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WO/1988/002753A2 |
New 9-alpha-hydroxy steroids are prepared by the introduction of substituents on the D-ring of 9-alpha-hydroxy-androst-4-ene-3,17-dione. The resulting compounds are useful intermediates in the synthesis of corticosteroids.
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WO/1988/001276A2 |
A process for producing (Z)-17alpha-halogenvinylsteroids having general formula (I), in which ..... represents a simple or a double bond, V represents a carbon-carbon bond or a methyl group, R1 is a hydrogen atom or a methyl group, X is ...
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WO/1988/001275A1 |
Agents having an oestrogenic activity, containing a compound of general formula (I), where R<1> represents a hydrogen atom, a methyl group or an acyl group with 1 to 12 carbon atoms, R<2> represents a hydrogen atom or an acyl group with ...
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WO/1988/000469A1 |
A method of providing hormonal replacement therapy and contraception for a pre-menopausal woman, which comprises administering to a pre-menopausal woman in need thereof a combination dosage form of an estrogen selected from 0.5-2.0 mg of...
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WO/1988/000202A1 |
Compounds obtained from the associative synthesis of sulfur-containig or sulfur-free amino-acids with derivatives of DELTA-4 pregnene 3,20-dione or with derivatives of DELTA-1,4 pregnadiene 3,20-dione having the general formulae (I), (II...
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WO/1987/007895A1 |
Androstane-type aminoesters (IV) and cortical aminoesters (VIII), more particularly 17-aminoesters (I), 11,17-diaminoesters (II), 3,17-diaminoesters (III), 21-aminoesters (V), 11-aminoesters (VI), and 3-aminoesters (VII) which are useful...
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WO/1987/006937A1 |
2,2;6,6-diethylene-3-oxo-17alpha-pregn-4-en-21,17-carbolacto
nes of general formula (I), wherein R1 is a hydrogen atom or a methyl group, R2 is a methyl or ethyl group and (II), (III) or (IV), as well as process for their production, and...
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WO/1987/006237A1 |
A process is used for producing 7alpha-propylsteroids having general formula (I), wherein R1 is a beta-hydroxy group and R2 is hydrogen or a alpha linked -CH2-CH2COOR5 residue, R1 and R2 form together the residue (A), R3 and R4 are hydro...
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WO/1987/005908A1 |
Products having the formula (I) wherein R1 is an aryl or aralkyl, R2 is a hydrocarbonated radical (1-18 carbon atoms), the dotted lines indicate an optional bond, the cycles A, B and C represent (II), (III), (IV), (V), (VI); R' and R'' a...
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WO/1987/005028A1 |
Compounds of formula (I), wherein one X is COOR, CH2COOR, CH(COOR)2, CONHR, CH2CONHR, or CN; remaining X's are H, F, CH3, OH, COOR, CH2COOR, CH(COOR)2, CONHR, CH2CONHR, or CN; Y is (i1), (i2), (i3), (i4), or (i5); R is H, alkyl of 1-5 ca...
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WO/1987/004166A1 |
Compounds (I) (either R1 = OH, C1-C4 alkoxy and R2 = H, C1-C4 alkyl, or R1 + R2 = a chemical bond; R3 = an aminodeoxy or aminodideoxy or aminotrideoxy sugar residue of the D and L series, the glycosidic linkage being alpha or beta: and e...
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WO/1987/004168A1 |
Compounds of formula (I), ADR1 = H or C1-C3 alkyl, R2 = an (alkyl-substituted) aminodeoxy or aminodideoxy or aminotrideoxy sugar residue of the D and L series, the glycosidic linkage being alpha or beta BD and their pharmaceutically acce...
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WO1987004167A2 |
Compounds of formula (I) (either R1 = OH, C1-C4 alkoxy and R2 = H, C1-C4 alkyl, or R1 + R2 = a chemical bond; R3 = an aminodeoxy or aminodideoxy or aminotrideoxy sugar residue of the D and L series, the glycosidic linkage being alpha or ...
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WO/1987/003599A1 |
A process for producing 7alpha-acetylsteroids having the formula (I), in which R1, R2, R3 and R4 are hydrogen or (a) is the group (b) and (c) is the group (d). The process is characterized by the fact that a 3-oxo-17alpha-pregna-4,6-dien...
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WO/1987/003620A1 |
Process for manufacturing 4-androstene-3,17 dion and 1,4 androstadiene-3,17-dion of the general formula (I) where ..... is a simple bond or a double bond, characterized by the fact that alpha-sitosterine of formula (II) is fermented with...
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WO/1987/002672A1 |
Novel tetrahydro steroids which are useful in inhibiting angiogenesis and have the following structure: A compound of formula (I), wherein R15 is = O or -OH; wherein R23 with R10 forms a cyclic phosphate of formula (II) or wherein R23 is...
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WO/1987/001705A1 |
New derivative of vitamin D3, 26,26,26,27,27-pentafluoro-1alpha-hydroxy-27-methoxy-choleca
lciferol and a process for preparing the same. The compound is characterized by some vitamin D-like activity except that it exhibits negligible ac...
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WO/1987/000175A1 |
9alpha, 11beta and 11beta-susbstituted estranes which exhibit elevated estrogenic and postcoital contraceptive activities. A process for their manufacture and their use in pharmaceuticals is also disclosed.
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WO/1986/007385A1 |
Process for the preparation of 4-androstene-3,17-dione and of 1,4-androstadiene-3,17-dione having the formula (I) wherein ..... represents a single bond or a double bond, characterized in that ergosterol of formula (II) is fermented with...
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WO/1986/006078A1 |
The claims cover skin treatment agents which are characterized by the fact that as active ingredients they contain one or two 17beta-methyl-18-norsteroids of the general formula (I), in which ..... represents a simple link or a double li...
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WO/1986/005813A1 |
A process for producing 1-methyl-1,4-androstadiene-3,17-dione characterized by the fact that 1-methyl-5alpha-androst-1-ene-3,17-dione (Metenolon) is fermented with a micro-organism culture of the genera Norcardia, Mycobacterim or Fusarium.
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WO/1986/004893A1 |
Preparation of alkyl fluorides by replacement of an aliphatic hydroxy group with fluorine. The reaction is performed by treating a sulfonyl derivative of an aliphatic hydroxy group with an inorganic fluoride in a polyglycol.
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WO/1986/004900A1 |
New 1alpha.7alpha-dithio substituted spirolactones having the general formula (I) wherein R1 is C1-3-alkyl and C1-3-acyl and R2 is hydrogen, C1-3-alkyl and C1-3-acyl, preparation thereof and utilization thereof as drug. The compounds hav...
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WO/1986/004333A1 |
Production of 26-homo Vitamin D-3 derivatives and intermediates in the production thereof. These compounds express excellent Vitamin-D like activity and could serve in the treatment of various disease states manifesting calcium and phosp...
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WO/1986/003750A1 |
A method for preparing a stable aerosol formulation of beclomethasone dipropionate in which the steroid is contacted with an alcohol containing 1 to 5 carbon atoms to form a crystalline solvate therewith, the crystalline material so form...
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WO/1986/002078A1 |
New 24-homo-vitamin D compounds, methods for preparing the same and novel intermediate compounds. The compounds are characterized by vitamin D-like activity of the order of 1alpha,25-dihydroxyvitamin D3, the recognized circulating hormon...
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WO/1986/001502A1 |
A process for the production of amino compounds from hydroxyl compounds (Voelter reaction), according to which a hydroxyl compound is converted with trifluormethanesulphonic acid anhydride in water-free conditions, the corresponding trif...
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WO/1986/001208A1 |
Stereoisometrically pure DELTA2 compound of formula (I) wherein R1 is hydrogen or -(C=O)-R2, wherein R2 is an organic substituent selected from the group consisting of alkyls, alkenyls, alkynyls, cycloalkyls, cycloalkylalkylenes, haloalk...
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WO/1986/000907A1 |
A process for the manufacture of 6alpha-methyl steroids having general formula (I) in which X is a hydroxy group and Y a hydrogen atom, or X and Y are together a carbon-carbon bond and R1 is a cyano group, an acetyl group or an alkanoylo...
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WO/1986/000908A1 |
Derivatives of 11-desoxy-17alpha-oxicorticosterone of general formula (I) where R = -OC(CH2)nC6H4N(CH2CH2Cl)2, n = 1, 3, having antitumoral, hormonal and immunodepressive activity.
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WO/1986/000311A1 |
Derivatives of steroids of androstane series constituting compounds of a general formula (I); where R1 = -OCOCH2C6H4N(CH2CH2Cl)2; -OH; -O-; R2 = -OCO(CH2)n C6H4N (CH2CH2X)2, where n = 1,3; X = Cl, Br, J; -OH; -O-; formula (II); R3 = -CH3...
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WO/1986/000066A1 |
New butyramide derivatives corresponding to formula (I), wherein X and Y independently represent hydroxymethyl; cyano; carboxy; functionally modified carboxy selected from esterified carboxy, carbamoyl, and N-substituted carbamoyl; 5-tet...
