHCOC 2-(2-Hydroxy

OMe CN H H H

2a ²⁸⁶ H SOsH SOsH H Hs ethoxy)ethyl

2a ²⁸⁷ SOsH H H SOsH NHCOC Phenyl (2-Hydroxy

OMe CN H H

2a ²⁸⁸ H SOsH SOsH H Hs ethoxy)ethyl

2a ²⁸⁹ SOsH H H SOsH H

NHCOC 3-(2-Phenoxy- H

H SOsH SOsH H OMe CN H

2a ²⁹⁰ Hs ethoxy)-propyl

2a ²⁹¹ SOsH H H SOsH NHCOC 3-lsopropoxy- 3-lsopropoxy-

OMe CN H H

2a ²⁹² H SOsH SOsH H Hs propyl propyl

2a ²⁹³ SOsH H H SOsH NHCOC 3-lsopropoxy-

OMe CN H H H

2a ²⁹⁴ H SOsH SOsH H Hs propyl

2a ²⁹⁵ SOsH H H SOsH NHCOC 3-lsopropoxy-

OMe CN H Phenyl H

2a ²⁹⁶ H SOsH SOsH H Hs propyl

2a ²⁹⁷ SOsH H H SOsH NHCOC 3-Ethoxy-

OMe CN 3-Ethoxy-propyl H H

2a ²⁹⁸ H SOsH SOsH H Hs propyl

2a ²⁹⁹ SOsH H H SOsH NHCOC

OMe CN 3-Ethoxy-propyl H H H

2a ³⁰⁰ H SOsH SOsH H Hs

2a ³⁰¹ SOsH H H SOsH NHCOC

OMe CN 3-Ethoxy-propyl H Phenyl H

2a ³⁰² H SOsH SOsH H Hs

2a ³⁰³ SOsH H H SOsH NHCOC

OMe CN 3-Ethoxybutyl H 3-Ethoxybutyl H

2a ³⁰⁴ H SOsH SOsH H Hs

2a ³⁰⁵ SOsH H H SOsH NHCOC

OMe CN 3-Ethoxybutyl H H H

2a ³⁰⁶ H SOsH SOsH H Hs

2a ³⁰⁷ SOsH H H SOsH NHCOC

OMe CN 3-Ethoxybutyl H Phenyl H

2a ³⁰⁸ H SOsH SOsH H Hs

2a ³⁰⁹ SOsH H H SOsH 4-(2-Hydroxy

NHCOC

H SOsH SOsH H OMe CN ethane sulfonyl)- H H H

2a ³¹² Hs

phenyl

2a ³¹¹ SOsH H H SOsH Ally I Ally I

Methyl Methyl CONH ₂ H H

2a ³¹² H SOsH SOsH H

2a ³¹³ SOsH H H SOsH 2-Methoxy ethyl Butyl

Methyl Methyl CONH2 H H

2a ³¹⁴ H SOsH SOsH H

2a ³¹⁵ SOsH H H SOsH 3-Methoxy

Methyl Methyl CONH2 3-Methoxy propyl H H

2a ³¹⁶ H SOsH SOsH H propyl

2a ³¹⁷ SOsH H H SOsH

H

2a ³¹⁸ H SOsH SOsH H Butyl

Methyl Methyl CONH2 3-Methoxy propyl H

2a ³¹⁹ SOsH H H SOsH 2-Methyl

Methyl Methyl CONH ₂ H Sec-butyl H

2a ³²⁰ H SOsH SOsH H thioethyl

2a ³²¹ SOsH H H SOsH 2-Methyl 2-

Methyl Methyl CONH2 H H

2a ³²² H SOsH SOsH H thioethyl Hydroxyethyl

2a ³²³ SOsH H H SOsH

2-

H SOsH SOsH H Methyl Methyl CONH2 Butyl Butyl H

2a ³²⁴ Hydroxyethyl

2a ³²⁵ SOsH H H SOsH 2-

SOsH S Methyl Methyl CONH2 Isopropyl Isopropyl H

2a ³²⁶ H OsH H Hydroxyethyl

2a ³²⁷ SOsH H H SOsH

Methyl Methyl CONH2 2-Fluoro ethyl H Butyl H

2a ³²⁸ H SOsH SOsH H

2a ³²⁹ SOsH H H SOsH

Methyl Methyl CONH2 2-Chloro ethyl H 2-Ethylhexyl H

2a ³³⁰ H SOsH SOsH H

2a ³³¹ SOsH H H SOsH

Methyl Methyl CONH2 3-Chloro propyl H 2-Ethylhexyl H

2a ³³² H SOsH SOsH H

2a ³³³ SOsH H H SOsH 2-(2-Hydroxy-

H SOsH SOsH H Methyl Methyl CONH2 ethyl sulfanyl)- H Butyl H

2a ³³⁴

ethyl]

2a ³³⁵ SOsH H H SOsH 2-(2-tert-Butyl

H SOsH SOsH H Methyl Methyl CONH2 sulfanyl- ethane H Butyl H

2a ³³⁶

sulfonyl)-ethyl

2a ³³⁷ SOsH H H SOsH 2-(2-Hydroxy

Methyl Methyl CONH2 H Butyl H

2a ³³⁸ H SOsH SOsH H ethoxy) propyl

2a ³³⁹ SO3H H H SO3H 2-(2-Hydroxy

Methyl Methyl CONH2 H Butyl H

2a ³⁴⁰ H SO3H SO3H H ethoxy) ethyl

2a ³⁴¹ SOsH H H SOsH 2-(2-Hydroxy-

H SOsH SOsH H Methyl Methyl CONH2 ethanesulf onyl)- H Butyl H

2a ³⁴²

ethyl

2a ³⁴³ SOsH H H SOsH 3-(4-

H SOsH SOsH H Methyl Methyl CONH2 H H Hydroxybutoxy H

2a ³⁴⁴

)- propyl

2a ³⁴⁵ SOsH H H SOsH 2-(2-Hydroxy

H SOsH SOsH H Methyl Methyl CONH ₂ H H ethoxy)eth yl H

2a ³⁴⁶

2a ³⁴⁷ SOsH H H SOsH 3-(4-Hydroxy

Methyl Methyl CONH2 H H H

2a ³⁴⁸ H SOsH SOsH H butoxy)- propyl

2a ³⁴⁹ SOsH H H SOsH 2-(2-Hydroxy

Methyl Methyl CONH2 H H H

2a ³⁵⁰ H SOsH SOsH H ethoxy) ethyl

2a ³⁵¹ SOsH H H SOsH 2-(2-Hydroxy

Methyl Methyl CONH2 Phenyl H H

2a ³⁵² H SOsH SOsH H ethoxy )ethyl

2a ³⁵³ SOsH H H SOsH 3-(2-Phenoxy-

Methyl Methyl CONH2 H H H

2a ³⁵⁴ H SOsH SOsH H ethoxy)- propyl

2a ³⁵⁵ SOsH H H SOsH 3-lsopropoxy- 3-lsopropoxy-

Methyl Methyl CONH2 H H

2a ³⁵⁶ H SOsH SOsH H propyl propyl

2a ³⁵⁷ SOsH H H SOsH 3-lsopropoxy-

Methyl Methyl CONH2 H H H

2a ³⁵⁸ H SOsH SOsH H propyl

2a ³⁵⁹ SOsH H H SOsH 3-lsopropoxy-

Methyl Methyl CONH2 H Phenyl H

2a ³⁶⁰ H SOsH SOsH H propyl

2a ³⁶¹ SOsH H H SOsH 3-Ethoxy-

Methyl Methyl CONH2 3-Ethoxy-propyl H H

2a ³⁶² H SOsH SOsH H propyl

2a ³⁶³ SOsH H H SOsH

Methyl Methyl CONH2 3-Ethoxy-propyl H H H

2a ³⁶⁴ H SOsH SOsH H

2a ³⁶⁵ SOsH H H SOsH

Methyl Methyl CONH2 3-Ethoxy-propyl H Phenyl H

2a ³⁶⁶ H SOsH SOsH H

2a ³⁶⁷ SOsH H H SOsH

Methyl Methyl CONH2 3-Ethoxybutyl H 3-Ethoxy butyl H

2a ³⁶⁸ H SOsH SOsH H

2a ³⁶⁹ SOsH H H SOsH

Methyl Methyl CONH2 3-Ethoxybutyl H H H

2a ³⁷⁰ H SOsH SOsH H

2a ³⁷¹ SOsH H H SOsH

2a ³⁷² H SOsH SOsH H

Methyl Methyl CONH2 3-Ethoxybutyl H Phenyl H

2a ³⁷³ SOsH H H SOsH 4-(2-Hydroxy

H SOsH SOsH H Methyl Methyl CONH ₂ ethane sulfonyl)- H H H

2a ³⁷⁴

phenyl

2a ³⁷⁵ SOsH H H SOsH NHCOC

OMe CONH2 Ally I H Ally I H

2a ³⁷⁶ H SOsH SOsH H Hs

2a ³⁷⁷ SOsH H H SOsH NHCOC

OMe CONH2 2-Methoxy ethyl H Butyl H

2a ³⁷⁸ H SOsH SOsH H Hs

2a ³⁷⁹ SOsH H H SOsH NHCOC

OMe CONH2 3-Methoxy propyl H Butyl H

2a ³⁸⁰ H SOsH SOsH H Hs

2a ³⁸¹ SOsH H H SOsH NHCOC 2-Methyl

OMe CONH2 H Sec-butyl H

2a ³⁸² H SOsH SOsH H Hs thioethyl

2a ³⁸³ SOsH H H SOsH

NHCOC 2-Methyl 2-

H SOsH SOsH H OMe CONH2 H H

2a ³⁸⁴ Hs thioethyl Hydroxyethyl

2a ³⁸⁵ SOsH H H SOsH NHCOC 2-

OMe CONH2 Butyl Butyl H

2a ³⁸⁶ H SOsH SOsH H Hs Hydroxyethyl

2a ³⁸⁷ SOsH H H SOsH

NHCOC 2-

H SOsH SOsH H OMe CONH2 Isopropyl Isopropyl H

2a ³⁸⁸ Hs Hydroxyethyl

2a ³⁸⁹ SOsH H H SOsH NHCOC Butyl

OMe CONH2 2-Fluoro ethyl H H

2a ³⁹⁰ H SOsH SOsH H Hs

2a ³⁹¹ SOsH H H SOsH NHCOC 2-ethylhexyl

OMe CONH2 2-Chloro ethyl H H

2a ³⁹² H SOsH SOsH H Hs

2a ³⁹³ SOsH H H SOsH NHCOC

OMe CONH2 3-Chloro propyl H 2-ethylhexyl H

2a ³⁹⁴ H SOsH SOsH H Hs

2a ³⁹⁵ SOsH H H SOsH 2-(2-Hydroxy-

NHCOC

H SOsH SOsH H OMe CONH2 ethyl sulfanyl)- H Butyl H

2a ³⁹⁶ Hs

ethyl

2a ³⁹⁷ SOsH H H SOsH 2-(2-tert-Butyl

NHCOC

H SOsH SOsH H OMe CONH2 sulfanyl- ethane H Butyl H

2a ³⁹⁸ Hs

sulfonyl)-ethyl

2a ³⁹⁹ SOsH H H SOsH NHCOC 2-(2-Hydroxy

OMe CONH ₂ H Butyl H

2a ⁴⁰⁰ H SOsH SOsH H Hs ethoxy propyl

2a ⁴⁰¹ SO3H H H SO3H H

NHCOC 2-(2-Hydroxy

H SO3H SO3H H OMe CONH2 H Butyl

2a ⁴⁰² Hs ethoxy)ethyl

2a ⁴⁰³ SOsH H H SOsH NHCOC 2-(Ethyl sulfonyl)

OMe CONH2 H Butyl H

2a ⁴⁰⁴ H SOsH SOsH H Hs ethanol

2a ⁴⁰⁵ SOsH H H SOsH NHCOC 3-(4-Hydroxy

OMe CONH2 H H H

2a ⁴⁰⁶ H SOsH SOsH H Hs butoxyjpropyl

2a ⁴⁰⁷ SOsH H H SOsH NHCOC 2-(2-Hydroxy

OMe CONH2 H H H

2a ⁴⁰⁸ H SOsH SOsH H Hs ethoxy)ethyl

2a ⁴⁰⁹ SOsH H H SOsH NHCOC 3-(4-Hydroxy

OMe CONH2 H H H

2a ⁴¹⁰ H SOsH SOsH H Hs butoxy propyl

2a ⁴¹¹ SOsH H H SOsH NHCOC 2-(2-Hydroxy

OMe CONH2 H H H

2a ⁴¹² H SOsH SOsH H Hs ethoxy)ethyl

2a ⁴¹³ SOsH H H SOsH NHCOC (2-Hydroxy

OMe CONH2 Phenyl H H

2a ⁴¹⁴ H SOsH SOsH H Hs ethoxy)ethyl

2a ⁴¹⁵ SOsH H H SOsH NHCOC 3-(2-Phenoxy-

OMe CONH2 H H H

2a ⁴¹⁶ H SOsH SOsH H Hs ethoxy)- propyl

2a ⁴¹⁷ SOsH H H SOsH NHCOC 3-lsopropoxy- 3-lsopropoxy-

OMe CONH2 H H

2a ⁴¹⁸ H SOsH SOsH H Hs propyl propyl

2a ⁴¹⁹ SOsH H H SOsH NHCOC 3-lsopropoxy-

OMe CONH2 H H H

2a ⁴²⁰ H SOsH SOsH H Hs propyl

2a ⁴²¹ SOsH H H SOsH NHCOC 3-lsopropoxy-

OMe CONH2 H Phenyl H

2a ⁴²² H SOsH SOsH H Hs propyl

2a ⁴²³ SOsH H H SOsH NHCOC 3-Ethoxy-

OMe CONH2 3-Ethoxy-propyl H H

2a ⁴²⁴ H SOsH SOsH H Hs propyl

2a ⁴²⁵ SOsH H H SOsH NHCOC

OMe CONH2 3-Ethoxy-propyl H H H

2a ⁴²⁶ H SOsH SOsH H Hs

2a ⁴²⁷ SOsH H H SOsH NHCOC

OMe CONH2 3-Ethoxy-propyl H Phenyl H

2a ⁴²⁸ H SOsH SOsH H Hs

2a ⁴²⁹ SOsH H H SOsH NHCOC

OMe CONH ₂ 3-Ethoxybutyl H 3-Ethoxybutyl H

2a ⁴³⁰ H SOsH SOsH H Hs

2a ⁴³¹ SOsH H H SOsH NHCOC

OMe CONH2 3-Ethoxybutyl H H H

2a ⁴³² H SOsH SOsH H Hs

2a ⁴³³ SOsH H H SOsH NHCOC

OMe CONH2 3-Ethoxybutyl H Phenyl H

2a ⁴³⁴ H SOsH SOsH H Hs

2a ⁴³⁵ SOsH H H SOsH 4-(2-Hydroxy

NHCOC

H SOsH SOsH H OMe CONH2 ethane sulfonyl)- H H H

2a ⁴³⁶ Hs

phenyl

2a ⁴³⁷ SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H Methyl H

2a ⁴³⁸ H SOsH SOsH H

2a ⁴³⁹ SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H Ethyl H

2a ⁴⁴⁰ H SOsH SOsH H

2a ⁴⁴¹ SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H n-Propyl H

2a ⁴⁴² H SOsH SOsH H

2a ⁴⁴³ SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H Isopropyl H

2a ⁴⁴⁴ H SOsH SOsH H

2a ⁴⁴⁵ SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H 1 -Ethyl propyl H

2a ⁴⁴⁶ H SOsH SOsH H

2a ⁴⁴⁷ SOsH H H SOsH 1 ,2-Dimethyl

Methyl Methyl CN 2-Sulfoethyl H H

2a ⁴⁴⁸ H SOsH SOsH H propyl

2a ⁴⁴⁹ SOsH H H SOsH 2,2-Dimethyl

Methyl Methyl CN 2-Sulfoethyl H H

2a ⁴⁵⁰ H SOsH SOsH H propyl

2a ⁴⁵¹ SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H Butyl H

2a ⁴⁵² H SOsH SOsH H

2a ⁴⁵³ SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H 2-Methyl butyl H

2a ⁴⁵⁴ H SOsH SOsH H

2a ⁴⁵⁵ SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H Tert butyl H

2a ⁴⁵⁶ H SOsH SOsH H

2a ⁴⁵⁷ SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H 3-Methyl butyl H

2a ⁴⁵⁸ H SOsH SOsH H

2a ⁴⁵⁹ SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H Sec butyl H

2a ⁴⁶⁰ H SOsH SOsH H

2a ⁴⁶¹ SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H Pentyl H

2a ⁴⁶² H SOsH SOsH H

2a ⁴⁶³ SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H Hexyl H

2a ⁴⁶⁴ H SOsH SOsH H

2a ⁴⁶⁵ SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H Cyclobutyl H

2a ⁴⁶⁶ H SOsH SOsH H

2a ⁴⁶⁷ SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H Cyclopentyl H

2a ⁴⁶⁸ H SOsH SOsH H

2a ⁴⁶⁹ SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H Cyclohexyl H

2a ⁴⁷⁰ H SOsH SOsH H

2a ⁴⁷¹ SOsH H H SOsH 2-Methyl

Methyl Methyl CN 2-Sulfoethyl H H

2a ⁴⁷² H SOsH SOsH H cyclohexyl

2a ⁴⁷³ SOsH H H SOsH 3-Methyl

Methyl Methyl CN 2-Sulfoethyl H H

2a ⁴⁷⁴ H SOsH SOsH H cyclohexyl

2a ⁴⁷⁵ SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H Pentan-2-yl H

2a ⁴⁷⁶ H SOsH SOsH H

2a ⁴⁷⁷ SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H 2-Ethylhexyl H

2a ⁴⁷⁸ H SOsH SOsH H

2a ⁴⁷⁹ SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H Phenyl H

2a ⁴⁸⁰ H SOsH SOsH H

2a ⁴⁸¹ SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H Benzyl H

2a ⁴⁸² H SOsH SOsH H

2a ⁴⁸³ SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H Ally I H

2a ⁴⁸⁴ H SOsH SOsH H

2a ⁴⁸⁵ SOsH H H SOsH 2-Methoxy

Methyl Methyl CN 2-Sulfoethyl H H

2a ⁴⁸⁶ H SOsH SOsH H ethyl

2a ⁴⁸⁷ SOsH H H SOsH

3-Methoxy

2a ⁴⁸⁸ H SOsH SOsH H Methyl Methyl CN 2-Sulfoethyl H H propyl

2a ⁴⁸⁹ SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H 3-Chloropropyl H

2a ⁴⁹⁰ H SOsH SOsH H

2a ⁴⁹¹ SOsH H H SOsH H

2-Methyl

H SOsH SOsH H Methyl Methyl CN 2-Sulfoethyl H

2a ⁴⁹² thioethyl

2a ⁴⁹³ SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H 2-Fluoroethyl H

2a ⁴⁹⁴ H SOsH SOsH H

2a ⁴⁹⁵ SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H 2-Chloro ethyl H

2a ⁴⁹⁶ H SOsH SOsH H

2a ⁴⁹⁷ SOsH H H SOsH 2-(2-Hydroxy

H SOsH SOsH H Methyl Methyl CN 2-Sulfoethyl H ethyl H

2a ⁴⁹⁸

sulfonyl)ethyl

2a ⁴⁹⁹ SOsH H H SOsH 2-(2-tert Butyl

H SOsH SOsH H Methyl Methyl CN 2-Sulfoethyl H sulfanyl ethyl H

2a ⁵⁰⁰

sulfonyl)ethyl

2a ⁵⁰¹ SOsH H H SOsH 2-(2-Hydroxy

Methyl Methyl CN 2-Sulfoethyl H H

2a ⁵⁰² H SOsH SOsH H ethoxy)pr opyl

2a ⁵⁰³ SOsH H H SOsH 2-(2-Hydroxy

Methyl Methyl CN 2-Sulfoethyl H H

2a ⁵⁰⁴ H SOsH SOsH H ethoxy)ethyl

2a ⁵⁰⁵ SOsH H H SOsH 3-(4-Hydroxy

Methyl Methyl CN 2-Sulfoethyl H H

2a ⁵⁰⁶ H SOsH SOsH H butoxy)pr opyl

2a ⁵⁰⁷ SOsH H H SOsH 3-(2-Phenoxy

Methyl Methyl CN 2-Sulfoethyl H H

2a ⁵⁰⁸ H SOsH SOsH H ethoxyl)pr opyl

2a ⁵⁰⁹ SOsH H H SOsH 3-lsopropxy

Methyl Methyl CN 2-Sulfoethyl H H

2a ⁵¹⁰ H SOsH SOsH H propyl

2a ⁵¹¹ SOsH H H SOsH 3-Ethoxy

Methyl Methyl CN 2-Sulfoethyl H H

2a ⁵¹² H SOsH SOsH H propyl

2a ⁵¹³ SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H 3-Ethoxy butyl H

2a ⁵¹⁴ H SOsH SOsH H

2a ⁵¹⁵ SOsH H H SOsH H

4-(2-Hydroxy

H SOsH SOsH H Methyl Methyl CN 2-Sulfoethyl H

2a ⁵¹⁶ ethane

sulfonyl)pheny

I

2a ⁵¹⁷ SOsH H H SOsH

Methyl Methyl CONH ₂ 2-Sulfoethyl H Methyl H

2a ⁵¹⁸ H SOsH SOsH H

2a ⁵¹⁹ SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl H Ethyl H

2a ⁵²⁰ H SOsH SOsH H

2a ⁵²¹ SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl H n-Propyl H

2a ⁵²² H SOsH SOsH H

2a ⁵²³ SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl H Isopropyl H

2a ⁵²⁴ H SOsH SOsH H

2a ⁵²⁵ SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl H 1 -Ethyl propyl H

2a ⁵²⁶ H SOsH SOsH H

2a ⁵²⁷ SOsH H H SOsH 1 ,2-Dimethyl

Methyl Methyl CONH2 2-Sulfoethyl H H

2a ⁵²⁸ H SOsH SOsH H propyl

2a ⁵²⁹ SOsH H H SOsH 2,2-Dimethyl

Methyl Methyl CONH2 2-Sulfoethyl H H

2a ⁵³⁰ H SOsH SOsH H propyl

2a ⁵³¹ SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl H Butyl H

2a ⁵³² H SOsH SOsH H

2a ⁵³³ SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl H 2-Methyl butyl H

2a ⁵³⁴ H SOsH SOsH H

2a ⁵³⁵ SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl H Tert butyl H

2a ⁵³⁶ H SOsH SOsH H

2a ⁵³⁷ SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl H 3-Methyl butyl H

2a ⁵³⁸ H SOsH SOsH H

2a ⁵³⁹ SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl H Sec butyl H

2a ⁵⁴⁰ H SOsH SOsH H

2a ⁵⁴¹ SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl H Pentyl H

2a ⁵⁴² H SOsH SOsH H

2a ⁵⁴³ SOsH H H SOsH

2a ⁵⁴⁴ H SOsH SOsH H Methyl Methyl CONH2 2-Sulfoethyl H Hexyl H

2a ⁵⁴⁵ SOsH H H SOsH H

H SOsH SOsH H Methyl Methyl CONH ₂ 2-Sulfoethyl H Cyclobutyl

2a ⁵⁴⁶

2a ⁵⁴⁷ SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl H Cyclopentyl H

2a ⁵⁴⁸ H SOsH SOsH H

2a ⁵⁴⁹ SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl H Cyclohexyl H

2a ⁵⁵⁰ H SOsH SOsH H

2a ⁵⁵¹ SOsH H H SOsH 2-Methyl

Methyl Methyl CONH2 2-Sulfoethyl H H

2a ⁵⁵² H SOsH SOsH H cyclohexyl

2a ⁵⁵³ SOsH H H SOsH 3-Methyl

Methyl Methyl CONH2 2-Sulfoethyl H H

2a ⁵⁵⁴ H SOsH SOsH H cyclohexyl

2a ⁵⁵⁵ SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl H Pentan-2-yl H

2a ⁵⁵⁶ H SOsH SOsH H

2a ⁵⁵⁷ SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl H 2-Ethylhexyl H

2a ⁵⁵⁸ H SOsH SOsH H

2a ⁵⁵⁹ SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl H Phenyl H

2a ⁵⁶⁰ H SOsH SOsH H

2a ⁵⁶¹ SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl H Benzyl H

2a ⁵⁶² H SOsH SOsH H

2a ⁵⁶³ SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl H Ally I H

2a ⁵⁶⁴ H SOsH SOsH H

2a ⁵⁶⁵ SOsH H H SOsH 2-Methoxy

Methyl Methyl CONH2 2-Sulfoethyl H H

2a ⁵⁶⁶ H SOsH SOsH H ethyl

2a ⁵⁶⁷ SOsH H H SOsH 3-Methoxy

Methyl Methyl CONH2 2-Sulfoethyl H H

2a ⁵⁶⁸ H SOsH SOsH H propyl

2a ⁵⁶⁹ SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl H 3-Chloropropyl H

