Title:
5'-MODIFIED NUCLEOSIDE AND NUCLEOTIDE USING SAME
Document Type and Number:
WIPO Patent Application WO/2020/158910
Kind Code:
A1
Abstract:
Disclosed are a 5'-modified nucleoside and a nucleotide using the same. The nucleoside according to the present invention is represented by formula (I). The 5'-modified nucleoside according to the present invention is usable as a substitute for a phosphorothioate-modified nucleic acid which has a risk of, for example, accumulation in a specific organ. Further, this 5'-modified nucleoside requires no step for diastereomer separation in manufacturing and, therefore, can be efficiently produced industrially.
More Like This:
| WO/1992/022548 | PROCESS FOR PRODUCING 2',3'-DIDEOXY-beta-NUCLEOSIDE |
| WO/2008/109080 | NUCLEOSIDE BASED PROLIFERATION IMAGING MARKERS |
| WO/1994/022886 | HETEROATOMIC OLIGONUCLEOSIDE LINKAGES |
Inventors:
OBIKA SATOSHI (JP)
YAMAGUCHI TAKAO (JP)
HABUCHI TAKAKI (JP)
KATO GO (JP)
INOUE TAKAO (JP)
YOSHIDA TOKUYUKI (JP)
SUGIURA TAKAYA (JP)
YAMAGUCHI TAKAO (JP)
HABUCHI TAKAKI (JP)
KATO GO (JP)
INOUE TAKAO (JP)
YOSHIDA TOKUYUKI (JP)
SUGIURA TAKAYA (JP)
Application Number:
PCT/JP2020/003597
Publication Date:
August 06, 2020
Filing Date:
January 31, 2020
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
C07H19/06; C07H19/10; C07H19/16; C07H19/20; C07H23/00; C12N15/11
Domestic Patent References:
| WO2015116248A1 | 2015-08-06 | |||
| WO2015125783A1 | 2015-08-27 | |||
| WO2010048549A2 | 2010-04-29 | |||
| WO2007134181A2 | 2007-11-22 | |||
| WO1994022890A1 | 1994-10-13 | |||
| WO2010048549A2 | 2010-04-29 | |||
| WO2010048585A2 | 2010-04-29 | |||
| WO2010077578A1 | 2010-07-08 |
Foreign References:
| CN108276463A | 2018-07-13 |
Other References:
HORIBA, M. ET AL.: "Synthesis of scpBNA-mC, -A, and -G Monomers and Evaluation of the Binding Affinities of scpBNA-Modified Oligonucleotides toward Complementary ssRNA and ssDNA", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 81, no. 22, 2016, pages 11000 - 11008, XP055376695, DOI: 10.1021/acs.joc.6b02036
S.OBIKA ET AL., TETRAHEDRON LETT., vol. 38, 1997, pages 8735 - 8738
S. SINGH ET AL., J. CHEM. COMMUN., 1998, pages 455 - 456
YAWMAN ET AL., J. ORG. CHEM., vol. 60, 1995, pages 788 - 789
MANOHARANET, J. ORG. CHEM., vol. 81, 2016, pages 2261 - 2279
M. KUWAHARA ET AL., NUCLEIC ACIDS RES., vol. 36, no. 13, 2008, pages 4257 - 4265
CARUTHERS ET AL., TETRAHEDRON LETT., vol. 37, no. 35, 1996, pages 6239 - 6242
LOMHOLT ET AL., J. ORG. CHEM., vol. 66, no. 25, 2001, pages 8504 - 8512
SUZUKI ET AL., BIOMACROMOLECULES, vol. 12, no. 5, 2011, pages 1449 - 1459
WEXSELLBLATT ET AL., BIOORG. MED. CHEM., vol. 18, no. 12, 2010, pages 4485 - 4497
OBIKA ET AL., NUCLEIC ACIDS RES., vol. 42, no. 12, 2014, pages 8174 - 8187
See also references of EP 3919501A4
S.OBIKA ET AL., TETRAHEDRON LETT., vol. 38, 1997, pages 8735 - 8738
S. SINGH ET AL., J. CHEM. COMMUN., 1998, pages 455 - 456
YAWMAN ET AL., J. ORG. CHEM., vol. 60, 1995, pages 788 - 789
MANOHARANET, J. ORG. CHEM., vol. 81, 2016, pages 2261 - 2279
M. KUWAHARA ET AL., NUCLEIC ACIDS RES., vol. 36, no. 13, 2008, pages 4257 - 4265
CARUTHERS ET AL., TETRAHEDRON LETT., vol. 37, no. 35, 1996, pages 6239 - 6242
LOMHOLT ET AL., J. ORG. CHEM., vol. 66, no. 25, 2001, pages 8504 - 8512
SUZUKI ET AL., BIOMACROMOLECULES, vol. 12, no. 5, 2011, pages 1449 - 1459
WEXSELLBLATT ET AL., BIOORG. MED. CHEM., vol. 18, no. 12, 2010, pages 4485 - 4497
OBIKA ET AL., NUCLEIC ACIDS RES., vol. 42, no. 12, 2014, pages 8174 - 8187
See also references of EP 3919501A4
Attorney, Agent or Firm:
NAKAMICHI, Yoshihiro et al. (JP)
Download PDF: