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WO2004022764A9 |
The present invention relates to a process for the preparation of enantiomerically enriched organic compounds. In particular, the present invention relates to an enzymatically operating process, in which, in a coupled enzymatic reaction ...
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WO/2005/026373A1 |
The present invention relates to a process for the preparation of enantiopure intermediates useful in the synthesis of valuable pharmaceutically active compounds, e.g. MAOB inhibitors, and to novel intermediates of formulae (I) and (II) ...
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WO/2005/026110A1 |
A useful novel intermediate and a novel synthesis method which enable an optically active (R)- or (S)-2-amino-3-mercapto-2-methylpropionic acid derivative or a salt thereof which each is useful as an intermediate for medicines, etc. to b...
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WO/2005/026338A1 |
The invention relates to biocatalysts showing alcohol dehydrogenase activity obtainable from Rhodococcus ruber, their preparation, their use in the oxidation of secondary alcohols and/or the reduction of ketones, as well as nucleic acids...
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WO/2005/016901A1 |
A compound 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-2,2-dimethylpiperazi
ne and salts thereof, pharmaceutical compositions comprising the compound and salts, and medical use thereof, including for treatment of schizophrenia and other psyc...
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WO/2005/017171A2 |
The present invention focuses on a process for the production of enantiopure D-amino acids. In particular, a mixture of D- and L-amino acids is treated with an enzymatic reaction system in such a way that the L-form of the amino acid is ...
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WO/2005/016900A1 |
4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiper
azine hydrogen succinate or hadrogen malonat, pharmaceutical compositions containing these salts and the medical use thereof, including for the treatment of schizophrenia and o...
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WO/2005/014509A1 |
The invention relates to a process for the preparation of an enantiomerically enriched ester, in which a mixture of the enantiomers of the corresponding chiral secondary alcohol in the presence of a racemisation catalyst for the substrat...
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WO2004097026B1 |
The present invention relates to a new process for the preparation of optically active alcohols represented by the general formula 2 and their esters represented by the general formula 3 by enzymatic method from racemic alcohols represen...
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WO/2005/005633A2 |
The present invention relates to methods for the stereospecific synthesis and for the enantiomeric enrichment of Beta-amino acids. A novel D-Beta-aminotransferase, which exhibits stereoselectivity for D-Beta phenyalanine D-3-amino-3-phen...
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WO/2005/001107A1 |
The invention relates to a method Method of enzymatically separating optical isomers of a protected amino acid. According to the invention, a (non-sidechain-carboxyl) protected aminoacid is used having the general formula (I) HR1N-...
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WO/2004/111227A2 |
The present invention relates to a screening process for hydantoin racemases and to novel hydantoin racemases, to the nucleic acid sequences coding therefor and to a proces for mutagenesis. Hydantoin racemases are of interest in connecti...
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WO/2004/108944A1 |
A method for producing an optically active chroman-carboxylate, which comprises esterifying one antipode of a racemic chroman-carboxylic acid in the presence of a biocatalyst in a solvent containing an alcohol, separating the unreacted o...
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WO/2004/104205A2 |
The present invention relates to a process for preparing a chiral indole ester by enzymatic resolution using a lipase from Pseudomonas fluorescens as the catalyst for the enantioselective hydrolysis of an ester.
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WO/2004/101513A2 |
A method has been developed to prepare (E)- and (Z)-2-methyl-2-butenoic acids (2M2BA) from a mixture of (E,Z)-2-methyl-2-butenenitriles (2M2BN) by the regioselective hydrolysis of (E)-2M2BN to (E)-2-methyl-2-butenoic acid (2M2BA) using e...
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WO/2004/094452A2 |
Macrocyclic isoquinoline are disclosed having the general formula: A compound of formula 1: wherein R1 to R9, Q and W are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit ...
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WO/2004/092113A1 |
A process by which an optically active 2-allylcarboxylic acid derivative which is useful as an intermediate for medicines can be easily and industrially produced from a material available at low cost; and a 2-allylcarboxamide derivative ...