2a ⁵⁷⁰ H SOsH SOsH H

2a ⁵⁷¹ SOsH H H SOsH 2-Methyl

Methyl Methyl CONH2 2-Sulfoethyl H H

2a ⁵⁷² H SOsH SOsH H thioethyl

2a ⁵⁷³ SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl H 2-Fluoroethyl H

2a ⁵⁷⁴ H SOsH SOsH H

2a ⁵⁷⁵ SOsH H H SOsH H

H SOsH SOsH H Methyl Methyl CONH ₂ 2-Sulfoethyl H 2-Chloro ethyl

2a ⁵⁷⁶

2a ⁵⁷⁷ SOsH H H SOsH 2-Sulfoethyl 2-(2-Hydroxy

H SOsH SOsH H Methyl Methyl CONH2 H ethyl H

2a ⁵⁷⁸

sulfonyl)ethyl

2a ⁵⁷⁹ SOsH H H SOsH 2-Sulfoethyl 2-(2-tert Butyl

H SOsH SOsH H Methyl Methyl CONH2 H sulfanyl ethyl H

2a ⁵⁸⁰

sulfonyl)ethyl

2a ⁵⁸¹ SOsH H H SOsH 2-Sulfoethyl 2-(2-Hydroxy

Methyl Methyl CONH2 H H

2a ⁵⁸² H SOsH SOsH H ethoxyjpropyl

2a ⁵⁸³ SOsH H H SOsH 2-Sulfoethyl 2-(2-Hydroxy

Methyl Methyl CONH2 H H

2a ⁵⁸⁴ H SOsH SOsH H ethoxy)ethyl

2a ⁵⁸⁵ SOsH H H SOsH 2-Sulfoethyl 3-(4-Hydroxy

Methyl Methyl CONH2 H H

2a ⁵⁸⁶ H SOsH SOsH H butoxy propyl

2a ⁵⁸⁷ SOsH H H SOsH 2-Sulfoethyl 3-(2-Phenoxy

Methyl Methyl CONH2 H H

2a ⁵⁸⁸ H SOsH SOsH H ethoxyl)pr opyl

2a ⁵⁸⁹ SOsH H H SOsH 2-Sulfoethyl 3-lsopropxy

Methyl Methyl CONH2 H H

2a ⁵⁹⁰ H SOsH SOsH H propyl

2a ⁵⁹¹ SOsH H H SOsH 2-Sulfoethyl 3-Ethoxy

Methyl Methyl CONH2 H H

2a ⁵⁹² H SOsH SOsH H propyl

2a ⁵⁹³ SOsH H H SOsH 2-Sulfoethyl

Methyl Methyl CONH2 H 3-Ethoxy butyl H

2a ⁵⁹⁴ H SOsH SOsH H

2a ⁵⁹⁵ SOsH H H SOsH 4-(2-Hydroxy

H SOsH SOsH H 2-Sulfoethyl ethane

Methyl Methyl CONH2 H H

2a ⁵⁹⁶ sulfonyl)pheny

I

2a ⁵⁹⁷ SOsH H H SOsH NHCOC 2-Sulfoethyl

OMe CN H Methyl H

2a ⁵⁹⁸ H SOsH SOsH H Hs

2a ⁵⁹⁹ SOsH H H SOsH 2-Sulfoethyl

NHCOC

2a ⁶⁰⁰ H SOsH SOsH H OMe CN H Ethyl H

Hs

2a ⁶⁰¹ SOsH H H SOsH 2-Sulfoethyl H

NHCOC

H SOsH SOsH H OMe CN H n-Propyl

2a ⁶⁰² Hs

2a ⁶⁰³ SOsH H H SOsH NHCOC

OMe CN 2-Sulfoethyl H Isopropyl H

2a ⁶⁰⁴ H SOsH SOsH H Hs

2a ⁶⁰⁵ SOsH H H SOsH NHCOC

OMe CN 2-Sulfoethyl H 1 -Ethyl propyl H

2a ⁶⁰⁶ H SOsH SOsH H Hs

2a ⁶⁰⁷ SOsH H H SOsH NHCOC 1 ,2-Dimethyl

OMe CN 2-Sulfoethyl H H

2a ⁶⁰⁸ H SOsH SOsH H Hs propyl

2a ⁶⁰⁹ SOsH H H SOsH NHCOC 2,2-Dimethyl

OMe CN 2-Sulfoethyl H H

2a ⁶¹⁰ H SOsH SOsH H Hs propyl

2a ⁶¹¹ SOsH H H SOsH NHCOC

OMe CN 2-Sulfoethyl H Butyl H

2a ⁶¹² H SOsH SOsH H Hs

2a ⁶¹³ SOsH H H SOsH NHCOC

OMe CN 2-Sulfoethyl H 2-Methyl butyl H

2a ⁶¹⁴ H SOsH SOsH H Hs

2a ⁶¹⁵ SOsH H H SOsH NHCOC

OMe CN 2-Sulfoethyl H Tert butyl H

2a ⁶¹⁶ H SOsH SOsH H Hs

2a ⁶¹⁷ SOsH H H SOsH NHCOC

OMe CN 2-Sulfoethyl H 3-Methyl butyl H

2a ⁶¹⁸ H SOsH SOsH H Hs

2a ⁶¹⁹ SOsH H H SOsH NHCOC

OMe CN 2-Sulfoethyl H Sec butyl H

2a ⁶²⁰ H SOsH SOsH H Hs

2a ⁶²¹ SOsH H H SOsH NHCOC

OMe CN 2-Sulfoethyl H Pentyl H

2a ⁶²² H SOsH SOsH H Hs

2a ⁶²³ SOsH H H SOsH NHCOC

OMe CN 2-Sulfoethyl H Hexyl H

2a ⁶²⁴ H SOsH SOsH H Hs

2a ⁶²⁵ SOsH H H SOsH NHCOC

OMe CN 2-Sulfoethyl H Cyclobutyl H

2a ⁶²⁶ H SOsH SOsH H Hs

2a ⁶²⁷ SOsH H H SOsH NHCOC

OMe CN 2-Sulfoethyl H Cyclopentyl H

2a ⁶²⁸ H SOsH SOsH H Hs

2a ⁶²⁹ SOsH H H SOsH NHCOC

OMe CN 2-Sulfoethyl H Cyclohexyl H

2a ⁶³⁰ H SOsH SOsH H Hs

2a ⁶³¹ SOsH H H SOsH H

NHCOC 2-Methyl

H SOsH SOsH H OMe CN 2-Sulfoethyl H

2a ⁶³² Hs cyclohexyl

2a ⁶³³ SOsH H H SOsH NHCOC 3-Methyl

OMe CN 2-Sulfoethyl H H

2a ⁶³⁴ H SOsH SOsH H Hs cyclohexyl

2a ⁶³⁵ SOsH H H SOsH NHCOC

OMe CN 2-Sulfoethyl H Pentan-2-yl H

2a ⁶³⁶ H SOsH SOsH H Hs

2a ⁶³⁷ SOsH H H SOsH NHCOC

OMe CN 2-Sulfoethyl H 2-Ethylhexyl H

2a ⁶³⁸ H SOsH SOsH H Hs

2a ⁶³⁹ SOsH H H SOsH NHCOC

OMe CN 2-Sulfoethyl H Phenyl H

2a ⁶⁴⁰ H SOsH SOsH H Hs

2a ⁶⁴¹ SOsH H H SOsH NHCOC

OMe CN 2-Sulfoethyl H Benzyl H

2a ⁶⁴² H SOsH SOsH H Hs

2a ⁶⁴³ SOsH H H SOsH NHCOC

OMe CN 2-Sulfoethyl H Ally I H

2a ⁶⁴⁴ H SOsH SOsH H Hs

2a ⁶⁴⁵ SOsH H H SOsH NHCOC 2-Methoxy

OMe CN 2-Sulfoethyl H H

2a ⁶⁴⁶ H SOsH SOsH H Hs ethyl

2a ⁶⁴⁷ SOsH H H SOsH NHCOC 3-Methoxy

OMe CN 2-Sulfoethyl H H

2a ⁶⁴⁸ H SOsH SOsH H Hs propyl

2a ⁶⁴⁹ SOsH H H SOsH NHCOC

OMe CN 2-Sulfoethyl H 3-Chloropropyl H

2a ⁶⁵⁰ H SOsH SOsH H Hs

2a ⁶⁵¹ SOsH H H SOsH NHCOC 2-Methyl

OMe CN 2-Sulfoethyl H H

2a ⁶⁵² H SOsH SOsH H Hs thioethyl

2a ⁶⁵³ SOsH H H SOsH NHCOC

OMe CN 2-Sulfoethyl H 2-Fluoroethyl H

2a ⁶⁵⁴ H SOsH SOsH H Hs

2a ⁶⁵⁵ SOsH H H SOsH NHCOC

OMe CN 2-Sulfoethyl H 2-Chloro ethyl H

2a ⁶⁵⁶ H SOsH SOsH H Hs

2a ⁶⁵⁷ SOsH H H SOsH

2-(2-Hydroxy

2a ⁶⁵⁸ H SOsH SOsH H NHCOC

OMe CN 2-Sulfoethyl H ethyl H

Hs

sulfonyl)ethyl

2a ⁶⁵⁹ SOsH H H SOsH H

2-(2-tert Butyl

H SOsH SOsH H NHCOC

OMe CN 2-Sulfoethyl H sulfanyl ethyl

2a ⁶⁶⁰ Hs

sulfonyl)ethyl

2a ⁶⁶¹ SOsH H H SOsH NHCOC 2-(2-Hydroxy

OMe CN 2-Sulfoethyl H H

2a ⁶⁶² H SOsH SOsH H Hs ethoxy)pr opyl

2a ⁶⁶³ SOsH H H SOsH NHCOC 2-(2-Hydroxy

OMe CN 2-Sulfoethyl H H

2a ⁶⁶⁴ H SOsH SOsH H Hs ethoxy)ethyl

2a ⁶⁶⁵ SOsH H H SOsH NHCOC 3-(4-Hydroxy

OMe CN 2-Sulfoethyl H H

2a ⁶⁶⁶ H SOsH SOsH H Hs butoxy)pr opyl

2a ⁶⁶⁷ SOsH H H SOsH 3-(2-Phenoxy

H SOsH SOsH H NHCOC ethoxyl)pr opyl

OMe CN 2-Sulfoethyl H H

2a ⁶⁶⁸ Hs

2a ⁶⁶⁹ SOsH H H SOsH NHCOC 3-lsopropxy

OMe CN 2-Sulfoethyl H H

2a ⁶⁷⁰ H SOsH SOsH H Hs propyl

2a ⁶⁷¹ SOsH H H SOsH NHCOC 3-Ethoxy

OMe CN 2-Sulfoethyl H H

2a ⁶⁷² H SOsH SOsH H Hs propyl

2a ⁶⁷³ SOsH H H SOsH NHCOC

OMe CN 2-Sulfoethyl H 3-Ethoxy butyl H

2a ⁶⁷⁴ H SOsH SOsH H Hs

2a ⁶⁷⁵ SOsH H H SOsH 4-(2-Hydroxy

H SOsH SOsH H NHCOC ethane

OMe CN 2-Sulfoethyl H H

2a ⁶⁷⁶ Hs sulfonyl)pheny

I

2a ⁶⁷⁷ SOsH H H SOsH NHCOC

OMe CONH ₂ 2-Sulfoethyl H Methyl H

2a ⁶⁷⁸ H SOsH SOsH H Hs

2a ⁶⁷⁹ SOsH H H SOsH NHCOC

OMe CONH2 2-Sulfoethyl H Ethyl H

2a ⁶⁸⁰ H SOsH SOsH H Hs

2a ⁶⁸¹ SOsH H H SOsH NHCOC

OMe CONH2 2-Sulfoethyl H n-Propyl H

2a ⁶⁸² H SOsH SOsH H Hs

2a ⁶⁸³ SOsH H H SOsH NHCOC

OMe CONH2 2-Sulfoethyl H Isopropyl H

2a ⁶⁸⁴ H SOsH SOsH H Hs

2a ⁶⁸⁵ SOsH H H SOsH NHCOC

OMe CONH ₂ 2-Sulfoethyl H 1 -Ethyl propyl H

2a ⁶⁸⁶ H SOsH SOsH H Hs

2a ⁶⁸⁷ SOsH H H SOsH NHCOC 1 ,2-Dimethyl

OMe CONH2 2-Sulfoethyl H H

2a ⁶⁸⁸ H SOsH SOsH H Hs propyl

2a ⁶⁸⁹ SOsH H H SOsH NHCOC 2,2-Dimethyl

OMe CONH2 2-Sulfoethyl H H

2a ⁶⁹⁰ H SOsH SOsH H Hs propyl

2a ⁶⁹¹ SOsH H H SOsH NHCOC

OMe CONH2 2-Sulfoethyl H Butyl H

2a ⁶⁹² H SOsH SOsH H Hs

2a ⁶⁹³ SOsH H H SOsH NHCOC

OMe CONH2 2-Sulfoethyl H 2-Methyl butyl H

2a ⁶⁹⁴ H SOsH SOsH H Hs

2a ⁶⁹⁵ SOsH H H SOsH NHCOC

OMe CONH2 2-Sulfoethyl H Tert butyl H

2a ⁶⁹⁶ H SOsH SOsH H Hs

2a ⁶⁹⁷ SOsH H H SOsH NHCOC

OMe CONH2 2-Sulfoethyl H 3-Methyl butyl H

2a ⁶⁹⁸ H SOsH SOsH H Hs

2a ⁶⁹⁹ SOsH H H SOsH NHCOC

OMe CONH2 2-Sulfoethyl H Sec butyl H

2a ⁷⁰⁰ H SOsH SOsH H Hs

2a ⁷⁰¹ SOsH H H SOsH NHCOC

OMe CONH2 2-Sulfoethyl H Pentyl H

2a ⁷⁰² H SOsH SOsH H Hs

2a ⁷⁰³ SOsH H H SOsH NHCOC

OMe CONH2 2-Sulfoethyl H Hexyl H

2a ⁷⁰⁴ H SOsH SOsH H Hs

2a ⁷⁰⁵ SOsH H H SOsH NHCOC

OMe CONH2 2-Sulfoethyl H Cyclobutyl H

2a ⁷⁰⁶ H SOsH SOsH H Hs

2a ⁷⁰⁷ SOsH H H SOsH NHCOC

OMe CONH2 2-Sulfoethyl H Cyclopentyl H

2a ⁷⁰⁸ H SOsH SOsH H Hs

2a ⁷⁰⁹ SOsH H H SOsH NHCOC

OMe CONH2 2-Sulfoethyl H Cyclohexyl H

2a ⁷¹⁰ H SOsH SOsH H Hs

2a ⁷¹¹ SOsH H H SOsH NHCOC 2-Methyl

OMe CONH2 2-Sulfoethyl H H

2a ⁷¹² H SOsH SOsH H Hs cyclohexyl

2a ⁷¹³ SOsH H H SOsH

NHCOC 3-Methyl

2a ⁷¹⁴ H SOsH SOsH H OMe CONH2 2-Sulfoethyl H H

Hs cyclohexyl

2a ⁷¹⁵ SOsH H H SOsH NHCOC

OMe CONH ₂ 2-Sulfoethyl H Pentan-2-yl H

2a ⁷¹⁶ H SOsH SOsH H Hs

2a ⁷¹⁷ SOsH H H SOsH NHCOC

OMe CONH2 2-Sulfoethyl H 2-Ethylhexyl H

2a ⁷¹⁸ H SOsH SOsH H Hs

2a ⁷¹⁹ SOsH H H SOsH NHCOC

OMe CONH2 2-Sulfoethyl H Phenyl H

2a ⁷²⁰ H SOsH SOsH H Hs

2a ⁷²¹ SOsH H H SOsH NHCOC

OMe CONH2 2-Sulfoethyl H Benzyl H

2a ⁷²² H SOsH SOsH H Hs

2a ⁷²³ SOsH H H SOsH NHCOC

OMe CONH2 2-Sulfoethyl H Ally I H

2a ⁷²⁴ H SOsH SOsH H Hs

2a ⁷²⁵ SOsH H H SOsH NHCOC 2-Methoxy

OMe CONH2 2-Sulfoethyl H H

2a ⁷²⁶ H SOsH SOsH H Hs ethyl

2a ⁷²⁷ SOsH H H SOsH NHCOC 3-Methoxy

OMe CONH2 2-Sulfoethyl H H

2a ⁷²⁸ H SOsH SOsH H Hs propyl

2a ⁷²⁹ SOsH H H SOsH NHCOC

OMe CONH2 2-Sulfoethyl H 3-Chloropropyl H

2a ⁷³⁰ H SOsH SOsH H Hs

2a ⁷³¹ SOsH H H SOsH NHCOC 2-Methyl

OMe CONH2 2-Sulfoethyl H H

2a ⁷³² H SOsH SOsH H Hs thioethyl

2a ⁷³³ SOsH H H SOsH NHCOC

OMe CONH2 2-Sulfoethyl H 2-Fluoroethyl H

2a ⁷³⁴ H SOsH SOsH H Hs

2a ⁷³⁵ SOsH H H SOsH NHCOC

OMe CONH2 2-Sulfoethyl H 2-Chloro ethyl H

2a ⁷³⁶ H SOsH SOsH H Hs

2a ⁷³⁷ SOsH H H SOsH 2-(2-Hydroxy

NHCOC

H SOsH SOsH H OMe CONH2 2-Sulfoethyl H ethyl H

2a ⁷³⁸ Hs

sulfonyl)ethyl

2a ⁷³⁹ SOsH H H SOsH 2-(2-tert Butyl

NHCOC

H SOsH SOsH H OMe CONH2 2-Sulfoethyl H sulfanyl ethyl H

2a ⁷⁴⁰ Hs

sulfonyl)ethyl

2a ⁷⁴¹ SOsH H H SOsH

NHCOC 2-(2-Hydroxy

2a ⁷⁴² H SOsH SOsH H OMe CONH2 2-Sulfoethyl H H

Hs ethoxyjpropyl

2a ⁷⁴³ SOsH H H SOsH NHCOC 2-(2-Hydroxy

OMe CONH ₂ 2-Sulfoethyl H H

2a ⁷⁴⁴ H SOsH SOsH H Hs ethoxy)ethyl

2a ⁷⁴⁵ SOsH H H SOsH NHCOC 3-(4-Hydroxy

OMe CONH2 2-Sulfoethyl H H

2a ⁷⁴⁶ H SOsH SOsH H Hs butoxy propyl

2a ⁷⁴⁷ SOsH H H SOsH NHCOC 3-(2-Phenoxy

OMe CONH2 2-Sulfoethyl H H

2a ⁷⁴⁸ H SOsH SOsH H Hs ethoxyl)pr opyl

2a ⁷⁴⁹ SOsH H H SOsH NHCOC 3-lsopropxy

OMe CONH2 2-Sulfoethyl H H

2a ⁷⁵⁰ H SOsH SOsH H Hs propyl

2a ⁷⁵¹ SOsH H H SOsH NHCOC 3-Ethoxy

OMe CONH2 2-Sulfoethyl H H

2a ⁷⁵² H SOsH SOsH H Hs propyl

2a ⁷⁵³ SOsH H H SOsH NHCOC

OMe CONH2 2-Sulfoethyl H 3-Ethoxy butyl H

2a ⁷⁵⁴ H SOsH SOsH H Hs

2a ⁷⁵⁵ SOsH H H SOsH 4-(2-Hydroxy

H SOsH SOsH H NHCOC ethane

OMe CONH2 2-Sulfoethyl H H

2a ⁷⁵⁶ Hs sulfonyl)pheny

I

2a ⁷⁵⁷ SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl Methyl Methyl H

2a ⁷⁵⁸ H SOsH SOsH H

2a ⁷⁵⁹ SOsH H H SOsH Methyl

Methyl Methyl CN 2-Sulfoethyl Ethyl H

2a ⁷⁶⁰ H SOsH SOsH H

2a ⁷⁶¹ SOsH H H SOsH Methyl

Methyl Methyl CN 2-Sulfoethyl n-Propyl H

2a ⁷⁶² H SOsH SOsH H

2a ⁷⁶³ SOsH H H SOsH Methyl

Methyl Methyl CN 2-Sulfoethyl Isopropyl H

2a ⁷⁶⁴ H SOsH SOsH H

2a ⁷⁶⁵ SOsH H H SOsH Methyl

Methyl Methyl CN 2-Sulfoethyl 1 -Ethyl propyl H

2a ⁷⁶⁶ H SOsH SOsH H

2a ⁷⁶⁷ SOsH H H SOsH Methyl 1 ,2-Dimethyl

Methyl Methyl CN 2-Sulfoethyl H

2a ⁷⁶⁸ H SOsH SOsH H propyl

2a ⁷⁶⁹ SOsH H H SOsH Methyl H

2,2-Dimethyl

H SOsH SOsH H Methyl Methyl CN 2-Sulfoethyl

2a ⁷⁷⁰ propyl

2a ⁷⁷¹ SOsH H H SOsH Methyl

Methyl Methyl CN 2-Sulfoethyl Butyl H

2a ⁷⁷² H SOsH SOsH H

2a ⁷⁷³ SOsH H H SOsH Methyl

Methyl Methyl CN 2-Sulfoethyl 2-Methyl butyl H

2a ⁷⁷⁴ H SOsH SOsH H

2a ⁷⁷⁵ SOsH H H SOsH Methyl

Methyl Methyl CN 2-Sulfoethyl Tert butyl H

2a ⁷⁷⁶ H SOsH SOsH H

2a ⁷⁷⁷ SOsH H H SOsH Methyl

Methyl Methyl CN 2-Sulfoethyl 3-Methyl butyl H

2a ⁷⁷⁸ H SOsH SOsH H

2a ⁷⁷⁹ SOsH H H SOsH Methyl

Methyl Methyl CN 2-Sulfoethyl Sec butyl H

2a ⁷⁸⁰ H SOsH SOsH H

2a ⁷⁸¹ SOsH H H SOsH Methyl

Methyl Methyl CN 2-Sulfoethyl Pentyl H

2a ⁷⁸² H SOsH SOsH H

2a ⁷⁸³ SOsH H H SOsH Methyl

Methyl Methyl CN 2-Sulfoethyl Hexyl H

2a ⁷⁸⁴ H SOsH SOsH H

2a ⁷⁸⁵ SOsH H H SOsH Methyl

Methyl Methyl CN 2-Sulfoethyl Cyclobutyl H

2a ⁷⁸⁶ H SOsH SOsH H

2a ⁷⁸⁷ SOsH H H SOsH Methyl

Methyl Methyl CN 2-Sulfoethyl Cyclopentyl H

2a ⁷⁸⁸ H SOsH SOsH H

2a ⁷⁸⁹ SOsH H H SOsH Methyl

Methyl Methyl CN 2-Sulfoethyl Cyclohexyl H

2a ⁷⁹⁰ H SOsH SOsH H

2a ⁷⁹¹ SOsH H H SOsH Methyl 2-Methyl

Methyl Methyl CN 2-Sulfoethyl H

2a ⁷⁹² H SOsH SOsH H cyclohexyl

2a ⁷⁹³ SOsH H H SOsH Methyl 3-Methyl

Methyl Methyl CN 2-Sulfoethyl H

2a ⁷⁹⁴ H SOsH SOsH H cyclohexyl

2a ⁷⁹⁵ SOsH H H SOsH Methyl

Methyl Methyl CN 2-Sulfoethyl Pentan-2-yl H

2a ⁷⁹⁶ H SOsH SOsH H

2a ⁷⁹⁷ SOsH H H SOsH Methyl

Methyl Methyl CN 2-Sulfoethyl 2-Ethylhexyl H

2a ⁷⁹⁸ H SOsH SOsH H

2a ⁷⁹⁹ SOsH H H SOsH Methyl H

Methyl Methyl CN 2-Sulfoethyl Phenyl

2a ⁸⁰⁰ H SOsH SOsH H

2a ⁸⁰¹ SOsH H H SOsH Methyl

Methyl Methyl CN 2-Sulfoethyl Benzyl H

2a ⁸⁰² H SOsH SOsH H

2a ⁸⁰³ SOsH H H SOsH Methyl

Methyl Methyl CN 2-Sulfoethyl Ally I H

2a ⁸⁰⁴ H SOsH SOsH H

2a ⁸⁰⁵ SOsH H H SOsH Methyl 2-Methoxy

Methyl Methyl CN 2-Sulfoethyl H

2a ⁸⁰⁶ H SOsH SOsH H ethyl

2a ⁸⁰⁷ SOsH H H SOsH Methyl 3-Methoxy

Methyl Methyl CN 2-Sulfoethyl H

2a ⁸⁰⁸ H SOsH SOsH H propyl

2a ⁸⁰⁹ SOsH H H SOsH Methyl

Methyl Methyl CN 2-Sulfoethyl 3-Chloropropyl H

2a ⁸¹⁰ H SOsH SOsH H

2a ⁸¹¹ SOsH H H SOsH Methyl 2-Methyl

Methyl Methyl CN 2-Sulfoethyl H

2a ⁸¹² H SOsH SOsH H thioethyl

2a ⁸¹³ SOsH H H SOsH Methyl

Methyl Methyl CN 2-Sulfoethyl 2-Fluoroethyl H

2a ⁸¹⁴ H SOsH SOsH H

2a ⁸¹⁵ SOsH H H SOsH Methyl

Methyl Methyl CN 2-Sulfoethyl 2-Chloro ethyl H

2a ⁸¹⁶ H SOsH SOsH H

2a ⁸¹⁷ SOsH H H SOsH Methyl 2-(2-Hydroxy

H SOsH SOsH H Methyl Methyl CN 2-Sulfoethyl ethyl H

2a ⁸¹⁸

sulfonyl)ethyl

2a ⁸¹⁹ SOsH H H SOsH Methyl 2-(2-tert Butyl

H SOsH SOsH H Methyl Methyl CN 2-Sulfoethyl sulfanyl ethyl H

2a ⁸²⁰

sulfonyl)ethyl

2a ⁸²¹ SOsH H H SOsH Methyl 2-(2-Hydroxy

Methyl Methyl CN 2-Sulfoethyl H

2a ⁸²² H SOsH SOsH H ethoxy propyl

2a ⁸²³ SOsH H H SOsH Methyl 2-(2-Hydroxy

Methyl Methyl CN 2-Sulfoethyl H

2a ⁸²⁴ H SOsH SOsH H ethoxy)ethyl

2a ⁸²⁵ SOsH H H SOsH Methyl 3-(4-Hydroxy

Methyl Methyl CN 2-Sulfoethyl H

2a ⁸²⁶ H SOsH SOsH H butoxy propyl

2a ⁸²⁷ SOsH H H SOsH Methyl 3-(2-Phenoxy H

Methyl Methyl CN 2-Sulfoethyl

2a ⁸²⁸ H SOsH SOsH H ethoxyl)propyl

2a ⁸²⁹ SOsH H H SOsH Methyl 3-lsopropxy

Methyl Methyl CN 2-Sulfoethyl H

2a ⁸³⁰ H SOsH SOsH H propyl

2a ⁸³¹ SOsH H H SOsH Methyl 3-Ethoxy

Methyl Methyl CN 2-Sulfoethyl H

2a ⁸³² H SOsH SOsH H propyl

2a ⁸³³ SOsH H H SOsH Methyl

Methyl Methyl CN 2-Sulfoethyl 3-Ethoxy butyl H

2a ⁸³⁴ H SOsH SOsH H

2a ⁸³⁵ SOsH H H SOsH Methyl 4-(2-Hydroxy

H SOsH SOsH H ethane

Methyl Methyl CN 2-Sulfoethyl H

2a ⁸³⁶ sulfonyl)pheny

I

2a ⁸³⁷ SOsH H H SOsH Methyl

Methyl Methyl CONH ₂ 2-Sulfoethyl Methyl H

2a ⁸³⁸ H SOsH SOsH H

2a ⁸³⁹ SOsH H H SOsH Methyl

Methyl Methyl CONH2 2-Sulfoethyl Ethyl H

2a ⁸⁴⁰ H SOsH SOsH H

2a ⁸⁴¹ SOsH H H SOsH Methyl

Methyl Methyl CONH2 2-Sulfoethyl n-Propyl H

2a ⁸⁴² H SOsH SOsH H

2a ⁸⁴³ SOsH H H SOsH Methyl

Methyl Methyl CONH2 2-Sulfoethyl Isopropyl H

2a ⁸⁴⁴ H SOsH SOsH H

2a ⁸⁴⁵ SOsH H H SOsH Methyl

Methyl Methyl CONH2 2-Sulfoethyl 1 -Ethyl propyl H

2a ⁸⁴⁶ H SOsH SOsH H

2a ⁸⁴⁷ SOsH H H SOsH Methyl 1 ,2-Dimethyl

Methyl Methyl CONH2 2-Sulfoethyl H

2a ⁸⁴⁸ H SOsH SOsH H propyl

2a ⁸⁴⁹ SOsH H H SOsH Methyl 2,2-Dimethyl

Methyl Methyl CONH2 2-Sulfoethyl H

2a ⁸⁵⁰ H SOsH SOsH H propyl

2a ⁸⁵¹ SOsH H H SOsH Methyl

Methyl Methyl CONH2 2-Sulfoethyl Butyl H

2a ⁸⁵² H SOsH SOsH H

2a ⁸⁵³ SOsH H H SOsH Methyl

Methyl Methyl CONH2 2-Sulfoethyl 2-Methyl butyl H

2a ⁸⁵⁴ H SOsH SOsH H

2a ⁸⁵⁵ SOsH H H SOsH Methyl H

Methyl Methyl CONH2 2-Sulfoethyl Tert butyl

2a ⁸⁵⁶ H SOsH SOsH H

2a ⁸⁵⁷ SOsH H H SOsH Methyl

Methyl Methyl CONH ₂ 2-Sulfoethyl 3-Methyl butyl H

2a ⁸⁵⁸ H SOsH SOsH H

2a ⁸⁵⁹ SOsH H H SOsH Methyl

Methyl Methyl CONH2 2-Sulfoethyl Sec butyl H

2a ⁸⁶⁰ H SOsH SOsH H

2a ⁸⁶¹ SOsH H H SOsH Methyl

Methyl Methyl CONH2 2-Sulfoethyl Pentyl H

2a ⁸⁶² H SOsH SOsH H

2a ⁸⁶³ SOsH H H SOsH Methyl

Methyl Methyl CONH2 2-Sulfoethyl Hexyl H

2a ⁸⁶⁴ H SOsH SOsH H

2a ⁸⁶⁵ SOsH H H SOsH Methyl

Methyl Methyl CONH2 2-Sulfoethyl Cyclobutyl H

2a ⁸⁶⁶ H SOsH SOsH H

2a ⁸⁶⁷ SOsH H H SOsH Methyl

Methyl Methyl CONH2 2-Sulfoethyl Cyclopentyl H

2a ⁸⁶⁸ H SOsH SOsH H

2a ⁸⁶⁹ SOsH H H SOsH Methyl

Methyl Methyl CONH2 2-Sulfoethyl Cyclohexyl H

2a ⁸⁷⁰ H SOsH SOsH H

2a ⁸⁷¹ SOsH H H SOsH Methyl 2-Methyl

Methyl Methyl CONH2 2-Sulfoethyl H

2a ⁸⁷² H SOsH SOsH H cyclohexyl

2a ⁸⁷³ SOsH H H SOsH Methyl 3-Methyl

Methyl Methyl CONH2 2-Sulfoethyl H

2a ⁸⁷⁴ H SOsH SOsH H cyclohexyl

2a ⁸⁷⁵ SOsH H H SOsH Methyl

Methyl Methyl CONH2 2-Sulfoethyl Pentan-2-yl H

2a ⁸⁷⁶ H SOsH SOsH H

2a ⁸⁷⁷ SOsH H H SOsH Methyl

Methyl Methyl CONH2 2-Sulfoethyl 2-Ethylhexyl H

2a ⁸⁷⁸ H SOsH SOsH H

2a ⁸⁷⁹ SOsH H H SOsH Methyl

Methyl Methyl CONH2 2-Sulfoethyl Phenyl H

2a ⁸⁸⁰ H SOsH SOsH H

2a ⁸⁸¹ SOsH H H SOsH Methyl

Methyl Methyl CONH2 2-Sulfoethyl Benzyl H

2a ⁸⁸² H SOsH SOsH H

2a ⁸⁸³ SOsH H H SOsH Methyl

Methyl Methyl CONH2 2-Sulfoethyl Ally I H

2a ⁸⁸⁴ H SOsH SOsH H

2a ⁸⁸⁵ SOsH H H SOsH Methyl 2-Methoxy H

Methyl Methyl CONH2 2-Sulfoethyl

2a ⁸⁸⁶ H SOsH SOsH H ethyl

2a ⁸⁸⁷ SOsH H H SOsH Methyl 3-Methoxy

Methyl Methyl CONH ₂ 2-Sulfoethyl H

2a ⁸⁸⁸ H SOsH SOsH H propyl

