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JPS63280095A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS63280094A |
3-Methylene-4-androsten-17-ones of the general formula I in which Ra is a hydrogen atom or a saturated or unsaturated, straight-chain or branched, optionally substituted alkyl radical with 1 - 6 carbon atoms, where Ra is in the alpha or ...
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JPS63280096A |
2 beta ,16 beta -diamino-3 alpha ,17 alpha -oxygenated androstanes having one quaternized group, process for the preparation of these compounds and pharmaceutical compositions comprising such compounds as the active ingredient. The afore...
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JPS6357438B2 |
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JPS63267722A |
PURPOSE: To obtain anti-obesity agent effective for human and animal obesity and preventing obesity, comprising dehydroepiandrosterone or a derivative thereof as an active ingredient. CONSTITUTION: An anti-obesity agent containing dehydr...
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JPS6352636B2 |
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JPS6350360B2 |
Fusidinic acid derivs. of formula (I) and their pharmaceutically acceptable salts and easily hydrolysable esters are new: (C24 and C25 are joined by a single or double bond, Q1 and Q2 are H HO or O. A=O, S or SO. R1 = opt. branched 1-8C ...
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JPS63233998A |
Use of fluticasone propionate in the treatment of bowel diseases when administered by the oral, stomal or rectal routes.
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JPS63233997A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS63222196A |
1-Methyl-15 alpha -(1-oxyalkyl)androsta-1,4-diene-3,17-diones of general Formula I (I) wherein R1 is a hydrogen atom or an acyl group of 1-10 carbon atoms, R2 is an OR4, NHR5 or an S(O)nR6 group, R4 being straight- or branched-chain alky...
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JPS63215695A |
NEW MATERIAL:A compound expressed by formula I (R1 and R2 are H or 1W6C alkyl; R3 is H, acetyl, 1W6C alkyl, 2W5C alkoxycarbonyl or 1W3C alkylthio; X is H or halogen; the dotted line, as necessary, indicates double bond). EXAMPLE: Desonid...
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JPS63201197A |
11 beta -substituted steroids of the formula wherein A and B together represent a second bond between the 6-position and 7-position carbon atoms, or, respectively, are each H; X is O, two H atoms or hydroximino; Z is the residue of a pen...
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JPS63196556A |
NEW MATERIAL:The compound of formula I (R1 is methyl or trifluoromethyl; R2 is trifluoromethyl when R1 is methyl or R2 is methyl when R1 is trifluoromethyl). EXAMPLE: 26,26,26,27,27,27-Hexafluoro-25-hydroxyvitamin D3. USE: Useful as a dr...
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JPS63192800A |
4-Aza-5-alpha-8(14)-17 substituted-androsten-3-ones having an 8(14), 7(8), or 16(17) double bond, optionally also having a 1(2) double bond, processes for their preparation, pharmaceutical compositions contaning them and their use in the...
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JPS6340198B2 |
17-Keto steroids (I) in their protected form (IIa or IIb) are reacted with a metalated olefin (VI) to give a 21-aldehyde (IV) which is readily transformed to a 16-unsaturated pregnane (V) which is useful in the production of commercially...
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JPS63501949A |
A process for producing 7 alpha -acetylsteroids having the formula (I), in which R1, R2, R3 and R4 are hydrogen or (a) is the group (b) and (c) is the group (d). The process is characterized by the fact that a 3-oxo-17 alpha -pregna-4,6-...
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JPS6337798B2 |
The present invention relates to novel 21-alkylated steroids of the pregnane series having the formula: wherein R1=alkyl (1-4 C); R2=carboxyacyl (1-18 C); X=H, F or Cl; Y=O, H(OH), H(lower acyloxy), H(F) or H(Cl) with the proviso that Y ...
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JPS6337799B2 |
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JPS63179890A |
PURPOSE: To efficiently obtain the titled steroid, capable of linking to a carrier, e.g. peptides, etc., and useful for immunoassay, e.g. various hormones, etc., by subjecting a 4-ene-3-oxosteroid to specific reaction steps. CONSTITUTION...
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JPS6337120B2 |
Compounds of the formula (I) wherein R1 represents a fluoro-, chloro- or bromo-methyl group or a 2'-fluoroethyl group, R2 represents a group COR6 where R6 is a C1-3 alkyl group or OR2 and R3 together form a 16 alpha ,17 alpha -isopropyli...
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JPS63145232A |
The present invention relates to a group of compounds of steroidal structure, favourably interfering in alterations of metabolism of cholesterol, and prepared in the form of pharmaceutical compositions with controlled and time-delayed re...
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JPS6383095A |
The invention relates to 4-substituted 6-alkylidenandrostene-3,17-dione derivatives of the following formula wherein each of R1, R2 and R3 is, independently, hydrogen or C1-C6 alkyl; R4 is hydrogen or fluorine; (x) represents a single or...
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JPS6360995A |
NEW MATERIAL:A compound expressed by formula I [R1 represents 1W6C alkyl, 5W6C cycloalkyl, phenyl, (substituted) benzyl or 2W6C alkanoyl; R2 represents H; R3 represents CH3 or links with R2 to form lower alkylidenedioxy; X represents hal...
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JPS6345294A |
NEW MATERIAL:The compound of formula I [R is CH3, CH2SCN, CH2SC(=S) OR' (R' is lower alkyl), etc.; X is SCN, N3, SCH2CH2X' (X is OH, acyloxy, N3 halogen or SCN), lower alkynyl or lower alkynyloxy; dotted line represents the presence or a...