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WO/2004/090094A2 |
The invention relates to proteins that have an enzymatic activity for reducing substituted alkanones, such as 3-methylamino-1-(2-thienyl)-propane-1-on. The invention also relates to nucleic acids that encode these proteins, to nucleic ac...
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WO/2004/090152A1 |
A process for producing a 2-alkylcysteinamide represented by the general formula (1) or a salt thereof, which comprises hydrolyzing a 4-alkylthiazolidine-4-carboxamide represented by the general formula (2) or a salt thereof. (In the gen...
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WO/2004/087629A1 |
The present invention relates to a new eco-friendly process for the preparation of chiral alcohols by asymmetric reduction of prochiral ketones in water using soked phaseolus aureus L (green grams).
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WO/2004/087932A2 |
The present invention relates to a method for preparing (2S,3R) alkyl trans-3-phenylglycidate or (2R,3S) methyl trans-3-phenylglycidate comprising:- enzymatic resolution by trans-esterification of ± methyl trans-3-phenylglycidate with e...
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WO/2004/087940A2 |
Process for producing enantiopure β-amino acid derivatives corresponding to general formula (I) R1-NZ-CHR2-CH2-COOR3 (I) in which R1 and R2 independently denote organic residues optionally forming a cyclic substituent, R3 denotes H or a...
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WO/2004/087638A1 |
Process for producing amino acid derivatives, in which (a) an organic amine, the amino functionality of which is protected, or an &agr -amino acid, the amino functionality of which is protected, is subjected to an electrochemical reactio...
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WO/2004/085651A2 |
The present invention relates to nucleotides sequences of a gene coding for a pantolactone hydrolase, as well as vectors and host cells containing such nucleotides sequences and pantolactone hydrolases encoded by such nucleotides sequenc...
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WO/2004/083163A1 |
3-Amino-3-arylpropionic acid n-alkyl esters represented by the general formula (I); a process for the production of the same; and optical isomers thereof: (I) [wherein Ar1 is optionally substituted aryl exclusive of phenyl and 4-methoxyp...
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WO/2004/083423A1 |
The invention relates to novel amidases that can be isolated from thermophilic bacteria, in particular from thermophilic actinomycetes, such as e.g. Pseudonocardia thermophila. The amidases obtained in this manner have a high temperature...
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WO/2004/083444A1 |
A process for preparing a second compound stereo-selectively is described. The process comprises reacting a substrate comprising at least one first compound with a reagent in the presence of a biological catalyst and a solvent comprising...
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WO/2004/081220A2 |
The present invention relates to a process for resolving an enantiomeric mixture of $g(a)-hydroxy acids or derivatives thereof through esterification and subsequent enzymatic hydrolysis of the $g(a)-hydroxy acids or derivatives. The pres...
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WO/2004/081219A1 |
The present invention relates to a novel and efficient chemoenzymatic process of preparation of optically active trans alkyl phenylglycidates. The invention particularly discloses a novel process for the chemoenzymatic synthesis of two e...
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WO/2004/078951A1 |
It has been required to economically produce a large amount of an optically active &gammad -lactone derivative (for example, pantolactone) which is useful as an intermediate in synthesizing a useful substance such as a drug. To achieve t...
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WO/2004/076390A1 |
The invention relates to a method for producing chiral, non-racemic, cis 1,3-disubstituted cyclohexanols of formula (I), in which the groups are defined as cited in the description, using an enzymatic resolution of racemates.
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WO/2004/076385A2 |
The invention relates to a method for producing chiral &agr -hydroxycarboxylic crystalline acids consisting in transforming cyanhydrins (R) or (S) into &agr -hydroxycarboxylic acids (R) or (S), respectively by enzymatic hydrolysis in the...
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WO/2004/070049A1 |
The present invention provides a new process for the preparation of optically active ethyl 3-hydroxy-3-phenylpropionate and their esters by enzymatic method. More particularly, the racemic ethyl 3-hydroxy-3-phenylpropionate is converted ...
