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WO/2004/071414A2 |
The present invention provides synthetic HCV epitopes, antibodies that recognize and bind to the synthetic HCV epitopes, polynucleotides that encode the synthetic HCV epitopes, and immune effector cells raised in response to the presenta...
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WO/2004/072105A2 |
The present invention features peptides, peptidomimetics and methods of their use for binding to Inhibitor of Apoptosis Proteins (IAPs) in cells and prevents the IAP's from exerting their apoptosis-suppressing function with caspases in t...
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WO/2004/065409A2 |
The present invention relates to peptide mimotopes of lipooligosaccharide from nontypeable Haemophilus influenzae as vaccines.
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WO/2004/065547A2 |
The present invention is directed to an antigen found on the surface of rat and human pancreatic cancer cells and provides antibodies of high specificity and selectivity to this antigen as well as hybridomas secreting the subject antibod...
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WO/2004/058803A2 |
The present invention relates to new peptides for targeting to vascular endothelial growth factor receptor 2, VEGFR-2. The invention further relates to their use in therapeutically effective treatment as well as for diagnostic imaging te...
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WO/2004/047762A2 |
The present invention relates generally to cancer treatment, prophylaxis, and detection, and more specifically, to Porimin binding partners and methods for using Porimin as a target for the treatment, prophylaxis and/or detection of canc...
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WO/2004/048591A2 |
This application includes methods and compositions for evaluating a genetic locus associated with longevity and methods for evaluating information from groups of individuals. A longevity-associated locus was identified in gene that encod...
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WO/2004/041182A2 |
Vaccines and methods against M. haemolytica infections in cattle. The vaccine compositions include a recombinant outer membrane protein of M. haemolytica designated PlpE and/or subunits thereof, alone or in combination with other antigen...
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WO/2004/037164A2 |
Described herein are crosslinked compounds useful in numerous treatments. Described herein are methods of making crosslinked compounds via (1) the oxidative coupling of two or more thiol compounds or (2) by the reaction between at least ...
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WO/2004/026898A1 |
The present invention provides peptide complexes comprising phospholipase D and one or morephospholipase D-interacting peptides. The peptide complexes are useful in screening assays foridentifying compounds effective in modulating the pe...
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WO/2004/021861A2 |
The invention relates to molecules inhibiting biologically active componds and further comprising moieties specifically cleavable by a reagent produced by a target cell. More specifically, the invention relates to inhibitors that bind, i...
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WO/2004/018684A2 |
The present invention relates to the field of immunology. The invention identifies determinants on staphylococcal enterotoxin B (SEB) able to evoke an immune response. In particular the invention is concerned with the identification of e...
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WO/2004/017810A2 |
The present invention describes oligosaccharide sequences, which are specifically expressed by human tumors. The present invention is related to a method of determining an oligosaccharide sequence, which comprises a tumor specific termin...
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WO2003033653B1 |
This invention relates to a kit containing a multivalent, multi-specific binding protein and a carrier molecule. The binding protein has two or more binding sites where at least one binding site binds with a hapten moiety and at least on...
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WO/2004/009066A1 |
The present invention relates to nitric oxide/releasing amidine diazeniumdiolates, compositions comprising same, methods of using same, and a method for preparing same from imidate diayeniumdiolates and primary or secondary amines.
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WO/2004/005508A1 |
It is intended to provide a technique of obtaining a recombinant vector wherein a single gene fragment is surely inserted into a single vector without causing self-ligation of the vector or forming any clones having plural fragments inse...
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WO/2003/104243A1 |
The present invention provides improved methods for synthesis of phosphinothiol reagents, as well as novel protected reagents, for use in formation of amide bonds, and particularly for peptide ligation. The invention provides phosphinebo...
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WO2003037172A9 |
The present invention relates to peptides and their derivatives which bind to endothelial cells and inhibit their proliferation in in vitro assays, e.g., also referred to herein as endothelial cell binding peptide (ECBP) or ECBP sequence...
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WO/2003/095496A1 |
The present invention relates to new active carbohydrate containing protecting reagents represented by a carbohydrate central unit, which is attached to a polymer chain at least at one of the hydroxyl groups and to an active linkage grou...
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WO/2003/089624A2 |
The invention relates to members of the Fc receptor homolog (FcRH) subfamily, as well as fragments and variants thereof. Each FcRH is a Type I transmembrane receptor, preferably, comprises an extracellular region, a transmembrane region,...
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WO/2003/082923A1 |
A process for crosslinking polypeptides containing tyrosine surrounded by uncharged amino acids having low−molecular side chains by treating such a polypeptide with a phenol oxidase. This crosslinking is catalyzed by phenol oxidases su...
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WO/2003/080650A1 |
This invention relates to compounds, and in particular to polypeptides, their use and methods for their production. These polypeptides are produced from 'pseudo-cysteine' amino acids that facilitate the assembly of polypeptides by native...
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WO/2003/071268A2 |
A method for discovering a novel biologically active substance, wherein the desired function of the substance is initially defined and a reference organism naturally exhibiting said function is selected.
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WO/2003/063888A1 |
A defined target for hepatitis and picornaviruses, and other viruses which utilize binding of the ribosomes to the internal ribosome entry site ('IRES') of eukaryotic cells for viral protein translation, has been identified. Useful anti-...
