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WO/2022/023461A1 |
A specific epitope has been identified in the present invention, which is herein used for detecting and/or quantifying autoantibodies against alpha-fetoprotein (AFP) in a biological sample, and consequently for the in vitro diagnosis of ...
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WO/2022/016751A1 |
Provided are a molecular diagnosis and treatment formulation, a preparation method therefor and use thereof. The formulation comprises: (1) an effect component, i.e. a diagnostic compound and/or a drug for treating endometriosis; and (2)...
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WO/2022/011466A1 |
There is provided a surface functionalized with cross linking groups adapted to receive antibodies and/or fragments thereof. The surface has an antibody binding biomolecule having a linker region which is covalently crosslinked to functi...
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WO/2022/003674A1 |
Disclosed are peptides that specifically bind to neutrophils and uses thereof for neutrophil-targeted delivery of drugs or diagnostic agents in medical conditions including cancer as well as infectious, inflammatory and autoimmune diseas...
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WO/2021/262625A1 |
Described are S-layer fusion proteins comprising a self-assembling domain of a S- layer protein and a viral spike protein or a fragment thereof, a pharmaceutical composition (such as a vaccine) comprising the S-layer fusion protein, and ...
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WO/2021/254868A1 |
The present invention provides methods and tools to determine a serological signature of antibodies against SARS-CoV-2 from a biological sample of a subject. More particularly, a method is provided for the detection of antibodies against...
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WO/2021/256674A1 |
The present invention relates to a method for increasing the stability of a target protein immobilized in a silica nanoparticle through salt treatment. The method of the present invention can be usefully utilized in, for example, bio-rel...
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WO/2021/249433A1 |
A SpyCatcher peptide-modified carrier, a protein immobilizing carrier, and a protein immobilizing method. The method comprises: linking a SpyCatcher peptide to a carrier so as to obtain a SpyCatcher peptide-modified carrier; and then bas...
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WO/2021/246620A1 |
The present invention relates to a metal compound having phase transformation, and a preparation method thereof, the metal compound being expressed by {M2+(OH)y(O)z}A(2-x')·nH2O and being 60-99 vol% amorphous.
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WO/2015/107335A9 |
The present invention provides a method for the functionalization of a polymeric surface with a protein by physical adsorption. The method enables a membrane spanning protein to be used as an anchor for proteins and/or peptides for displ...
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WO/2021/241528A1 |
The present invention pertains to a method for using a nucleic acid compound that contains a selectively cleavable site. Also, the present invention pertains to a DNA-encoded library, said DNA containing a selectively cleavable site, a c...
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WO/2021/243203A1 |
Provided herein are methods of producing a distinct bilayer culture of retinal epithelial cells (RPE) with photoreceptor cells and/or photoreceptor precursor cells (PR/PRP). Further provided herein is a therapy comprising transplantation...
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WO/2021/237280A1 |
This invention relates to polypeptides, including variants of inhibin, and related therapeutics and compositions. Further, the invention relates to the use in the treatment or prevention of conditions associated with reduced levels of in...
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WO/2021/241446A1 |
A method for detecting a target molecule in a specimen, comprising: a (target molecule)-(labelled binding molecule)-(capturing molecule) complex formation step for reacting the target molecule in the specimen, a capture molecule that is ...
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WO/2021/235767A1 |
The present invention relates to a method for obtaining a collagen peptide from starfish, an elastic liposome comprising the starfish-derived collagen peptide, and a cosmetic composition comprising same. According to the present inventio...
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WO/2021/234579A1 |
Provided is a recombinant polypeptide comprising a resistin trimerization domain and a polypeptide of interest. Further provided is an expression vector encoding the recombinant polypeptide and a method of expressing the recombinant poly...
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WO/2021/224833A1 |
The present invention relates to a bio-nanocompound including: metal oxide particles as a substrate; an amino organosilane as a bonding agent; a dialdehyde as a cross-linking agent; and a nucleating agent that uses the nucleating activit...
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WO/2021/224375A1 |
The present invention relates to a method of producing a composition, the composition comprising a solid carrier, a functional constituent and a protective layer to protect the functional constituent.
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WO/2021/217252A1 |
Methods are provided for determining the presence of antibodies in blood or a blood product, using immobilized self-assembled polypeptides comprising an ectodomain and being recognized by the antibodies. The self-assembled polypeptide co...
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WO/2021/217251A1 |
Surfaces and processes are provided for immobilization of multimer polypeptides that preserves the functionality and active conformation of the native multimeric polypeptides. The multimer polypeptide is a self-assembled multimer and com...
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WO/2021/221050A1 |
A structure characterized by having water-insoluble fibers and minibodies connected to the water-insoluble fibers; and a method for producing a structure, the method being characterized by including a step for connecting water-insoluble ...
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WO/2021/210681A1 |
The present invention addresses the issue of providing a composition for cerebral infarction treatment, that is effective for many cerebral infarctions including those not indicated for acute recanalization therapy. This composition for ...
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WO/2021/207826A1 |
Acute lymphoblastic leukemia (ALL) has not benefited from innovative immunotherapies, mainly because of the lack of actionable immune targets. Novel tumor-specific antigens (TSAs) specifically expressed by ALL cells are described herein....
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WO/2021/204920A1 |
The present invention relates to methods for diagnosing infections with Burkholderia pseudomallei and/or Burkholderia mallei comprising the steps of - providing a patient serum sample containing antibodies, - bringing the serum sample in...
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WO/2021/193589A1 |
Provided is a testing method capable of determining with high accuracy the amount, in a sample, of an antigen having a specific sugar chain. In this testing method, the amount, in a sample, of an antigen having a specific sugar chain i...
