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WO/2022/220042A1 |
The purpose of the present disclosure is to provide a method for purifying a protein derived from a membrane protein complex by eluting the membrane protein complex in the form of a complex even when the protein complex is formed. The pr...
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WO/2022/221163A1 |
A solid-phase glycan remodeling (SPGR) system for the glycoengineering of glycoproteins to provide glycoprotein compositions comprising particular predominant glycoforms is described.
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WO/2022/217395A1 |
The present invention belongs to the technical field of preparation methods for polypeptides, and particularly relates to high-purity corticotropin (human-derived sequence) or an analog thereof, and a large-scale preparation method there...
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WO/2022/216928A1 |
Disclosed are depot formulations comprising a biodegradable silica hydrogel composite, wherein the hydrogel composite comprises (i) a silica hydrogel; and (ii) a plurality of microparticles comprising silica and an oligopeptide or a pept...
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WO/2022/215055A1 |
Provided is a cell hydrolysate composition comprising substantially all protein polypeptides and/or polypeptide fragments derived substantially from all the proteins in a cell from an in vitro cell culture.
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WO/2022/207907A1 |
The invention relates to an apparatus for removing proteins taken up in a carrier liquid. The invention further relates to a method for removing proteins taken up in a carrier liquid, with a corresponding apparatus. The invention also re...
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WO/2022/209422A1 |
This method for estimating a purified state comprises: quantifying components contained in a treated liquid obtained by subjecting a liquid containing a specific protein and contaminants other than protein to a purification treatment. Th...
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WO/2022/207615A1 |
Herein is reported a method for producing or purifying an antibody using a mixed mode chromatography material that comprises ion exchange functional groups and hydrophobic interaction functional groups (MM HIC/IEX) operated in flowthroug...
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WO/2022/204806A1 |
Bioconjugates for mediating cytosolic/nuclear and/or intracellular delivery of a membrane impermeable cargo are described herein. The bioconjugates comprise one or more synthetic peptide shuttle agents conjugated in a cleavable or non-cl...
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WO/2022/211014A1 |
The objective of the present invention is to provide a method for visualizing an aggregate of an aggregating protein in an environment similar to biological conditions, and more specifically relates to: a method for recovering an aggrega...
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WO/2022/210004A1 |
The present invention provides an improved means for extracting a protein in foods, which is capable of solving problems such as safety, speed, and reliability. The extraction reagent of the present invention is a reagent for extracting ...
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WO/2022/212647A1 |
The present disclosure is related to peptides comprising modified aspartic acid and glutamic acid moieties, methods of making such peptides, and methods of using such modified peptides to selectively direct cleavage of peptide bonds. Sel...
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WO/2022/206026A1 |
Disclosed in the present application are a protein crystallization nucleating agent and a preparation method therefor. The nucleating agent comprises a multi-layer organic framework, wherein a step structure is arranged between layers of...
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WO/2022/204906A1 |
A protein crystallization nucleating agent and a preparation method for the protein crystallization nucleating agent. The nucleating agent has a hydrophobic three-dimensional porous structure. In the hydrophobic three-dimensional porous ...
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WO/2022/202191A1 |
A chemical synthesis device, which transfers a chemical without contacting the atmosphere, is provided which can improve synthesis efficiency of carrier and chemical inside of a reactor vessel unit. Specifically, this chemical synthesis ...
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WO/2022/201917A1 |
The present invention makes it possible to efficiently extract and purify a target foreign protein expressed using Escherichia coli from the periplasm. A protein production method that includes steps (a)–(c). (a) A step for introdu...
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WO/2022/201056A1 |
The invention provided herein a pharmaceutical process used for an extraction of proteins from pancreatic sample and estimation of the extracted proteins. Moreover, the invention provides a use of suitable is selected from citrate-phosph...
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WO/2022/203219A1 |
The present invention relates to a novel oligopeptide AQTGTGKT analog compound and, more specifically, provides an analog compound of the oligopeptide AQTGTGKT, which exhibits an excellent anticancer effect and is stably present in human...
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WO/2022/200280A1 |
The invention relates to a device for a continuous virus inactivation during a protein production process, comprising a first and a second fluid inlet (2, 3), each of which is designed to introduce a liquid flow into the device (1), comp...
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WO/2022/198790A1 |
Provided are an oligonucleotide aptamer of cardiac troponin and the uses thereof, wherein the sequence of the aptamer is one of SEQ ID NOs: 1-10, or the aptamer is a variant which has a function equivalent to one of the sequences of SEQ ...
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WO/2022/202985A1 |
The present invention provides: a peptide that can be readily consumed on a daily basis and has various effects but few side effects; and a composition that contains the peptide as an active ingredient. Provided is a peptide that compr...
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WO/2022/203512A1 |
The invention provides a method for providing a cargo to a C-terminal end (111) of a peptide (110), the method comprising a first stage and a second stage, wherein the first stage comprises reacting the C-terminal end (111) of the peptid...
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WO/2022/197184A1 |
The invention provides a method for providing a cargo to a C-terminal end (111) of a peptide (110), the method comprising a first stage and a second stage, wherein the first stage comprises reacting the C-terminal end (111) of the peptid...
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WO/2022/194257A1 |
A compound of formula (II) and a preparation method therefor, and a method for preparing a camptothecin derivative and an antibody drug conjugate from the compound of formula (II). The preparation method for the compound of formula (II) ...
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WO/2022/193482A1 |
The present application relates to a synthetic method for a cyclosporine derivative. The synthetic method comprises: pre-mixing a precursor fluid and an alkaline fluid to obtain a pre-mixed solution; inputting the pre-mixed solution into...