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WO/2003/064452A2 |
The present invention relates to a method for the preparation of highly branched or dendritic graft polypeptides from alpha-amino acid N-carboxyanhydrides (NCA), to the polypeptides obtainable with said method and the use of the polypept...
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WO/2003/062468A2 |
A method for identifying a binding site for a ligand on a macromolecule and the configuration of the ligand when bound, said method comprising using a multiscale approach to represent the ligand as a plurality of models having different ...
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WO/2003/059385A2 |
This invention is directed to pharmaceutical compositions comprising an HIV antigen and a mucosal adjuvant and methods for raising an immune response in a subject by administering these compositions. Preferably, the pharmaceutical compos...
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WO/2003/059252A2 |
This invention relates to use of a novel cell surface protease protein of Group B Streptococcus (GBS), called CspA, as a vaccine to prevent GBS infection.
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WO/2003/057829A2 |
This invention relates to multi−specific, multivalent binding proteins and methods of generating these agents from VH and VL domains. The binding protein has three or more binding sites where at least one binding site binds with a hapt...
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WO/2003/056299A2 |
The present invention provides compounds which are useful as multifunctional labels in proteomics studies. The labels of the present invention are both lysine specific and increase the overall sequence coverage obtained in polypeptide ma...
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WO/2003/055901A1 |
A peptide SY is produced by applying peptides, which have been obtained by treating fish meat with protease, to a peptide−adsorbing resin (ODS resin, etc.), then eluting successively with a 11 to 18 V&sol V % aqueous solution of ethano...
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WO/2003/055113A1 |
A multiplexing system and method for conveying simultaneously a multiplicity of communication channels over a single transmission medium. Multiplexing (15) is effected by transforming a digital bit stream of each respective incoming chan...
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WO/2003/048390A1 |
Anthrax toxin, comprising of protective antigen (PA), lethal factor (LF) and edema factor (EF) is a major virulent factor of B.anthracis. Protective antigen, PA is the main component of all the vaccines against anthrax. The protective ef...
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WO/2003/046201A2 |
The invention provides probes, antibodies and methods for detecting a gene that is only found in Enterobacteriaceae, the deoxyguanosine triphosphate triphosphohydrolase gene. These probes and methods are useful for the detecting whether ...
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WO/2003/042249A2 |
A polymer substrate functionalized with a functionality comprising at least one cyclic, metal ion coordinating ligand group, the cyclic ligand group comprising at least 3 metal ion coordinating donor atoms independently selected from the...
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WO/2003/037915A1 |
The present invention relates to new biocompatible polymer derivatives including peptide spacers of formula (I) and their methods of preparation. The present invention also relates to the conjugates formed by covalent or non−covalent b...
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WO/2003/031571A2 |
Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, ...
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WO/2003/027328A2 |
This invention is directed to methods, kits, non-nucleotide probes as well as other compositions pertaining to the suppression of binding of detectable nucleic acid probes to undesired nucleotide sequences of genomic nucleic acid in assa...
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WO/2003/022126A2 |
Compositions and methods for the therapy and diagnosis of cancer, particularly colon cancer, are disclosed. Illustrative compositions comprise one or more colon tumor polypeptides, immunogenic portions thereof, polynucleotides that encod...
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WO/2003/016915A1 |
The present invention describes oligosaccharide sequences, which are specifically expressed by human tumors. The present inventionis related to a method of determining an oligosaccharide sequence, which comprises a tumor specific termina...
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WO/2003/014388A2 |
The present invention relates to chemically modified genomic sequences, oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to methods for ascertaining genetic and/or epigenetic p...
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WO/2003/012127A2 |
A method for measuring heterodimerization of HIV RT, which comprises the steps of:a) providing a first solution comprising p66 subunit homodimers in the presence of a dissociation agent; b) contacting the first solution with p51 RT subun...
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WO/2003/004569A1 |
The invention relates to fluorescent label compounds of formula or , wherein Z is a reactive group that can be used for covalent coupling of the fluorescent label compound to other molecules. Either the fluorophore is a dipyrromethenebor...
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WO/2002/088667A2 |
An enzymatic synthesis and composition of oligomers and co-oligomers comprised of $g(a)-hydroxy carboxylic acids and $g(a)-amino acids or peptides is disclosed. In a preferred embodiment, a $g(a)-hydroxy carboxylic acid with a specific c...
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WO/2002/085418A2 |
Improved sst-receptor binding peptidic ligands for diagnostic and therapeutic applications in nuclear medicine are provided. The improved ligands contain either natural or unnatural amino acids or peptidomimetic structures that are modif...
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WO/2002/083916A2 |
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WO/2002/083928A2 |
A novel gene (designated 158P3D2) and its encoded protein, and variants thereof, are described wherein l58P3D2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Cons...
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WO/2002/083917A2 |
A novel gene (designated 161P5C5) and its encoded protein, and variants thereof, are described wherein 161P5C5 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Cons...
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WO/2002/083711A2 |
Molecular mimetics of a surface-exposed epitope on loop 4 of PorA of Neisseria meningitidis serogroup B (MenB) P1.2 serosubtype and antibodies produced against the same are disclosed. Compositions containing such molecular mimetics or th...
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WO2001040232A9 |
Novel C-13<2>-COXR1, C-17<2>-COXR2 and C-13<2>-COXR1, C-17<2>-COXR1 derivatives of chlorophyll and bacteriochlorophyll compounds are provided wherein X is O, S or N and R1 and R2 , the same or different, may be an optionally substituted ...
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