Heterocyclic Compounds

Matches 51 - 100 out of 5,408	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >

Document	Document Title
WO/2004/069846A1	PYRIMIDINES, METHODS FOR THE PRODUCTION THEREOF, AND USE THEREOF The invention relates to pyrimidines of formula (I), wherein Ln have the meaning indicated in the description while the substituents R1, R2, and R3 have the following meaning: R1 represents C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkinyl, C...
WO/2004/067537A1	TRIAZOLE DERIVATIVES AND ANTIFUNGAL AGENTS CONTAINING THE SAME It is intended to provide a compound represented by the following general formula (I) (wherein n represents an integer of 0 or 1; R1 represents hydrogen or alkyl; and A represents an optionally substituted imidazo[2,1-b]thiazole ring) or...
WO/2004/065381A1	PROCESS FOR MAKING ONDANSETRON AND INTERMEDIATES THEREOF The invention relates to a process for producing a compound of formula (I), wherein a carbazolone of formula II, formaldehyde or a formaldehyde precursor, an amine of formula III or a salt thereof wherein R1 and R2 each independently rep...
WO/2004/064764A2	SUBSTITUTED ALKYL AMIDO PIPERIDINES This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compou...
WO/2004/062609A2	PYRIMIDINE DERIVATIVES AS IL-8 RECEPTOR ANTAGONISTS Compounds containing the pyrimidine nucleus and their use to treat diseases and conditions related to inappropriate Interleukin-8 receptor activity are disclosed. The compounds are of the formula (I). In these compounds, Q is preferably ...
WO/2004/060870A1	NOVEL CB 1 RECEPTOUR INVERSE AGONISTS The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, m and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment . a...
WO/2004/060894A1	PYRROLO&grave 2,1-C!&grave 1,4! BENZODIAZEPINES AS VASOPRESSIN AGONISTS Novel compounds of Formula (I) (I) and pharmaceutically acceptable salts thereof, and pharmaceutical formulations containing such compounds which are useful as anti-aquaretic agents in the treatment of nocturnal urinary enuresis, nocturn...
WO/2004/056784A1	NOVEL CARBOXAMIDES, THE PRODUCTION AND USE THEREOF AS MEDICAMENTS The invention relates to novel substituted carboxamides of general formula (I), in which A, B and R1 to R5 are as defined in claim 1, the tautomers, enantiomers, diastereomers, mixtures and salts thereof, in particular the physiologicall...
WO/2004/054983A2	1-N-PHENYLAMINO-1H-IMIDAZOLE DERIVATIVES AS AROMATASE INHIBITORS The present invention relates to imidazole derivatives of the formula: (I) in which R1, R2, R3, R4, R5, R6 and n are as defined in the specification.The invention also relates to pharmaceutical compositions containing these derivatives, ...
WO/2004/054991A1	IONIC LIQUIDS COMPRISING [N(CF3)2]- ANIONS The invention relates to salts consisting of bis(trifluoromethyl)imide anions and saturated, or partially or fully unsaturated heterocyclic cations, to a method for their production and to their use in ionic liquids.
WO/2004/050610A2	MODULATORS OF MELANOCORTIN RECEPTOR This invention provides compounds and methods for treating melanocortin receptor associated disorders, such as weight loss disorders including cachexia resulting from cancer and other chronic illnesses. The compounds are represented by f...
WO/2004/048335A2	MANDELIC ACID DERIVATIVES The invention is concerned with novel mandelic acid derivatives of formula (I), wherein R1 to R10, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit ...
WO2003062388A9	INHIBITION OF RNA FUNCTION Inhibition of RNA function, and treatment or control of associated diseases or conditions, e.g. infectious diseases such as viruses and viral infections (including HIV) and microbial infections, is inhibited by the use contacting of the ...
WO2004014885B1	AMINO BENZOTHIAZOLE COMPOUNDS WITH NOS INHIBITORY ACTIVITY The present invention provides novel amino benzothiazole compounds, compositions comprising these compounds and methods of using these compounds as neuroprotectants. In particular, the compounds described in the present invention are use...
WO/2004/035567A1	HIGH PURITY ONDANSETRON HYDROCHLORIDE DIHYDRATE AND PROCESS FOR ITS SYNTHESIS The invention relates to high purity ondansetron hydrochloride dihydrate containing not more than 0.10 w/w % chemical impurities as well as to the process for its synthesis.
WO/2004/031401A2	NOVEL TYROSINE KINASES INHIBITORS The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit tyrosine kinase enzymes thereby making them useful as anti-cancer agents.