2a ⁸⁸⁹ SOsH H H SOsH Methyl

Methyl Methyl CONH2 2-Sulfoethyl 3-Chloropropyl H

2a ⁸⁹⁰ H SOsH SOsH H

2a ⁸⁹¹ SOsH H H SOsH Methyl 2-Methyl

Methyl Methyl CONH2 2-Sulfoethyl H

2a ⁸⁹² H SOsH SOsH H thioethyl

2a ⁸⁹³ SOsH H H SOsH Methyl

Methyl Methyl CONH2 2-Sulfoethyl 2-Fluoroethyl H

2a ⁸⁹⁴ H SOsH SOsH H

2a ⁸⁹⁵ SOsH H H SOsH Methyl

Methyl Methyl CONH2 2-Sulfoethyl 2-Chloro ethyl H

2a ⁸⁹⁶ H SOsH SOsH H

2a ⁸⁹⁷ SOsH H H SOsH Methyl 2-(2-Hydroxy

H SOsH SOsH H Methyl Methyl CONH2 2-Sulfoethyl ethyl H

2a ⁸⁹⁸

sulfonyl)ethyl

2a ⁸⁹⁹ SOsH H H SOsH Methyl 2-(2-tert Butyl

H SOsH SOsH H Methyl Methyl CONH2 2-Sulfoethyl sulfanyl ethyl H

2a ⁹⁰⁰

sulfonyl)ethyl

2a ⁹⁰¹ SOsH H H SOsH Methyl 2-(2-Hydroxy

Methyl Methyl CONH2 2-Sulfoethyl H

2a ⁹⁰² H SOsH SOsH H ethoxyjpropyl

2a ⁹⁰³ SOsH H H SOsH Methyl 2-(2-Hydroxy

Methyl Methyl CONH2 2-Sulfoethyl H

2a ⁹⁰⁴ H SOsH SOsH H ethoxy)ethyl

2a ⁹⁰⁵ SOsH H H SOsH Methyl 3-(4-Hydroxy

Methyl Methyl CONH2 2-Sulfoethyl H

2a ⁹⁰⁶ H SOsH SOsH H butoxyjpropyl

2a ⁹⁰⁷ SOsH H H SOsH Methyl 3-(2-Phenoxy

Methyl Methyl CONH2 2-Sulfoethyl H

2a ⁹⁰⁸ H SOsH SOsH H ethoxyl)propyl

2a ⁹⁰⁹ SOsH H H SOsH Methyl 3-lsopropxy

Methyl Methyl CONH2 2-Sulfoethyl H

2a ⁹¹⁰ H SOsH SOsH H propyl

2a ⁹¹¹ SOsH H H SOsH Methyl 3-Ethoxy

Methyl Methyl CONH2 2-Sulfoethyl H

2a ⁹¹² H SOsH SOsH H propyl

2a ⁹¹³ SOsH H H SOsH Methyl

Methyl Methyl CONH2 2-Sulfoethyl 3-Ethoxy butyl H

2a ⁹¹⁴ H SOsH SOsH H

2a ⁹¹⁵ SOsH H H SOsH Methyl 4-(2-Hydroxy

H SOsH SOsH H Methyl Methyl CONH ₂ 2-Sulfoethyl ethane2sulfon H

2a ⁹¹⁶

yl)phenyl

2a ⁹¹⁷ SOsH H H SOsH NHCOC Methyl

OMe CN 2-Sulfoethyl Methyl H

2a ⁹¹⁸ H SOsH SOsH H Hs

2a ⁹¹⁹ SOsH H H SOsH NHCOC Methyl

OMe CN 2-Sulfoethyl Ethyl H

2a ⁹²⁰ H SOsH SOsH H Hs

2a ⁹²¹ SOsH H H SOsH NHCOC Methyl

OMe CN 2-Sulfoethyl n-Propyl H

2a ⁹²² H SOsH SOsH H Hs

2a ⁹²³ SOsH H H SOsH NHCOC Methyl

OMe CN 2-Sulfoethyl Isopropyl H

2a ⁹²⁴ H SOsH SOsH H Hs

2a ⁹²⁵ SOsH H H SOsH NHCOC Methyl

OMe CN 2-Sulfoethyl 1 -Ethyl propyl H

2a ⁹²⁶ H SOsH SOsH H Hs

2a ⁹²⁷ SOsH H H SOsH NHCOC Methyl 1 ,2-Dimethyl

OMe CN 2-Sulfoethyl H

2a ⁹²⁸ H SOsH SOsH H Hs propyl

2a ⁹²⁹ SOsH H H SOsH NHCOC Methyl 2,2-Dimethyl

OMe CN 2-Sulfoethyl H

2a ⁹³⁰ H SOsH SOsH H Hs propyl

2a ⁹³¹ SOsH H H SOsH NHCOC Methyl

OMe CN 2-Sulfoethyl Butyl H

2a ⁹³² H SOsH SOsH H Hs

2a ⁹³³ SOsH H H SOsH NHCOC Methyl

OMe CN 2-Sulfoethyl 2-Methyl butyl H

2a ⁹³⁴ H SOsH SOsH H Hs

2a ⁹³⁵ SOsH H H SOsH NHCOC Methyl

OMe CN 2-Sulfoethyl Tert butyl H

2a ⁹³⁶ H SOsH SOsH H Hs

2a ⁹³⁷ SOsH H H SOsH NHCOC Methyl

OMe CN 2-Sulfoethyl 3-Methyl butyl H

2a ⁹³⁸ H SOsH SOsH H Hs

2a ⁹³⁹ SOsH H H SOsH NHCOC Methyl

OMe CN 2-Sulfoethyl Sec butyl H

2a ⁹⁴⁰ H SOsH SOsH H Hs

2a ⁹⁴¹ SOsH H H SOsH Methyl

H

2a ⁹⁴² H SOsH SOsH H NHCOC

OMe CN 2-Sulfoethyl Pentyl

Hs

2a ⁹⁴³ SOsH H H SOsH NHCOC Methyl

OMe CN 2-Sulfoethyl Hexyl H

2a ⁹⁴⁴ H SOsH SOsH H Hs

2a ⁹⁴⁵ SOsH H H SOsH NHCOC Methyl

OMe CN 2-Sulfoethyl Cyclobutyl H

2a ⁹⁴⁶ H SOsH SOsH H Hs

2a ⁹⁴⁷ SOsH H H SOsH NHCOC Methyl

OMe CN 2-Sulfoethyl Cyclopentyl H

2a ⁹⁴⁸ H SOsH SOsH H Hs

2a ⁹⁴⁹ SOsH H H SOsH NHCOC Methyl

OMe CN 2-Sulfoethyl Cyclohexyl H

2a ⁹⁵⁰ H SOsH SOsH H Hs

2a ⁹⁵¹ SOsH H H SOsH NHCOC Methyl 2-Methyl

OMe CN 2-Sulfoethyl H

2a ⁹⁵² H SOsH SOsH H Hs cyclohexyl

2a ⁹⁵³ SOsH H H SOsH NHCOC Methyl 3-Methyl

OMe CN 2-Sulfoethyl H

2a ⁹⁵⁴ H SOsH SOsH H Hs cyclohexyl

2a ⁹⁵⁵ SOsH H H SOsH NHCOC Methyl

OMe CN 2-Sulfoethyl Pentan-2-yl H

2a ⁹⁵⁶ H SOsH SOsH H Hs

2a ⁹⁵⁷ SOsH H H SOsH NHCOC Methyl

OMe CN 2-Sulfoethyl 2-Ethylhexyl H

2a ⁹⁵⁸ H SOsH SOsH H Hs

2a ⁹⁵⁹ SOsH H H SOsH NHCOC Methyl

OMe CN 2-Sulfoethyl Phenyl H

2a ⁹⁶⁰ H SOsH SOsH H Hs

2a ⁹⁶¹ SOsH H H SOsH NHCOC Methyl

OMe CN 2-Sulfoethyl Benzyl H

2a ⁹⁶² H SOsH SOsH H Hs

2a ⁹⁶³ SOsH H H SOsH NHCOC Methyl

OMe CN 2-Sulfoethyl Ally I H

2a ⁹⁶⁴ H SOsH SOsH H Hs

2a ⁹⁶⁵ SOsH H H SOsH NHCOC Methyl 2-Methoxy

OMe CN 2-Sulfoethyl H

2a ⁹⁶⁶ H SOsH SOsH H Hs ethyl

2a ⁹⁶⁷ SOsH H H SOsH NHCOC Methyl 3-Methoxy

OMe CN 2-Sulfoethyl H

2a ⁹⁶⁸ H SOsH SOsH H Hs propyl

2a ⁹⁶⁹ SOsH H H SOsH NHCOC Methyl 3-Chloropropyl

OMe CN 2-Sulfoethyl H

2a ⁹⁷⁰ H SOsH SOsH H Hs

2a ⁹⁷¹ SOsH H H SOsH Methyl

NHCOC 2-Methyl

2a ⁹⁷² H SOsH SOsH H OMe CN 2-Sulfoethyl H

Hs thioethyl

2a ⁹⁷³ SOsH H H SOsH NHCOC Methyl

OMe CN 2-Sulfoethyl 2-Fluoroethyl H

2a ⁹⁷⁴ H SOsH SOsH H Hs

2a ⁹⁷⁵ SOsH H H SOsH NHCOC Methyl

OMe CN 2-Sulfoethyl 2-Chloro ethyl H

2a ⁹⁷⁶ H SOsH SOsH H Hs

2a ⁹⁷⁷ SOsH H H SOsH Methyl 2-(2-Hydroxy

NHCOC

H SOsH SOsH H OMe CN 2-Sulfoethyl ethyl H

2a ⁹⁷⁸ Hs

sulfonyl)ethyl

2a ⁹⁷⁹ SOsH H H SOsH Methyl 2-(2-tert Butyl

NHCOC

H SOsH SOsH H OMe CN 2-Sulfoethyl sulfanyl ethyl H

2a ⁹⁸⁰ Hs

sulfonyl)ethyl

2a ⁹⁸¹ SOsH H H SOsH NHCOC Methyl 2-(2-Hydroxy

OMe CN 2-Sulfoethyl H

2a ⁹⁸² H SOsH SOsH H Hs ethoxyjpropyl

2a ⁹⁸³ SOsH H H SOsH NHCOC Methyl 2-(2-Hydroxy

OMe CN 2-Sulfoethyl H

2a ⁹⁸⁴ H SOsH SOsH H Hs ethoxy)eth yl

2a ⁹⁸⁵ SOsH H H SOsH NHCOC Methyl 3-(4-Hydroxy

OMe CN 2-Sulfoethyl H

2a ⁹⁸⁶ H SOsH SOsH H Hs butoxyjpropyl

2a ⁹⁸⁷ SOsH H H SOsH NHCOC Methyl 3-(2-Phenoxy

OMe CN 2-Sulfoethyl H

2a ⁹⁸⁸ H SOsH SOsH H Hs ethoxyl)propyl

2a ⁹⁸⁹ SOsH H H SOsH NHCOC Methyl 3-lsopropxy

OMe CN 2-Sulfoethyl H

2a ⁹⁹⁰ H SOsH SOsH H Hs propyl

2a ⁹⁹¹ SOsH H H SOsH NHCOC Methyl 3-Ethoxy

OMe CN 2-Sulfoethyl H

2a ⁹⁹² H SOsH SOsH H Hs propyl

2a ⁹⁹³ SOsH H H SOsH NHCOC Methyl

OMe CN 2-Sulfoethyl 3-Ethoxy butyl H

2a ⁹⁹⁴ H SOsH SOsH H Hs

2a ⁹⁹⁵ SOsH H H SOsH Methyl 4-(2-Hydroxy

H SOsH SOsH H NHCOC ethane

OMe CN 2-Sulfoethyl H

2a ⁹⁹⁶ Hs sulfonyl)pheny

I

2a ⁹⁹⁷ SOsH H H SOsH Methyl

H

2a ⁹⁹⁸ H SOsH SOsH H NHCOC

OMe CONH ₂ 2-Sulfoethyl Methyl

Hs

2a ⁹⁹⁹ SOsH H H SOsH NHCOC Methyl

2a 1000 OMe CONH ₂ 2-Sulfoethyl Ethyl H

H SOsH SOsH H Hs

_2a 1001 SOsH H H SOsH NHCOC Methyl

_2a 1002 OMe CONH2 2-Sulfoethyl n-Propyl H

H SOsH SOsH H Hs

2g1003 SOsH H H SOsH NHCOC Methyl

_2a 1004 OMe CONH2 2-Sulfoethyl Isopropyl H

H SOsH SOsH H Hs

2g1005 SOsH H H SOsH NHCOC Methyl

2a 1006 OMe CONH2 2-Sulfoethyl 1 -Ethyl propyl H

H SOsH SOsH H Hs

_2a 1007 SOsH H H SOsH NHCOC Methyl 1 ,2-Dimethyl

2g1008 OMe CONH2 2-Sulfoethyl H

H SOsH SOsH H Hs propyl

2a 1009 SOsH H H SOsH NHCOC Methyl 2,2-Dimethyl

_2a ioio OMe CONH2 2-Sulfoethyl H

H SOsH SOsH H Hs propyl

_2a 1011 SOsH H H SOsH NHCOC Methyl

_2a 1012 OMe CONH2 2-Sulfoethyl Butyl H

H SOsH SOsH H Hs

_2a 1013 SOsH H H SOsH NHCOC Methyl

_2a 1014 OMe CONH2 2-Sulfoethyl 2-Methyl butyl H

H SOsH SOsH H Hs

_2a 1015 SOsH H H SOsH NHCOC Methyl

_2a 1016 OMe CONH2 2-Sulfoethyl Tert butyl H

H SOsH SOsH H Hs

_2a 1017 SOsH H H SOsH NHCOC Methyl

_2a 1018 OMe CONH2 2-Sulfoethyl 3-Methyl butyl H

H SOsH SOsH H Hs

_2a 1019 SOsH H H SOsH NHCOC Methyl

_2a 1020 OMe CONH2 2-Sulfoethyl Sec butyl H

H SOsH SOsH H Hs

_2a 1021 SOsH H H SOsH NHCOC Methyl

_2a 1022 OMe CONH2 2-Sulfoethyl Pentyl H

H SOsH SOsH H Hs

_2a 1023 SOsH H H SOsH NHCOC Methyl

_2a 1024 OMe CONH2 2-Sulfoethyl Hexyl H

H SOsH SOsH H Hs

_2a 1025 SOsH H H SOsH NHCOC Methyl

_2a 1026 OMe CONH2 2-Sulfoethyl Cyclobutyl H

H SOsH SOsH H Hs

_2a 1027 SOsH H H SOsH Methyl H

NHCOC

_2a 1028 H SOsH SOsH H OMe CONH2 2-Sulfoethyl Cyclopentyl

Hs

_2a 1029 SOsH H H SOsH NHCOC Methyl

2g1030 OMe CONH2 2-Sulfoethyl Cyclohexyl H

H SOsH SOsH H H ₃

_2a 1031 SOsH H H SOsH NHCOC Methyl 2-Methyl

_2a 1032 OMe CONH2 2-Sulfoethyl H

H SOsH SOsH H H ₃ cyclohexyl

2g1033 SOsH H H SOsH NHCOC Methyl 3-Methyl

_2a 1034 OMe CONH2 2-Sulfoethyl H

H SOsH SOsH H H ₃ cyclohexyl

2g1035 SOsH H H SOsH NHCOC Methyl

2g1036 OMe CONH2 2-Sulfoethyl Pentan-2-yl H

H SOsH SOsH H H ₃

_2a 1037 SOsH H H SOsH NHCOC Methyl

2g1038 OMe CONH2 2-Sulfoethyl 2-Ethylhexyl H

H SOsH SOsH H H ₃

2g1039 SOsH H H SOsH NHCOC Methyl

_2a 1040 OMe CONH2 2-Sulfoethyl Phenyl H

H SOsH SOsH H H ₃

_2a 1041 SOsH H H SOsH NHCOC Methyl

_2a 1042 OMe CONH2 2-Sulfoethyl Benzyl H

H SOsH SOsH H H ₃

_2a 1043 SOsH H H SOsH NHCOC Methyl

_2a 1044 OMe CONH2 2-Sulfoethyl Ally I H

H SOsH SOsH H H ₃

_2a 1045 SOsH H H SOsH NHCOC Methyl 2-Methoxy

_2a 1046 OMe CONH2 2-Sulfoethyl H

H SOsH SOsH H H ₃ ethyl

_2a 1047 SOsH H H SOsH NHCOC Methyl 3-Methoxy

_2a 1048 OMe CONH2 2-Sulfoethyl H

H SOsH SOsH H H ₃ propyl

_2a 1049 SOsH H H SOsH NHCOC Methyl

_2a 1050 OMe CONH2 2-Sulfoethyl 3-Chloropropyl H

H SOsH SOsH H H ₃

_2a 1051 SOsH H H SOsH NHCOC Methyl 2-Methyl

_2a 1052 OMe CONH2 2-Sulfoethyl H

H SOsH SOsH H H ₃ thioethyl

_2a 1053 SOsH H H SOsH NHCOC Methyl

_2a 1054 OMe CONH2 2-Sulfoethyl 2-Fluoroethyl H

H SOsH SOsH H H ₃

₂ g1055 SOsH H H SOsH NHCOC Methyl

₂ g1056 OMe CONH2 2-Sulfoethyl 2-Chloro ethyl H

H SOsH SOsH H H ₃

_2a 1057 SOsH H H SOsH Methyl 2-(2-Hydroxy

NHCOC

_2a 1058 H SOsH SOsH H OMe CONH2 2-Sulfoethyl ethyl H

H ₃

sulfonyl)ethyl

2a loss SOsH H H SOsH

2a 1086 Methyl Methyl CN 2-Carboxyethyl H 1 -Ethyl propyl H

H SOsH SOsH H

_2a 1087 SOsH H H SOsH 1 ,2-Dimethyl

2a 1088 Methyl Methyl CN 2-Carboxyethyl H H

H SOsH SOsH H propyl

2a 1089 SOsH H H SOsH 2,2-Dimethyl

Methyl Methyl CN 2-Carboxyethyl H H

_2a 1091 propyl

H SOsH SOsH H

_2a 1092 SOsH H H SOsH

2 _g 1093 Methyl Methyl CN 2-Carboxyethyl H Butyl H

H SOsH SOsH H

_2a 1094 SOsH H H SOsH

2a 1095 Methyl Methyl CN 2-Carboxyethyl H 2-Methyl butyl H

H SOsH SOsH H

2a 1096 SOsH H H SOsH

_2a 1097 Methyl Methyl CN 2-Carboxyethyl H Tert butyl H

H SOsH SOsH H

2a 1098 SOsH H H SOsH

2a 1099 Methyl Methyl CN 2-Carboxyethyl H 3-Methyl butyl H

H SOsH SOsH H

_2a i i oo SOsH H H SOsH

_2a 1 101 Methyl Methyl CN 2-Carboxyethyl H Sec butyl H

H SOsH SOsH H

_2a 1 102 SOsH H H SOsH

_2a 1 103 Methyl Methyl CN 2-Carboxyethyl H Pentyl H

H SOsH SOsH H

_2a 1 104 SOsH H H SOsH

_2a 1 105 Methyl Methyl CN 2-Carboxyethyl H Hexyl H

H SOsH SOsH H

_2a 1 106 SOsH H H SOsH

_2a 1 107 Methyl Methyl CN 2-Carboxyethyl H Cyclobutyl H

H SOsH SOsH H

_2a 1 108 SOsH H H SOsH

_2a 1 109 Methyl Methyl CN 2-Carboxyethyl H Cyclopentyl H

H SOsH SOsH H

_2a 1 1 10 SOsH H H SOsH

_2a 1 1 1 1 Methyl Methyl CN 2-Carboxyethyl H Cyclohexyl H

H SOsH SOsH H

_2g 1 1 12 SOsH H H SOsH 2-Methyl

_2g 1 1 13 Methyl Methyl CN 2-Carboxyethyl H H

H SOsH SOsH H cyclohexyl

_2g 1 1 14 SOsH H H SOsH 3-Methyl

_2a 1 1 15 Methyl Methyl CN 2-Carboxyethyl H H

H SOsH SOsH H cyclohexyl

_2a 1116 SOsH H H SOsH

_2a 1117 Methyl Methyl CN 2-Carboxyethyl H Pentan-2-yl H

H SOsH SOsH H

_2a 1118 SOsH H H SOsH

_2g 1119 Methyl Methyl CN 2-Carboxyethyl H 2-Ethylhexyl H

H SOsH SOsH H

_2a 1120 SOsH H H SOsH

_2g 1121 Methyl methyl CN 2-Carboxyethyl H Phenyl H

H SOsH SOsH H

_2a 1122 SOsH H H SOsH

_2a 1123 Methyl methyl CN 2-Carboxyethyl H Benzyl H

H SOsH SOsH H

_2a 1124 SOsH H H SOsH

_2a 1125 Methyl Methyl CN 2-Carboxyethyl H Ally I H

H SOsH SOsH H

_2a 1126 SOsH H H SOsH 2-Methoxy

_2a 1127 Methyl Methyl CN 2-Carboxyethyl H H

H SOsH SOsH H ethyl

_2a 1128 SOsH H H SOsH 3-Methoxy

_2a 1129 Methyl Methyl CN 2-Carboxyethyl H H

H SOsH SOsH H propyl

_2a 1130 SOsH H H SOsH

_2g 1131 Methyl Methyl CN 2-Carboxyethyl H 3-Chloropropyl H

H SOsH SOsH H

_2a 1132 SOsH H H SOsH 2-Methyl

_2a 1133 Methyl Methyl CN 2-Carboxyethyl H H

H SOsH SOsH H thioethyl

_2a 1134 SOsH H H SOsH

_2a 1135 Methyl Methyl CN 2-Carboxyethyl H 2-Fluoroethyl H

H SOsH SOsH H

_2a 1136 SOsH H H SOsH 2-Carboxyethyl

_2a 1137 Methyl Methyl CN H 2-Chloro ethyl H

H SOsH SOsH H

_2a 1138 SOsH H H SOsH 2-(2-Hydroxy

_2a 1139 H SOsH SOsH H Methyl Methyl CN 2-Carboxyethyl H ethyl H sulfonyl)ethyl

_2a 1140 SOsH H H SOsH 2-(2-tert Butyl

_2g 1141 H SOsH SOsH H Methyl Methyl CN 2-Carboxyethyl H sulfanyl ethyl H sulfonyl)ethyl

_2a 1142 SOsH H H SOsH H

2-(2-Hydroxy

_2a 1143 H SOsH SOsH H Methyl Methyl CN 2-Carboxyethyl H

ethoxyjpropyl

_2a 1144 SOsH H H SOsH 2-(2-Hydroxy

_2a 1145 Methyl Methyl CN 2-Carboxyethyl H H

H SOsH SOsH H ethoxy)ethyl

_2a 1146 SOsH H H SOsH 3-(4-Hydroxy

_2a 1147 Methyl Methyl CN 2-Carboxyethyl H H

H SOsH SOsH H butoxy)pr opyl

_2a 1148 SOsH H H SOsH 3-(2-Phenoxy

_2a 1149 Methyl Methyl CN 2-Carboxyethyl H H

H SOsH SOsH H ethoxyl)pr opyl

_2a 1150 SOsH H H SOsH 3-lsopropxy

_2a 1151 Methyl Methyl CN 2-Carboxyethyl H H

H SOsH SOsH H propyl

_2a 1152 SOsH H H SOsH 3-Ethoxy

_2a 1153 Methyl Methyl CN 2-Carboxyethyl H H

H SOsH SOsH H propyl

_2a 1154 SOsH H H SOsH

_2a 1155 Methyl Methyl CN 2-Carboxyethyl H 3-Ethoxy butyl H

H SOsH SOsH H

_2a 1156 SOsH H H SOsH 4-(2-Hydroxy

H SOsH SOsH H ethane

_2a 1157 Methyl Methyl CN 2-Carboxyethyl H H sulfonyl)pheny

I

_2a 1158 SOsH H H SOsH

_2a 1159 Methyl Methyl CONH2 2-Carboxyethyl H Methyl H

H SOsH SOsH H

_2a 1160 SOsH H H SOsH

_2g 1161 Methyl Methyl CONH2 2-Carboxyethyl H Ethyl H

H SOsH SOsH H

_2a 1162 SOsH H H SOsH

_2a 1163 Methyl Methyl CONH2 2-Carboxyethyl H n-Propyl H

H SOsH SOsH H

_2a 1164 SOsH H H SOsH

_2a 1165 Methyl Methyl CONH2 2-Carboxyethyl H Isopropyl H

H SOsH SOsH H

_2a 1166 SOsH H H SOsH

_2a 1167 Methyl Methyl CONH2 2-Carboxyethyl H 1 -Ethyl propyl H

H SOsH SOsH H

_2a 1168 SOsH H H SOsH

_2a 1169 H

H SOsH SOsH H

1 ,2-Dimethyl

Methyl Methyl CONH2 2-Carboxyethyl H

propyl

_2a 1170 SOsH H H SOsH 2,2-Dimethyl

_2a 1171 Methyl Methyl CONH2 2-Carboxyethyl H H

H SOsH SOsH H propyl

_2a 1172 SOsH H H SOsH

_2a 1173 Methyl Methyl CONH2 2-Carboxyethyl H Butyl H

H SOsH SOsH H

_2a 1174 SOsH H H SOsH

_2a 1175 Methyl Methyl CONH2 2-Carboxyethyl H 2-Methyl butyl H

H SOsH SOsH H

_2a 1176 SOsH H H SOsH

_2a 1177 Methyl Methyl CONH2 2-Carboxyethyl H Tert butyl H

H SOsH SOsH H

_2a 1178 SOsH H H SOsH

_2a 1179 Methyl Methyl CONH2 2-Carboxyethyl H 3-Methyl butyl H

H SOsH SOsH H

_2a 1180 SOsH H H SOsH

_2a 1181 Methyl Methyl CONH2 2-Carboxyethyl H Sec butyl H

H SOsH SOsH H

_2a 1182 SOsH H H SOsH

_2a 1183 Methyl Methyl CONH2 2-Carboxyethyl H Pentyl H

H SOsH SOsH H

_2a 1184 SOsH H H SOsH

_2a 1185 Methyl Methyl CONH2 2-Carboxyethyl H Hexyl H

H SOsH SOsH H

_2a 1186 SOsH H H SOsH

_2a 1187 Methyl Methyl CONH2 2-Carboxyethyl H Cyclobutyl H

H SOsH SOsH H

_2a 1188 SOsH H H SOsH

_2a 1189 Methyl Methyl CONH2 2-Carboxyethyl H Cyclopentyl H

H SOsH SOsH H

_2a 1190 SOsH H H SOsH 2-Carboxyethyl

_2g 1191 Methyl Methyl CONH2 H Cyclohexyl H

H SOsH SOsH H

_2a 1192 SOsH H H SOsH 2-Methyl

_2a 1193 Methyl Methyl CONH2 2-Carboxyethyl H H

H SOsH SOsH H cyclohexyl

_2a 1194 SOsH H H SOsH 3-Methyl

_2a 1195 Methyl Methyl CONH2 2-Carboxyethyl H H

H SOsH SOsH H cyclohexyl

_2a 1196 SOsH H H SOsH

_2a 1197 Methyl Methyl CONH2 2-Carboxyethyl H Pentan-2-yl H

H SOsH SOsH H

_2a 1198 SOsH H H SOsH H

_2a 1199 H SOsH SOsH H Methyl Methyl CONH2 2-Carboxyethyl H 2-Ethylhexyl

_2a 1200 SOsH H H SOsH

_2a 1201 Methyl Methyl CONH2 2-Carboxyethyl H Phenyl H

H SOsH SOsH H

_2a 1202 SOsH H H SOsH

_2a 1203 Methyl Methyl CONH2 2-Carboxyethyl H Benzyl H

H SOsH SOsH H

_2a 1204 SOsH H H SOsH

_2a 1205 Methyl Methyl CONH2 2-Carboxyethyl H Ally I H

H SOsH SOsH H

_2a 1206 SOsH H H SOsH 2-Methoxy

_2a 1207 Methyl Methyl CONH2 2-Carboxyethyl H H

H SOsH SOsH H ethyl

_2a 1208 SOsH H H SOsH 3-Methoxy

_2a 1209 Methyl Methyl CONH2 2-Carboxyethyl H H

H SOsH SOsH H propyl

_2a 1210 SOsH H H SOsH 2-Carboxyethyl

_2g 1211 Methyl Methyl CONH2 H 3-Chloropropyl H

H SOsH SOsH H

_2g 1212 SOsH H H SOsH 2-Methyl

_2a 1213 Methyl Methyl CONH2 2-Carboxyethyl H H

H SOsH SOsH H thioethyl

_2g 1214 SOsH H H SOsH

_2a 1215 Methyl Methyl CONH2 2-Carboxyethyl H 2-Fluoroethyl H

H SOsH SOsH H

_2g 1216 SOsH H H SOsH

_2g 1217 Methyl Methyl CONH2 2-Carboxyethyl H 2-Chloro ethyl H

H SOsH SOsH H

_2a 1218 SOsH H H SOsH 2-(2-Hydroxy

_2g 1219 H SOsH SOsH H Methyl Methyl CONH2 2-Carboxyethyl H ethyl H sulfonyl)ethyl

_2a 1220 SOsH H H SOsH 2-(2-tert Butyl

_2g 1221 H SOsH SOsH H Methyl Methyl CONH2 2-Carboxyethyl H sulfanyl ethyl H sulfonyl)ethyl

