Title:
1,4-BENZODIAZEPINE COMPOUND AND USE THEREOF IN PREPARATION OF ANTI-TUMOR DRUG
Document Type and Number:
WIPO Patent Application WO/2023/241738
Kind Code:
A2
Abstract:
The invention belongs to the technical field of pharmaceutical chemistry and medicines, relating to a 1,4-benzodiazepine compound and a use thereof in the preparation of an antitumor drug, in particular, to a use of the 1,4-benzodiazepine compound in the preparation of an annexin A3 (ANXA3) degradation agent and a use of the 1,4-benzodiazepine compound in the preparation of a drug for treating cancers. In particular, disclosed is a use of the 1,4-benzodiazepine compound, or a pharmaceutically acceptable salt or stereoisomer thereof, or a pharmaceutical composition using the compound as an active ingredient in the preparation of a drug for preventing and treating tumors. The compound can bind to ANXA3 protein, induce ANXA3 protein degradation, inhibit the proliferation, cloning, migration, invasion and other functions of tumor cells, and exert an anti-tumor treatment effect in vivo. The method can be used for treating solid tumors, blood tumors and other diseases, and the involved tumors comprise breast cancer, cervical cancer, ovarian cancer, intestinal cancer, gastric cancer, pancreatic cancer, lung cancer, esophageal cancer, liver cancer, leukemia and melanoma.
Inventors:
SUN XUN (CN)
Application Number:
PCT/CN2023/112421
Publication Date:
December 21, 2023
Filing Date:
August 11, 2023
Export Citation:
Assignee:
UNIV FUDAN (CN)
International Classes:
C07D243/24; A61K31/5513; A61P35/00; C07D243/28
Attorney, Agent or Firm:
SHANGHAI KESHENG INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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