WO/2004/026823A1	AMIDE AND SULFONAMIDE LIGANDS FOR THE ESTROGEN RECEPTOR The present invention provides estrogen receptor (ER) ligands of structural formula (I) the pharmaceutically acceptable salts, stereoisomers, and prodrugs thereof, and the pharmaceutically acceptable salts of the prodrugs, wherein R1, R2...
WO/2004/026866A1	N-AROYL CYCLIC AMINES AS OREXIN RECEPTOR ANTAGONISTS This invention relates to N-aroyl cyclic amine derivatives and their use as pharmaceuticals.
WO/2004/024699A1	BENZIMIDAZOLONES AND THEIR USE AS CYTOKINE INHIBITORS Disclosed are benzimidazolone compounds of formulas (II) wherein X is O, S or NR5. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions inv...
WO/2004/024691A1	COX-2 INHIBITING PYRIDINE DERIVATIVES Compounds of formula (I) or pharmaceutically acceptable salts thereof are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever and inflammation of a variety of conditions and diseases.
WO/2004/020414A1	OXYTOCIN INHIBITORS This invention relates to compounds of formula (I).
WO/2004/018486A1	AZOLE DERIVATIVES AS ANTIFUNGAL AGENTS The present invention relates to novel azole derivatives of Formula I, as potential antifungal agents.This invention also relates to pharmaceutical compositions containing the compounds of the present invention and their use in treating ...
WO/2004/018485A1	AZOLE DERIVATIVES AS ANTIFUNGAL AGENTS The present invention relates to novel azole derivatives of Formula (I), as potential antifungal agents. This invention also relates to pharmaceutical compositions containing the compounds of the present invention and their use in treati...
WO/2004/018455A1	PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 New pyrrole based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the...
WO/2004/018436A2	COMPOUNDS DERIVED FROM ARYL CARBAMATES, PREPARATION THEREOF AND USES OF SAME The invention relates to novel compounds, the preparation thereof and the uses, particularly therapeutic, of same. More specifically, the invention relates to compounds derived from aryl carbamates, the preparation thereof and the uses o...
WO2002083067A9	PRODRUGS VIA ACYLATION WITH CINNAMATE A prodrug composition containing a cinnamate moiety and a biologically active molecule moiety which can be released by hydrolysis or activated by light is disclosed. The cinnamate moiety can have substituents of various electronically do...
WO2002098424B1	NOVEL ANTI-INFECTIVES Compounds useful as HCV anti-infectives having the formula: wherein the formula variables are as defined herein, are disclosed. Also disclosed are methods of making and using the same.
WO/2004/014877A1	PROCESS FOR PREPARING RIZATRIPTAN In particular, rizatriptan or a pharmaceutically acceptable salt thereof, which includes a) Preparation of the diazonium salt of the aniline hydrochloride (II); followed by reduction and acidification to give the hydrazine (III); b) reac...
WO/2004/014377A1	4-HYDROXYQUINOLINE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS This invention provides compounds defined by Formula I or a pharmaceutically acceptable salt thereof, wherein R1, Q, Y3, Y4, U5, U6, U8, R2, and R3 are as defined in the specification. The invention also provides pharmaceutical compositi...
WO/2004/014870A1	FLUORINATED PHENYL-NAPHTHALENYL-UREA COMPOUNDS AS INHIBITORS OF CYTOKINES INVOLVED IN INFLAMMATORY PROCESSES Disclosed are compounds of formula (I) wherein R1, R2, W and X of formula (I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological...
WO/2004/014381A2	MATRIX METALLOPROTEINASE INHIBITORS AND METHODS FOR IDENTIFICATION OF LEAD COMPOUNDS The invention relates to compounds that are selective inhibitors of matrix metalloproteinases, to pharmaceutical compositions containing them and to their use in the prevention and/or treatment of MMP-associated diseases. The invention a...
WO/2004/014378A1	3-ISOQUINOLINONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIITORS This invention provides compounds defined by Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, Q, R2, R3, R4, and n are as defined in the specification. The invention also provides pharmaceutical compositions compris...
WO/2004/014869A2	5,6-FUSED 3,4-DIHYDROPYRIMIDINE-2-ONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS This invention provides compounds defined by Formula I or a pharmaceuticafy acceptable salt theme, wherein R1, Q, Y3, Y4, Y5, Y6, Y8, R2, and R4 are as defined in the specification. The invention also provides pharmaceutical compositions...
WO/2004/014892A1	MONOCYCLIC DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS This invention provides compounds defined by Formula (I) or a pharmaceutically acceptable salt thereof, wherein R', Q, D, V', m, and R2 are as defined in the specification. The invention also provides pharmaceutical compositions comprisi...
