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JPH0250919B2 |
Two processes are disclosed (one-pot and two-pot) for the transformation of a 6 beta -fluoro- DELTA 1,4-3-keto steroid (IV) to a 6 alpha -fluoro- DELTA 1,4-3-keto steroid (VI). These processes permit the introduction of a fluorine atom a...
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JPH0247479B2 |
The title compounds of formula I and their salts are, with certain exceptions, new: W is H or OH; X is ethyl, 1-hydroxyethyl, or acetyl; or W + X = ethylidene; R, is H or Me; R2 and R3 are each H, alkyl or hydroxyalkyl, R3 alternatively ...
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JPH02243698A |
PURPOSE: To provide the subject compsn. for treating uterine cancer containing a diluent or a carrier and a specific (substd.) estrogen nucleus as a part of a molecular structure and a therapeutically effective amt. of a sexual steroid a...
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JPH02207096A |
PURPOSE: To provide the subject compound useful as a synthetic intermediate in a good yield by removing a diethynyl compound from a reaction solution and subsequently subjecting the purified compound to the next processes, the diethynyl ...
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JPH0226639B2 |
21-Hydroxycorticosteroid esters which can have good solution stability and are therefore suitable for formulation into aqueous compositions for injection or infusion, have the formula… St-O-CO-Y-(CH2)n-X-CH2)m-SO3H… wherein St is the...
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JPH02134396A |
NEW MATERIAL:A compound of formula I (R1 is 1-4C alkyl or methylthiomethyl; R2 is 2-5C alkanoyl; R3 is H or methyl; X is H or halogen; the bond between the positions 1 and 2 may be a double bond). EXAMPLE: Diflorasone-17-propionate-21-me...
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JPH0218071B2 |
A process for preparing 11 beta ,21-dihydroxy-2'-methyl-5' beta H-1,4-pregnadieno(16,17-d)-oxazole-3,20-dione, comprises fermenting 11 beta ,21-dihydroxy-2'-methyl-5' beta H-4-pregneno (16,17-d)-oxazole-3,20-dione with a living culture o...
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JPH0215559B2 |
Novel esters of 9a-fluoro- and chloro-corticosteroids of the formulawherein Y is chlorine or OR1, R1 and R2 represent an acyl group of 2-6 carbon atoms or a benzoyl group and where R1 and R2 can be the same or different in the same molec...
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JPH0212479B2 |
Steroid compounds of the 20-spiroxane series and their analogues having an open ring E of the formula, (I) in which -A-A- represents the group -CH2-CH2- or -CH=CH-, R1 represents hydrogen, and R2 represents an alpha -oriented lower alkox...
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JPH0211600B2 |
Perchloryl fluoride when reacted with the appropriately protected 9 alpha -hydroxyandrostenedione stereoselectively produces the corresponding 6 beta -fluoro steroid.
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JPH02360B2 |
3-enol ethers of 11 beta -hydroxy- DELTA 4-pregnene-3-ones are prepared by reacting triethylorthoacetate with an 11 beta -hydroxy- DELTA 4-pregnene-3-one in a solvent which is at least 40% by weight or more ethanol and 60% by weight or l...
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JPH0160479B2 |
A process for preparing 16 alpha -hydroxy-17 alpha -aminopregnane derivatives through the opening of the corresponding 16 alpha , 17 alpha -epoxides with amines. The use of the thus obtained compounds as intermediates in the synthesis of...
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JPH0159879B2 |
1. Process for manufacturing 11 alpha-hydroxy-20 alpha-hydroxymethyl- 1,4-pregnadien-3-one, characterised in that 20 alpha-hydroxymethyl-1,4-pregnadien-3-one is fermented with a live culture of Aspergillus occhraceus which is capable of ...
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JPH0149278B2 |
6 alpha -Methylprednisolone derivatives of Formula I (I) wherein R1 is 1-oxoalkyl of 2-6 carbon atoms or benzoyl and R2 is 1-oxoalkyl of 2-6 carbon atoms, are pharmacologically efficacious compounds, e.g., as antiinflammatories.
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JPH0148917B2 |
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JPH01238598A |
NEW MATERIAL: A compound represented by the formula I(wherein: R is H or an alkyl or aralkyl group; R1 is H; X is O or an easily eliminable, carbonyl functional protecting group; R2 is H2 or O; R4 is H or an acyl group; and the dotted li...
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JPH01221391A |
NEW MATERIAL: A compd. of formula I (where R is OH or H; R1 and R2 are each =CH2 or -CH2O-; R3 is H, OH, HSO3O or HOCOCH2CH2CO2; R4 is OH, HOC15H30CO2, AcO or H; when R3 is H, a double bond does not exist in the cyclopentane ring; R5 is ...
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JPH0133115B2 |
Novel steroids of the formula I' wherein R is selected from the group consisting of R1 and R2, R1 is selected from the group consisting of alkyl of 1 to 8 carbon atoms and alkenyl and alkynyl of 2 to 8 carbon atoms R2 is -(CH2)n-R3, n is...
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JPH0129199B2 |
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JPH0128040B2 |
Corticoids of the formula wherein X is fluorine, chlorine and R is hydrogen, C1-6 alkanoyl, benzoyl or -OCO-A-COOH wherein A is a carbon-to-carbon bond or a C1-6 hydrocarbon chain, or when R is -OCO-A-COOH, the physiologically acceptable...
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JPH0124159B2 |
A process for preparing 16 alpha -hydroxy-17 alpha -aminopregnane derivatives through the opening of the corresponding 16 alpha , 17 alpha -epoxides with amines. The use of the thus obtained compounds as intermediates in the synthesis of...
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JPH0123475B2 |
A process for preparing a DELTA 9(11)- and/or DELTA 16-unsaturated steroid comprises heating the corresponding steroid of the pregnane series substituted by 9 alpha -chloro- and/or 16 alpha -chloro- or 17 alpha -acyloxy, in an inert, apr...
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JPH0121840B2 |
New DELTA 1,3,5-3-chloro-pregnane derivatives of the general formula (I), (I) wherein X is hydrogen atom, acetyl group or a chloroacetyl group, and Y and Z represent hydrogen atom or a halogen atom, with the proviso that at least one of ...
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JPH0120876B2 |
1. Process for the manufacture of 12 alpha-hydroxysteroids of the general formula I see diagramm : EP0019162,P3,F1 in which X represents a hydrogen atom or a fluorine atom, R1 represents a hydrogen atom or a methyl group, and R2 represen...
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JPH0113719B2 |
This invention discloses a general process for the production of corticoids from androstenes. This invention provides an economically viable alternative synthesis of 17 alpha -hydroxyprogesterones and the corticoids.
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JPH0113718B2 |
This invention discloses a general process for the production of corticoids from androstenes. This invention provides an economically viable alternative synthesis of 17 alpha -hydroxyprogesterones and the corticoids.
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JPH0112758B2 |
What is disclosed is corticoid 17-(alkyl carbonates) of the formula as defined in the specification, which compounds can be used in veterinary therapy and human therapy, in the form of suspensions, ointments, creams, sprays and the like,...
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JPS6411036B2 |
A process for 9 alpha -debromination of 9 alpha -bromo-11 beta -hydroxy steroids without eliminating the 11 beta -hydroxyl group utilizing chromous chloride or chromous sulfate and thioglycolic acid.
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JPS6411038B2 |
The 17 alpha -monoesters and 17 alpha ,21-diesters of corticosteriods are well known and represent nowadays the most efficient group of anti-inflammatory compounds for topical application, having minimal systemic action.
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JPS6411037B2 |
NEW MATERIAL:Compounds of formula I (R1 is 1-10C alkyl, monohydroxy- 2-10C-alkyl; R2 is 1-10C alkyl, 3-8C cycloalkyl; R3 is H, alpha-OH, d-methyl; R4 is H, F, Cl; R5 is H, F, Cl; X is O, S; Z is carbonyl, beta-hydroxymethylene; the dotte...
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JPS6411039B2 |
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JPS649996B2 |
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JPS649320B2 |
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JPS6365678B2 |
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JPS6363555B2 |
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JPS6362516B2 |
The invention relates to a novel process for the preparation of pregnane derivatives of formula I, (I) wherein R1 stands for a methyl or an ethyl group, R2 represents a hydrogen atom or a methyl group, and X is a hydrogen atom or a formy...
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JPS6361000B2 |
In the prodn. of 11 beta-hydroxy-steroids of the pregnane series substd. in the 17 alpha-position by an acetal residue of the formula -3-CHR2-Or1 (I) (where R1 is alkyl opt. interrupted by an O-atom and R2 is H or alkyl; or R1+R2 is tetr...
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JPS6360036B2 |
This invention relates to novel 3,20-dioxo-1,4-pregnadiene-17 alpha -ol 17-aromatic heterocyclic carboxylates, to pharmaceutical formulations thereof, and their use in the treatment and control of inflammatory conditions.
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JPS6360034B2 |
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JPS63277694A |
NEW MATERIAL:A compound of the formula [W, X form >W-X such as carbonyl or β-hydroxyl; Y, Z form -Y-Z such as -PPSe)CH-CH2-(PP is phenyl, 2-pyridyl), -CH=CH-, -CBr=CH-, OR1, OR2 are acyloxy, sulfate ester or phosphate ester]. USE: A syn...
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JPS6357436B2 |
1. 9-chloroprednisolone derivatives of the general formula I see diagramm : EP0023713,P4,F1 in which R1 represents a 1-oxoalkyl group containing from 2 to 5 carbon atoms.
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JPS6356235B2 |
A process for preparing a 6-methylene- DELTA 4-3-keto steroid of the formula wherein R is hydrogen, alkoxy of up to 6 carbon atoms or acyloxy of up to 6 carbon atoms wherein the acyl group is that of a carboxylic acid, and R' is the CD-r...
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JPS6352631B2 |
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JPS6352637B2 |
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JPS6352640B2 |
A process for preparing an 11-keto steroid consists essentially of heating the corresponding 9 alpha -halo-11 beta -hydroxy steroid, to 180 DEG -350 DEG C. in an inert, aprotic, high-boiling solvent.
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JPS6350000B2 |
A steroid of the formula in which @ is a single or double bond is manufactured by fermenting at pH 6 to 8 a sterol containing a free hydroxyl group in the 3-position or a corresponding compound containing another oxygen- containing funct...
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JPS63201197A |
11 beta -substituted steroids of the formula wherein A and B together represent a second bond between the 6-position and 7-position carbon atoms, or, respectively, are each H; X is O, two H atoms or hydroximino; Z is the residue of a pen...
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JPS63196598A |
NEW MATERIAL:A compound expressed by formula I (R is formula IIWIV). EXAMPLE: (11β,17-Dihydroxy-3,20-dioxo-1,4-pregnadien-21-yl) 1-(4-chlorobenzoyl)-5- methoxy-2-methylindole-3-acetate. USE: An anti-inflammatory agent having powerful an...
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JPS6340198B2 |
17-Keto steroids (I) in their protected form (IIa or IIb) are reacted with a metalated olefin (VI) to give a 21-aldehyde (IV) which is readily transformed to a 16-unsaturated pregnane (V) which is useful in the production of commercially...
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JPS63190897A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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