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WO/1985/005622A1 |
New derivatives of vitamin D3 and specifically (22E,24R)-1,24-dihydroxy-DELTA22-vitamin D3 and (22E,24S)-1,24-dihydroxy-DELTA22-vitamin D3. The compounds exhibit vitamin D-like activity in their ability to stimulate intestinal calcium tr...
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WO/1985/005270A1 |
A pharmaceutical formulation for use in treating female scalp loss which comprises cyproterone acetate (a metabolite, analogue or derivative thereof) and at least one oestrogen wherein when prepared in unit dosage form the formulation is...
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WO/1985/005361A1 |
Novel compounds having the general formula (I), wherein: R1 is hydrogen or an acyl substitutent of formula -(C=O)-R2, wherein: R2 is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkylene, haloalkyl, aryl, haloaryl or arylalkylene. T...
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WO/1985/005272A1 |
A pharmaceutical formulation for use in treating female scalp hair loss or in hormonal replacement therapy which comprises medroxyprogesterone acetate or its pharmacologically-active equivalent and at least one oestrogen, wherein when pr...
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WO/1985/003299A1 |
Novel 1-hydroxylated vitamin D compounds containing a 22, 23-cis double bond in the side chain. The compounds are characterized by an unexpectedly high binding affinity for the protein receptor forecasting their ready applicability as su...
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WO/1985/003300A1 |
Novel vitamin D derivative, 1alpha,25-dihydroxy-22Z-dehydrovitamin D2. The compound is characterized by unexpectedly high ability to raise serum calcium levels. The compound could therefore, find ready application as a substitute for vit...
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WO/1985/000818A1 |
New derivative of vitamin D, 23,23-difluoro-25-hydroxycholecalciferol, a method for preparing said compound and various new intermediates utilized in such process. The compound is characterized by vitamin D-like activity as evidenced by ...
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WO/1985/000609A1 |
Novel steroids having formula (I), wherein, R1 is selected from the group consisting of methyl, ethyl, and propyl; R2 is selected from the group consisting of H and methyl; R3 is selected from the group consisting of OXO and H(OR5);$(12,...
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WO/1984/003094A1 |
In a process for reacting sodium with a polycyclic aromatic compound in a reaction solvent to prepare a radical anion, and introducing androsta-1,4-diene-3,17-dione-17-acetal into the obtained reaction mixture to reduce it to estrone ace...
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WO/1984/001155A1 |
Hydroxylated derivatives of vitamin D2., processes for preparing such compounds, intermediates utilized in such processes and certain isotopically labelled vitamin D2 compounds. The vitamin D2 derivatives would find application in the tr...
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WO/1983/003604A1 |
Process for preparing substitued polycyclo-alkylidene polycyclo-alkanes, such as substituted adamantylidene adamantanes, and the corresponding epidioxy compounds, in which polycyclo-alkylidene polycyclo-alkanes are halogenated with an N-...
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WO/1983/003414A1 |
The esters are represented by the formula (I), wherein R1 and R2, which may be the same or different, are the rest of an amino acid, from the carbon atom in the beta position (if it is present), R3 is the rest of a steroid or of a pharma...
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WO/1983/003099A1 |
The invention relates to products having the general formula I, wherein R1 is thienyl or phenyl optionally substituted, furyl, cycloalkyl, naphtyl, phenyl-phenyl, alkyl or alkenyl; R2 is methyl or ethyl; R3 is H, OH, alkyl, alkenyl, opti...
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WO/1983/000694A1 |
A nondenaturing zwitterionic detergent for proteins which, for example, consists of an effective amount of 3- AD(3-cholamidopropyl)dimethylammonio BD-1-propanesulfonate (CHAPS). This detergent is of extreme interest in the biological stu...
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WO/1983/000335A1 |
New derivative of vitamin D, 26,26,26,27,27,27-hexafluoro-1alpha,25-dihydroxycholecalcife
rol, a process for preparing the same, and novel intermediate compounds. The compound is characterized by vitamin D-like activity substantially gre...
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WO/1982/000465A1 |
Methods for preparing the various isomeric forms of 25-hydroxyvitamin D3-26, 23-lactone utilizing cyanohydrin formation with readily prepared steroid materials followed by actinic radiation of the products and recovery of the desired 25-...
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WO/1982/000294A1 |
5(Beta)-hydroxy-(Alpha)6-steroid derivatives having the general formula (FORMULA) wherein R1 represents a hydrogen atom, an acyl, lower alkyl or tetrahydropyranyl residue and R2, R3 each a hydrogen atom or in common a methylene residue a...
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WO/1981/002427A1 |
Process for the fermentation of bile which includes the step of cultivating one or more aerobic microorganisms which have the ability to selectively degrade bile acids or bile acid conjugates contained in bile. The fermentation is carrie...
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