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WO/2021/193108A1 |
The present invention provides bio-bead particles which can independently detect an object to be detected via a probe and with which the immobilized probe quantity is increased. The bio-bead particles are obtained by immobilizing, thro...
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WO/2021/187406A1 |
The purpose of the present invention is to provide a method for testing Helicobacter pylori infection at a higher sensitivity by sensitively detecting catalase of Helicobacter pylori in a biological sample. More specifically, the present...
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WO/2021/184017A1 |
The present disclosure relates to extracellular vesicles (EVs) that are capable of targeting a cell in the CNS of a subject. Also provided herein are methods for producing the EVs and methods for using the EVs to treat and/or prevent dis...
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WO/2019/109822A9 |
Provided is a type of rhizobium, with the classified nomenclature of Bradyrhizobium sp.KTMS 0001 or Bradyrhizobium sp.KTMS 0002, and the deposit number of CCTCC No: M2017580 or CCTCC No: M2017581. Also provided are a bacterial preparatio...
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WO/2021/168083A1 |
Described herein are methods for selectively cleaving the C-terminal amino acid of a peptide or protein. The methods described herein may be applicable for, for example, single-molecule peptide or protein sequencing.
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WO/2021/167098A1 |
The purpose of the present invention is to provide an assessment and diagnosis method for predicting neurodevelopmental disorders at an early stage, determining the optimal treatment policy, and assessing the effect of intervention treat...
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WO/2021/158849A1 |
Disclosed herein arc β-barrel polypeptides including self-complementing multipartite β-barrel polypeptides and circularly permuted β-barrel polypeptides and methods for their design and use in mediating real-time monitoring of polypep...
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WO/2021/156877A1 |
The present invention provides antimicrobial matrices comprising a water- insoluble polymer and a mixture comprising a plurality of synthetic peptides attached thereto via a linker, the peptides comprise cationic amino acid residues, hyd...
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WO/2021/152121A1 |
The invention relates to a method of reducing or preventing the adsorption of a polypeptide on a surface, or the aggregation of a polypeptide in a liquid composition in contact with a surface comprising the steps of a) providing a compos...
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WO/2021/143576A1 |
Provided is a lectin-magnetic carrier conjugate complex for isolating glycosylated exosomes from clinical samples. The lectin-magnetic carrier conjugate complex comprises: a magnetic carrier; and a lectin conjugated on the outside of the...
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WO/2021/113495A1 |
The present disclosure provides compositions comprising an isolated polysaccharide comprising β-1,4 linked galactosamine and glucosamine monomers, wherein the amino groups of each of the galactosamine and glucosamine are partially subst...
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WO/2021/109684A1 |
Provided are a capturing magnetic bead for capturing a weakly interacting protein molecule by employing a photoaffinity covalent attachment, and a preparation method therefor and a use thereof. The capturing magnetic bead is coated with ...
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WO/2021/105688A1 |
The invention relates to self-assembling proteins that are capable of being used to deliver cargo proteins to phagocytic cells, and the subsequent delivery and utility of these self-assembling proteins by the phagocytic cells at sites of...
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WO/2021/108482A1 |
A synthetic peptide including the sequence SHXGY (SEQ ID NO:2) is described as are methods of using the same for promoting wound healing and epithelial cell migration.
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WO/2021/107836A1 |
An electrochemical catch-release system (1) for repeated use comprising pH- responsive polymers (2) covalently linked to a structure (3) via a monolayer (4) of eletrochemically insensitive aryl bonds, forming a polyelectrolyte arrangemen...
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WO/2021/100855A1 |
The present invention provides a method for quantitatively detecting β-1,3-1,6-glucan separately from β-1,3-glucan and β-1,3-1,4-glucan. The present invention is a method for measuring β-1,3-1,6-glucan, the method comprising: a step ...
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WO/2021/092426A1 |
This disclosure relates generally to compositions of carbon dots, doxorubicin, and transferrin and methods for use of the same in the treatment of DLBCL tumors.
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WO/2021/081345A1 |
The present invention includes a bi-peptide, a method of making, and a method using the bi-peptide to treat a disease or condition, wherein the bi-peptide comprises the formula: peptide 1n - linkern - peptide 2n, or peptide 2n - linkern ...
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WO/2021/069691A1 |
Disclosed herein is a method for covalent immobilization of molecular compounds on a substrate surface, comprising the steps: Providing a substrate surface; Treating the substrate surface with a plasma at atmospheric pressure, thereby ge...
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WO/2021/062960A1 |
An application of an PEG interferon and a proto-oncogene product targeted inhibitor in synergistic treatment of renal carcinoma. Specifically, provided is use of a combination of active components, the combination of active components co...
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WO/2021/062961A1 |
An application of PEG-interferon and a protooncogene product targeting inhibitor in synergistic inhibition of tumors. Specifically, provided is use of an active ingredient combination. The active ingredient combination comprises PEG-inte...
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WO/2021/055467A1 |
This disclosure relates generally to orally administrable nanoparticle for treating and preventing viral infection, specifically ZIKA and coronavirus infections. Methods for using the orally administrable nanoparticle are also provided f...
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WO/2021/055083A1 |
In some examples, a CSS-MBs includes a solid magnetic core, a first shell material which surrounds the solid magnetic core and a second shell material which surrounds the first shell material. The first shell material may be a protective...
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WO/2021/043865A1 |
The present invention relates to a "one-pot" method for preparing an aqueous solution of nanoparticles with amphiphilic block copolymers and comprising polypeptide units, the method comprising at least one step (E1), in an aqueous solven...
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WO/2021/039884A1 |
Provided is a novel vesicle that is useful for introducing a functional molecule to a plant cell. A cell membrane-permeable vesicle, which comprises a polyion complex vesicle and a cell-penetrating peptide presented at the surface ther...
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