Title:
2-ALKYLCARBONYL[2,3-b]FURAN-4,9-DIONE PRODUCTION METHOD AND PRODUCTION INTERMEDIATE THEREFOR
Document Type and Number:
WIPO Patent Application WO/2020/251015
Kind Code:
A1
Abstract:
Provided is a method for producing a substance related to 2-alkylcarbonylnaphtho[2,3-b]furan-4,9-dione that is suitable for industrial production. The present disclosure provides: a method for producing two production intermediates for 2-alkylcarbonyl[2,3-b]furan-4,9-dione by reacting commercially available 2-hydroxy-1,4-naphthoquinone with equally inexpensive, commercially available induced N,N-substituted formamide dimethyl acetal, and further reacting the product with an inexpensive commercially available 2-halo-1,4-diketone compound in the presence of water; and a substance related to the same.
Inventors:
TAKAHASHI YOKO (JP)
YAMAI YUSUKE (JP)
YAMAI YUSUKE (JP)
Application Number:
PCT/JP2020/023198
Publication Date:
December 17, 2020
Filing Date:
June 12, 2020
Export Citation:
Assignee:
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
International Classes:
C07C221/00; C07C225/24; C07D307/92
Domestic Patent References:
| WO2018102427A1 | 2018-06-07 |
Foreign References:
| CN102267964A | 2011-12-07 | |||
| JP2010539097A | 2010-12-16 |
Other References:
YOSHIOKA EITO, KOHTANI SHIGERU, MIYABE HIDETO: "Three-component coupling reactions of arynes for the synthesis of Benzofurans and Coumarins", MOLECULES, vol. 19, no. 1, 13 January 2014 (2014-01-13), pages 863 - 880, XP055771016
LEE, YONG ROK ET AL.: "Ceriic Ammonium Nitrate (CAN) -Mediated oxidative cycloaddition of 1,3-dicarbonyls to conjugated compounds", EFFICIENT SYNTHESIS OF DIHYDROFURANS, DIHYDROFUROCOUMARINS, DIHYDROFUROQUINOLINONES, DIHYDROFUROPHENALENONES, AND FURONAPHTHOQUINONE NATURAL PRODUCTS., TETRAHEDRON, vol. 56, 2000, pages 8845 - 8853, XP004238537, DOI: 10.1016/S0040-4020(00)00839-5
LEE, YONG ROK ET AL.: "Ceriic Ammonium Nitrate (CAN) -Mediated oxidative cycloaddition of 1,3-dicarbonyls to conjugated compounds", EFFICIENT SYNTHESIS OF DIHYDROFURANS, DIHYDROFUROCOUMARINS, DIHYDROFUROQUINOLINONES, DIHYDROFUROPHENALENONES, AND FURONAPHTHOQUINONE NATURAL PRODUCTS., TETRAHEDRON, vol. 56, 2000, pages 8845 - 8853, XP004238537, DOI: 10.1016/S0040-4020(00)00839-5
Attorney, Agent or Firm:
YAMAMOTO, Shusaku et al. (JP)
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