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WO/2022/197266A1 |
The present invention provides the beta-lactoglobulin protein and beta-lactoglobulin derived bioactive peptides from the whey fraction of goat milk and antiviral uses thereof, is preventive from infectious diseases and have effects of di...
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WO/2022/195000A1 |
The present invention relates to a composition comprising a solid carrier, a capture moiety, afunctional protein, a first linker connecting the capture moiety to the solid carrier, a second linker connecting the functional protein to the...
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WO/2022/196797A1 |
The present invention addresses the problem of providing: a highly efficient peptide production method by which a protecting group of a side chain can be de-protected via a weak acid; a reagent for forming a protecting group, the reagent...
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WO/2022/188628A1 |
Provided is a novel peripherally restricted multi-target cyclopeptide molecule for an opioid receptor and a neuropeptide FF (NPFF) receptor, or a pharmaceutically acceptable salt thereof. By using DN-9 as a chemical template, structural ...
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WO/2022/191223A1 |
The present invention addresses the problem of, in a method for extracting a target protein from prokaryotic cells expressing the target protein, preventing the contamination of the target protein with foreign substances and increasing t...
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WO/2022/192664A1 |
Provided are stapled antimicrobial peptides (i.e., StAMPs) and methods of using the same (e.g., for treating bacterial infections caused by Gram-negative bacteria). In certain embodiments, the stapled peptides are based on the amino acid...
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WO/2022/192504A1 |
Parallel chromatography systems and continuous manufacturing methods are described herein that utilize two or more chromatography column skids having columns operating in parallel with automation controls governing which column to load a...
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WO/2022/189620A1 |
The present disclosure provides transmembrane chimeric proteins derived from transposable element (TE)-exon fusion transcripts, as well as nucleic acids, antibodies, CARs, non-HLA restricted TCR and immune cells targeting such chimeric p...
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WO/2022/191158A1 |
Disclosed is a method for producing a fusion protein in which an antibody is fused with a lysosomal enzyme. This method for producing a fusion protein in which an antibody is fused with a human lysosomal enzyme comprises: (a) culturing m...
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WO/2022/190486A1 |
The present invention provides, as a novel compound that can be utilized for efficient synthesis or the like of a polypeptide comprising various amino acids, a silane-containing condensed cyclic dipeptide compound represented by formula ...
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WO/2022/191971A1 |
Parallel chromatography systems and continuous manufacturing methods are described herein that utilize two or more chromatography column skids having columns operating in parallel with automation controls governing which column to load a...
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WO/2022/184005A1 |
Provided herein are thiosuccinyl-crosslinked hemoglobin conjugates useful as blood replacement agents and therapeutic proteins, pharmaceutical compositions comprising the same and the methods of use and preparation thereof.
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WO/2022/183993A1 |
Provided is a compound targeting a prostate specific membrane antigen (PSMA). The compound has a structure as represented by formula (I), wherein R1 is a compound targeting a prostate specific membrane antigen; L1 is -(X)n-(CH 2)m-(Y)q-,...
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WO/2022/184163A1 |
Disclosed in the present invention is a modified nonapeptide, which is an alkyl acylated and/or phosphorylated nonapeptide. The amino acid sequence of the alkyl acylated nonapeptide is sequence I: R-Co-Trp-Ala-Gly-Gly-Phe-Ala-Ser-Gly-Glu...
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WO/2022/184165A1 |
Provided in the present invention are a polypeptide for inhibiting intracellular lipid accumulation and a synthesis method therefor. The polypeptide has a relatively high target affinity and reduces the activity of sterol O-acyltransfera...
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WO/2022/187273A1 |
Provided herein are, inter alia, bioreactive unnatural amino acids, compounds containing the unnatural amino acids, and methods of using same.
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WO/2022/186243A1 |
Provided is a protein folding agent able to fold a protein with high efficiency. Provided is a protein folding agent including, as an active ingredient, at least one substance selected from among the compounds represented by formulas (...
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WO/2022/180264A1 |
Method for purifying a biomolecule (protein, DNA) of interest from a culture of gram-negative bacteria, comprising the use of polyoxyethylene (10) isooctylcyclohexyl ether to eliminate endotoxins, and use in chromatography of a solution ...
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WO/2022/182493A1 |
In some aspects, the present disclosure pertains to sample treatment methods that comprise: contacting an acidic elution solution that is free of primary amine, secondary amine and thiol groups with a sorbent having bound target antibody...
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WO/2022/182261A1 |
The present invention provides an artificial TRAP-cage comprising a selected number of TRAP rings which are held in place by cross-linkers, wherein the cross-linkers are selected for their specific characteristics whereby the cages are p...
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WO/2022/182388A1 |
Protein separation can be provided based on a High Performance Countercurrent Membrane Purification (HPCMP), which can exploit highly selective diffusive transport across thin walls of a hollow fiber membrane for separation of proteins. ...
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WO/2022/181672A1 |
The purpose of the present invention is to provide a modified milk protein that has high solubility in an acidic region, excellent foaming properties and high safety, and a method for producing the milk protein while minimizing the risk ...
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WO/2022/180117A1 |
The invention relates to a simple and very rapid method for simultaneously isolating nucleic acids from sedimentable and nonsedimentable biomolecules in water samples. The water samples can be, inter alia, drinking water, industrial wate...
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WO/2022/180062A1 |
The present invention relates to a method of processing or fractionating a sample comprising proteins, polypeptides and/or peptides, said method comprising (a) changing the physicochemical conditions of said sample; and (b) performing on...
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WO/2022/181717A1 |
The present invention addresses the problem of providing a simple oxytocin purifying method and measuring method and kit. The present invention pertains to an oxytocin purifying method, comprising treating a sample with an acid or a salt...
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