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WO/2004/063384A1 |
This invention relates to a process for the synthesis of enantiomerically enriched (1S,4R) 1-acetoxy-4-hydroxycyclopent-2-ene of Formula (I), a compound useful as an intermediate in the synthesis fo prostaglandins and prostanoids.
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WO/2004/063385A1 |
It is intended to provide a process for conveniently and industrially producing an optically active &agr -methylcysteine derivative, which is useful as a drug intermediate and so on, from a less expensive and easily available material. A...
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WO/2004/058701A2 |
Methods for preparing enantiomerically enriched aminopentanenitriles are provided. The methods involve selective acylation of an enantiomeric mixture of 3-aminopentanenitrile or selective hydrolysis of an enantiomeric mixture of 3-aminop...
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WO/2004/055194A1 |
A chemoenzymatic process for the stereoselective preparation of both the (R) and (S) enantiomers of 3-hydroxy-3-(2-thienyl) propanenitrile has been developed. These optically pure key intermediates were prepared by enzymatic resolution o...
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WO/2004/055218A1 |
The invention relates to novel bacterial strains of Delftia acidovorans MC1-R, to methods for their production and to their use in the production of extremely pure R enantiomers of 2-phenoxypropionic acid derivatives. The invention parti...
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WO/2004/055195A1 |
The present invention provides methods for stereospecifically preparing (R)- or (S)-N-(2,6-dimethyl phenyl) alanine and counter ester compounds thereto using enzyme, which comprises reacting an enzyme having hydrolytic activity specific ...
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WO/2004/055172A1 |
The invention relates to novel bacterial strains Delftia acidovorans MC1-S, method for production and use thereof for the production of highly pure S enantiomers of 2-phenoxypropionic acid derivatives. The invention particularly relates ...
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WO/2004/052829A1 |
A process for easily producing from an inexpensive material an optically active 3-hydroxypropionic ester derivative useful as an intermediate for medicines. The process, which is for producing an optically active 3-hydroxypropionic ester...
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WO/2004/053131A1 |
The invention relates to a method for the production of R-&agr -lipoic acid by fermentation, characterised in that a cell with a weakened lipoyl protein ligase A activity is cultivated in a culture medium, whereby the cell precipitates e...
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WO/2004/048590A1 |
The present invention relates to a process for producing a compound of formula (I); said process comprising the steps of: a) subjecting a compound of formula (II) to an enzymatic diastereomeric resolution in the presence of a suitable am...
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WO/2004/039998A1 |
The invention provides a process for preparing a chiral hydroxy ester by reacting a compound having botha ketone group and an acyloxy group in a molecule with a hydrogen donor which reduces the ketone group into an hydroxyl group; a meta...
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WO2002092828A9 |
A process for the preparation of 2(S)-alkyl-5-halogenpent-4-ene carboxylic esters by enzymatic hydrolysis, comprising the steps: a) enzymatic hydrolysis of racemic 2-alkyl-5-halogenpent-4-ene carboxylic esters in aqueous and alkaline med...
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WO/2004/024934A1 |
A process which comprises asymmetrically hydrolyzing an N-acylated DL-erythro 3-substituted serine represented by the following general formula (1): (1) (wherein R1 represents C1-10 alkanoyl, benzoyl, C1-5 alkanoyl substituted by halogen...
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WO/2004/022766A1 |
A process for easily producing an L-&agr -methylcysteine derivative or its salt, which is useful as a drug intermediate, from a cheap easily procurable raw material through an enzymatic D-stereoselective hydrolysis of racemic 5-halomethy...
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WO/2004/018466A2 |
The present invention is directed to a method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives.
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WO/2004/016767A2 |
Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The power of Nature and the flexibility of'organic synthesis are combined in nucleic acid-templated synthesis....
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WO/2004/007741A1 |
A process for efficiently producing an optically active β-aminonitrile compound that is useful as a starting material or synthetic intermediate for drugs, agricultural chemicals, etc. In particular, a process for producing an optically ...
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