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JP2005336088A |
To provide a new bioactive substance having activities for inhibiting MRSA and VRE.The thiazole-based compound is represented by formula A (wherein, R is a group represented by formula B or an amino group). The compound has the anti-MRSA...
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JP2005523275A |
The present invention provides compounds of formula: wherein R a and R b together with the carbon to which they are attached form a group of formula: where each X 1 is independently selected from hydrogen or substituted or unsubstituted ...
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JP2005517227A |
A crystalline composition comprising a crystal of the IL-6 receptor I chain is provided. Also provided are methods of using the crystal and related structural information to screen for and design compounds that interact with IL-6R, or va...
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JP2005514387A |
Provided are new crystalline Forms III, IV, V and VI of clopidogrel hydrogensulfate and the amorphous form of clopidogrel hydrogensulfate, as well as their pharmaceutical compositions, and method of treatments with such compositions. Als...
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JP2005509650A |
Improved dosing schedules for ecteinascidin 743 are given for treatment of cancer.
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JP2005508898A |
The invention relates to novel substituted, annelated indole and heteroindole derivatives of general formula (I), to tautomers, stereoisomers, mixtures and pharmaceutically acceptable salts thereof and to the production and use thereof a...
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JP2004526676A |
This invention is directed to macroheterocyclic compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
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JP2003508535A |
The present invention is directed to macrocyclic compounds which inhibit prenyl-protein transferase (FTase) and the prenylation of the oncogene protein Ras. The invention is further directed to chemothera-peutic compositions containing t...
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JP2003012953A |
To provide a method capable of efficiently preparing an azomethine colorant without the necessity for heat.This method for preparing an azomethine colorant comprises exposing an azomethine colorant precursor represented by general formul...
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JP2002544231A |
ET743 is used in the preparation of a medicament for the treatment of the human body for cancer,
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JP2002544231A5 |
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JP2002520365A |
Novel thiazolyl peptide antibiotic compounds, including nocathiacin I, II and III, are disclosed. Also, novel microorganism ATCC-202099 is disclosed.
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JP2002519376A |
The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions contai...
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JP2002519427A |
The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions contai...
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JP2002517502A |
The current invention relates to compounds of Formula Ipharmaceutical compositions and methods of use as nitric oxide synthase inhibitors, wherein the substituents are defined in the application.
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JP2002517502A5 |
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JP3226920B2 |
PCT No. PCT/FR92/00392 Sec. 371 Date Dec. 27, 1993 Sec. 102(e) Date Dec. 27, 1993 PCT Filed Apr. 30, 1992 PCT Pub. No. WO92/19613 PCT Pub. Date Nov. 12, 1992.The present invention relates to therapeutic compositions based on compounds ch...
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JP3098029B2 |
Ecteinascidins 722 and 736 (Et's 722 and 736) have been isolated from the Caribbean tunicate Ecteinascidia turbinata and their structures have been assigned as tetrahydro- beta -carboline-substituted bis(tetrahydro- isoquinolines) relate...
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JP2000007565A |
To obtain an antibiotic exhibiting an excellent antitumor action against solid tumor and multiple medicine-resistant tumor and capable of being used for cancer chemotherapy by compounding a specific compound (salt) as an active ingredien...
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JP2950795B2 |
The invention is concerned with a new process for the preparation of compounds of formula wherein R<1> is trityl, acetyl, tetrahydropyranyl or cyclopentyl; R<2> is hydrogen, hydroxy, lower alkyl, cycloalkyl, lower alkoxy, lower alkenyl, ...
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JPH10508036A |
Novel macrocyclic compounds are constructed to include large cyclic structures that are interrupted by at least one ring system. Each interrupting ring system includes two bridgehead atoms. Bridgehead atoms are bonded to one or more brid...
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JPH09512549A |
The invention relates to antimicrobial 5-(N-heterosubstituted amino) quinolone compounds having a structure according to Formula (I) or (II): (I) (II) wherein (1) R1, R2, R3, R9 and R10 form any of a variety of quinolone and related hete...
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JP2569455B2 |
PURPOSE: To efficiently obtain the subject derivative useful as a synthetic intermediate, etc., for antimicrobial agents according to simple operation by treating a specific azathiazabicycloalkane compound (salt) with a base in the prese...
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JP2562162B2 |
Novel compounds ecteinascidins 729, 743, 745, 759A, 759B, and 770 having antibacterial and antitumor properties.
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JPH08269058A |
To obtain a piperidine derivative useful in the treatment and prevention of disorders involving 5-HT3, and 5-HT4 receptors, central nervous system disorders, dysgnosia, headache (including sick headache), digestive tract dysfunction, car...
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JP2531183B2 |
The compounds, having a 4,10-dioxo-3-oxa-7-thia-1-azatricyclo[6,2,0,0<2.6>]decane-2-
carboxylic acid skeleton as the base structure, their esters and their salts, are useful antibacterial agents.
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JPH0780889B2 |
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JPH0629248B2 |
(A) Bicyclic cpds. of formula (I) and their salts are new; where n = 0 or 1; m = 0-3; X = CH2, O, S, SO, SO2, NH or 1-4C alkylimino; X1 = CH2, O, S, SO or SO2; Y+Y1 = O, or Y = H and Y1 = OH or in-vivo hydrolysable acyloxy; Z = CH2, CHMe...