_2a 1222 SOsH H H SOsH 2-(2-Hydroxy

_2a 1223 Methyl Methyl CONH2 2-Carboxyethyl H H

H SOsH SOsH H ethoxyjpropyl

_2a 1224 SOsH H H SOsH 2-(2-Hydroxy

_2a 1225 Methyl Methyl CONH2 2-Carboxyethyl H H

H SOsH SOsH H ethoxy)ethyl

_2a 1226 SOsH H H SOsH

_2a 1227 3-(4-Hydroxy

H SOsH SOsH H Methyl Methyl CONH2 2-Carboxyethyl H H butoxyjpropyl

_2a 1228 SOsH H H SOsH 3-(2-Phenoxy

_2a 1229 Methyl Methyl CONH2 2-Carboxyethyl H H

H SOsH SOsH H ethoxyl)propyl

_2a 1230 SOsH H H SOsH 3-lsopropxy

_2a 1231 Methyl Methyl CONH2 2-Carboxyethyl H H

H SOsH SOsH H propyl

_2a 1232 SOsH H H SOsH 3-Ethoxy

_2a 1233 Methyl Methyl CONH2 2-Carboxyethyl H H

H SOsH SOsH H propyl

_2a 1234 SOsH H H SOsH

_2a 1235 Methyl Methyl CONH2 2-Carboxyethyl H 3-Ethoxy butyl H

H SOsH SOsH H

_2a 1236 SOsH H H SOsH 4-(2-Hydroxy

H SOsH SOsH H ethane

_2a 1237 Methyl Methyl CONH2 2-Carboxyethyl H H sulfonyl)pheny

I

_2a 1238 SOsH H H SOsH NHCOC

_2a 1239 OMe CN 2-Carboxyethyl H Methyl H

H SOsH SOsH H H ₃

_2a 1240 SOsH H H SOsH NHCOC

_2g 1241 OMe CN 2-Carboxyethyl H Ethyl H

H SOsH SOsH H H ₃

_2a 1242 SOsH H H SOsH NHCOC

_2a 1243 OMe CN 2-Carboxyethyl H n-Propyl H

H SOsH SOsH H H ₃

_2a 1244 SOsH H H SOsH NHCOC

_2a 1245 OMe CN 2-Carboxyethyl H Isopropyl H

H SOsH SOsH H H ₃

_2a 1246 SOsH H H SOsH NHCOC

_2a 1247 OMe CN 2-Carboxyethyl H 1 -Ethyl propyl H

H SOsH SOsH H H ₃

_2a 1248 SOsH H H SOsH NHCOC 1 ,2-Dimethyl

_2a 1249 OMe CN 2-Carboxyethyl H H

H SOsH SOsH H H ₃ propyl

_2a 1250 SOsH H H SOsH NHCOC 2,2-Dimethyl

_2a 1251 OMe CN 2-Carboxyethyl H H

H SOsH SOsH H H ₃ propyl

_2a 1252 SOsH H H SOsH NHCOC

_2a 1253 OMe CN 2-Carboxyethyl H Butyl H

H SOsH SOsH H H ₃

_2a 1252 SOsH H H SOsH H

NHCOC

_2a 1255 H SOsH SOsH H OMe CN 2-Carboxyethyl H 2-Methyl butyl

H ₃

_2a 1256 SOsH H H SOsH NHCOC

_2a 1257 OMe CN 2-Carboxyethyl H Tert butyl H

H SOsH SOsH H H ₃

_2a 1258 SOsH H H SOsH NHCOC

_2a 1259 OMe CN 2-Carboxyethyl H 3-Methyl butyl H

H SOsH SOsH H H ₃

_2a 1260 SOsH H H SOsH NHCOC

_2g 1261 OMe CN 2-Carboxyethyl H Sec butyl H

H SOsH SOsH H H ₃

_2a 1262 SOsH H H SOsH NHCOC

_2a 1263 OMe CN 2-Carboxyethyl H Pentyl H

H SOsH SOsH H H ₃

_2a 1264 SOsH H H SOsH NHCOC

_2a 1265 OMe CN 2-Carboxyethyl H Hexyl H

H SOsH SOsH H H ₃

_2a 1266 SOsH H H SOsH NHCOC

_2a 1267 OMe CN 2-Carboxyethyl H Cyclobutyl H

H SOsH SOsH H H ₃

_2a 1268 SOsH H H SOsH NHCOC

_2a 1269 OMe CN 2-Carboxyethyl H Cyclopentyl H

H SOsH SOsH H H ₃

_2a 1270 SOsH H H SOsH NHCOC

_2g 1271 OMe CN 2-Carboxyethyl H Cyclohexyl H

H SOsH SOsH H H ₃

_2a 1272 SOsH H H SOsH NHCOC 2-Methyl

_2a 1273 OMe CN 2-Carboxyethyl H H

H SOsH SOsH H H ₃ cyclohexyl

_2a 1274 SOsH H H SOsH NHCOC 3-Methyl

_2a 1275 OMe CN 2-Carboxyethyl H H

H SOsH SOsH H H ₃ cyclohexyl

_2a 1276 SOsH H H SOsH NHCOC

_2a 1277 OMe CN 2-Carboxyethyl H Pentan-2-yl H

H SOsH SOsH H H ₃

_2a 1278 SOsH H H SOsH NHCOC

_2a 1279 OMe CN 2-Carboxyethyl H 2-Ethylhexyl H

H SOsH SOsH H H ₃

_2a 1280 SOsH H H SOsH NHCOC

_2g 1281 OMe CN 2-Carboxyethyl H Phenyl H

H SOsH SOsH H H ₃

_2a 1282 SOsH H H SOsH NHCOC

_2a 1283 OMe CN 2-Carboxyethyl H Benzyl H

H SOsH SOsH H H ₃

_2a 1284 SOsH H H SOsH H

NHCOC

_2a 1285 H SOsH SOsH H OMe CN 2-Carboxyethyl H Ally I

H ₃

_2a 1286 SOsH H H SOsH NHCOC 2-Methoxy

_2a 1287 OMe CN 2-Carboxyethyl H H

H SOsH SOsH H H ₃ ethyl

_2a 1288 SOsH H H SOsH NHCOC 3-Methoxy

_2a 1289 OMe CN 2-Carboxyethyl H H

H SOsH SOsH H H ₃ propyl

_2a 1290 SOsH H H SOsH NHCOC

_2g 1291 OMe CN 2-Carboxyethyl H 3-Chloropropyl H

H SOsH SOsH H H ₃

_2a 1292 SOsH H H SOsH NHCOC 2-Methyl

_2a 1293 OMe CN 2-Carboxyethyl H H

H SOsH SOsH H H ₃ thioethyl

_2a 1294 SOsH H H SOsH NHCOC

_2a 1295 OMe CN 2-Carboxyethyl H 2-Fluoroethyl H

H SOsH SOsH H H ₃

_2a 1296 SOsH H H SOsH NHCOC

_2a 1297 OMe CN 2-Carboxyethyl H 2-Chloro ethyl H

H SOsH SOsH H H ₃

_2a 1298 SOsH H H SOsH 2-(2-Hydroxy

NHCOC

_2a 1299 H SOsH SOsH H OMe CN 2-Carboxyethyl H ethyl H

H ₃

sulfonyl)ethyl

_2a 1300 SOsH H H SOsH 2-(2-tert Butyl

NHCOC

_2a 1301 H SOsH SOsH H OMe CN 2-Carboxyethyl H sulfanyl ethyl H

H ₃

sulfonyl)ethyl

_2a 1302 SOsH H H SOsH NHCOC 2-(2-Hydroxy

_2a 1303 OMe CN 2-Carboxyethyl H H

H SOsH SOsH H H ₃ ethoxy propyl

_2a 1304 SOsH H H SOsH NHCOC 2-(2-Hydroxy

_2a 1305 OMe CN 2-Carboxyethyl H H

H SOsH SOsH H H ₃ ethoxy)ethyl

_2g 1306 SOsH H H SOsH NHCOC 3-(4-Hydroxy

_2a 1307 OMe CN 2-Carboxyethyl H H

H SOsH SOsH H H ₃ butoxy propyl

_2g 1308 SOsH H H SOsH NHCOC 3-(2-Phenoxy

_2g 1309 OMe CN 2-Carboxyethyl H H

H SOsH SOsH H H ₃ ethoxyl)propyl

_2a 1310 SOsH H H SOsH NHCOC 3-lsopropxy

_2g 131 1 OMe CN 2-Carboxyethyl H H

H SOsH SOsH H H ₃ propyl

_2g 1312 SOsH H H SOsH

_2g 1313 NHCOC 3-Ethoxy

H SOsH SOsH H OMe CN 2-Carboxyethyl H H

H ₃ propyl

_2a 1314 SOsH H H SOsH NHCOC

_2a 1315 OMe CN 2-Carboxyethyl H 3-Ethoxy butyl H

H SOsH SOsH H H ₃

_2a 1316 SOsH H H SOsH 4-(2-Hydroxy

H SOsH SOsH H NHCOC ethane

OMe CN 2-Carboxyethyl H H a ¹³¹⁷ H ₃ sulfonyl)pheny

I

_2a 1318 SOsH H H SOsH NHCOC

_2g 1319 OMe CONH2 2-Carboxyethyl H Methyl H

H SOsH SOsH H H ₃

_2a 1320 SOsH H H SOsH NHCOC

_2g 1321 OMe CONH2 2-Carboxyethyl H Ethyl H

H SOsH SOsH H H ₃

_2a 1322 SOsH H H SOsH NHCOC

_2a 1323 OMe CONH2 2-Carboxyethyl H n-Propyl H

H SOsH SOsH H H ₃

_2a 1324 SOsH H H SOsH NHCOC

_2a 1325 OMe CONH2 2-Carboxyethyl H Isopropyl H

H SOsH SOsH H H ₃

_2a 1326 SOsH H H SOsH NHCOC

_2a 1327 OMe CONH2 2-Carboxyethyl H 1 -Ethyl propyl H

H SOsH SOsH H H ₃

_2a 1328 SOsH H H SOsH NHCOC 1 ,2-Dimethyl

_2a 1329 OMe CONH2 2-Carboxyethyl H H

H SOsH SOsH H H ₃ propyl

_2a 1330 SOsH H H SOsH NHCOC 2,2-Dimethyl

_2a 1331 OMe CONH2 2-Carboxyethyl H H

H SOsH SOsH H H ₃ propyl

_2a 1332 SOsH H H SOsH NHCOC

_2a 1333 OMe CONH2 2-Carboxyethyl H Butyl H

H SOsH SOsH H H ₃

_2a 1334 SOsH H H SOsH NHCOC

_2a 1335 OMe CONH2 2-Carboxyethyl H 2-Methyl butyl H

H SOsH SOsH H H ₃

_2g 1336 SOsH H H SOsH NHCOC 2-Carboxyethyl

_2a 1337 OMe CONH2 H Tert butyl H

H SOsH SOsH H H ₃

_2g 1338 SOsH H H SOsH NHCOC

_2g 1339 OMe CONH2 2-Carboxyethyl H 3-Methyl butyl H

H SOsH SOsH H H ₃

_2a 1340 SOsH H H SOsH H

NHCOC

_2g 1341 H SOsH SOsH H OMe CONH2 2-Carboxyethyl H Sec butyl

H ₃

_2a 1342 SOsH H H SOsH NHCOC

_2a 1343 OMe CONH2 2-Carboxyethyl H Pentyl H

H SOsH SOsH H H ₃

_2a 1344 SOsH H H SOsH NHCOC

_2a 1345 OMe CONH2 2-Carboxyethyl H Hexyl H

H SOsH SOsH H H ₃

_2a 1346 SOsH H H SOsH NHCOC

_2a 1347 OMe CONH2 2-Carboxyethyl H Cyclobutyl H

H SOsH SOsH H H ₃

_2a 1348 SOsH H H SOsH NHCOC

_2a 1349 OMe CONH2 2-Carboxyethyl H Cyclopentyl H

H SOsH SOsH H H ₃

_2a 1350 SOsH H H SOsH NHCOC

_2a 1351 OMe CONH2 2-Carboxyethyl H Cyclohexyl H

H SOsH SOsH H H ₃

_2a 1352 SOsH H H SOsH NHCOC 2-Methyl

_2a 1353 OMe CONH2 2-Carboxyethyl H H

H SOsH SOsH H H ₃ cyclohexyl

_2a 1354 SOsH H H SOsH NHCOC 3-Methyl

₂ g1355 OMe CONH2 2-Carboxyethyl H H

H SOsH SOsH H H ₃ cyclohexyl

_2g 1356 SOsH H H SOsH NHCOC 2-Carboxyethyl

_2a 1357 OMe CONH2 H Pentan-2-yl H

H SOsH SOsH H H ₃

_2g 1358 SOsH H H SOsH NHCOC

₂ g1359 OMe CONH2 2-Carboxyethyl H 2-ethylhexyl H

H SOsH SOsH H H ₃

_2g 1360 SOsH H H SOsH NHCOC

_2a 1361 OMe CONH2 2-Carboxyethyl H Phenyl H

H SOsH SOsH H H ₃

_2a 1362 SOsH H H SOsH NHCOC

_2a 1363 OMe CONH2 2-Carboxyethyl H Benzyl H

H SOsH SOsH H H ₃

_2a 1364 SOsH H H SOsH NHCOC

_2a 1365 OMe CONH2 2-Carboxyethyl H Ally I H

H SOsH SOsH H H ₃

_2g 1366 SOsH H H SOsH NHCOC 2-Methoxy

_2a 1367 OMe CONH2 2-Carboxyethyl H H

H SOsH SOsH H H ₃ ethyl

_2a 1368 SOsH H H SOsH NHCOC 3-Methoxy

_2g 1369 OMe CONH2 2-Carboxyethyl H H

H SOsH SOsH H H ₃ propyl

_2a 1370 SOsH H H SOsH H

NHCOC

_2g 1371 H SOsH SOsH H OMe CONH2 2-Carboxyethyl H 3-Chloropropyl

H ₃

_2a 1372 SOsH H H SOsH NHCOC 2-Methyl

_2a 1373 OMe CONH2 2-Carboxyethyl H H

H SOsH SOsH H H ₃ thioethyl

_2a 1374 SOsH H H SOsH NHCOC

_2a 1375 OMe CONH2 2-Carboxyethyl H 2-Fluoroethyl H

H SOsH SOsH H H ₃

_2a 1376 SOsH H H SOsH NHCOC

_2a 1377 OMe CONH2 2-Carboxyethyl H 2-Chloro ethyl H

H SOsH SOsH H H ₃

_2a 1378 SOsH H H SOsH 2-(2-Hydroxy

NHCOC

_2a 1379 H SOsH SOsH H OMe CONH2 2-Carboxyethyl H ethyl H

H ₃

sulfonyl)ethyl

_2a 1380 SOsH H H SOsH 2-(2-tert Butyl

NHCOC

_2a 1381 H SOsH SOsH H OMe CONH2 2-Carboxyethyl H sulfanyl ethyl H

H ₃

sulfonyl)ethyl

_2a 1382 SOsH H H SOsH NHCOC 2-(2-Hydroxy

_2a 1383 OMe CONH2 2-Carboxyethyl H H

H SOsH SOsH H H ₃ ethoxyjpropyl

_2a 1384 SOsH H H SOsH NHCOC 2-(2-Hydroxy

_2a 1385 OMe CONH2 2-Carboxyethyl H H

H SOsH SOsH H H ₃ ethoxy)ethyl

_2g 1386 SOsH H H SOsH NHCOC 3-(4-Hydroxy

_2a 1387 OMe CONH2 2-Carboxyethyl H H

H SOsH SOsH H H ₃ butoxy propyl

_2g 1388 SOsH H H SOsH NHCOC 3-(2-Phenoxy

_2g 1389 OMe CONH2 2-Carboxyethyl H H

H SOsH SOsH H H ₃ ethoxyl)propyl

_2g 1390 SOsH H H SOsH NHCOC 3-lsopropxy

_2a 1391 OMe CONH2 2-Carboxyethyl H H

H SOsH SOsH H H ₃ propyl

_2a 1392 SOsH H H SOsH NHCOC 3-Ethoxy

_2a 1393 OMe CONH2 2-Carboxyethyl H H

H SOsH SOsH H H ₃ propyl

_2a 1394 SOsH H H SOsH NHCOC

_2a 1395 OMe CONH2 2-Carboxyethyl H 3-Ethoxy butyl H

H SOsH SOsH H H ₃

_2g 1396 SOsH H H SOsH

_2a 1397 4-(2-Hydroxy

H SOsH SOsH H

NHCOC ethane

OMe CONH2 2-Carboxyethyl H H

H ₃ sulfonyl)pheny

I

_2a 1397 SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H Ethyl Ethyl

2a 1398 H SOsH SOsH H

2a 1399 SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H Propyl Propyl

_2a 1400 H SOsH SOsH H

_2a 1401 SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H Butyl Butyl

_2a 1402 H SOsH SOsH H

_2a 1403 SOsH H H SOsH 2-Hydroxy 2-Hydrox

Methyl Methyl CN

_2a 1404 H SOsH SOsH H 2-Sulfoethyl H

ethyl ethyl

_2a 1405 SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H Hexyl Hexyl

_2a 1406 H SOsH SOsH H

_2a 1407 SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H Butyl Methyl

_2a 1408 H SOsH SOsH H

_2a 1409 SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H Butyl Ethyl

_2a 1410 H SOsH SOsH H

_2a 141 1 SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H Cyclohexyl Methyl

_2a 1412 H SOsH SOsH H

_2a 1413 SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl H Cyclohexyl Ethyl

_2a 1414 H SOsH SOsH H

_2a 1415 SOsH H H SOsH 2-Hydrox

Methyl Methyl CN

_2a 1416 H SOsH SOsH H 2-Sulfoethyl H Cyclohexyl

ethyl

_2a 1417 SOsH H H SOsH

H SOsH SOsH H Ethyl

Methyl Methyl CONH ₂ 2-Sulfoethyl H Ethyl

_2a 1418

_2a 1419 SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl H Propyl Propyl

_2a 1420 H SOsH SOsH H

_2a 1421 SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl H Butyl Butyl

_2a 1422 H SOsH SOsH H

_2a 1423 SOsH H H SOsH 2-Hydroxy 2-Hydrox

Methyl Methyl

_2a 1424 H SOsH SOsH H CONH2 2-Sulfoethyl H

ethyl ethyl

_2a 1425 SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl H Hexyl Hexyl

_2a 1426 H SOsH SOsH H

_2a 1427 SOsH H H SOsH

Methyl Methyl Butyl Methyl

_2a 1428 H SOsH SOsH H CONH2 2-Sulfoethyl H

_2a 1429 SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl H Butyl Ethyl

_2a 1430 H SOsH SOsH H

_2a 1431 SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl H Cyclohexyl Methyl

_2a 1432 H SOsH SOsH H

_2a 1433 SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl H Cyclohexyl Ethyl

_2a 1434 H SOsH SOsH H

_2a 1435 SOsH H H SOsH 2-Hydrox

Methyl Methyl CONH2 2-Sulfoethyl H Cyclohexyl

_2a 1436 H SOsH SOsH H ethyl

_2a 1437 SOsH H H SOsH NHCOC

OMe CN 2-Sulfoethyl H Ethyl Ethyl

_2a 1438 H SOsH SOsH H H ₃

Propyl

_2a 1439 SOsH H H SOsH

NHCOC

H SOsH SOsH H OMe CN

H ₃ 2-Sulfoethyl H Propyl

_2a 1440

_2a 1441 SOsH H H SOsH NHCOC

OMe CN Butyl Butyl

_2a 1442 H SOsH SOsH H H ₃ 2-Sulfoethyl H

_2a 1443 SOsH H H SOsH NHCOC 2-Hydroxy 2-Hydrox

OMe CN

SOsH SOsH H 2-Sulfoethyl H

_2a 1444 H H ₃ ethyl ethyl

_2a 1445 SOsH H H SOsH NHCOC

OMe CN

H H ₃ 2-Sulfoethyl H Hexyl Hexyl

_2a 1446 H SOsH SOsH

_2a 1447 SOsH H H SOsH NHCOC

OMe CN Butyl Methyl

_2a 1448 H SOsH SOsH H H ₃ 2-Sulfoethyl H

_2a 1449 SOsH H H SOsH NHCOC

OMe CN 2-Sulfoethyl H Butyl Ethyl

_2a 1450 H SOsH SOsH H H ₃

_2a 1451 SOsH H H SOsH NHCOC

OMe CN Methyl

_2a 1452 H SOsH SOsH H H ₃ 2-Sulfoethyl H Cyclohexyl

_2a 1453 SOsH H H SOsH NHCOC

OMe CN

H ₃ 2-Sulfoethyl H Cyclohexyl Ethyl

_2a 1454 H SOsH SOsH H

_2a 1455 SOsH H H SOsH NHCOC 2-Hydrox

OMe CN l

_2a 1456 H SOsH SOsH H H ₃ 2-Sulfoethyl H Cyclohexy

ethyl

_2a 1457 SOsH H H SOsH NHCOC

OMe CONH2 2-Sulfoethyl H Ethyl Ethyl

_2a 1458 H SOsH SOsH H H ₃

_2a 1459 SOsH H H SOsH NHCOC

OMe

H ₃ CONH2 2-Sulfoethyl H Propyl Propyl

_2a 1460 H SOsH SOsH H

_2g 1461 SOsH H H SOsH NHCOC

OMe Butyl

_2a 1462 H SOsH SOsH H H ₃ CONH2 2-Sulfoethyl H Butyl

_2a 1463 SOsH H H SOsH NHCOC 2-Hydroxy 2-Hydrox

OMe

_2a 1464 H SOsH SOsH H H ₃ CONH2 2-Sulfoethyl H

ethyl ethyl

_2a 1465 SOsH H H SOsH NHCOC

OMe 2-Sulfoethyl H Hexyl Hexyl

_2a 1466 H SOsH SOsH H H ₃ CONH2

_2a 1467 SOsH H H SOsH NHCOC

OMe H Butyl Methyl

_2a 1468 H SOsH SOsH H H ₃ CONH2 2-Sulfoethyl

_2a 1469 SOsH H H SOsH NHCOC

OMe Butyl Ethyl

_2a 1470 H SOsH SOsH H H ₃ CONH2 2-Sulfoethyl H

_2g 1471 SOsH H H SOsH NHCOC

OMe

H ₃ CONH2 2-Sulfoethyl H Cyclohexyl Methyl

_2a 1472 H SOsH SOsH H

_2a 1473 SOsH H H SOsH NHCOC

OMe Cyclohexyl Ethyl

_2a 1474 H SOsH SOsH H H ₃ CONH2 2-Sulfoethyl H

_2a 1475 SOsH H H SOsH

NHCOC 2-Hydrox

H SOsH SOsH H OMe hexyl

_2a 1476 H ₃ CONH2 2-Sulfoethyl H Cyclo

ethyl

_2a 1477 SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl Methyl Ethyl Ethyl

_2a 1478 H SOsH SOsH H

_2a 1479 SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl Methyl Propyl Propyl

_2a 1480 H SOsH SOsH H

_2a 1481 SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl Methyl Butyl Butyl

_2a 1482 H SOsH SOsH H

_2a 1483 SOsH H H SOsH 2-Hydroxy 2-Hydrox

Methyl Methyl CN

_2a 1484 H SOsH SOsH H 2-Sulfoethyl Methyl ethyl ethyl

_2a 1485 SOsH H H SOsH Hexyl

H SOsH SOsH H Methyl Methyl CN 2-Sulfoethyl Methyl Hexyl

_2a 1486

_2a 1487 SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl Methyl Butyl Methyl

_2a 1488 H SOsH SOsH H

_2a 1489 SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl Methyl Butyl Ethyl

_2a 1490 H SOsH SOsH H

_2g 1491 SOsH H H SOsH

Methyl Methyl CN

H 2-Sulfoethyl Methyl Cyclohexyl Methyl

_2a 1492 H SOsH SOsH

_2a 1493 SOsH H H SOsH

Methyl Methyl CN 2-Sulfoethyl Methyl Cyclohexyl Ethyl

_2a 1494 H SOsH SOsH H

_2a 1495 SOsH H H SOsH 2-Hydrox

Methyl Methyl CN 2-Sulfoethyl Methyl Cyclohexyl

_2a 1496 H SOsH SOsH H ethyl

_2a 1497 SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl Methyl Ethyl Ethyl

_2a 1498 H SOsH SOsH H

_2a 1499 SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl Methyl Propyl Propyl

_2a 1500 H SOsH SOsH H

_2a 1501 SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl Methyl Butyl Butyl

_2a 1502 H SOsH SOsH H

_2a 1503 SOsH H H SOsH 2-Hydroxy 2-Hydrox

Methyl Methyl

₂ CONH2 2-Sulfoethyl Methyl

a1504 H SOsH SOsH H ethyl ethyl

₂ g1505 SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl Methyl Hexyl Hexyl

_2g 1506 H SOsH SOsH H

_2a 1507 SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl Methyl Butyl Methyl

_2g 1508 H SOsH SOsH H

₂ g1509 SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl Methyl Butyl Ethyl

_2a 1510 H SOsH SOsH H

_2a 1511 SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl Methyl Cyclohexyl Methyl

_2a 1512 H SOsH SOsH H

_2a 1513 SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfoethyl Methyl Cyclohexyl Ethyl

_2a 1514 H SOsH SOsH H

_2a 1515 SOsH H H SOsH 2-Hydrox

Methyl Methyl

_2a 1516 H SOsH SOsH H CONH2 2-Sulfoethyl Methyl Cyclohexyl

ethyl

_2a 1517 SOsH H H SOsH NHCOC

OMe CN 2-Sulfoethyl Methyl Ethyl Ethyl

_2a 1518 H SOsH SOsH H H ₃

_2a 1519 SOsH H H SOsH NHCOC

OMe CN ethyl Propyl Propyl

_2a 1520 H SOsH SOsH H H ₃ 2-Sulfoethyl M

_2a 1521 SOsH H H SOsH NHCOC

OMe CN

H ₃ 2-Sulfoethyl Methyl Butyl Butyl

_2a 1522 H SOsH SOsH H

_2a 1523 SOsH H H SOsH NHCOC 2-Hydroxy 2-Hydrox

OMe CN 2-Sulfoethyl Methyl

_2a 1524 H SOsH SOsH H H ₃ ethyl ethyl

_2a 1525 SOsH H H SOsH NHCOC

OMe CN

H ₃ 2-Sulfoethyl Methyl Hexyl Hexyl

_2a 1526 H SOsH SOsH H

_2a 1527 SOsH H H SOsH NHCOC

OMe CN

H H H ₃ 2-Sulfoethyl Methyl Butyl Methyl

_2a 1528 H SOsH SOs

_2a 1529 SOsH H H SOsH NHCOC

OMe CN Sulfoethyl Methyl Butyl Ethyl

_2a 1530 H SOsH SOsH H H ₃ 2-

_2a 1531 SOsH H H SOsH NHCOC

OMe CN Methyl

_2a 1532 H SOsH SOsH H H ₃ 2-Sulfoethyl Methyl Cyclohexyl

_2a 1533 SOsH H H SOsH NHCOC

OMe CN Cyclohexyl Ethyl

_2a 1534 H SOsH SOsH H H ₃ 2-Sulfoethyl Methyl

_2a 1557 SOsH H H SOsH

Methyl Methyl CN 2-Carboxy ethyl H Ethyl Ethyl

2a 1558 H SOsH SOsH H

2a 1559 SOsH H H SOsH

Methyl Methyl CN 2-Carboxy ethyl H Propyl Propyl

2a 1560 H SOsH SOsH H

_2a 1561 SOsH H H SOsH

Methyl Methyl CN 2-Carboxy ethyl H Butyl Butyl

_2a 1562 H SOsH SOsH H

2 _g 1563 SOsH H H SOsH 2-Hydroxy 2-Hydrox

Methyl Methyl CN

_2a 1564 H SOsH SOsH H 2-Carboxy ethyl H

ethyl ethyl

2a 1565 SOsH H H SOsH

Methyl Methyl CN 2-Carboxy ethyl H Hexyl Hexyl

2a 1566 H SOsH SOsH H

_2a 1567 SOsH H H SOsH

Methyl Methyl CN 2-Carboxy ethyl H Butyl Methyl

2a 1568 H SOsH SOsH H

2a 1569 SOsH H H SOsH

Methyl Methyl CN 2-Carboxy ethyl H Butyl Ethyl

_2a 1570 H SOsH SOsH H

_2a 1571 SOsH H H SOsH

Methyl Methyl CN 2-Carboxy ethyl H Cyclohexyl Methyl

_2a 1572 H SOsH SOsH H

_2a 1573 SOsH H H SOsH

Methyl Methyl CN 2-Carboxy ethyl H Cyclohexyl Ethyl

_2a 1574 H SOsH SOsH H

_2a 1575 SOsH H H SOsH 2-Hydrox

Methyl Methyl CN

_2a 1576 H SOsH SOsH H 2-Carboxy ethyl H Cyclohexyl

ethyl

_2a 1577 SOsH H H SOsH Ethyl

H SOsH SOsH H Methyl Methyl CONH ₂ 2-Carboxy ethyl H Ethyl

_2a 1578

_2a 1625 SOsH H H SOsH NHCOC

OMe Hexyl

_2a 1626 H SOsH SOsH H H ₃ CONH2 2-Carboxy ethyl H Hexyl

_2a 1627 SOsH H H SOsH NHCOC

OMe

SOsH H H ₃ CONH2 2-Carboxy ethyl H Butyl Methyl

_2a 1628 H SOsH

_2a 1629 SOsH H H SOsH NHCOC

OMe

H ₃ CONH2 2-Carboxy ethyl H Butyl Ethyl

_2a 1630 H SOsH SOsH H

_2a 1631 SOsH H H SOsH NHCOC

OMe

H ₃ CONH2 2-Carboxy ethyl H Cyclohexyl Methyl

_2a 1632 H SOsH SOsH H

_2a 1633 SOsH H H SOsH NHCOC

OMe H Cyclohexyl Ethyl

_2a 1634 H SOsH SOsH H H ₃ CONH2 2-Carboxy ethyl

_2a 1635 SOsH H H SOsH NHCOC 2-Hydrox

OMe Cyclohexyl

_2g 1636 H SOsH SOsH H H ₃ CONH2 2-Carboxy ethyl H

ethyl

_2a 1637 SOsH H H SOsH 2-(4-Sulfophenyl)

Methyl Methyl CN H Methyl H

_2g 1638 H SOsH SOsH H ethyl

_2g 1639 SOsH H H SOsH 2-(4-Sulfophenyl)

Methyl Methyl CN H Ethyl H

_2a 1640 H SOsH SOsH H ethyl

_2g 1641 SOsH H H SOsH 2-(4-Sulfophenyl)

Methyl Methyl CN H n-Propyl H

_2a 1642 H SOsH SOsH H ethyl

_2a 1643 SOsH H H SOsH 2-(4-Sulfophenyl) H

H SOsH H Methyl Methyl CN H Isopropyl

_2a 1644 H SOs ethyl

_2a 1645 SOsH H H SOsH 2-(4-Sulfophenyl)

Methyl Methyl CN H 1 -Ethyl propyl H

_2a 1646 H SOsH SOsH H ethyl

_2a 1647 SOsH H H SOsH 2-(4-Sulfophenyl) 1 ,2-Dimethyl

Methyl Methyl CN H H

_2a 1648 H SOsH SOsH H ethyl propyl

_2a 1649 SO3H H H SO3H 2-(4-Sulfophenyl) 2,2-Dimethyl

Methyl Methyl CN H H

2g1650 H SO3H SO3H H ethyl propyl

_2a 1651 SO3H H H SO3H 2-(4-Sulfophenyl)

Methyl Methyl CN H Butyl H

_2a 1652 H SO3H SO3H H ethyl

2g1653 SO3H H H SO3H 2-(4-Sulfophenyl)

Methyl Methyl CN H 2-Methyl butyl H

_2a 1654 H SO3H SO3H H ethyl

2g1655 SO3H H H SO3H 2-(4-Sulfophenyl)

Methyl Methyl CN H Tert butyl H

2g1656 H SO3H SO3H H ethyl

_2a 1657 SO3H H H SO3H 2-(4-Sulfophenyl)

Methyl Methyl CN H 3-Methyl butyl H

2g1658 H SO3H SO3H H ethyl

2g 1659 SO3H H H SO3H 2-(4-Sulfophenyl)

Methyl Methyl CN H Sec butyl H

2g 1660 H SO3H SO3H H ethyl

₂ g1661 SO3H H H SO3H 2-(4-Sulfophenyl)

Methyl Methyl CN H Pentyl H

₂ g1662 H SO3H SO3H H ethyl

2g1663 SO3H H H SO3H 2-(4-Sulfophenyl)

Methyl Methyl CN H Hexyl H

₂ g1664 H SO3H SO3H H ethyl

2g1665 SO3H H H SO3H 2-(4-Sulfophenyl)

Methyl Methyl CN H Cyclobutyl H

2g1666 H SO3H SO3H H ethyl

₂ g1667 SO3H H H SO3H 2-(4-Sulfophenyl)

Methyl Methyl CN H Cyclopentyl H

2g1668 H SO3H SO3H H ethyl

2g 1669 SO3H H H SO3H 2-(4-Sulfophenyl)

Methyl Methyl CN H Cyclohexyl H

₂ g 1670 H SO3H SO3H H ethyl

₂ g 1671 SO3H H H SO3H 2-(4-Sulfophenyl) 2-Methyl

Methyl Methyl CN H H

₂ g1672 H SO3H SO3H H ethyl cyclohexyl

_2a 1673 SOsH H H SOsH 2-(4-Sulfophenyl) 3-Methyl

Methyl Methyl CN H H

_2a 1674 H SO3H SOsH H ethyl cyclohexyl

_2a 1675 SO3H H H SO3H 2-(4-Sulfophenyl)

Methyl Methyl CN H Pentan-2-yl H

_2a 1676 H SOsH SOsH H ethyl

_2a 1677 SO3H H H SOsH 2-(4-Sulfophenyl)

Methyl Methyl CN H 2-Ethylhexyl H

_2a 1678 H SOsH SOsH H ethyl

_2a 1679 SOsH H H SOsH 2-(4-Sulfophenyl)

Methyl Methyl CN H Phenyl H

_2a 1680 H SOsH SOsH H ethyl

_2a 1681 SOsH H H SOsH 2-(4-Sulfophenyl)

Methyl Methyl CN H Benzyl H

_2a 1682 H SOsH SOsH H ethyl

_2a 1683 SOsH H H SOsH 2-(4-Sulfophenyl)

Methyl Methyl CN H Ally I H

_2a 1684 H SOsH SOsH H ethyl

_2a 1685 SO3H H H SO3H 2-(4-Sulfophenyl) 2-Methoxy

Methyl Methyl CN H H

_2a 1686 H SO3H SOsH H ethyl ethyl

_2a 1687 SO3H H H SOsH 2-(4-Sulfophenyl) 3-Methoxy

Methyl Methyl CN H H

_2g 1688 H SOsH SOsH H ethyl propyl

_2g 1689 SO3H H H SOsH 2-(4-Sulfophenyl)

Methyl Methyl CN H 3-Chloropropyl H

_2g 1690 H SOsH SOsH H ethyl

_2a 1691 SOsH H H SOsH 2-(4-Sulfophenyl) 2-Methyl

Methyl Methyl CN H H

_2a 1692 H SOsH SOsH H ethyl thioethyl

_2a 1693 SOsH H H SOsH 2-(4-Sulfophenyl)

Methyl Methyl CN H 2-Fluoroethyl H

_2a 1694 H SOsH SOsH H ethyl

_2a 1695 SOsH H H SOsH 2-(4-Sulfophenyl)

Methyl Methyl CN H 2-Chloro ethyl H

₂ g1696 H SO3H SOsH H ethyl

_2a 1697 SOsH H H SOsH 2-(4-Sulfophenyl) 2-(2-Hydroxy

OsH SOsH H Methyl Methyl CN H ethyl H

2a 1698 H S ethyl sulfonyl)ethyl

2a 1699 SOsH H H SOsH 2-(4-Sulfophenyl) 2-(2-tert Butyl

sH SOsH H Methyl Methyl CN H sulfanyl ethyl H

_2a 1 00 H SO ethyl sulfonyl)ethyl

_2a 1 01 SOsH H H SOsH 2-(4-Sulfophenyl) H

2-(2-Hydroxy

Methyl Methyl CN H

_2a 1 02 H SOsH SOsH H ethyl ethoxyjpropyl

_2a 1 03 SOsH H H SOsH 2-(4-Sulfophenyl) 2-(2-Hydroxy

Methyl Methyl CN H H

_2a 1704 H SOsH SOsH H ethyl ethoxy)ethyl

_2a 1705 SOsH H H SOsH 2-(4-Sulfophenyl) 3-(4-Hydroxy

Methyl Methyl CN H H

_2a 1706 H SOsH SOsH H ethyl butoxy propyl

_2a 1707 SOsH H H SOsH 2-(4-Sulfophenyl) 3-(2-Phenoxy

Methyl Methyl CN H H

_2a 1708 H SOsH SOsH H ethyl ethoxyl)propyl

_2a 1709 SOsH H H SOsH 2-(4-Sulfophenyl) 3-lsopropxy

Methyl Methyl CN H H

_2a 1710 H SOsH SOsH H ethyl propyl

_2a 171 1 SOsH H H SOsH 2-(4-Sulfophenyl) 3-Ethoxy

Methyl Methyl CN H H

_2a 1712 H SOsH SOsH H ethyl propyl

_2a 1713 SOsH H H SOsH 2-(4-Sulfophenyl)

Methyl Methyl CN H 3-Ethoxy butyl H

_2a 1714 H SOsH SOsH H ethyl

_2a 1715 SOsH H H SOsH 2-(4-Sulfophenyl) 4-(2-Hydroxy

H SOsH SOsH H ethane

Methyl Methyl CN ethyl H H

_2a 1716 sulfonyl)pheny

I

_2a 1717 SOsH H H SOsH 2-(4-Sulfophenyl)

Methyl Methyl CONH ₂ H Methyl H

_2a 1718 H SOsH SOsH H ethyl

_2a 1719 SO3H H H SO3H 2-(4-Sulfophenyl)

Methyl Methyl CONH2 H Ethyl H

_2a 1720 H SO3H SO3H H ethyl

_2a 1721 SO3H H H SO3H 2-(4-Sulfophenyl)

Methyl Methyl CONH2 H n-Propyl H

_2a 1722 H SO3H SO3H H ethyl

_2a 1723 SO3H H H SO3H 2-(4-Sulfophenyl)

Methyl Methyl CONH2 H Isopropyl H

_2a 1724 H SO3H SO3H H ethyl

_2a 1725 SO3H H H SO3H 2-(4-Sulfophenyl)

Methyl Methyl CONH2 H 1 -Ethyl propyl H

_2a 1726 H SO3H SO3H H ethyl

_2a 1727 SO3H H H SO3H 2-(4-Sulfophenyl) H

H SO3H SO3H H 1 ,2-Dimethyl

Methyl Methyl CONH2 ethyl H

_2a 1728 propyl

_2a 1729 SO3H H H SO3H 2-(4-Sulfophenyl) 2,2-Dimethyl

Methyl Methyl CONH2 H H

_2a 1730 H SO3H SO3H H ethyl propyl

_2a 1731 SO3H H H SO3H 2-(4-Sulfophenyl)

Methyl Methyl CONH2 H Butyl H

_2a 1732 H SO3H SO3H H ethyl

_2a 1733 SO3H H H SO3H 2-(4-Sulfophenyl)

Methyl Methyl CONH2 H 2-Methyl butyl H

_2a 1734 H SO3H SO3H H ethyl

_2a 1735 SO3H H H SO3H 2-(4-Sulfophenyl)

Methyl Methyl CONH2 H Tert butyl H

_2a 1736 H SO3H SO3H H ethyl

_2a 1737 SO3H H H SO3H 2-(4-Sulfophenyl)

Methyl Methyl CONH2 H 3-Methyl butyl H

_2a 1738 H SO3H SO3H H ethyl

_2a 1739 SO3H H H SO3H 2-(4-Sulfophenyl)

_2a 1740 H SO3H SO3H H Methyl Methyl CONH2 ethyl H Sec butyl H

2a 1741 SOsH H H SOsH 2-(4-Sulfophenyl)

Methyl Methyl CONH ₂ H Pentyl H

2a 1742 H SOsH SOsH H ethyl

_2a 1743 SOsH H H SOsH 2-(4-Sulfophenyl)

Methyl Methyl CONH2 H Hexyl H

_2a 1744 H SOsH SOsH H ethyl

_2a 1745 SOsH H H SOsH 2-(4-Sulfophenyl)

Methyl Methyl CONH2 H Cyclobutyl H

_2a 1746 H SOsH SOsH H ethyl

2a 1747 SOsH H H SOsH 2-(4-Sulfophenyl)

Methyl Methyl CONH2 H Cyclopentyl H

2a 1748 H SOsH SOsH H ethyl

2a 1749 SOsH H H SOsH 2-(4-Sulfophenyl)

Methyl Methyl CONH2 H Cyclohexyl H

_2a 1 50 H SOsH SOsH H ethyl

2a ¹⁷⁵¹ SOsH H H SOsH 2-(4-Sulfophenyl) 2-Methyl

Methyl Methyl CONH2 H H

2a ¹⁷⁵² H SOsH SOsH H ethyl cyclohexyl

_2a 1753 SOsH H H SOsH 2-(4-Sulfophenyl) 3-Methyl

Methyl Methyl CONH2 H H

2a 1754 H SOsH SOsH H ethyl cyclohexyl

2a 1755 SOsH H H SOsH 2-(4-Sulfophenyl)

Methyl Methyl CONH2 H Pentan-2-yl H

2a 1756 H SOsH SOsH H ethyl

_2a 1757 SOsH H H SOsH 2-(4-Sulfophenyl) H

H SOsH SOsH H Methyl Methyl CONH2 H 2-Ethylhexyl

_2a 1758 ethyl

_2a 1 59 SOsH H H SOsH 2-(4-Sulfophenyl)

Methyl Methyl CONH2 H Phenyl H

_2a 1760 H SOsH SOsH H ethyl

_2a 1761 SOsH H H SOsH 2-(4-Sulfophenyl)

Methyl Methyl CONH2 H Benzyl H

2a 1762 H SOsH SOsH H ethyl

2a 1763 SOsH H H SOsH 2-(4-Sulfophenyl)

Methyl Methyl CONH2 H Allyl H

_2a 1764 H SOsH SOsH H ethyl

_2a 1765 SOsH H H SOsH 2-(4-Sulfophenyl) 2-Methoxy

Methyl Methyl CONH2 H H

_2a 1766 H SOsH SOsH H ethyl ethyl

_2a 1767 SOsH H H SOsH 2-(4-Sulfophenyl) 3-Methoxy

Methyl Methyl CONH2 H H

_2a 1768 H SOsH SOsH H ethyl propyl

_2a 1769 SOsH H H SOsH 2-(4-Sulfophenyl)

Methyl Methyl CONH2 H 3-Chloropropyl H

_2a 1770 H SOsH SOsH H ethyl

_2g 1771 SOsH H H SOsH 2-(4-Sulfophenyl) 2-Methyl

Methyl Methyl CONH2 H H

_2a 1772 H SOsH SOsH H ethyl thioethyl

_2a 1773 SOsH H H SOsH 2-(4-Sulfophenyl)

Methyl Methyl CONH2 H 2-Fluoroethyl H

_2a 1774 H SOsH SOsH H ethyl

_2a 1775 SOsH H H SOsH 2-(4-Sulfophenyl)

Methyl Methyl CONH2 H 2-Chloro ethyl H

_2g 1776 H SOsH SOsH H ethyl

_2g 1777 SOsH H H SOsH 2-(4-Sulfophenyl) 2-(2-Hydroxy

Methyl Methyl CONH2 H ethyl H

_2a 1778 H SOsH SOsH H ethyl sulfonyl)ethyl

_2a 1779 SOsH H H SOsH 2-(4-Sulfophenyl) 2-(2-tert Butyl

Methyl Methyl CONH2 H sulfanyl ethyl H

_2a 1780 H SOsH SOsH H ethyl sulfonyl)ethyl

_2a 1781 SOsH H H SOsH 2-(4-Sulfophenyl) 2-(2-Hydroxy

Methyl Methyl CONH2 H H

_2a 1782 H SOsH SOsH H ethyl ethoxyjpropyl

_2a 1783 SOsH H H SOsH 2-(4-Sulfophenyl) 2-(2-Hydroxy

Methyl Methyl CONH2 H H

_2a 1784 H SOsH SOsH H ethyl ethoxy)ethyl

_2a 1785 SOsH H H SOsH 2-(4-Sulfophenyl)

_2a 1786 H SOsH SOsH H ethyl 3-(4-Hydroxy

Methyl Methyl CONH2 H H butoxy propyl

_2a 1787 SOsH H H SOsH 2-(4-Sulfophenyl) 3-(2-Phenoxy

Methyl Methyl CONH2 H H

_2a 1782 H SOsH SOsH H ethyl ethoxyl)propyl

_2a 1789 SOsH H H SOsH 2-(4-Sulfophenyl) 3-lsopropxy

Methyl Methyl CONH2 H H

_2a 1790 H SOsH SOsH H ethyl propyl

_2g 1791 SOsH H H SOsH 2-(4-Sulfophenyl) 3-Ethoxy

Methyl Methyl CONH2 H H

_2a 1792 H SOsH SOsH H ethyl propyl

_2a 1793 SOsH H H SOsH 2-(4-Sulfophenyl)

Methyl Methyl CONH2 H 3-Ethoxy butyl H

_2a 1794 H SOsH SOsH H ethyl

_2a 1795 SOsH H H SOsH 2-(4-Sulfophenyl) 4-(2-Hydroxy

H SOsH SOsH H ethane

Methyl Methyl CONH2 ethyl H H

_2a 1796 sulfonyl)pheny

I

_2a 1797 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CN H Methyl H

_2a 1798 H SOsH SOsH H H ₃ ethyl

_2a 1799 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CN H Ethyl H

_2a 1800 H SOsH SOsH H H ₃ ethyl

_2a 1801 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CN H n-Propyl H

_2a 1802 H SOsH SOsH H H ₃ ethyl

_2a 1803 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CN H Isopropyl H

_2a 1804 H SOsH SOsH H H ₃ ethyl

_2a 1805 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CN H 1 -Ethyl propyl H

_2g 1806 H SOsH SOsH H H ₃ ethyl

_2a 1807 SOsH H H SOsH 2-(4-Sulfophenyl)

_2g 1808 H SOsH SOsH H NHCOC 1 ,2-Dimethyl

OMe CN

H ₃ ethyl H H propyl

2a 1809 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl) 2,2-Dimethyl

OMe CN H H

_2a 1810 H SOsH SOsH H Hs ethyl propyl

_2a 181 1 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CN H Butyl H

_2a 1812 H SOsH SOsH H Hs ethyl

_2a 1813 SOsH H H SOsH

NHCOC 2-(4-Sulfophenyl) H sH SOsH H OMe CN H 2-Methyl butyl

_2a 1814 H SO Hs ethyl

_2a 1815 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CN H Tert butyl H

_2a 1816 H SOsH SOsH H Hs ethyl

_2a 1817 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CN H 3-Methyl butyl H

_2g 1818 H SOsH SOsH H Hs ethyl

_2g 1819 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CN H Sec butyl H

_2a 1820 H SOsH SOsH H Hs ethyl

_2g 1821 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CN H Pentyl H

_2a 1822 H SOsH SOsH H Hs ethyl

_2a 1823 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CN H Hexyl H

_2a 1824 H SOsH SOsH H Hs ethyl

_2a 1825 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CN H Cyclobutyl H

_2a 1826 H SOsH SOsH H Hs ethyl

_2a 1827 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CN H Cyclopentyl H

_2a 1828 H SOsH SOsH H Hs ethyl

_2a 1829 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CN H Cyclohexyl H

_2a 1830 H SOsH SOsH H Hs ethyl

_2a 1831 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl) 2-Methyl

OMe CN H H

_2a 1832 H SOsH SOsH H Hs ethyl cyclohexyl

2g1833 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl) 3-Methyl

OMe CN H H

_2a 1834 H SOsH SOsH H H ₃ ethyl cyclohexyl

2g1835 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CN H Pentan-2-yl H

_2a 1832 H SOsH SOsH H H ₃ ethyl

_2a 1837 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CN H 2-Ethylhexyl H

2g1838 H SOsH SOsH H H ₃ ethyl

2g1839 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CN H Phenyl H

_2a 1840 H SOsH SOsH H H ₃ ethyl

_2a 1841 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CN H Benzyl H

_2a 1842 H SOsH SOsH H H ₃ ethyl

_2a 1843 SOsH H H SOsH H

NHCOC 2-(4-Sulfophenyl)

H SOsH SOsH H OMe CN H Ally I

_2a 1844 H ₃ ethyl

_2a 1845 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl) 2-Methoxy

OMe CN H H

_2a 1846 H SOsH SOsH H H ₃ ethyl ethyl

_2a 1847 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl) 3-Methoxy

OMe CN H H

_2a 1848 H SOsH SOsH H H ₃ ethyl propyl

_2a 1849 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CN H 3-Chloropropyl H

_2a 1850 H SOsH SOsH H H ₃ ethyl

_2a 1851 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl) 2-Methyl

OMe CN H H

_2a 1852 H SOsH SOsH H H ₃ ethyl thioethyl

_2a 1853 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CN H 2-Fluoroethyl H

_2a 1854 H SOsH SOsH H H ₃ ethyl

₂ g1855 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CN H 2-Chloro ethyl H

₂ g1856 H SOsH SOsH H H ₃ ethyl

_2a 1857 SOsH H H SOsH 2-(2-Hydroxy

NHCOC 2-(4-Sulfophenyl)

OsH SOsH H OMe CN H ethyl H

2a 1858 H S Hs ethyl sulfonyl)ethyl

2a 1859 SOsH H H SOsH

NHCOC 2-(4-Sulfophenyl) 2-(2-tert Butyl sH SOsH H OMe CN H sulfanyl ethyl H

2a 1860 H SO Hs ethyl sulfonyl)ethyl

_2a 1861 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl) 2-(2-Hydroxy

OMe CN H H

_2a 1862 H SOsH SOsH H Hs ethyl ethoxyjpropyl

2 _g 1863 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl) 2-(2-Hydroxy

OMe CN H H

_2a 1864 H SOsH SOsH H Hs ethyl ethoxy)ethyl

2a 1865 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl) 3-(4-Hydroxy

OMe CN H H

2a 1866 H SOsH SOsH H Hs ethyl butoxy propyl

_2a 1867 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl) 3-(2-Phenoxy

OMe CN H H

2a 1868 H SOsH SOsH H Hs ethyl ethoxyl)propyl

_2a 1862 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl) 3-lsopropxy

OMe CN H H

_2a 1870 H SOsH SOsH H Hs ethyl propyl

_2a 1871 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl) 3-Ethoxy

OMe CN H H

_2a 1872 H SOsH SOsH H Hs ethyl propyl

_2a 1873 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CN H 3-Ethoxy butyl H

_2a 1874 H SOsH SOsH H Hs ethyl

_2a 1875 SOsH H H SOsH 2-(4-Sulfophenyl) 4-(2-Hydroxy

H SOsH SOsH H NHCOC ethane

OMe CN ethyl H H

_2a 1876 Hs sulfonyl)pheny

I

_2a 1877 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CONH ₂ H Methyl H

_2a 1878 H SOsH SOsH H Hs ethyl

2g1903 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CONH ₂ H Hexyl H

_2a 1904 H SOsH SOsH H Hs ethyl

2a 1905 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CONH2 H Cyclobutyl H

2a 1906 H SOsH SOsH H Hs ethyl

_2a 1907 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CONH2 H Cyclopentyl H

2a 1908 H SOsH SOsH H Hs ethyl

2a 1909 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CONH2 H Cyclohexyl H

_2a 1910 H SOsH SOsH H Hs ethyl

_2a 1911 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl) 2-Methyl

OMe CONH2 H H

_2a 1912 H SOsH SOsH H Hs ethyl cyclohexyl

_2a 1913 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl) 3-Methyl

OMe CONH2 H H

_2a 1914 H SOsH SOsH H Hs ethyl cyclohexyl

_2a 1915 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CONH2 H Pentan-2-yl H

_2a 1916 H SOsH SOsH H Hs ethyl

_2a 1917 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CONH2 H 2-Ethylhexyl H

_2a 1918 H SOsH SOsH H Hs ethyl

_2a 1919 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CONH2 H Phenyl H

_2a 1920 H SOsH SOsH H Hs ethyl

_2a 1921 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CONH2 H Benzyl H

_2a 1922 H SOsH SOsH H Hs ethyl

_2a 1923 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CONH2 H Ally I H

_2a 1924 H SOsH SOsH H Hs ethyl

_2a 1925 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl) 2-Methoxy

OMe CONH2 H H

_2a 1926 H SOsH SOsH H Hs ethyl ethyl

_2a 1927 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl) 3-Methoxy

OMe CONH2 H H

_2a 1928 H SOsH SOsH H H ₃ ethyl propyl

_2a 1929 SOsH H H SOsH H

NHCOC 2-(4-Sulfophenyl)

OMe CONH2 H 3-Chloropropyl

2g1930 H SOsH SOsH H H ₃ ethyl

_2a 1931 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl) 2-Methyl

OMe CONH2 H H

_2a 1932 H SOsH SOsH H H ₃ ethyl thioethyl

_2a 1933 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CONH2 H 2-Fluoroethyl H

_2a 1934 H SOsH SOsH H H ₃ ethyl

_2a 1935 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CONH2 H 2-Chloro ethyl H

_2g 1936 H SOsH SOsH H H ₃ ethyl

_2a 1937 SOsH H H SOsH 2-(2-Hydroxy

NHCOC 2-(4-Sulfophenyl)

H SOsH SOsH H OMe CONH2 H ethyl H

_2g 1938 H ₃ ethyl sulfonyl)ethyl

_2g 1939 SOsH H H SOsH

NHCOC 2-(4-Sulfophenyl) 2-(2-tert Butyl

H SOsH SOsH H OMe CONH2 H sulfanyl ethyl H

_2a 1940 H ₃ ethyl sulfonyl)ethyl

_2g 1941 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl) 2-(2-Hydroxy

OMe CONH2 H H

_2a 1942 H SOsH SOsH H H ₃ ethyl ethoxyjpropyl

_2a 1943 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl) 2-(2-Hydroxy

OMe CONH2 H H

_2a 1944 H SOsH SOsH H H ₃ ethyl ethoxy)ethyl

_2a 1945 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl) 3-(4-Hydroxy

OMe CONH2 H H

_2a 1946 H SOsH SOsH H H ₃ ethyl butoxy propyl

_2a 1947 SOsH H H SOsH 2-(4-Sulfophenyl)

_2a 1948 H SOsH SOsH H NHCOC 3-(2-Phenoxy

OMe CONH2

H ₃ ethyl H H ethoxyl)propyl

_2a 1949 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl) 3-lsopropxy

OMe CONH ₂ H H

2a 1950 H SOsH SOsH H Hs ethyl propyl

_2a 1951 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl) 3-Ethoxy

OMe CONH2 H H

_2a 1952 H SOsH SOsH H Hs ethyl propyl

2g1953 SOsH H H SOsH NHCOC 2-(4-Sulfophenyl)

OMe CONH2 H 3-Ethoxy butyl H

_2a 1954 H SOsH SOsH H Hs ethyl

2g1955 SOsH H H SOsH 2-(4-Sulfophenyl) 4-(2-Hydroxy

H SOsH SOsH H NHCOC ethane

OMe CONH2 ethyl H H

2a 1956 Hs sulfonyl)pheny

I

_2a 1957 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CN H Methyl H

2g1958 H SOsH SOsH H methyl

2a 1959 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CN H Ethyl H

2a i960 H SOsH SOsH H methyl

_2a 1961 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CN H n-Propyl H

_2a 1962 H SOsH SOsH H methyl

2 _g 1963 SOsH H H SOsH (4-Sulfophenyl) H 964 H SOsH S Methyl CN H Isopropyl

_2a 1 OsH H Methyl

methyl

2a 1965 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CN H 1 -Ethyl propyl H

2a 1966 H SOsH SOsH H methyl

_2a 1967 SOsH H H SOsH (4-Sulfophenyl) 1 ,2-Dimethyl

Methyl Methyl CN H H

2a 1968 H SOsH SOsH H methyl propyl

2a 1969 SOsH H H SOsH (4-Sulfophenyl) 2,2-Dimethyl

Methyl Methyl CN H H

_2a 1970 H SOsH SOsH H methyl propyl

_2a 1971 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CN H Butyl H

_2a 1972 H SO3H SOsH H methyl

_2a 1973 SO3H H H SO3H (4-Sulfophenyl)

Methyl Methyl CN H 2-Methyl butyl H

_2a 1974 H SOsH SOsH H methyl

_2a 1975 SO3H H H SOsH (4-Sulfophenyl)

Methyl Methyl CN H Tert butyl H

_2a 1976 H SOsH SOsH H methyl

_2a 1977 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CN H 3-Methyl butyl H

_2a 1978 H SOsH SOsH H methyl

_2a 1979 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CN H Sec butyl H

_2a 1980 H SOsH SOsH H methyl

_2a 1981 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CN H Pentyl H

_2a 1982 H SOsH SOsH H methyl

_2a 1983 SO3H H H SO3H (4-Sulfophenyl)

Methyl Methyl CN H Hexyl H

_2a 1984 H SO3H SOsH H methyl

_2a 1985 SO3H H H SOsH (4-Sulfophenyl)

Methyl Methyl CN H Cyclobutyl H

_2g 1986 H SOsH SOsH H methyl

_2a 1987 SO3H H H SOsH (4-Sulfophenyl)

Methyl Methyl CN H Cyclopentyl H

_2g 1988 H SOsH SOsH H methyl

_2g 1989 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CN H Cyclohexyl H

_2g 1990 H SOsH SOsH H methyl

_2a 1991 SOsH H H SOsH (4-Sulfophenyl) 2-Methyl

Methyl Methyl CN H H

_2a 1992 H SOsH SOsH H methyl cyclohexyl

_2a 1993 SOsH H H SOsH (4-Sulfophenyl) 3-Methyl

Methyl Methyl CN H H

₂ g1994 H SO3H SOsH H methyl cyclohexyl

2a 1995 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CN H Pentan-2-yl H

2a 1996 H SOsH SOsH H methyl

_2a 1997 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CN H 2-Ethylhexyl H

2a 1998 H SOsH SOsH H methyl

2a 1999 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CN H Phenyl H

2 _a 2000 H SOsH SOsH H methyl

_2a 2001 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CN H Benzyl H

_2a 2002 H SOsH SOsH H methyl

2 _a 2003 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CN H Ally I H

_2a 2004 H SOsH SOsH H methyl

2 _a 2005 SOsH H H SOsH (4-Sulfophenyl) 2-Methoxy

Methyl Methyl CN H H

2 _a 2006 H SOsH SOsH H methyl ethyl

_2a 2007 SOsH H H SOsH (4-Sulfophenyl) 3-Methoxy

Methyl Methyl CN H H

2 _g 2008 H SOsH SOsH H methyl propyl

2 _g 2009 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CN H 3-Chloropropyl H

_2a 2010 H SOsH SOsH H methyl

_2a 201 1 SOsH H H SOsH (4-Sulfophenyl) 2-Methyl

Methyl Methyl CN H H

_2a 2012 H SOsH SOsH H methyl thioethyl

_2a 2013 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CN H 2-Fluoroethyl H

_2a 2014 H SOsH SOsH H methyl

_2a 2015 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CN H 2-Chloro ethyl H

_2a 2016 H SOsH SOsH H methyl

_2a 2017 SOsH H H SOsH (4-Sulfophenyl) 2-(2-Hydroxy

Methyl Methyl CN H ethyl H

_2a 2018 H SOsH SOsH H methyl sulfonyl)ethyl

_2a 2019 SOsH H H SOsH (4-Sulfophenyl) 2-(2-tert Butyl

SOsH H Methyl Methyl CN H sulfanyl ethyl H

_2a 2020 H SOsH methyl sulfonyl)ethyl

_2a 2021 SO3H H H SO3H (4-Sulfophenyl) H

2-(2-Hydroxy

SOsH H Methyl Methyl CN H

_2a 2022 H SO3H methyl ethoxyjpropyl

_2a 2023 SO3H H H SOsH (4-Sulfophenyl) 2-(2-Hydroxy

Methyl Methyl CN H H

_2a 2024 H SOsH SOsH H methyl ethoxy)ethyl

_2a 2025 SOsH H H SOsH (4-Sulfophenyl) 3-(4-Hydroxy

Methyl Methyl CN H H

_2a 2026 H SOsH SOsH H methyl butoxy)pr opyl

_2a 2027 SOsH H H SOsH (4-Sulfophenyl) 3-(2-Phenoxy

Methyl Methyl CN H H

_2a 2028 H SOsH SOsH H methyl ethoxyl)pr opyl

_{1 a} 2029 SOsH H H SOsH (4-Sulfophenyl) 3-lsopropxy

Methyl Methyl CN H H

_2a 2032 H SOsH SOsH H methyl propyl

_2a 2031 SO3H H H SO3H (4-Sulfophenyl) 3-Ethoxy

Methyl Methyl CN H H

_2a 2032 H SO3H SOsH H methyl propyl

_2a 2033 SO3H H H SOsH (4-Sulfophenyl)

Methyl Methyl CN H 3-Ethoxy butyl H

_2a 2034 H SOsH SOsH H methyl

_2a 2035 SOsH H H SOsH (4-Sulfophenyl) 4-(2-Hydroxy

H SOsH SOsH H ethane

Methyl Methyl CN methyl H H

_2g 2036 sulfonyl)pheny

I

_2a 2037 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CONH2 H Methyl H

_2g 2038 H SOsH SOsH H methyl

_2a 2039 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CONH2 H Ethyl H

_2a 2040 H SO3H SOsH H methyl

_2a 2041 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CONH2 H n-propyl H

_2a 2042 H SOsH SOsH H methyl

_2a 2043 SOsH H H SO3H (4-Sulfophenyl)

Methyl Methyl CONH2 H Isopropyl H

_2a 2044 H SOsH SO3H H methyl

_2a 2045 SOsH H H SO3H (4-Sulfophenyl)

Methyl Methyl CONH2 H 1 -Ethyl propyl H

_2a 2046 H SOsH SO3H H methyl

_2a 2047 SOsH H H SOsH (4-Sulfophenyl) H

H SOsH SOsH H 1 ,2-Dimethyl

Methyl Methyl CONH2

048 ethyl H

_2a 2 m

propyl

_2a 2049 SOsH H H SOsH (4-Sulfophenyl) 2,2-Dimethyl

Methyl Methyl CONH2 H H

_2a 2050 H SOsH SOsH H methyl propyl

_2a 2051 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CONH2 H Butyl H

_2a 2052 H SO3H SO3H H methyl

_2a 2053 SOsH H H SO3H (4-Sulfophenyl)

Methyl Methyl CONH2 H 2-Methyl butyl H

_2a 2054 H SOsH SO3H H methyl

₂ g2055 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CONH2 H Tert butyl H

_2a 2056 H SOsH SOsH H methyl

_2a 2057 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CONH2 H 3-Methyl butyl H

_2a 2058 H SOsH SOsH H methyl

_2a 2059 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CONH2 H Sec butyl H

_2g 2060 H SOsH SOsH H methyl

_2a 2061 SOsH H H SOsH (4-Sulfophenyl)

_2a 2062 H SO3H SO3H H Methyl Methyl CONH2 methyl H Pentyl H

2g2063 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CONH ₂ H Hexyl H

_2a 2064 H SOsH SOsH H methyl

2g2065 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CONH2 H Cyclobutyl H

2g2066 H SOsH SOsH H methyl

_2a 2067 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CONH2 H Cyclopentyl H

2 g 2068 H SOsH SOsH H methyl

2 g 2069 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CONH2 H Cyclohexyl H

_2a 2070 H SOsH SOsH H methyl

_2a 2071 SOsH H H SOsH (4-Sulfophenyl) 2-Methyl

Methyl Methyl CONH2 H H

_2a 2072 H SOsH SOsH H methyl cyclohexyl

_2a 2073 SOsH H H SOsH (4-Sulfophenyl) 3-Methyl

Methyl Methyl CONH2 H H

_2a 2074 H SOsH SOsH H methyl cyclohexyl

_2a 2075 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CONH2 H Pentan-2-yl H

_2a 2076 H SOsH SOsH H methyl

_2a 2077 SOsH H H SOsH (4-Sulfophenyl) H

H SOsH SOsH H Methyl Methyl CONH2 H 2-Ethylhexyl

_2a 2078 methyl

_2a 2079 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CONH2 H Phenyl H

2 _g 2080 H SOsH SOsH H methyl

_2a 2081 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CONH2 H Benzyl H

_2a 2082 H SOsH SOsH H methyl

2 _a 2083 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CONH2 H Ally I H

2 _a 2084 H SOsH SOsH H methyl

2 _a 2085 SOsH H H SOsH (4-Sulfophenyl) 2-Methoxy

Methyl Methyl CONH2 H H

2 _a 2086 H SOsH SOsH H methyl ethyl

_2a 2087 SOsH H H SOsH (4-Sulfophenyl) 3-Methoxy

Methyl Methyl CONH ₂ H H

2 _a 2088 H SOsH SOsH H methyl propyl

2 _a 2089 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CONH2 H 3-Chloropropyl H

2g2090 H SOsH SOsH H methyl

_2a 2091 SOsH H H SOsH (4-Sulfophenyl) 2-Methyl

Methyl Methyl CONH2 H H

_2a 2092 H SOsH SOsH H methyl thioethyl

2g2093 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CONH2 H 2-Fluoroethyl H

_2a 2094 H SOsH SOsH H methyl

2 a 2095 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CONH2 H 2-Chloro ethyl H

2 a 2096 H SOsH SOsH H methyl

_2a 2097 SOsH H H SOsH (4-Sulfophenyl) 2-(2-Hydroxy

H SOsH SOsH H Methyl Methyl CONH2 H ethyl H

2 a 2098 methyl sulfonyl)ethyl

2 _a 2099 SOsH H H SOsH (4-Sulfophenyl) 2-(2-tert Butyl

SOsH SOsH H Methyl Methyl CONH2 H sulfanyl ethyl H

_2a 2100 H methyl sulfonyl)ethyl

_2a 2101 SOsH H H SOsH (4-Sulfophenyl) 2-(2-Hydroxy

Methyl Methyl CONH2 H H

_2a 2102 H SOsH SOsH H methyl ethoxyjpropyl

2a ²¹⁰³ SOsH H H SOsH (4-Sulfophenyl) 2-(2-Hydroxy

Methyl Methyl CONH2 H H

_2a 2104 H SOsH SOsH H methyl ethoxy)ethyl

_2a 2105 SOsH H H SOsH (4-Sulfophenyl) 3-(4-Hydroxy

Methyl Methyl CONH2 H H

_2a 2106 H SOsH SOsH H methyl butoxyjpropyl

_2a 2107 SOsH H H SOsH (4-Sulfophenyl)

_2a 2108 H SOsH SOsH H methyl 3-(2-Phenoxy

Methyl Methyl CONH2 H H ethoxyl)propyl

_2a 2109 SOsH H H SOsH (4-Sulfophenyl) 3-lsopropxy

Methyl Methyl CONH2 H H

_2a 2110 H SOsH SOsH H methyl propyl

_2a 2111 SOsH H H SOsH (4-Sulfophenyl) 3-Ethoxy

Methyl Methyl CONH2 H H

_2a 2112 H SOsH SOsH H methyl propyl

_2a 21 13 SOsH H H SOsH (4-Sulfophenyl)

Methyl Methyl CONH2 H 3-Ethoxy butyl H

_2a 21 14 H SOsH SOsH H methyl

_2a 21 15 SOsH H H SOsH (4-Sulfophenyl) 4-(2-Hydroxy

H SOsH SOsH H ethane

Methyl Methyl CONH2 methyl H H

_2a 21 16 sulfonyl)pheny

I

_2a 21 17 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CN H Methyl H

_2a 21 18 H SOsH SOsH H H ₃ methyl

_2a 21 19 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CN H Ethyl H

_2a 2120 H SOsH SOsH H H ₃ methyl

_2g 2121 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CN H n-Propyl H

_2a 2122 H SOsH SOsH H H ₃ methyl

_2a 2123 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CN H Isopropyl H

_2a 2124 H SOsH SOsH H H ₃ methyl

_2a 2125 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CN H 1 -Ethyl propyl H

_2a 2126 H SOsH SOsH H H ₃ methyl

_2a 2127 SOsH H H SOsH NHCOC (4-Sulfophenyl) 1 ,2-Dimethyl

OMe CN H H

_2a 2128 H SOsH SOsH H H ₃ methyl propyl

_2a 2129 SOsH H H SOsH (4-Sulfophenyl)

_2a 2130 H SOsH SOsH H NHCOC 2,2-Dimethyl

OMe CN

H ₃ methyl H H propyl

_2a 2131 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CN H Butyl H

_2a 2132 H SOsH SOsH H H ₃ methyl

_2a 2133 SOsH H H SOsH

NHCOC (4-Sulfophenyl) H

H SOsH SOsH H OMe CN H 2-Methyl butyl

_2a 2134 H ₃ methyl

_2a 2135 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CN H Tert butyl H

_2a 2136 H SOsH SOsH H H ₃ methyl

_2a 2137 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CN H 3-Methyl butyl H

_2a 2138 H SOsH SOsH H H ₃ methyl

_2a 2139 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CN H Sec butyl H

_2a 2140 H SOsH SOsH H H ₃ methyl

_2g 2141 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CN H Pentyl H

_2a 2142 H SOsH SOsH H H ₃ methyl

_2a 2143 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CN H Hexyl H

_2a 2144 H SOsH SOsH H H ₃ methyl

_2a 2145 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CN H Cyclobutyl H

_2a 2146 H SOsH SOsH H H ₃ methyl

_2a 2147 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CN H Cyclopentyl H

_2a 2148 H SOsH SOsH H H ₃ methyl

_2a 2149 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CN H Cyclohexyl H

_2a 2150 H SOsH SOsH H H ₃ methyl

_2a 2151 SOsH H H SOsH NHCOC (4-Sulfophenyl) 2-Methyl

OMe CN H H

_2a 2152 H SOsH SOsH H H ₃ methyl cyclohexyl

_2a 2153 SOsH H H SOsH NHCOC (4-Sulfophenyl) 3-Methyl

OMe CN H H

_2a 2154 H SOsH SOsH H H ₃ methyl cyclohexyl

_2a 2155 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CN H Pentan-2-yl H

_2a 2156 H SOsH SOsH H H ₃ methyl

_2a 2157 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CN H 2-Ethylhexyl H

_2a 2158 H SOsH SOsH H H ₃ methyl

_2a 2159 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CN H Phenyl H

_2a 2160 H SOsH SOsH H H ₃ methyl

_2g 2161 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CN H Benzyl H

_2a 2162 H SOsH SOsH H H ₃ methyl

_2a 2163 SOsH H H SOsH (4-Sulfophenyl) H

NHCOC

OMe CN H Ally I

_2a 2164 H SOsH SOsH H H ₃ methyl

_2a 2165 SOsH H H SOsH NHCOC (4-Sulfophenyl) 2-Methoxy

OMe CN H H

_2a 2166 H SOsH SOsH H H ₃ methyl ethyl

_2a 2167 SOsH H H SOsH NHCOC (4-Sulfophenyl) 3-Methoxy

OMe CN H H

_2a 2168 H SOsH SOsH H H ₃ methyl propyl

_2a 2169 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CN H 3-Chloropropyl H

_2a 2170 H SOsH SOsH H H ₃ methyl

_2g 2171 SOsH H H SOsH NHCOC (4-Sulfophenyl) 2-Methyl

OMe CN H H

_2a 2172 H SOsH SOsH H H ₃ methyl thioethyl

_2a 2173 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CN H 2-Fluoroethyl H

_2a 2174 H SOsH SOsH H H ₃ methyl

_2a 2175 SOsH H H SOsH (4-Sulfophenyl)

_2a 2176 H SOsH SOsH H NHCOC methyl

OMe CN H 2-Chloro ethyl H

H ₃

_2a 2177 SOsH H H SOsH 2-(2-Hydroxy

NHCOC (4-Sulfophenyl)

OsH SOsH H OMe CN H ethyl H

_2a 2178 H S H ₃ methyl sulfonyl)ethyl

_2a 2179 SOsH H H SOsH

NHCOC (4-Sulfophenyl) 2-(2-tert Butyl

OsH SOsH H OMe CN H sulfanyl ethyl H

_2a 2180 H S H ₃ methyl sulfonyl)ethyl

_2a 2181 SOsH H H SOsH NHCOC (4-Sulfophenyl) 2-(2-Hydroxy

OMe CN H H

_2a 2182 H SOsH SOsH H H ₃ methyl ethoxyjpropyl

_2a 2183 SOsH H H SOsH NHCOC (4-Sulfophenyl) 2-(2-Hydroxy

OMe CN H H

_2a 2184 H SOsH SOsH H H ₃ methyl ethoxy)ethyl

_2a 2185 SOsH H H SOsH NHCOC (4-Sulfophenyl) 3-(4-Hydroxy

OMe CN H H

_2a 2186 H SOsH SOsH H H ₃ methyl butoxy propyl

_2a 2187 SOsH H H SOsH NHCOC (4-Sulfophenyl) 3-(2-Phenoxy

OMe CN H H

_2a 2188 H SOsH SOsH H H ₃ methyl ethoxyl)propyl

_2a 2189 SOsH H H SOsH NHCOC (4-Sulfophenyl) 3-lsopropxy

OMe CN H H

_2a 2190 H SOsH SOsH H H ₃ methyl propyl

_2g 2191 SOsH H H SOsH NHCOC (4-Sulfophenyl) 3-Ethoxy

OMe CN H H

_2a 2192 H SOsH SOsH H H ₃ methyl propyl

_2a 2193 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CN H 3-Ethoxy butyl H

_2a 2194 H SOsH SOsH H H ₃ methyl

_2a 2195 SOsH H H SOsH (4-Sulfophenyl) 4-(2-Hydroxy

H SOsH SOsH H NHCOC ethane

OMe CN methyl H H

_2a 2196 H ₃ sulfonyl)pheny

I

_2a 2197 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CONH2 H Methyl H

_2a 2198 H SOsH SOsH H H ₃ methyl

_2a 2199 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CONH2 H Ethyl H

_2a 2200 H SOsH SOsH H H ₃ methyl

_2a 2201 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CONH2 H n-Propyl H

_2a 2202 H SOsH SOsH H H ₃ methyl

_2a 2203 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CONH2 H Isopropyl H

_2a 2204 H SOsH SOsH H H ₃ methyl

_2a 2205 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CONH2 H 1 -Ethyl propyl H

_2a 2206 H SOsH SOsH H H ₃ methyl

_2a 2207 SOsH H H SOsH NHCOC (4-Sulfophenyl) 1 ,2-Dimethyl

OMe CONH2 H H

_2a 2208 H SOsH SOsH H H ₃ methyl propyl

_2a 2209 SOsH H H SOsH NHCOC (4-Sulfophenyl) 2,2-Dimethyl

OMe CONH2 H H

_2a 2210 H SOsH SOsH H H ₃ methyl propyl

_2a 2211 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CONH2 H Butyl H

_2a 2212 H SOsH SOsH H H ₃ methyl

_2a 2213 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CONH2 H 2-Methyl butyl H

_2a 2214 H SOsH SOsH H H ₃ methyl

_2a 2215 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CONH2 H Tert butyl H

_2a 2216 H SOsH SOsH H H ₃ methyl

_2a 2217 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CONH2 H 3-Methyl butyl H

_2a 2218 H SOsH SOsH H H ₃ methyl

_2a 2219 SOsH H H SOsH

NHCOC (4-Sulfophenyl) H

SOsH H OMe CONH2 H Sec butyl

_2a 2220 H SOsH H ₃ methyl

_2a 2221 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CONH2 H Pentyl H

_2a 2222 H SOsH SOsH H H ₃ methyl

_2a 2223 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CONH2 H Hexyl H

_2a 2224 H SOsH SOsH H H ₃ methyl

_2a 2225 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CONH2 H Cyclobutyl H

_2a 2226 H SOsH SOsH H H ₃ methyl

_2a 2227 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CONH2 H Cyclopentyl H

_2a 2228 H SOsH SOsH H H ₃ methyl

_2a 2229 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CONH2 H Cyclohexyl H

_2a 2230 H SOsH SOsH H H ₃ methyl

_2a 2231 SOsH H H SOsH NHCOC (4-Sulfophenyl) 2-Methyl

OMe CONH2 H H

_2a 2232 H SOsH SOsH H H ₃ methyl cyclohexyl

_2a 2233 SOsH H H SOsH NHCOC (4-Sulfophenyl) 3-Methyl

OMe CONH2 H H

_2a 2234 H SOsH SOsH H H ₃ methyl cyclohexyl

_2a 2235 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CONH2 H Pentan-2-yl H

_2a 2236 H SOsH SOsH H H ₃ methyl

_2a 2237 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CONH2 H 2-Ethylhexyl H

_2a 2238 H SOsH SOsH H H ₃ methyl

_2a 2239 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CONH2 H Phenyl H

_2a 2240 H SOsH SOsH H H ₃ methyl

_2a 2241 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CONH2 H Benzyl H

_2a 2242 H SOsH SOsH H H ₃ methyl

_2a 2243 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CONH2 H Ally I H

_2a 2244 H SOsH SOsH H H ₃ methyl

_2a 2245 SOsH H H SOsH NHCOC (4-Sulfophenyl) 2-Methoxy

OMe CONH2 H H

_2a 2246 H SOsH SOsH H H ₃ methyl ethyl

_2a 2247 SOsH H H SOsH NHCOC (4-Sulfophenyl) 3-Methoxy

OMe CONH2 H H

_2a 2248 H SOsH SOsH H H ₃ methyl propyl

_2a 2249 SOsH H H SOsH H

NHCOC (4-Sulfophenyl)

H OMe CONH2 H 3-Chloropropyl

_2a 2250 SOsH SOsH H H ₃ methyl

_2a 2251 SOsH H H SOsH NHCOC (4-Sulfophenyl) 2-Methyl

OMe CONH2 H H

_2a 2252 H SOsH SOsH H H ₃ methyl thioethyl

_2a 2253 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CONH2 H 2-Fluoroethyl H

_2a 2254 H SOsH SOsH H H ₃ methyl

_2a 2255 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CONH2 H 2-Chloro ethyl H

_2a 2256 H SOsH SOsH H H ₃ methyl

_2a 2257 SOsH H H SOsH 2-(2-Hydroxy

NHCOC (4-Sulfophenyl)

sH H OMe CONH2 H ethyl H

_2a 2258 H SOsH SO H ₃ methyl sulfonyl)ethyl

_2a 2259 SOsH H H SOsH

NHCOC (4-Sulfophenyl) 2-(2-tert Butyl

H SOsH SOsH H OMe CONH2 H sulfanyl ethyl H

_2a 2260 H ₃ methyl sulfonyl)ethyl

_2a 2261 SOsH H H SOsH NHCOC (4-Sulfophenyl) 2-(2-Hydroxy

OMe CONH2 H H

_2a 2262 H SOsH SOsH H H ₃ methyl ethoxyjpropyl

_2a 2263 SOsH H H SOsH NHCOC (4-Sulfophenyl) 2-(2-Hydroxy

OMe CONH2 H H

_2a 2264 H SOsH SOsH H H ₃ methyl ethoxy)ethyl

_2a 2265 SOsH H H SOsH NHCOC (4-Sulfophenyl) 3-(4-Hydroxy

OMe CONH2 H H

_2a 2266 H SOsH SOsH H H ₃ methyl butoxy propyl

_2a 2267 SOsH H H SOsH (4-Sulfophenyl)

_2a 2268 H SOsH SOsH H NHCOC 3-(2-Phenoxy

OMe CONH2

H ₃ methyl H H ethoxyl)propyl

_2a 2269 SOsH H H SOsH NHCOC (4-Sulfophenyl) 3-lsopropxy

OMe CONH2 H H

_2a 2270 H SOsH SOsH H H ₃ methyl propyl

_2a 2271 SOsH H H SOsH NHCOC (4-Sulfophenyl) 3-Ethoxy

OMe CONH2 H H

_2a 2272 H SOsH SOsH H H ₃ methyl propyl

_2a 2273 SOsH H H SOsH NHCOC (4-Sulfophenyl)

OMe CONH2 H 3-Ethoxy butyl H

_2a 2274 H SOsH SOsH H H ₃ methyl

SOsH H H SOsH (4-Sulfophenyl) 4-(2-Hydroxy

_2a 2275 NHCOC ethane

OMe CONH2 methyl H H

H ₃ sulfonyl)pheny

I

_2a 2276 SOsH H H SOsH

Methyl Methyl CN 3-Sulfophenyl H Methyl H

_2a 2277 H SOsH SOsH H

_2a 2278 SOsH H H SOsH 3-Sulfophenyl

Methyl Methyl CN H Ethyl H

_2a 2279 H SOsH SOsH H

_2a 2280 SOsH H H SOsH 3-Sulfophenyl

Methyl Methyl CN H n-Propyl H

_2a 2281 H SOsH SOsH H

_2a 2282 SOsH H H SOsH 3-Sulfophenyl H

Methyl Methyl CN H Isopropyl

_2a 2283 H SOsH SOsH H

_2a 2284 SOsH H H SOsH 3-Sulfophenyl

Methyl Methyl CN H 1 -Ethyl propyl H

_2a 2285 H SOsH SOsH H

_2a 2286 SOsH H H SOsH 3-Sulfophenyl 1 ,2-Dimethyl

Methyl Methyl CN H H

_2a 2287 H SOsH SOsH H propyl

_2a 2288 SOsH H H SOsH 3-Sulfophenyl 2,2-Dimethyl

Methyl Methyl CN H H

_2a 2289 H SOsH SOsH H propyl

_2a 2290 SOsH H H SOsH 3-Sulfophenyl

Methyl Methyl CN H Butyl H

_2a 2291 H SOsH SOsH H

_2a 2292 SOsH H H SOsH 3-Sulfophenyl

Methyl Methyl CN H 2-Methyl butyl H

_2a 2293 H SOsH SOsH H

_2a 2294 SOsH H H SOsH 3-Sulfophenyl

Methyl Methyl CN H Tert butyl H

_2a 2295 H SOsH SOsH H

_2a 2296 SOsH H H SOsH 3-Sulfophenyl

Methyl Methyl CN H 3-Methyl butyl H

_2a 2297 H SOsH SOsH H

_2a 2298 SOsH H H SOsH 3-Sulfophenyl

Methyl Methyl CN H Sec butyl H

_2a 2299 H SOsH SOsH H

_2a 2300 SOsH H H SOsH 3-Sulfophenyl

Methyl Methyl CN H Pentyl H

_2a 2301 H SOsH SOsH H

_2a 2302 SOsH H H SOsH 3-Sulfophenyl

Methyl Methyl CN H Hexyl H

_2a 2303 H SOsH SOsH H

_2a 2304 SOsH H H SOsH 3-Sulfophenyl

Methyl Methyl CN H Cyclobutyl H

_2a 2305 H SOsH SOsH H

_2g 2306 SOsH H H SOsH 3-Sulfophenyl

Methyl Methyl CN H Cyclopentyl H

_2a 2307 H SOsH SOsH H

_2g 2308 SOsH H H SOsH 3-Sulfophenyl

Methyl Methyl CN H Cyclohexyl H

_2g 2309 H SOsH SOsH H

_2a 2310 SOsH H H SOsH 3-Sulfophenyl 2-Methyl

Methyl Methyl CN H H

_2a 231 1 H SOsH SOsH H cyclohexyl

_2a 2312 SOsH H H SOsH 3-Sulfophenyl 3-Methyl

Methyl Methyl CN H H

_2a 2313 H SOsH SOsH H cyclohexyl

_2a 2314 SOsH H H SOsH 3-Sulfophenyl

Methyl Methyl CN H Pentan-2-yl H

_2a 2315 H SOsH SOsH H

_2a 2316 SOsH H H SOsH 3-Sulfophenyl

Methyl Methyl CN H 2-Ethylhexyl H

_2a 2317 H SOsH SOsH H

_2a 2318 SOsH H H SOsH 3-Sulfophenyl

Methyl methyl CN H Phenyl H

_2a 2319 H SOsH SOsH H

_2a 2320 SOsH H H SOsH 3-Sulfophenyl

Methyl methyl CN H Benzyl H

_2a 2321 H SOsH SOsH H

_2a 2322 SOsH H H SOsH 3-Sulfophenyl

Methyl Methyl CN H Ally I H

_2a 2323 H SOsH SOsH H

_2a 2324 SOsH H H SOsH 3-Sulfophenyl 2-Methoxy

Methyl Methyl CN H H

_2a 2325 H SOsH SOsH H ethyl

_2a 2326 SOsH H H SOsH 3-Sulfophenyl 3-Methoxy

Methyl Methyl CN H H

_2a 2327 H SOsH SOsH H propyl

_2a 2328 SOsH H H SOsH 3-Sulfophenyl

Methyl Methyl CN H 3-Chloropropyl H

_2a 2329 H SOsH SOsH H

_2a 2330 SOsH H H SOsH 3-Sulfophenyl 2-Methyl

Methyl Methyl CN H H

_2a 2331 H SOsH SOsH H thioethyl

_2a 2332 SOsH H H SOsH 3-Sulfophenyl

Methyl Methyl CN H 2-Fluoroethyl H

_2a 2333 H SOsH SOsH H

_2a 2334 SOsH H H SOsH 3-Sulfophenyl

Methyl Methyl CN H 2-Chloro ethyl H

_2a 2335 H SOsH SOsH H

_2g 2336 SOsH H H SOsH 3-Sulfophenyl 2-(2-Hydroxy

Methyl Methyl CN H ethyl H

_2a 2337 H SOsH SOsH H

sulfonyl)ethyl

_2a 2428 SOsH H H SOsH 3-Sulfophenyl 3-lsopropxy

Methyl Methyl CONH2 H H

_2a 2429 H SOsH SOsH H propyl

_2a 2430 SOsH H H SOsH 3-Sulfophenyl 3-Ethoxy

Methyl Methyl CONH2 H H

_2a 2431 H SOsH SOsH H propyl

_2a 2432 SOsH H H SOsH 3-Sulfophenyl

Methyl Methyl CONH2 H 3-Ethoxy butyl H

_2a 2433 H SOsH SOsH H

_2a 2434 SOsH H H SOsH 3-Sulfophenyl 4-(2-Hydroxy

H SOsH SOsH H ethane

Methyl Methyl CONH2 H H

_2a 2435 sulfonyl)pheny

I

_2a 2436 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CN H Methyl H

_2a 2437 H SOsH SOsH H H ₃

_2a 2438 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CN H Ethyl H

_2a 2439 H SOsH SOsH H H ₃

_2a 2440 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CN H n-propyl H

_2a 2441 H SOsH SOsH H H ₃

_2a 2442 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CN H Isopropyl H

_2a 2443 H SOsH SOsH H H ₃

_2a 2444 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CN H 1 -Ethyl propyl H

_2a 2445 H SOsH SOsH H H ₃

_2a 2446 SOsH H H SOsH NHCOC 3-Sulfophenyl 1 ,2-Dimethyl

OMe CN H H

_2a 2447 H SOsH SOsH H H ₃ propyl

_2a 2448 SOsH H H SOsH NHCOC 3-Sulfophenyl 2,2-Dimethyl

OMe CN H H

_2a 2449 H SOsH SOsH H H ₃ propyl

_2a 2450 SOsH H H SOsH OMe CN 3-Sulfophenyl H Butyl H

_2a 2451 H SOsH SOsH H NHCOC

H ₃

_2a 2452 SOsH H H SOsH

NHCOC 3-Sulfophenyl H

OMe CN H 2-Methyl butyl

_2a 2453 H SOsH SOsH H H ₃

_2a 2454 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CN H Tert butyl H

_2a 2455 H SOsH SOsH H H ₃

_2a 2456 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CN H 3-Methyl butyl H

_2a 2457 H SOsH SOsH H H ₃

_2a 2458 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CN H Sec butyl H

_2a 2459 H SOsH SOsH H H ₃

_2a 2460 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CN H Pentyl H

_2a 2461 H SOsH SOsH H H ₃

_2a 2462 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CN H Hexyl H

_2a 2463 H SOsH SOsH H H ₃

_2a 2464 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CN H Cyclobutyl H

_2a 2465 H SOsH SOsH H H ₃

_2a 2466 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CN H Cyclopentyl H

_2a 2467 H SOsH SOsH H H ₃

_2a 2468 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CN H Cyclohexyl H

_2a 2469 H SOsH SOsH H H ₃

_2a 2470 SOsH H H SOsH NHCOC 3-Sulfophenyl 2-Methyl

OMe CN H H

_2a 2471 H SOsH SOsH H H ₃ cyclohexyl

_2a 2472 SOsH H H SOsH NHCOC 3-Sulfophenyl 3-Methyl

OMe CN H H

_2a 2473 H SOsH SOsH H H ₃ cyclohexyl

_2a 2474 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CN H Pentan-2-yl H

_2a 2475 H SOsH SOsH H H ₃

_2a 2476 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CN H 2-Ethylhexyl H

_2a 2477 H SOsH SOsH H H ₃

_2a 2478 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CN H Phenyl H

_2a 2479 H SOsH SOsH H H ₃

_2a 2480 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CN H Benzyl H

_2a 2481 H SOsH SOsH H H ₃

_2a 2482 SOsH H H SOsH H

NHCOC 3-Sulfophenyl

OMe CN H Ally I

_2a 2483 H SOsH SOsH H H ₃

_2a 2484 SOsH H H SOsH NHCOC 3-Sulfophenyl 2-Methoxy

OMe CN H H

_2a 2485 H SOsH SOsH H H ₃ ethyl

_2a 2486 SOsH H H SOsH NHCOC 3-Sulfophenyl 3-Methoxy

OMe CN H H

_2a 2487 H SOsH SOsH H H ₃ propyl

_2a 2488 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CN H 3-Chloropropyl H

_2a 2489 H SOsH SOsH H H ₃

_2a 2490 SOsH H H SOsH NHCOC 3-Sulfophenyl 2-Methyl

OMe CN H H

_2a 2491 H SOsH SOsH H H ₃ thioethyl

_2a 2492 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CN H 2-Fluoroethyl H

_2a 2493 H SOsH SOsH H H ₃

_2a 2494 SOsH H H SOsH 3-Sulfophenyl

_2a 2495 H SOsH SOsH H NHCOC

OMe CN H 2-Chloro ethyl H

H ₃

_2a 2496 SOsH H H SOsH 2-(2-Hydroxy

NHCOC 3-Sulfophenyl

SOsH SOsH H OMe CN H ethyl H

_2a 2497 H H ₃

sulfonyl)ethyl

_2a 2498 SOsH H H SOsH yl 2-(2-tert Butyl

NHCOC 3-Sulfophen

SOsH SOsH H OMe CN H sulfanyl ethyl H

_2a 2499 H H ₃

sulfonyl)ethyl

_2a 2500 SOsH H H SOsH NHCOC 3-Sulfophenyl 2-(2-Hydroxy

OMe CN H H

_2a 2501 H SOsH SOsH H H ₃ ethoxyjpropyl

_2a 2502 SOsH H H SOsH NHCOC 3-Sulfophenyl 2-(2-Hydroxy

OMe CN H H

_2a 2503 H SOsH SOsH H H ₃ ethoxy)ethyl

_2a 2504 SOsH H H SOsH NHCOC 3-Sulfophenyl 3-(4-Hydroxy

OMe CN H H

₂ g2505 H SOsH SOsH H H ₃ butoxy propyl

_2g 2506 SOsH H H SOsH NHCOC 3-Sulfophenyl 3-(2-Phenoxy

OMe CN H H

_2a 2507 H SOsH SOsH H H ₃ ethoxyl)propyl

_2g 2508 SOsH H H SOsH NHCOC 3-Sulfophenyl 3-lsopropxy

OMe CN H H

_2g 2509 H SOsH SOsH H H ₃ propyl

_2a 2510 SOsH H H SOsH NHCOC 3-Sulfophenyl 3-Ethoxy

OMe CN H H

_2a 2511 H SOsH SOsH H H ₃ propyl

_2a 2512 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CN H 3-Ethoxy butyl H

_2a 2512 H SOsH SOsH H H ₃

_2a 2514 SOsH H H SOsH 3-Sulfophenyl 4-(2-Hydroxy

H SOsH SOsH H NHCOC ethane

OMe CN H H

_2a 2515 H ₃ sulfonyl)pheny

I

_2a 2516 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CONH2 H Methyl H

_2a 2517 H SOsH SOsH H H ₃

_2a 2518 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CONH2 H Ethyl H

_2a 2519 H SOsH SOsH H H ₃

_2a 2520 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CONH2 H n-Propyl H

_2a 2521 H SOsH SOsH H H ₃

_2a 2522 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CONH2 H Isopropyl H

_2a 2523 H SOsH SOsH H H ₃

_2a 2524 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CONH2 H 1 -Ethyl propyl H