WO2003060078A9	HETROCYCLIC MODULATORS OF NUCLEAR RECEPTORS Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of farnesoid X receptor (FXR), liver X receptor (LXR) and/o...
WO/2004/014365A1	PHTHALIMIDE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS This invention provides compounds defined by Formula I or a pharmaceutically acceptable salt thereof, wherein Rl, Q, Y1, Y3, Y5, Y6, Y8, and RZ are as defined in the specification. The invention also provides pharmaceutical compositions ...
WO/2004/014865A1	PHENYLPYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS A class of 4-phenylpyridazine derivatives of Formula (I), being selective ligands for GABAA receptors, in particular having high affinity for the &agr 2 and/or &agr 3 and or &agr 5 subunit thereof, are accordingly of benefit in the treat...
WO/2004/014867A2	MATRIX METALLOPROTEINASE INHIBITORS AND METHODS FOR IDENTIFICATION OF LEAD COMPOUNDS The invention relates to compounds that are selective inhibitors of matrix metalloproteinases, to pharmaceutical compositions containing them and to their use in the prevention and/or treatment of MMP-associated diseases. The invention a...
WO/2004/014366A1	HETERO BIARYL DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS This invention provides compounds defined by Formula I or a pharmaceutically acceptable salt thereof, wherein Rl, Q, S, T, U, V, and R2 are as defined in the specification. The invention also provides pharmaceutical compositions comprisi...
WO/2004/014379A1	ISOQUINOLINE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS This invention provides compounds defined by Formula I or a pharmaceutically acceptable salt thereof, wherein R1, Q, Y, R2, R3, R4, R5, and n are as defined in the specification ás MMP-13 enzyme inhibitors. The invention also provides p...
WO/2004/013135A1	2-PHENYLPYRIDIN-4-YL DERIVATIVES AS ALK5 INHIBITORS This invention relates to novel 2-phenylpyridin-4-yl heterocyclyl derivatives which are inhibitors of the transforming growth factor, ('TGF')-ß signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type ...
WO/2004/011410A1	CHEMICAL COMPOUNDS Compounds of formula (I):wherein variable groups are as defined within; for use in the inhibition of 11$g(b)HSD1 are described.
WO/2004/011436A1	QUINOLINE DERIVATIVES AND THEIR USE AS MYCOBACTERIAL INHIBITORS The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or the general Formula (Ib), the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeri...
WO/2004/011460A2	PYRAZOLYLBENZOTHIAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of formula (I): wherein R1, R2 and R3 at each occurrence are independently selected from amino, aminosulfinyl, aminosulfonyl, aryl, azido, hal...
WO/2004/011399A1	IONIC LIQUID OSMIUM OXIDE A novel ionic liquid osmium oxide usable safely on an industrial scale and reusable which is osmium oxide dissolved in a solution of a compound represented by the general formula [1]: [1] (wherein R1 and R2 each independently represents ...
WO/2004/011437A1	NOVEL IMIDAZOLE ALCOHOL COMPOUND, PROCESS FOR PRODUCING THE SAME, AND SURFACE-TREATING AGENT COMPRISING THE SAME A novel imidazole alcohol compound which is strongly adsorbed onto the surface of metals, especially copper, aluminum, and steel products, and which has an excellent rust-preventive effect even in a thin film form; and a surface-treating...
WO/2004/007469A1	NEW ALKYNYLATED QUINAZOLIN COMPOUNDS AS MMP-13 INHIBITORS A compound selected from those of formula (I) wherein W¿1? represents O, S, or -NR¿3? in which R¿3? represents hydrogen, alkyl, OH or CN; W¿2? represents a group selected from hydrogen, CF¿3?, NH¿2?, monoalkylamino, dialkylamino, a...
WO/2004/007455A1	HETEROCYCLICALLY SUBSTITUTED BENZOYLUREAS, METHOD FOR THEIR PRODUCTION AND THEIR USE AS MEDICAMENTS The invention relates to heterocyclically substituted benzoylureas, in addition to their physiologically compatible salts and physiologically functional derivatives. The invention relates in particular to compounds of formula (I), in whi...
WO/2004/005249A1	PYRROLIDINE DERIVATIVES AS OXYTOCIN ANTAGONISTS The present invention relates to novel pyrrolidine derivative of formula (I), its geometrical isomers, its optically active forms as enantiomers, diastereomers, mixtures of these and its racemate forms, as well as salts thereof, wherein ...
WO/2004/002985A1	PEPTIDIC THROMBIN INHIBITOR COMPOUND The present invention relates to a novel thrombin inhibitor compound which has a good inhibitory effect against thrombosis and can be orally administered, a process for preparing the same, and to a composition for the therapeutic and/or ...

Matches 51 - 100 out of 5,408	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >