Title:
25-HYDROXYCHOLECALCIFEROL MONOHYDRATE CRYSTAL AND PREPARATION METHOD THEREFOR, AND MICROEMULSION USING 25-HYDROXYCHOLECALCIFEROL MONOHYDRATE CRYSTAL
Document Type and Number:
WIPO Patent Application WO/2019/153673
Kind Code:
A1
Abstract:
The present invention provides a 25-hydroxycholecalciferol monohydrate crystal and a preparation method therefor, and a microemulsion using the 25-hydroxycholecalciferol monohydrate crystal. The X-ray powder diffraction spectrum of the 25-hydroxycholecalciferol monohydrate crystal of the present invention shows characteristic peaks at 2θ of 10.035°, 11.623°, 14.631°, 15.054°, 15.551°, 16.471°, 17.198°, 19.002°, 19.628°, 20.109°, 21.886°, 23.113°, 23.661°, 24.701°, 25.220°, 25.440°, and 28.527°. The 25-hydroxycholecalciferol monohydrate crystal of the present invention can effectively enhance the stability of 25-hydroxycholecalciferol, and is more beneficial to the production and storage of related preparations, and thus the biological characteristics of the 25-hydroxycholecalciferol can be effectively utilized.
Inventors:
TANG FEI (CN)
CAO JINDANG (CN)
LI XIN (CN)
ZHANG CHAO (CN)
LUO HAO (CN)
LI QIANGQIANG (CN)
CAO ZHI (CN)
SHU LIANG (CN)
CAO JINDANG (CN)
LI XIN (CN)
ZHANG CHAO (CN)
LUO HAO (CN)
LI QIANGQIANG (CN)
CAO ZHI (CN)
SHU LIANG (CN)
Application Number:
PCT/CN2018/099257
Publication Date:
August 15, 2019
Filing Date:
August 07, 2018
Export Citation:
Assignee:
SHANDONG HAINENG BIOENGINEERING CO LTD (CN)
SHANDONG HAINENG PHARMACEUTICAL CO LTD (CN)
SHANDONG HAINENG PHARMACEUTICAL CO LTD (CN)
International Classes:
C07C401/00; A23K20/174; A61K9/107; A61K31/593; A61K47/26; A61P3/02
Foreign References:
| US20110105444A1 | 2011-05-05 | |||
| US4310467A | 1982-01-12 | |||
| CN103898004A | 2014-07-02 | |||
| US3565924A | 1971-02-23 |
Other References:
TRINH TOAN ET AL.: "Crystal Structure of 25-hydroxy-vitamin D3 Monohydrate: A Stereochemical Analysis of Vitamin D Molecules", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 2: PHYSICAL ORGANIC CHEMISTRY, no. 4, 31 December 1977 (1977-12-31), pages 395, XP055630745, ISSN: 0300-9580
See also references of EP 3750874A4
See also references of EP 3750874A4
Attorney, Agent or Firm:
LEADER PATENT & TRADEMARK FIRM (CN)
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