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JPS634560B2 |
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JPS631958B2 |
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JPS631959B2 |
A 7 alpha -acylthio-4-en-3-oxosteroid such as 7 alpha -acetylthio-17-hydroxy-3-oxo-17 alpha -pregn-4-ene-21-carboxylic acid gamma -lactone (spironolactone) which is an antialdosteronic diuretic effective in therapy is prepared by contact...
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JPS6257638B2 |
Novel 11 beta -substituted- DELTA 1,3,5(10)-estratrienes of the formula I wherein R1 is selected from the group consisting of optionally substituted unsaturated alkyl of 2 to 8 carbon atoms, optionally substituted aryl of 6 to 12 carbon ...
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JPS62273994A |
A method of preparation of halogen labeled organic compounds is described. In particular, estradiol derivatives labeled by halogen substitution at C-16 are synthesized according to the present invention. A triflate intermediate is prepar...
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JPS6252759B2 |
What is disclosed are steroid-21-halogeno-17-(alkyl carbonates), useful as medicaments for the treatment of inflammatory dermatoses, and a method for making them.
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JPS62240697A |
NEW MATERIAL:6α-[β-D-Galactopyranosyl-(1→4)-[β-D-fucopyrano
syl-(1→2)]β-D- glucopyranosyl-(1→4)-[β-D-quinovopyranosyl(1→2)]β-D-xy
lopyranosyl-(1→3)-β-D- quinovopyranosyl]-(20R, 22R, 23S, 24S)-22,23-epoxy-24-methyl-3β-su...
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JPS6238360B2 |
The present invention relates to a new series of fusidic acid derivatives, to salts and easily hydrolysable esters thereof, to the preparation of these compounds, and to pharmaceutical compositions containing the compounds, the new fusid...
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JPS6234040B2 |
Corticoid-21-sulphopropionate derivs. of formula (I) and their salts with pharmaceutically-acceptable bases are new: (St = steroid residue of an antiinflammatory corticoid; esp. it has formula (X = H, Cl, F or CH3; Y = H, F or Cl; Z = ox...
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JPS6228157B2 |
New and useful steroids of the pregnane series and compositions therefor are disclosed of the formula: (I) wherein R1 is selected from the group consisting of H, F, OH, and OR2, and R2 is carbacyl of one to eighteen carbon atoms, which s...
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JPS62135490A |
Described are derivatives of glycolipids with substituted steroids bridged via a medium length hydrocarbon chain to 1-thio-D-mannopyranoses or 1-thio-L-fucopyranoses. These compounds protect an immunocompromised human or animal host agai...
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JPS6228158B2 |
This invention discloses a general process for the production of corticoids from androstenes. This invention provides an economically viable alternative synthesis of 17 alpha -hydroxyprogesterones and the corticoids.
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JPS6227075B2 |
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JPS6227078B2 |
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JPS62501446A |
An immunoassay is provided for cholesterol epoxide. To prepare the antibodies used in the immunoassay, novel immunogens, are prepared which comprise a 3,5(6)-transdiaxial-dihydroxycholestane-6(5)-yl-hapten adduct linked to a covalently b...
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JPS6224432B2 |
New hexanor-brassinolid-22-ethers are disclosed, of the formula I wherein Z is the group OR2 and OR3 are oriented cis 2 alpha , 3 alpha or 2 beta , 3 beta , R2 and R3 are the same or different and are each hydrogen formyl, C2-C7-alkyl-CO...
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JPS6222998B2 |
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JPS6220998B2 |
2 alpha -Cyano-3-oxosteroids having a 4 alpha ,5 alpha -epoxy group and alkylated in the 4- and/or 6-position, useful as interceptive agents, are prepared by alkaline cleavage of the corresponding steroido[2,3-d]isoxazoles.
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JPS6220197B2 |
The novel compounds of the formula I, in which the substituents have the meaning indicated in Patent Claim 1, are prepared by esterifying a compound of the formula II with salicylic acid or acetylsalicylic acid. The novel compounds of th...
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JPS6214558B2 |
The present invention relates to pregnane derivatives of the formula wherein R1 and R3 are hydroxyl groups or readily cleavable etherified or esterified hydroxyl groups and R20 is hydroxymethyl or readily cleavable etherified or esterifi...
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JPS6214557B2 |
9 alpha ,21-Dihalo-11 beta ,17 alpha -dihydroxy-6 alpha -fluoro-16 alpha -methylpregna-1,4-diene -3,20-dione 17-esters of the formula in which X1 is chlorine or fluorine, X2 is bromine or chlorine, and Ac is an acyl group derived from a ...
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JPS6212237B2 |
A steroidal 7 alpha -acylthio-4-en-3-one is produced by adding a thiocarboxylic acid to a steroidal 4,6-dien-3-one in the presence of a strong acid in a neutral organic solvent.
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JPS6253960A |
NEW MATERIAL:A 24,24-difluoro-26,27-dimethylvitamin D3 derivative expressed by formula I (X is H or OH). EXAMPLE: 3β-24ζ-Dihydroxy-24-tris(methylthio)methylchol-5-ene. USE: A medicine, having osteogenetic action and useful for treating...
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JPS6210238B2 |
Novel 17-spirosultines of steroids and the corresponding gamma -hydroxy acids of the formula I wherein R1 is alkyl of 1 to 4 carbon atoms, A is hydrogen and B is hydrogen or hydroxyl of beta configuration or A and B together form a doubl...
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JPS6160080B2 |
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JPS6159640B2 |
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