_2a 2525 H SOsH SOsH H H ₃

_2a 2526 SOsH H H SOsH NHCOC 3-Sulfophenyl 1 ,2-Dimethyl

OMe CONH2 H H

_2a 2527 H SOsH SOsH H H ₃ propyl

_2a 2528 SOsH H H SOsH NHCOC 3-Sulfophenyl 2,2-Dimethyl

OMe CONH2 H H

_2a 2529 H SOsH SOsH H H ₃ propyl

_2a 2530 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CONH2 H Butyl H

_2a 2531 H SOsH SOsH H H ₃

_2a 2532 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CONH2 H 2-Methyl butyl H

_2a 2533 H SOsH SOsH H H ₃

_2a 2534 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CONH2 H Tert butyl H

_2a 2535 H SOsH SOsH H H ₃

_2g 2536 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CONH2 H 3-Methyl butyl H

_2a 2537 H SOsH SOsH H H ₃

_2g 2538 SOsH H H SOsH

NHCOC 3-Sulfophenyl H

H SOsH SOsH H OMe CONH2 H Sec butyl

_2g 2539 H ₃

_2a 2540 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CONH2 H Pentyl H

_2a 2541 H SOsH SOsH H H ₃

_2a 2542 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CONH2 H Hexyl H

_2a 2543 H SOsH SOsH H H ₃

_2a 2544 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CONH2 H Cyclobutyl H

_2a 2545 H SOsH SOsH H H ₃

_2a 2546 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CONH2 H Cyclopentyl H

_2a 2547 H SOsH SOsH H H ₃

_2a 2548 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CONH2 H Cyclohexyl H

_2a 2549 H SOsH SOsH H H ₃

₂ g2550 SOsH H H SOsH NHCOC 3-Sulfophenyl 2-Methyl

OMe CONH2 H H

_2a 2551 H SOsH SOsH H H ₃ cyclohexyl

_2a 2552 SOsH H H SOsH NHCOC 3-Sulfophenyl 3-Methyl

OMe CONH2 H H

₂ g2553 H SOsH SOsH H H ₃ cyclohexyl

_2a 2554 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CONH2 H Pentan-2-yl H

₂ g2555 H SOsH SOsH H H ₃

_2g 2556 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CONH2 H 2-Ethylhexyl H

_2a 2557 H SOsH SOsH H H ₃

_2g 2558 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CONH2 H Phenyl H

_2g 2559 H SOsH SOsH H H ₃

_2g 2560 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CONH2 H Benzyl H

_2a 2561 H SOsH SOsH H H ₃

_2a 2562 SOsH H H SOsH NHCOC 3-Sulfophenyl

OMe CONH2 H Ally I H

_2a 2563 H SOsH SOsH H H ₃

_2a 2564 SOsH H H SOsH NHCOC 3-Sulfophenyl 2-Methoxy

OMe CONH2 H H

_2a 2565 H SOsH SOsH H H ₃ ethyl

Further particular preferred embodiments of the present invention are the dyes of formula (2b) and mixtures thereof

(2b), wherein

R ^{1 b} , R ^2b , R ^3b , R ^4b , R ^5b , R ^6b , R ^7b and R ^8b independent of each other is hydrogen, alkyl, alkoxy, halogen, trifluoromethyl or SO3M, whereby at least two of them are SO3M, R ^9b , R ^10b , R ^13b and R ^14b independent of each other is hydrogen, (Ci-C )-alkyl, (Ci-C )- alkoxy, halogen, trifluoromethyl(Ci-C ₄ )-acylamino or SO3M,

R ^23b and R ^29b independent of each other is unsubstituted, linear or branched (Ci-C ₄ )- alkyl, unsubstituted (Cs-CzJ-cycloalkyl or substituted (Cs-CzJ-cycloalkyl with one or more substituents preferably selected from the group consisting of methyl, ethyl, isobutyl, sec-butyl, tert-butyl and methylbutyl, R ^24b and R ^30b independent of each other is cyano, carbamoyl or alkoxycarbonyl,

_R 25b_ _R 26b _R 27b_ _R 33b _{a nd R} 34b independent of each other is hydrogen, alkyl, hydroxyalkyl, alkoxy, alkenyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, carbamoyl, alkylureido, phenylureido, hydroxyalkylsulfonylalkyl, aminoalkyl, amino- hydroxy-alkyl, alkoxyalkylaminoalkyl, thioalkoxyalkyl-aminoalkyl, aminoalkyloxyalkyl, aminoalkylthioxyalkyl, cycloalkylalkyl, aryloxyalkyl, arylthioxyalkyl, heteroarylalkyl, heterocycloalkylalkyl

or

alkyl interrupted by one or more heteroatoms selected from the group consisting of oxygen and sulphur

or

alkyl substituted by one or more substituents selected from the group consisting of hydroxy, aryl, cycloalkyl, alkoxy, amino, N-monoalkyl-amino, Ν,Ν-dialkyl-amino, N- monoaryl-amino, Ν,Ν-diaryl-amino, N-alkyl-N-aryl-amino, N-monocycloalkyl-amino, Ν,Ν-dicycloalkyl-amino, N-monoalkyl-monocycloalkyl-amino, N,N-monoaryl-mono- cycloalkyl-amino, N-acylamino, N-alkylsulfonyl-amino, ureido, alkylureido, phenylureido, halogen, cyano, COOM, nitro, acyl, alkylsulfonyl, aryloyl, trifluoromethyl, heteroaryl, heterocycloalkyl, alkoxycarbonyl, acyloxy, aryloyloxy, carbamoyl, sulfamoyl and SO ₃ M

or

alkyl interrupted by one or more heteroatoms selected from the group consisting of oxygen and sulphur and substituted by one or more substituents selected from the group consisting of hydroxy, aryl, cycloalkyl, alkoxy, amino, N-monoalkyl-amino, N,N- dialkyl-amino, N-monoaryl-amino, Ν,Ν-diaryl-amino, N-alkyl-N-aryl-amino, N- monocycloalkyl-amino, Ν,Ν-dicycloalkyl-amino, N-monoalkyl-monocycloalkyl-amino, Ν,Ν-monoaryl-monocycloalkyl-amino, N-acylamino, N-alkylsulfonyl-amino, ureido, alkylureido, phenylureido, halogen, cyano, COOM, nitro, acyl, alkylsulfonyl, aryloyl, trifluoromethyl, heteroaryl, heterocycloalkyl, alkoxycarbonyl, acyloxy, aryloyloxy, carbamoyl, sulfamoyl and SO3M

or

joined together to form five or six membered ring being unsubstituted or substituted by one or more (Ci-C ₄ )-alkyl-groups and the ring being uninterrupted or interrupted by one or more heteroatoms selected from the group consting of oxygen and sulphur and

M is hydrogen, an alkali metal, ammonium, one equivalent of an alkali earth metal or a monovalent organic cation. In especially preferred dyes of formula (2b)

R ^{1 b} , R ^3b , R ^4b , R ^5b , R ^6b and R ^8b independent of each other is SO ₃ M, hydrogen, alkyl, alkoxy or halogen, - whereby at least two of them are SO3M,

R ^2b and R ^7b is hydrogen,

R ^9b , R ^10b , R ^13b and R ^14b independent of each other is hydrogen, methyl, halogen, - SO3M or acetylamino,

R ^23b and R ^29b is methyl,

R ^24b and R ^30b independent of each other is cyano or carbamoyl,

_R 25b_ _R 26b_ _R 27b_ ρ>28^ ρ>3ΐ ^ _R 32b_ _R 33b _{a nd R} 34b independent of each other is hydrogen, methyl, ethyl, n-propyl, n-butyl, n-pentyl, n-hexyl, cyclobutyl, cyclopentyl, cyclohexyl, 2-methylcyclohexyl, 3-methylcyclohexyl, isopropyl, sec-butyl, 2-methylbutyl, 1 - ethylpropyl, 1 ,2-dimethylpropyl, tert-butyl, 3-methylbutyl, pentan-2-yl, 2-ethylhexyl, 2,2- dimethylpropyl, phenyl, benzyl, 2-hydroxyethyl, allyl, 2-methoxyethyl, 3-methoxy- propyl, 2-cyanoethyl, 2-(methylthio)ethyl, 2-fluoroethyl, 2-chloroethyl, 3-chloropropyl, 2-(2-hydroxyethylsulfanyl)-ethyl, 2-(2-tertbutylsulfanylethanesulfonyl)-ethyl, 2-(2- hydroxyethoxy)propyl, 2-(2-hydroxy ethoxy)ethyl, 3-(4-hydroxybutoxy)propyl, 2-(2- hydroxyethanesulfonyl)-ethyl, 3-(2-phenoxy-ethoxy)-propyl, 3-isopropoxy-propyl, 3- ethoxy-propyl, 3-ethoxybutyl

or

(C2-C6) alkyl substituted by COOM or by SO3M

or

joined together to form six membered ring being unsubstituted or substituted by one or more (Ci-C ₄ )-alkyl-groups and the ring being uninterrupted or interrupted by one or more heteroatoms selected from the group consting of oxygen and sulphur

and M is hydrogen, sodium, potassium, lithium or ammonium.

Examples of preferred dyes of formula (2b) are the compounds of formulae (2b ¹ 2b ¹⁹² ) and mixtures thereof, (Table 4) whereby R ^{1 b} , R ^2b , R ^7b and R ^8b are hydrogen

Table 4

2b ²³ SOsH H H SOsH 4-(2-Hydroxyethane

NHCOCHs OMe CN H *

sulfonyl)phenyl *

2b ²⁴ H SOsH SOsH H

2b ²⁵ SOsH H H SOsH

Methyl Methyl CONH2 2-Hydroxy ethyl H *

2b ²⁶ H SOsH SOsH H *

2b ²⁷ SOsH H H SOsH

2-(2-Hydroxy ethyl *

Methyl Methyl CONH2 H

sulfanyl)ethyl *

2b ²⁸ H SOsH SOsH H

2b ²⁹ SOsH H H SOsH

Methyl Methyl CONH2 2-(2-Hydroxy ethyl)propyl H *

2b 30 H SOsH SOsH H *

2b 31 SOsH H H SOsH

Methyl Methyl CONH2 2-(2-Hydroxy ethoxy)ethyl H *

2b 32 H SOsH SOsH H *

2b 33 SOsH H H SOsH *

Methyl Methyl CONH2 3-(4-Hydroxy butoxy)propyl H *

2b 34 H SOsH SOsH H

2b ⁴⁷ SOsH H H SOsH 4-(2-Hydroxyethane *

NHCOCHs OMe CONH2 H

sulfonyl)phenyl *

2b ⁴⁸ H SOsH SOsH H

2b ⁴⁹ SOsH H H SOsH

Methyl Methyl CN 2-Sulfo ethyl H *

2b 50 H SOsH SOsH H *

2b 51 SOsH H H SOsH

NHCOCHs OMe CN 2-Sulfo ethyl H *

2b ⁵² H SOsH SOsH H *

2b ⁵³ SOsH H H SOsH

Methyl Methyl CONH2 2-Sulfo ethyl H *

*

2b ⁵⁴ H SOsH SOsH H

2b ⁵⁵ SOsH H H SOsH

NHCOCHs OMe CONH2 2-Sulfo ethyl H *

2b ⁵⁶ H SOsH SOsH H *

2b ⁵⁷ SOsH H H SOsH *

Methyl Methyl CN 2-Sulfo ethyl Me *

2b ⁵⁸ H SOsH SOsH H

2b ⁷⁹ SOsH H H SOsH

Methyl Methyl CN 2-(2-Hydroxy ethoxy)ethyl H

2b ⁸⁰ H SOsH SOsH H

2b ⁸¹ SOsH H H SOsH

Methyl Methyl CN 3-(4-Hydroxy butoxy)propyl H

2b ⁸² H SOsH SOsH H

2b ⁸³ SOsH H H SOsH

4-(2-Hydroxyethane

Methyl Methyl CN H sulfonyl)phenyl

2b ⁸⁴ H SOsH SOsH H

2b ⁸⁵ SOsH H H SOsH

NHCOCHs OMe CN 2-Hydroxy ethyl H

2b ⁸⁶ H SOsH SOsH H

2b ⁸⁷ SOsH H H SOsH

2-(2-Hydroxy ethyl

NHCOCHs OMe CN H sulfanyl)ethyl

2b ⁸⁸ H SOsH SOsH H

2b ⁸⁹ SOsH H H SOsH

NHCOCHs OMe CN 2-(2-Hydroxy ethyl)propyl H

2b ⁹⁰ H SOsH SOsH H

2b ⁹¹ SOsH H H SOsH

NHCOCHs OMe CN 2-(2-Hydroxy ethoxy)ethyl H

2b ⁹² H SOsH SOsH H

2b ⁹³ SOsH H H SOsH

NHCOCHs OMe CN 3-(4-Hydroxy butoxy)propyl H

2b ⁹⁴ H SOsH SOsH H

2b ⁹⁵ SOsH H H SOsH

4-(2-Hydroxyethane

NHCOCHs OMe CN H sulfonyl)phenyl

2b ^' 96 H SOsH SOsH H

2b ⁹⁷ SOsH H H SOsH

Methyl Methyl CONH2 2-Hydroxy ethyl H

2b , ^' 98 H SOsH SOsH H

2b ^' 99 SOsH H H SOsH

2-(2-Hydroxy ethyl

Methyl Methyl CONH2 H sulfanyl)ethyl

2b 100 H SOsH SOsH H

2b 101 SOsH H H SOsH

Methyl Methyl CONH2 2-(2-Hydroxy ethyl)propyl H

2b 102 H SOsH SOsH H

_2b 111 SOsH H H SOsH

2-(2-Hydroxy ethyl

NHCOCH3 OMe CONH2 H sulfanyl)ethyl

_2b 112 H SOsH SOsH H

_2b 113 SOsH H H SOsH

NHCOCH3 OMe CONH2 2-(2-Hydroxy ethyl)propyl H

_2b 114 H SOsH SOsH H

_2b 115 SOsH H H SOsH

NHCOCH3 OMe CONH2 2-(2-Hydroxy ethoxy)ethyl H

_2b 116 H SOsH SOsH H

_2b 117 SOsH H H SOsH

NHCOCH3 OMe CONH2 3-(4-Hydroxy butoxy)propyl H

_2b 118 H SOsH SOsH H

^* f t th i t f tt h t t th it t

Further preferred embodiments of the present invention are the dyes of formula (2c) and mixtures thereof

(2c), wherein

R ^1c , R ^2c , R ^3c , R ^4c , R ^5c , R ^6c , R ^7c and R ^8c independent of each other is hydrogen, alkyl, alkoxy, halogen, trifluoromethyl or SO3M, whereby at least two of them are SO3M

R ^9c , R ^10c , R ^13c and R ^14c independent of each other is hydrogen, (Ci-C )-alkyl, (Ci-C )- alkoxy, halogen, trifluoromethyl(Ci-C ₄ )-acylamino or SO3M,

R ^23c and R ^29c independent of each other is unsubstituted, linear or branched (Ci-C ₄ )- alkyl, unsubstituted (Cs-CzJ-cycloalkyl or substituted (Cs-CzJ-cycloalkyl with one or more substituents preferably selected from the group consisting of methyl, ethyl, isobutyl, sec-butyl, tert-butyl and methylbutyl,

R ^24c and R ^30c independent of each other is cyano, carbamoyl or alkoxycarbonyl, _R 25 _{Cj R} 26c _R 27 _{Cj R} 28 _{Cj R} 3i _{Cj R} 32 _{Cj R} 33c _{a nd R} 34c independent of each other is hydrogen, alkyl, hydroxyalkyl, alkoxy, alkenyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, carbamoyl, alkylureido, phenylureido, hydroxyalkylsulfonylalkyl, aminoalkyl, amino- hydroxy-alkyl, alkoxyalkylaminoalkyl, thioalkoxyalkyl-aminoalkyl, aminoalkyloxyalkyl, aminoalkylthioxyalkyl, cycloalkylalkyl, aryloxyalkyl, arylthioxyalkyl, heteroarylalkyl, heterocycloalkylalkyl

or

alkyl interrupted by one or more heteroatoms selected from the group consisting of oxygen and sulphur

or

alkyl substituted by one or more substituents selected from the group consisting of hydroxy, aryl, cycloalkyl, alkoxy, amino, N-monoalkyl-amino, Ν,Ν-dialkyl-amino, N- monoaryl-amino, Ν,Ν-diaryl-amino, N-alkyl-N-aryl-amino, N-monocycloalkyl-amino, Ν,Ν-dicycloalkyl-amino, N-monoalkyl-monocycloalkyl-amino, N,N-monoaryl-mono- cycloalkyl-amino, N-acylamino, N-alkylsulfonyl-amino, ureido, alkylureido, phenylureido, halogen, cyano, COOM, nitro, acyl, alkylsulfonyl, aryloyl, trifluoromethyl, heteroaryl, heterocycloalkyl, alkoxycarbonyl, acyloxy, aryloyloxy, carbamoyl, sulfa-

or

alkyl interrupted by one or more heteroatoms selected from the group consisting of oxygen and sulphur and substituted by one or more substituents selected from the group consisting of hydroxy, aryl, cycloalkyl, alkoxy, amino, N-monoalkyl-amino, N,N- dialkyl-amino, N-monoaryl-amino, Ν,Ν-diaryl-amino, N-alkyl-N-aryl-amino, N- monocycloalkyl-amino, Ν,Ν-dicycloalkyl-amino, N-monoalkyl-monocycloalkyl-amino, Ν,Ν-monoaryl-monocycloalkyl-amino, N-acylamino, N-alkylsulfonyl-amino, ureido, alkylureido, phenylureido, halogen, cyano, COOM, nitro, acyl, alkylsulfonyl, aryloyl, trifluoromethyl, heteroaryl, heterocycloalkyl, alkoxycarbonyl, acyloxy, aryloyloxy, carbamoyl, sulfamoyl and SO3M

and

M is hydrogen, an alkali metal, ammonium, one equivalent of an alkali earth metal or a monovalent organic cation.

In especially preferred dyes of formula (2c) R ^1c , R ^3c , R ^4c , R ^5c , R ^6c and R ^8c independent of each other is SO ₃ M, hydrogen, alkyl, alkoxy or halogen, - whereby at least two of them are SO3M,

R ^2c and R ^7c is hydrogen,

R ^9c , R ^10c , R ^13c and R ^14c independent of each other is hydrogen, methyl, halogen, SO3M or acetylamino,

R ^23c and R ^29c is methyl,

R ^24c and R ^30c independent of each other is cyano or carbamoyl,

_R 25 _{Cj R} 26c _R 27 _{Cj R} 28 _{Cj R} 3i _{Cj R} 32 _{Cj R} 33c _{a nd R} 34c independent of each other is hydrogen, methyl, ethyl, n-propyl, n-butyl, n-pentyl, n-hexyl, cyclobutyl, cyclopentyl, cyclohexyl, 2-methylcyclohexyl, 3-methylcyclohexyl, isopropyl, sec-butyl, 2-methylbutyl, 1 - ethylpropyl, 1 ,2-dimethylpropyl, tert-butyl, 3-methylbutyl, pentan-2-yl, 2-ethylhexyl, 2,2-dimethylpropyl, phenyl, benzyl, 2-hydroxyethyl, allyl, 2-methoxyethyl, 3-methoxy- propyl, 2-cyanoethyl, 2-(methylthio)ethyl, 2-fluoroethyl, 2-chloroethyl, 3-chloropropyl, 2-(2-hydroxyethylsulfanyl)-ethyl, 2-(2-tertbutylsulfanylethanesulfonyl)-ethyl, 2-(2- hydroxyethoxy)propyl, 2-(2-hydroxy ethoxy)ethyl, 3-(4-hydroxybutoxy)propyl, 2-(2- hydroxyethanesulfonyl)-ethyl, 3-(2-phenoxy-ethoxy)-propyl, 3-isopropoxy-propyl, 3- ethoxy-propyl or 3-ethoxybutyl

or

(C2-C6) alkyl substituted by COOM or by SO ₃ M

and

M is hydrogen, sodium, potassium, lithium or ammonium.

Examples of preferred dyes of formula (2c) are the compounds of formulae (2c ¹ to 2c ¹⁸⁴ ) (Table 5) and mixtures thereof:

hereby R ^1c , R ^2c , R ^7c and R ^8c are hydrogen Table 5

2c ²⁷ SOsH H H SOsH 6-SOsH H 2-Methyl

CN 2-Methyl butyl H H

2c ²⁸ H SOsH SOsH H butyl

2c ²⁹ SOsH H H SOsH 6-SOsH H CN 1 -Ethyl propyl H 1 -Ethyl propyl H

2c ³⁰ H SOsH SOsH H

2c ³¹ SOsH H H SOsH 6-SOsH H 1 ,2-Dimethyl 1 ,2-Dimethyl

CN H H

2c ³² H SOsH SOsH H propyl propyl

2c ³³ SOsH H H SOsH 6-SOsH H CN Tert-butyl H Tert-butyl H

2c ³⁴ H SOsH SOsH H

2c ³⁵ SOsH H H SOsH 6-SOsH H CN 3-Methyl butyl H 3-Methyl butyl H

2c ³⁶ H SOsH SOsH H

2c ³⁷ SOsH H H SOsH 6-SOsH H CN Pentan-2-yl H Pentan-2-yl H

2c ³⁸ H SOsH SOsH H

2c ³⁹ SOsH H H SOsH 6-SOsH H CN 2-Ethylhexyl H 2-Ethylhexyl H

2c ⁴⁰ H SOsH SOsH H

2c ⁴¹ SOsH H H SOsH 6-SOsH H 2,2-Dimethyl 2,2-Dimethyl

CN H H

2c ⁴² H SOsH SOsH H propyl propyl

2c ⁴³ SOsH H H SOsH 6-SOsH H CN Phenyl H Phenyl H

2c ⁴⁴ H SOsH SOsH H

2c ⁴⁵ SOsH H H SOsH 6-SOsH H CN Benzyl H Benzyl H

2c ⁴⁶ H SOsH SOsH H

2c ⁴⁷ SOsH H H SOsH

7-SOsH H CN Methyl H Methyl H

2c ⁴⁸ H SOsH SOsH H

2c ⁴⁹ SOsH H H SOsH 7-SOsH H CN Ethyl H Ethyl H

2c ⁵⁰ H SOsH SOsH H

2c ⁵¹ SOsH H H SOsH 7-SOsH H CN Propyl H Propyl H

2c ⁵² H SOsH SOsH H

2c ⁵³ SOsH H H SOsH 7-SOsH H CN Butyl H Butyl H

2c ⁵⁴ H SOsH SOsH H

2c ⁵⁵ SOsH H H SOsH 7-SOsH H

CN Pentyl H Pentyl H

2c ⁵⁶ H SOsH SOsH H

2c ⁵⁷ SOsH H H SOsH 7-SOsH H CN Hexyl H Hexyl H

2c ⁵⁸ H SOsH SOsH H

2c ⁵⁹ SOsH H H SOsH 7-SOsH H CN Cyclobutyl H Cyclobutyl H

2c ⁶⁰ H SOsH SOsH H

2c ⁶¹ SOsH H H SOsH 7-SOsH H CN Cyclopentyl H Cyclopentyl H

2c ⁶² H SOsH SOsH H

2c ⁶³ SOsH H H SOsH 7-SOsH H CN Cyclohexyl H Cyclohexyl H

2c ⁶⁴ H SOsH SOsH H

2c ⁶⁵ SOsH H H SOsH 7-SOsH H 2-Methyl 2-Methyl

CN H H

2c ⁶⁶ H SOsH SOsH H cyclohexyl cyclohexyl

2c ⁶⁷ SOsH H H SOsH 7-SOsH H 3-Methyl 3-Methyl

CN H H

2c ⁶⁸ H SOsH SOsH H cyclohexyl cyclohexyl

2c ⁶⁹ SOsH H H SOsH 7-SOsH H CN Isopropyl H Isopropyl H

2c ⁷⁰ H SOsH SOsH H

2c ⁷¹ SOsH H H SOsH 7-SOsH H CN Sec-butyl H Sec-butyl H

2c ⁷² H SOsH SOsH H

2c ⁷³ SOsH H H SOsH 7-SOsH H 2-Methyl

CN 2-Methyl butyl H H

2c ⁷⁴ H SOsH SOsH H butyl

2c ⁷⁵ SOsH H H SOsH 7-SOsH H CN 1 -Ethyl propyl H 1 -Ethyl propyl H

2c ⁷⁶ H SOsH SOsH H

2c ⁷⁷ SOsH H H SOsH 7-SOsH H 1 ,2-Dimethyl 1 ,2-Dimethyl

CN H H

2c ⁷⁸ H SOsH SOsH H propyl propyl

2c ⁷⁹ SOsH H H SOsH 7-SOsH H CN Tert-butyl H Tert-butyl H

2c ⁸⁰ H SOsH SOsH H

2c ⁸¹ SOsH H H SOsH 7-SOsH H CN 3-Methyl butyl H 3-Methyl butyl H

2c ⁸² H SOsH SOsH H

2c ⁸³ SOsH H H SOsH 7-SOsH H CN Pentan-2-yl H Pentan-2-yl H

2c ⁸⁴ H SOsH SOsH H

2c ⁸⁵ SOsH H H SOsH 7-SOsH H H

H SOsH SOsH H CN 2-Ethylhexyl H 2-Ethylhexyl

2c ⁸⁶

2c ⁸⁷ SOsH H H SOsH 7-SOsH H 2,2-Dimethyl 2,2-Dimethyl

CN H H

2c ⁸⁸ H SOsH SOsH H propyl propyl

2c ⁸⁹ SOsH H H SOsH 7-SOsH H CN Phenyl H Phenyl H

2c ⁹⁰ H SOsH SOsH H

2c ⁹¹ SOsH H H SOsH 7-SOsH H CN Benzyl H Benzyl H

2c ⁹² H SOsH SOsH H

2c ⁹³ SOsH H H SOsH

6-SOsH H CONH ₂ Methyl H Methyl H

2c ⁹⁴ H SOsH SOsH H

2c ⁹⁵ SOsH H H SOsH 6-SOsH H CONH2 Ethyl H Ethyl H

2c ⁹⁶ H SOsH SOsH H

2c ⁹⁷ SOsH H H SOsH 6-SOsH H CONH2 Propyl H Propyl H

2c ⁹⁸ H SOsH SOsH H

2c" SOsH H H SOsH 6-SOsH H

_2c ioo CONH2 Butyl H Butyl H

H SOsH SOsH H

_2c 101 SOsH H H SOsH 6-SOsH H

_2c 102 CONH2 Pentyl H Pentyl H

H SOsH SOsH H

_2c 103 SOsH H H SOsH 6-SOsH H

_2c 104 CONH2 Hexyl H Hexyl H

H SOsH SOsH H

_2c 105 SOsH H H SOsH 6-SOsH H

_2c 106 CONH2 Cyclobutyl H Cyclobutyl H

H SOsH SOsH H

_2c 107 SOsH H H SOsH 6-SOsH H

_2c 108 CONH2 Cyclopentyl H Cyclopentyl H

H SOsH SOsH H

_2c 109 SOsH H H SOsH 6-SOsH H

_2c 110 CONH2 Cyclohexyl H Cyclohexyl H

H SOsH SOsH H

_2c 111 SOsH H H SOsH 6-SOsH H 2-Methyl 2-Methyl

CONH2 H H

2c ¹¹² H SOsH SOsH H cyclohexyl cyclohexyl

_2c 1 13 SOsH H H SOsH 6-SOsH H 3-Methyl 3-Methyl

_2c 1 14 CONH2 H H

H SOsH SOsH H cyclohexyl cyclohexyl

_2c 1 15 SOsH H H SOsH 6-SOsH H H

_2c 1 16 H SOsH SOsH H CONH2 Isopropyl H Isopropyl

2c ¹¹⁷ SOsH H H SOsH 6-SOsH H

_2c 118 CONH ₂ Sec-butyl H Sec-butyl H

H SOsH SOsH H

_2c 119 SOsH H H SOsH 6-SOsH H 2-Methyl

_2c 120 CONH2 2-Methyl butyl H H

H SOsH SOsH H butyl

2c ¹²¹ SOsH H H SOsH 6-SOsH H CONH2 1 -Ethyl propyl H 1 -Ethyl propyl H

2c ¹²² H SOsH SOsH H

_2c 123 SOsH H H SOsH 6-SOsH H 1 ,2-Dimethyl 1 ,2-Dimethyl

CONH2 H H

2c ¹²⁴ H SOsH SOsH H propyl propyl

_2c 125 SOsH H H SOsH 6-SOsH H

_2c 126 CONH2 Tert-butyl H Tert-butyl H

H SOsH SOsH H

2c ¹²⁷ SOsH H H SOsH 6-SOsH H

_2c 128 CONH2 3-Methyl butyl H 3-Methyl butyl H

H SOsH SOsH H

_2c 129 SOsH H H SOsH 6-SOsH H

_2c 130 CONH2 Pentan-2-yl H Pentan-2-yl H

H SOsH SOsH H

_2c 131 SOsH H H SOsH 6-SOsH H

_2c 132 CONH2 2-Ethylhexyl H 2-Ethylhexyl H

H SOsH SOsH H

_2c 133 SOsH H H SOsH 6-SOsH H 2,2-Dimethyl 2,2-Dimethyl

_2c 134 CONH2 H H

H SOsH SOsH H propyl propyl

_2c 135 SOsH H H SOsH 6-SOsH H

_2c 136 CONH2 Phenyl H Phenyl H

H SOsH SOsH H

_2c 137 SOsH H H SOsH 6-SOsH H

_2c 138 CONH2 Benzyl H Benzyl H

H SOsH SOsH H

_2c 139 SOsH H H SOsH

_2c 140 7-SOsH H CONH2 Methyl H Methyl H

H SOsH SOsH H

_2c 141 SOsH H H SOsH 7-SOsH H CONH2 Ethyl H Ethyl H

2c ¹⁴² H SOsH SOsH H

_2c 143 SOsH H H SOsH 7-SOsH H

_2c 144 CONH2 Propyl H Propyl H

H SOsH SOsH H

_2c 145 SOsH H H SOsH 7-SOsH H H

_2c 146 H SOsH SOsH H CONH2 Butyl H Butyl

2c ¹⁴⁷ SOsH H H SOsH 7-SOsH H

_2c 148 CONH2 Pentyl H Pentyl H

H SOsH SOsH H

_2c 149 SOsH H H SOsH 7-SOsH H

_2c 150 CONH2 Hexyl H Hexyl H

H SOsH SOsH H

_2c 151 SOsH H H SOsH 7-SOsH H

_2c 152 CONH2 Cyclobutyl H Cyclobutyl H

H SOsH SOsH H

_2c 153 SOsH H H SOsH 7-SOsH H

_2c 154 CONH2 Cyclopentyl H Cyclopentyl H

H SOsH SOsH H

_2c 155 SOsH H H SOsH 7-SOsH H

_2c 156 CONH2 Cyclohexyl H Cyclohexyl H

H SOsH SOsH H

_2c 157 SOsH H H SOsH 7-SOsH H 2-Methyl 2-Methyl

_2c 158 CONH2 H H

H SOsH SOsH H cyclohexyl cyclohexyl

_2c 159 SOsH H H SOsH 7-SOsH H 3-Methyl 3-Methyl

_2c 160 CONH2 H H

H SOsH SOsH H cyclohexyl cyclohexyl

_2c 161 SOsH H H SOsH 7-SOsH H

_2c 162 CONH2 Isopropyl H Isopropyl H

H SOsH SOsH H

_2c 163 SOsH H H SOsH 7-SOsH H

_2c 164 CONH2 Sec-butyl H Sec-butyl H

H SOsH SOsH H

_2c 165 SOsH H H SOsH 7-SOsH H

_2c 166 CONH2 2-Methyl butyl H 2-Methyl butyl H

H SOsH SOsH H

_2c 167 SOsH H H SOsH 7-SOsH H

_2c 168 CONH2 1 -Ethyl propyl H 1 -Ethyl propyl H

H SOsH SOsH H

_2c 169 SOsH H H SOsH 7-SOsH H 1 ,2-Dimethyl 1 ,2-Dimethyl

_2c 170 CONH2 H H

H SOsH SOsH H propyl propyl

2c ¹⁷¹ SOsH H H SOsH 7-SOsH H CONH2 Tert-butyl H Tert-butyl H

2c ¹⁷² H SOsH SOsH H

_2c 173 SOsH H H SOsH 7-SOsH H CONH2 3-Methyl butyl H 3-Methyl butyl H

2c ¹⁷⁴ H SOsH SOsH H

_2c 175 SOsH H H SOsH 7-SOsH H

_2c 176 CONH2 Pentan-2-yl H Pentan-2-yl H

H SOsH SOsH H

2c ¹⁷⁷ SOsH H H SOsH 7-SOsH H

_2c 178 CONH2 2-Ethylhexyl H 2-Ethylhexyl H

H SOsH SOsH H

_2c 179 SOsH H H SOsH 7-SOsH H 2,2-Dimethyl 2,2-Dimethyl

_2c 180 CONH2 H H

H SOsH SOsH H propyl propyl

_2c 181 SOsH H H SOsH 7-SOsH H

_2c 182 CONH2 Phenyl H Phenyl H

H SOsH SOsH H

_2c 183 SOsH H H SOsH 7-SOsH H

_2c 184 CONH2 Benzyl H Benzyl H

H SOsH SOsH H

The present invention also provides a process for the production of dyes of formula (I) comprising the steps of:

a) diazotization of a compound of formula (3)

wherein R ¹ to R ⁸ are defined as above,

b) reacting the diazonium salt obtained in step a) with compounds of the formula (4) and (5)

c) diazotization of the compound of formula (6), d) reacting the diazonium salt obtained in step c) with compounds of formula (7) and (8), (9) and (10), (1 1 ) and (12) or mixtures thereof:

wherein R ¹⁷ to R ¹⁹ and R ²⁰ to R ²² and R ²³ to R ²⁸ and R ²⁹ to R ³⁴ are defined as given above.

