Title:
ACID AMIDE COMPOUND AND USE THEREOF IN TREATMENT OF CANCERS
Document Type and Number:
WIPO Patent Application WO/2019/179436
Kind Code:
A1
Abstract:
The present invention relates to the field of pharmaceutical chemistry. Disclosed are an acid amide compound and use thereof in the treatment of cancers. Disclosed is use of an acid amide compound represented by formula (I), or its crystalline form, or its stereoisomer, or its isotopologue, or its tautomer, or its pharmaceutically acceptable salt, or its solvate, or its prodrug, or its metabolite in the treatment of cancers. The experimental results show that the present compound can inhibit the proliferation of prostate cancer cells, and in particular, has an obvious inhibition effect on a drug-resistant prostate cancer cell line (22RV1). In addition, the present compound can also significantly inhibit the proliferation of various cancer cells. Furthermore, the present compound has good pharmacokinetics, and has a potential treatment effect on cancers, in particular, prostate cancer, and provides a new option for clinically screening and/or preparing cancer drugs.
Inventors:
DU WU (CN)
WEN KUN (CN)
REN WEN (CN)
AI CHAOWU (CN)
LI HAIBO (CN)
CHEN JIANG (CN)
LI YU (CN)
LI XINGHAI (CN)
CHEN YUANWEI (CN)
WEN KUN (CN)
REN WEN (CN)
AI CHAOWU (CN)
LI HAIBO (CN)
CHEN JIANG (CN)
LI YU (CN)
LI XINGHAI (CN)
CHEN YUANWEI (CN)
Application Number:
PCT/CN2019/078725
Publication Date:
September 26, 2019
Filing Date:
March 19, 2019
Export Citation:
Assignee:
HINOVA PHARMACEUTICALS INC (CN)
International Classes:
C07D233/84; A61K31/167; A61K31/277; A61K31/426; A61K31/4409; A61K31/455; A61P35/00; C07C231/12; C07C237/40; C07C237/42; C07C335/22; C07D213/81; C07D213/82
Domestic Patent References:
| WO2016210289A1 | 2016-12-29 | |||
| WO2013165606A1 | 2013-11-07 | |||
| WO2005085188A2 | 2005-09-15 |
Foreign References:
| CN103130696A | 2013-06-05 | |||
| CN1555364A | 2004-12-15 |
Other References:
OGATA, MASARU ET AL.: "Synthesis and antiviral activity of sulfonamidobenzophenone oximes and sulfonamidobenzamides", JOURNAL OF MEDICINAL CHEMISTRY, 31 December 1986 (1986-12-31), pages 417 - 423, XP002096176
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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