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JPH0576480B2 |
NEW MATERIAL:A compound expressed by formula I (Y is =CH- or N; R is lower alkyl). EXAMPLE:7beta-[2-(2-Aminothiazol-4-yl)-2-(Z)-methoxyiminoace
tami-do]-3 -(1-morpho lino[4,3-b]pyrazolio)methyl-3-cephem-4-car-boxy-late expressed by formu...
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JPH0565515B2 |
A herbicidal composition which comprises a carrier and, as active ingredient, a compound of the general formula I or where possible, an acid addition salt thereof: in which Y represents a sulphur, selenium or tellurium atom; R<1> and R<2...
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JPH0516428B2 |
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JPH0368582A |
NEW MATERIAL: A compd. of formula I, (where R1 = a lower alkyl, an alkoxy, a halogen; n=0, 1 or 2; R2=H, a lower alkyl or an acyl; R3=H, a lower alkyl, an alkoxycarbonyl or optionally a substd. phenyl; A = a saturated heterocycle compose...
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JPH0321543B2 |
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JPH02218686A |
NEW MATERIAL:A compound expressed by the formula (X is Cl or Br). USE: Anti-fungus agent or anti-tumor agent. PREPARATION: Microorganism [e.g. Trichoderma longibrachiatum) KAC-13125 (FERM BP-1824)] belonging to genus Trichodermae and hav...
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JPH02111772A |
NEW MATERIAL: A compd. represented by formula I [wherein R, R1, and R2 are each H provided R and R1 may combine with each other to form a 5- to 6-membered satd. heterocycle and so may do R1 and R5; R3 is H or OH; R4 is C(R11)-XR12 (where...
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JPH0138119B2 |
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JPS6466120A |
PURPOSE: To obtain an active oxygen production increase, containing a pentalene compound as an active ingredient, effective in breaking cancerous cells, etc., and having high safety. CONSTITUTION: An active oxygen production increase con...
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JPS62283960A |
The invention relates to new di- and tetrahydroisoquinoline derivatives having interesting cytostatic properties, to the preparation of the said new compounds, and to compositions comprising such a compound as a cytostatically active sub...
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JPS6252754B2 |
A process for preparing 5-methyl- 1,2,4-triazolo[3,4-b]benzothiazole, effective in controlling rice blast, involves the reaction of 2-hydrazino- 4-methylbenzothiazole and excess formic acid and utilizes an aromatic hydrocarbon during wor...
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JPS6236388A |
The invention provides a method of combating a microorganism which comprises allowing a heterocyclic pentalene derivative of general formula I wherein X represents an oxygen atom, a sulphur atom or an -SO- moiety; Y represents a sulphur,...
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JPS61277690A |
NEW MATERIAL:A compound expressed by formula I (R1WR3 are H or acetyl). EXAMPLE: (S)-(-)-14-Hydroxy-15-aminomethyl-2, 8-dithia[9](2, 5)pyridinophaneS, S, S', S'-tetraoxide. USE: A synthetic reagent for optically active amino acids. PREPA...
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JPS6157317B2 |
The new antibiotic of the formula: wherein R represents the group-CONH2, designated 35665 RP, possesses growth-promoting properties when added to animal feed.
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JPS6111954B2 |
1,4-Oxathiino[2,3-c]pyrrole derivatives of the formula: wherein A represents a phenyl, 2-pyridyl, 3-pyridazinyl, 2-quinolyl or naphthyridinyl radical, or a said radical substituted by one or two atoms or radicals selected from halogen, a...
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JPS60166627A |
Process for the formation of carbon-containing free radicals R., which optionally include functional groups, wherein thermal and/or photochemical energy is supplied to a thiocarbonyl-containing ester corresponding to the general formula ...
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JPS6029716B2 |
1,4-Oxathiino[2,3-c]pyrrole derivatives of the formula: wherein A represents a phenyl, 2-pyridyl, 3-pyridazinyl, 2-quinolyl or naphthyridinyl radical, or a said radical substituted by one or two atoms or radicals selected from halogen, a...
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JPS5933595B2 |
PURPOSE:Spiropyrane compounds of formula I -(Z is S, NR<1>;R<1> is alkyl, aralkyl, aryl, acyl; Y is O, NR<2>;R<2> is alkyl, aralkyl, aryl, in the proviso that when Y is O, X is not acyl); for example, 1',3',4',-triphenylspiro [2H-benzopy...
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JPS5850669B2 |
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JPS588085A |
Optically active trans-6-substituted-5(R)-2-penem-3-carboxylic acid derivatives of formula wherein R and R1 are each organic groups and R2 is hydrogen, a cation or a carboxy protecting group, are prepared by a multi-stage process of whic...
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JPS5653689A |
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JPS55124791A |
NEW MATERIAL:The title derivative of formula I [R1 is H, halogen, nitro, amino, lower alkyl(amino) group, etc.; R2 is lower alkyl group]. EXAMPLE: 12-Methyl-7-oxo-3H, 7H -4, 5-dihydro-2, 1, 4-oxathiazepino[4,3-b]-isoquinoline-2, 2-dioxid...
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