6,5 WESTERN CORE COMPOUNDS AS MGLU5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME

Title:

6,5 WESTERN CORE COMPOUNDS AS MGLU5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME

Document Type and Number:

WIPO Patent Application WO/2024/059210

Kind Code:

A3

Abstract:

Negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGlu5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions.

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Inventors:

LINDSLEY CRAIG W (US)
CONN P JEFFREY (US)
FELTS ANDREW S (US)
CAPSTICK RORY A (US)
TEMPLE KAYLA J (US)
HENDERSON SCOTT H (US)
WHOMBLE DAVID L (US)
RINGUETTE ANNA E (US)
ENGERS JULIE L (US)

Application Number:

PCT/US2023/032764

Publication Date:

May 10, 2024

Filing Date:

September 14, 2023

Export Citation:

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Assignee:

UNIV VANDERBILT (US)

International Classes:

A61K31/44; A61K31/166; A61K31/395; A61K31/415; A61K31/33

Attorney, Agent or Firm:

MYERS JR., Richard S et al. (US)

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