The diazotization of the compound of the formula (3) and (6) can be performed by means of diazotization methods that are known to a person skilled in the art, preferably by using sodium nitrite or nitrosylsulphuric acid in acidic medium using inorganic acids such as hydrochloric acid, sulphuric acid or phosphoric acid or mixtures thereof or organic acids such as acetic acid or propionic acid or mixtures thereof. Also mixtures of inorganic acid with organic acids can be advantageously used.

The coupling reaction of the diazonium salt obtained by diazotization of the compound of the formula (3) onto the compounds of formulae (4) and (5) as well as the coupling reaction of the the diazonium salt obtained by diazotization of the compound of the formula (6) onto the compounds of formulae (7) and (8) or (9) and (10) or (1 1 ) and (12) or mixtures thereof can likewise be performed by known methods. The compounds of the formula (3) are known and commercially available or can be synthesised by means of common chemical reactions known to a person skilled in the art such as the methods disclosed in US 5,728,874 or DE172106.

The pyridones of formula (7) and (8) in which R ¹⁸ and R ²¹ are cyano are commercially available or can be synthesized via methods disclosed in the literature such as US 2004006234 A1 . The obtained pyridone nitriles can be further derivatized by reactions known to persons skilled in the art, such as hydrolysis to form pyridones of formula (7) and (8) in which R ¹⁸ and R ²¹ are carbonamide or by hydrolysis and further esterification to form pyridones of formula (7) and (8) in which R ¹⁸ and R ²¹ are alkoxycarbonyl.

The pyridines of formula (9), (10), (1 1 ) and (12) in which R ²⁴ and R ³⁰ denote cyano are commercially available or can be synthesized via methods disclosed in the literature such as DE2230392. Through analogy, all the diamino pyridines that are used in this invention can be synthesized with the protocol. The obtained pyridines can be further derivatized by reactions known to persons skilled in the art, such as hydrolysis to form pyridines of formula (7), (8), (9) and (10) in which R ²⁴ and R ³⁰ are carbonamide or by hydrolysis and further esterification to form pyridines in which R ²⁴ and R ³⁰ are alkoxycarbonyl. The above-mentioned derivatization reactions can be carried out in alkaline or acidic media, preferably in acidic media using strong inorganic acids such as sulphuric acid or hydrochloric acid gaseous or solution, acidic resins or chlorotrimethylsilane or other suitable acid catalyst in the presence of the corresponding alkohol. The reactions are advantageously carried out under inert atmosphere at temperatures in the range from 40 °C to 150 °C.

Alternatively, the above mentioned derivatization reactions can be undertaken as a final step after the synthesis of the corresponding dyes with pyridone nitriles. The dyes of the present invention can be used alone or as a mixture with other dyes according to the present invention and/or other substances.

Thus a chemical composition comprising one or more dye(s) as described above is also an aspect of the present invention.

A chemical composition consisting of two or more dyes as described above forms another preferred aspect of the present invention. Also an aqueous solution for dying comprising one or more dye(s) as described above forms an aspect of the present invention.

The dyes of the present invention are suitable for dyeing and printing of natural, manufactured regenerated, modified or synthetic hydroxyl- amino-, and/or carboxamido-containing fiber materials and their blends by the application methods numerously described in the art for acid dyes.

Therefore, the present invention also is directed to a Process for dyeing or printing carboxamido- and/or hydroxyl-containing material, comprising contacting the carboxamido- and/or hydroxyl-containing material with a dye as described above.

The use of a dye as described above, a chemical composition as described above or of an aqueous solution as described above for dying fibers, as well as blends of such fibres selected from the group consisting of: synthetic fiber materials, nylon materials, nylon-6, nylon-6.6 and aramid fibres, vegetable fibres, seed fibres, cotton, organic cotton, kapok, coir from coconut husk; bast fibers, flax, hemp, jute, kenaf, ramie, rattan; leaf fibres, sisal, henequen, banana; stalk fibres, bamboo; fibres from animals, wool, organic wool, silk, cashmere wool, alpaca fiber, mohair, Angora fibre as well as fur and leather materials; manufactured, regenerated and recycled fibres, cellulosic fibres; paper fibres, cellulosic regenerated fibres, viscose rayon fibres, acetate and triacetate fibers and Lyocell fibers forms another aspect of the present invention.

Still another aspect of the present invention is/are: Fiber and blends containing such fiber selected from the group consisting of: synthetic fiber materials, nylon materials, nylon-6, nylon-6.6 and aramid fibres, vegetable fibres, seed fibres, cotton, organic cotton, kapok, coir from coconut husk; bast fibers, flax, hemp, jute, kenaf, ramie, rattan; leaf fibres, sisal, henequen, banana; stalk fibres, bamboo; fibres from animals, wool, organic wool, silk, cashmere wool, alpaca fiber, mohair, Angora fibre as well as fur and leather materials; manufactured, regenerated and recycled fibres, cellulosic fibres; paper fibres, cellulosic regenerated fibres, viscose rayon fibres, acetate and triacetate fibers, and Lyocell fibers comprising one or more dye(s) of the present invention either in chemically and/or physically bound form. The above-mentioned substrates to be dyed can be present in various forms such as but not limited to yarn, woven fabric, loop-formingly knitted fabric or carpet. For instance in the form of sheetlike structures, such as paper and leather, in the form of films, such as nylon films, or in the form of a bulk mass, for example composed of polyamide and polyurethane, in particular in the form of fibers, for example cellulose fibers. The fibers are preferably textile fibers, for example in the form of woven fabrics or yarns or in the form of hanks or wound packages.

The dyes of the present invention and their salts and/or mixtures can be used as a single dyeing colorant in dyeing or printing processes or can be part of a di-, tri- or multi-component combination colorant in dyeing or in printing compositions. The di-, tri- or multi-component shade dyeings show similar fastness level as compared to dyeing performed with a single colorant component.

Dyes of the present invention and their salts or mixtures are highly compatible with other known and/or commercially available acid dyes and they can be used together with such dyes of related chromophores and similar technical performance to obtain specific hues. Similar technical performance includes: comparable build-up, comparable fastness properties and comparable exhaustion rates during dyeings. The dyes according to the invention can be applied to the materials mentioned, especially the fiber materials mentioned, by the application techniques known for water-soluble dyes. This applies to both, dyeing and printing processes. It applies in particular to the production of dyeings on fiber materials composed of wool or other natural polyamides or of synthetic polyamides and their mixtures with other fiber material. In general, the material to be dyed is introduced into the bath at a temperature of about 40 °C, agitated therein for some time, the dyebath is then adjusted to the desired weakly acidic, preferably weakly acetic acid, pH and the actual dyeing is carried out at a temperature between 60 and 98 °C. However, the dyeings can also be carried out at the boil or in a sealed dyeing apparatus at temperatures of up to 106 °C. Since the water solubility of the dyes according to the invention is very good, they can also be used with advantage in customary continuous dyeing processes.

The dyes of the present invention can also be used in digital printing processes, in particular in digital textile printing. For this the dyes of the present invention need to be formulated in aqueous inks.

An Ink for digital textile printing, comprising a dye of the present invention is another aspect of the present invention. The inks of the present invention comprise the dye of the present invention in amounts which preferably range from 0.1 to 50 % by weight, more preferably from 0.5 to 30 % by weight and most preferably from 1 to 15 % by weight, based on the total weight of the ink. If desired the inks may contain further dyes used in digital printing in addition to the one or more dyes of the present invention.

For the inks of the present invention to be used in the continuous flow process, a conductivity of 0.5 to 25 mS/m can be set by adding an electrolyte. Useful electrolytes include for example lithium nitrate and potassium nitrate. The inks of the present invention may include organic solvents at a total level of 1 to 50 % by weight and preferably 5 to 30 % by weight. Suitable organic solvents are for example alcohols, for example methanol, ethanol, 1 -propanol, isopropanol, 1 -butanol, tert-butanol, pentyl alcohol, polyhydric alcohols for example: 1 ,2-ethanediol, 1 ,2,3-propanetriol, butanediol, 1 ,3-butanediol, 1 ,4-butanediol, 1 ,2-propanediol, 2,3-propanediol, pentanediol, 1 ,4-pentanediol, 1 ,5-pentanediol, hexanediol, D,L-1 ,2-hexanediol, 1 ,6- hexanediol, 1 ,2,6-hexanetriol, 1 ,2-octanediol, polyalkylene glycols, for example: polyethylene glycol, polypropylene glycol, alkylene glycols having 1 to 8 alkylene groups, for example: monoethylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, thioglycol, thiodiglycol, butyltriglycol, hexylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, low alkyl ethers of polyhydric alcohols, for example: ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol monohexyl ether, triethylene glycol monomethyl ether, triethylene glycol monobutyl ether, tripropylene glycol monomethyl ether, tetraethylene glycol monomethyl ether, tetraethylene glycol monobutyl ether, tetraethylene glycol dimethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether, tripropylene glycol isopropyl ether, polyalkylene glycol ethers, such as for example: polyethylene glycol monomethyl ether, polypropylene glycol glycerol ether, polyethylene glycol tridecyl ether, polyethylene glycol nonylphenyl ether, amines, such as for example: methylamine, ethylamine, triethylamine, diethylamine, dimethylamine, trimethylamine, dibutylamine, diethanolamine, triethanolamine, N-acetylethanolamine, N-formylethanolamine, ethylenediamine, urea derivatives, such as for example: urea, thiourea, N-methylurea, Ν,Ν'-epsilon dimethylurea, ethyleneurea, 1 ,1 ,3,3- tetramethylurea, amides, such as for example: dimethylformamide, dimethylacetamide, acetamide, ketones or keto alcohols, such as for example: acetone, diacetone alcohol, cyclic ethers, such as for example: tetrahydrofuran, trimethylolethane, trimethylolpropane, 2-butoxyethanol, benzyl alcohol, 2- butoxyethanol, gamma butyrolactone, epsilon-caprolactam, further sulfolane, dimethylsulfolane, methylsulfolane, 2,4-dimethylsulfolane, dimethyl sulfone, butadiene sulfone, dimethyl sulfoxide, dibutyl sulfoxide, N-cyclohexylpyrrolidone, N-methyl-2- pyrrolidone, N-ethylpyrrolidone, 2-pyrrolidone, 1 -(2-hydroxyethyl)-2-pyrrolidone, 1 -(3-hydroxypropyl)-2-pyrrolidone, 1 ,3-dimethyl-2-imidazolidinone, 1 ,3-dimethyl- 2-imidazolinone, 1 ,3-bismethoxymethylimidazolidine, 2-(2-methoxyethoxy)ethanol, 2- (2-ethoxyethoxy)ethanol, 2-(2-butoxyethoxy)ethanol, 2-(2-propoxyethoxy)ethanol, pyridine, piperidine, butyrolactone, trimethylpropane, 1 ,2-dimethoxypropane, dioxane ethyl acetate, ethylenediaminetetraacetate ethyl pentyl ether, 1 ,2-dimethoxypropane and trimethylpropane.

The inks of the present invention may further include customary additives, for example viscosity moderators to set viscosities in the range from 1 .5 to 40.0 mPas in a temperature range from 20 to 50 °C. Preferred inks have a viscosity of 1 .5 to 20 mPas and particularly preferred inks have a viscosity of 1 .5 to 15 mPas.

Useful viscosity moderators include rheological additives, for example:

polyvinylcaprolactam, polyvinylpyrrolidone and their copolymers polyetherpolyol, associative thickeners, polyurea, polyurethane, sodium alginates, modified galactomannans, polyetherurea, polyurethane, nonionic cellulose ethers.

As further additives the inks of the invention may include surface-active substances to set surface tensions of 20 to 65 mlM/m, which are adapted if necessary as a function of the process used (thermal or piezo technology). Useful surface-active substances include for example: all surfactants, preferably nonionic surfactants, butyldiglycol, 1 ,2- hexanediol.

The inks of the present invention may further comprise customary additives, for example substances to inhibit fungal and bacterial growth in amounts from 0.01 to 1 % by weight based on the total weight of the ink.

The inks may be prepared in a conventional manner by mixing the components in water.

The inks of the invention are particularly useful in inkjet printing processes for printing a wide variety of pretreated materials, such as silk, leather, wool, polyamide fibers and polyurethanes, and cellulosic fiber materials of any kind. Blend fabrics, for example blends of cotton, silk, wool with polyester fibers or polyamide fibers can similarly be printed.

In contrast to conventional textile printing, where the printing ink already contains all necessary chemicals, in digital or inkjet printing the auxiliaries have to be applied to the textile substrate in a separate pretreatment step. The pretreatment of the textile substrate, for example cellulose and regenerated cellulose fibers and also silk and wool, is effected with an aqueous alkaline liquor prior to printing. In addition there is a need for thickeners to prevent flowing of the motives when the printing ink is applied, for example sodium alginates, modified polyacrylates or highly etherified galactomannans.

These pretreatment reagents are uniformly applied to the textile substrate in a defined amount using suitable applicators, for example using a 2- or 3-roll pad, contactless spraying technologies, by means of foam application or using appropriately adapted inkjet technologies, and subsequently dried.

The examples below serve to illustrate the invention. Parts and percentages are by weigh unless noted otherwise. The relationship between parts by weight and parts by volume is that of the kilogram to the liter.

Examples:

Production Example 1 :

8.62 g of 4,4'-Diamino-biphenyl-2,2'-disulfonic acid were first dissolved in water at slightly acidic pH to give a complete solution. Ice was added to the solution and when temperature reached 10 to 15 °C, 10.6 ml of 5N sodium nitrite solution were added dropwise into the 4,4'-Diamino-biphenyl-2,2'-disulfonic acid solution. The reaction mixture was further cooled down to 0 to 8 °C using an ice-salt-water bath. When the temperature reached 0 to 8 °C, the mixture was added dropwise into 12.38 g of concentrated HCI with 12 g of ice. The reaction mixture was stirred for one hour until completion and a yellow suspension has formed.

6.55 g of 2,5-Dimethyl-phenylamine were added directly into the yellow suspension and stirred. A violet precipitate was observed upon addition. The intermediate precipitate, 4,4'-Bis-(4-amino-2,5-dimethyl-phenylazo)-biphenyl-2,2'-disu lfonic acid, obtained was filtered off with suction and washed with organic solvent and dried.

14.50 g of the dried intermediate, 4,4'-Bis-(4-amino-2,5-dimethyl-phenylazo)-biphenyl- 2,2'-disulfonic acid, were then dissolved in water at slightly acidic pH to give a complete reddish violet solution. Ice was added to the solution and when the temperature reached 10 to 15 °C, 10.1 ml of 5N sodium nitrite solution was added dropwise into the 4,4'-Bis-(4-amino-2,5-dimethyl-phenylazo)-biphenyl-2,2'-disu lfonic acid solution. The reaction mixture was further cooled down to 0 to 8 °C using an ice-salt-water bath. When the temperature reached 0 to 8 °C, the mixture was added dropwise into concentrated HCI with ice. A violet suspension formed and reaction mixture was stirred until completion.

The obtained reaction mixture was used in the next step as described below without further purification:

10.93 g of 1 -Ethyl-6-hydroxy-4-methyl-2-oxo-1 ,2-dihydro-pyridine-3-carbonitrile were stirred in methanol and adjusted to slightly acidic. The violet suspension was added dropwise into the methanol solution and stirred. Brilliant orange precipitate was observed upon addition. The obtained precipitate was filtered off with suction and washed with brine giving product of formula 1 a ⁸ .

The analytic data are consistent with the assigned structure for product 1 a ⁸ .

Product 1 a ⁸ dyes the targeted fibre materials in brilliant orange shades. Through analogy, all the dyes of formulae (1 a ¹ -1 a ¹²⁴⁹ ) can be synthesized according to the method described above.

Dyeing example 1 -1 :

1 part of the dye 1 a ⁸ of this invention was dissolved in 2000 parts of water and 1 part of levelling assistant (based on condensation product of a higher aliphatic amine and ethylene oxide) and 6 parts of sodium acetate were added. The pH was then adjusted to 5 using acetic acid (80 %). The dyebath was heated to 50 °C for 10 minutes and then entered with 100 parts of a woven polyamide-6 fabric. The temperature was raised to 98 °C over the course of 50 minutes and then dyeing was carried out at this temperature for 60 minutes. This was followed by cooling to 60 °C and removal of the dyed material. The polyamide-6 fabric was washed with hot and cold water, soaped and then spunned and dried. The orange dyeings obtained have very good light and wet fastness and also good levelness in the fibre.

Dyeing example 1 -2:

1 part of the dye 1 a ⁸ of this invention was dissolved in 2000 parts of water and 1 part of levelling assistant (based on condensation product of a higher aliphatic amine and ethylene oxide) and 6 parts of sodium acetate were added. The pH was then adjusted to 5.5 using acetic acid (80 %). The dyebath was heated to 50 °C for 10 minutes and then entered with 100 parts of a woven polyamide-6,6 fabric. The temperature was raised to 120 °C in the closed dyeing beaker over the course of 50 minutes and then dyeing was carried out at this temperature for 60 minutes. This was followed by cooling to 60 °C and removal of the dyed material. The polyamide-6,6 fabric was washed with hot and cold water, soaped and then spun and dried. The orange dyeings obtained have very good light and wet fastness and also good levelness in the fibre.

Dyeing example 1 -3:

100 parts of polyamide-6 material were padded with a 1000 parts 50 °C liquor solution that consisted of 40 parts of the dye 1 a ⁸ , 100 parts of urea, 20 parts of a non ionic solubilizer based on butyldiglycol, 20 parts of acetic acid to adjust the pH to 4.0, 10 parts of levelling assistant (based on ethoxylated aminopropyl fatty acid amide) and 815 parts of water. The material was rolled up and placed into a steaming chamber at 85 °C to 98 °C for 3 to 6 hours. After fixation, the fabric was washed with hot and cold water, soaped and then spun and dried.

The orange dyeings obtained have very good light and wet fastness and also good levelness in the fibre. Dyeing example 1 -4:

1 part of the dye 1 a ⁸ of this invention was dissolved in 2000 parts of water and 5 parts of sodium sulphate, and 1 part of levelling assistant (based on condensation product of a higher aliphatic amine and ethylene oxide) and 5 parts of sodium acetate were added. The pH was then adjusted to 4.5 using acetic acid (80%). The dyebath was heated to 50 °C for 10 minutes and then entered with 100 parts of a woven wool fabric. The temperature was raised to 100 °C over the course of 50 minutes and then dyeing was carried out at this temperature for 60 minutes. This was followed by cooling to 90 °C and removal of the dyed material. The wool fabric was washed with hot and cold water, soaped and then spun and dried.

The orange dyeings obtained have very good light and wet fastness and also good levelness in the fibre. Dyeing example 1 -5:

1 part of the dye 1 a ⁸ of this invention was dissolved in 1000 parts of soft water and 7.5 parts of sodium sulphate, and 1 part of a wetting agent (anionic) was added. 100 parts of bleached cotton knitted fabric were added to this solution. The dye bath was then heated up to 98 °C with a gradient of 2 °C/min then dyeing was carried out at this temperature for 60 minutes. This was followed by cooling down to 80 °C. At 80 °C the dyeing was continued for another 20 minutes. The dyed material was then removed and was washed with hot and cold water, soaped and then spunned and dried.

The orange dyeings obtained have very good light and wet fastness and also good levelness in the fibre.

Dyeing example 1 -6:

4 parts of chemically bleached (pine wood) sulphite pulp were mixed with 100 parts of 55 °C water. 1 part of the dye 1 a ⁸ of this invention was dissolved in 100 parts of hot water. 80 parts of this solution were given to the mixed-up pulp and mixed for 2 minutes. After that the mixture was sized with resin size in a conventional manner and mixed for another 2 minutes. 55 parts of this solution were then diluted with 2000 parts of cold water and the paper was produced out of this solution. The orange dyed paper has good wet fastnesses.

Production example 2 - Preparation of an Ink:

3 parts of the dye 1 a ⁸ of this invention were dissolved in 82 parts of deionized water and were added into the dyebath with 15 parts of diethylene glycol at 60 °C. On cooling, an orange printing ink was obtained. The orange printing ink can be used for ink jet printing on paper, polyamide or wool textiles.

Production example 3:

8.62 g of 4,4'-Diamino-biphenyl-2,2'-disulfonic acid was first dissolved in water at slightly acidic pH to give a complete solution. Ice was added to the solution and when temperature reached 10 to 15 °C, 10.6 ml of 5 N sodium nitrite solution were added dropwise. The reaction mixture was further cooled down to 0 to 8 °C when the mixture was added dropwise into 12.38 g of concentrated HCI with 12 g of ice. Yellow suspension was formed and reaction mixture was completed within an hour.

6.30 g of 2,5-Dimethyl-phenylamine were added directly into the diazo suspension and stirred. A violet precipitate was observed upon addition. The obtained intermediate precipitate, 4,4'-Bis-(4-amino-2,5-dimethyl-phenylazo)-biphenyl-2,2'-disu lfonic acid, was filtered off with suction and washed with organic solvent and dried.

15.22 g of the dried intermediate, 4,4'-Bis-(4-amino-2,5-dimethyl-phenylazo)-biphenyl- 2,2'-disulfonic acid, was then dissolved in water at slightly acidic pH to give a complete reddish orange solution. Ice was added to the solution and when the temperature reached 10 to 15 °C, 10.1 ml of 5 N sodium nitrite solution were added dropwise. The reaction mixture was further cooled down to 0 to 8 °C when the mixture was added dropwise into concentrated HCI with ice. Violet suspension was formed and reaction mixture was completed in 90 mins. The obtained reaction mixture was used in the next step as described below:

14.62 g of 2,6-Bis-(3-methoxy-propylamino)-4-methyl-nicotinonitrile were stirred in methanol and adjusted to slightly acidic. The reaction mixture was added dropwise into the methanol solution and stirred. Brilliant orange precipitate was observed upon addition. Precipitate obtained was filtered off with suction and washed with brine giving product of the formula 2a ⁸⁴² . The analytic data are consistent with the assigned structure for product 2a ⁸⁴² . The product dyes the targeted fibre materials in brilliant orange to red shades. Through analogy, all the dyes of formulae (2a ¹ -2a ¹⁹³⁸ ) can be synthesized according to the method described above.

Dyeing example 3-1 :

1 part of the dye 2a ⁸⁴² of this invention was dissolved in 2000 parts of water and 1 part of levelling assistant (based on condensation product of a higher aliphatic amine and ethylene oxide) and 6 parts of sodium acetate were added. The pH was then adjusted to 5 using acetic acid (80 %). The dyebath was heated to 50 °C for 10 minutes and then entered with 100 parts of a woven polyamide-6 fabric. The temperature was raised to 98 °C over the course of 50 minutes and then dyeing was carried out at this temperature for 60 minutes. This was followed by cooling to 60 °C and removal of the dyed material. The polyamide-6 fabric was washed with hot and cold water, soaped and then spun and dried. The dyeing obtained gave red shade and has very good light and wet fastness and also good levelness in the fibre.

Dyeing example 3-2:

1 part of the dye 2a ⁸⁴² of this invention was dissolved in 2000 parts of water and 1 part of levelling assistant (based on condensation product of a higher aliphatic amine and ethylene oxide) and 6 parts of sodium acetate were added. The pH was then adjusted to 5.5 using acetic acid (80 %). The dyebath was heated to 50 °C for 10 minutes and then entered with 100 parts of a woven polyamide-6, 6 fabric. The temperature was raised to 120 °C over the course of 50 minutes and then dyeing was carried out at this temperature for 60 minutes. This was followed by cooling to 60 °C and removal of the dyed material. The polyamide-6, 6 fabric was washed with hot and cold water, soaped and then spun and dried. The dyeing obtained gave red shade and has very good light and wet fastness and also good levelness in the fibre.

Dyeing example 3-3:

100 parts of polyamide-6 material were padded with a 1000 parts 50 °C liquor solution that consisted of 40 parts of the dye 2a ⁸⁴² , 100 parts of urea, 20 parts of a non ionic solubilizer based on butyldiglycol, 20 parts of acetic acid to adjust the pH to 4.0, 10 parts of levelling assistant (based on ethoxylated aminopropyl fatty acid amide) and 815 parts of water. The material was rolled up and placed into a steaming chamber at 85 to 98 °C for 3 to 6 hours. After fixation, the fabric was washed with hot and cold water, soaped and then spun and dried. The dyeing obtained gave red shade and has very good light and wet fastness and also good levelness in the fibre.

Dyeing example 3-4:

1 part of the dye 2a ⁸⁴² of this invention was dissolved in 2000 parts of water and 5 parts of sodium sulphate, and 1 part of levelling assistant (based on condensation product of a higher aliphatic amine and ethylene oxide) and 5 parts of sodium acetate are added. The pH was then adjusted to 4.5 using acetic acid (80 %). The dyebath was heated to 50 °C for 10 minutes and then entered with 100 parts of a woven wool fabric. The temperature was raised to 100 °C over the course of 50 minutes and then dyeing was carried out at this temperature for 60 minutes. This was followed by cooling to 90 °C and removal of the dyed material. The wool fabric was washed with hot and cold water, soaped and then spun and dried. The dyeing obtained gave red shade and has very good light and wet fastness and also good levelness in the fibre.

Dyeing example 3-5:

1 part of the dye 2a ⁸⁴² of this invention was dissolved in 1000 parts of soft water and 7.5 parts of sodium sulphate and 1 part of a wetting agent (anionic) were added. 100 parts of bleached cotton knitted fabric were added to this solution. The dye bath was then heated up to 98 °C with a gradient of 2 °C/min, then dyeing was carried out at this temperature for 60 minutes. This was followed by cooling down to 80 °C. At 80 °C the dyeing was continued for another 20 minutes. The dyed material was then removed and was washed with hot and cold water, soaped and then spun and dried. The dyeings obtained gave red shade and has very good light and wet fastness and also good levelness in the fibre.

Dyeing example 3-6:

4 parts of chemically bleached (pine wood) sulphite pulp was mixed up with 100 parts of 55 °C water. 1 part of the dye 2a ⁸⁴² of this invention was dissolved in 100 parts of hot water. 80 parts of this solution were given to the mixed-up pulp and mixed for 2 minutes. After that the mixture was sized with resin size in a conventional manner and mixed for another 2 minutes. 55 parts of this solution were then diluted with 2000 parts of cold water and the paper was produced out of this solution. The red paper produced from the mixture has good wet fastnesses. Production example 4 - Preparation of an Ink:

3 parts of the dye 2a ⁸⁴² of this invention dissolved in 82 parts of deionized water was added into the dyebath with 15 parts of diethylene glycol at 60 °C. On cooling, a red printing ink was obtained. The red printing ink can be used for ink jet printing on paper, polyamide or wool textiles.