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JP3488263B2 |
PURPOSE: To remove an allyl group of an allyl ester of a penem compound by reacting the allyl ester of a penem compound with a carboxylic acid alkali metal salt in the presence of palladium acetate and a trialkyl phosphite. CONSTITUTION:...
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JP3488457B2 |
PCT No. PCT/EP93/02894 Sec. 371 Date Apr. 28, 1995 Sec. 102(e) Date Apr. 28, 1995 PCT Filed Oct. 20, 1993 PCT Pub. No. WO94/10178 PCT Pub. Date May 11, 1994 (I) (a) Compounds of formula (I) in which: R1 is hydrogen or an organic substitu...
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JP2003533480A |
The present invention describes a method for programming a specific course and rate of metabolism for a parent drug compound that leads to an inactive or very weakly active and nontoxic metabolite when the modified drug compound is admin...
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JP2003532698A |
The invention provides autoinducer-2 analogs that regulate the activity of autoinducer-2 and methods of using such analogs for regulating bacterial growth and pathogenesis.
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JP2003531147A |
Highly crystalline, highly filterable sodium Cefoperazone in the form of needle crystal aggregates, obtainable by a process comprising the controlled addition of acetone to a solution of water/acetone/alcohols/sodium Cefoperazone at 20~4...
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JP3459134B2 |
PURPOSE: To obtain the subject high-purity compound useful as a synthetic intermediate for β-lactamase inhibitors in high yield according to simple operations by using a specific halogenated β-lactam compound as a starting raw material...
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JP3452596B2 |
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JP3445664B2 |
PURPOSE: To obtain an aminomethylpenam derivative expressed by a specific formula, useful as a starting material for triazolylmethylpenam derivatives to be used as synthetic intermediates for antibiotics, and freed from problems concerni...
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JP2003520814A |
Nitrate salts of antimicrobial agents for the preparation of antimicrobial medicaments, specifically antiviral, antifungal and antibacterial medicaments.
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JP2003515526A |
Compounds or their salts of general formula (I): A-B-N(O)2 wherein: A is a drug radical selected from ferulic acid and sulindac; B= -O-R1B-X-R2B-O- wherein R1B and R2B, equal to or different from each other, are linear or branched C1-C6 ...
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JP2003114227A |
To develop a quick detection method of a general β-lactam antibiotic in milk and meat.This method has wide specificity over main first generation β-lactams, and can be used for testing milk, meat or the like on the existence of the rem...
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JP3377795B2 |
A novel process for producing a penicillin G phenyl ester of the formula: or a salt thereof which comprises reacting a compound of the formula: or a salt thereof with a compound of the formula: or a salt thereof.o
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JP2002541242A |
Compounds or their salts of general formula (I): A-(B) wherein A = R-T1-, wherein R is the drug radical and T1 = (CO)t or (X)t', wherein X = O, S, NR1C, R1C is H or an alkyl having from 1 to 5 carbon atoms, or a free valence, t and t' ar...
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JP2002541233A |
Compounds or their salts having general formula: A-B-C-NO2 wherein: A is a drug radical; B is a linker; and C is a bivalent radical.
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JP2002541236A |
Compounds or their salts having general formulas (I) and (II) wherein: s=is an integer equal to 1 or 2, preferably s=2; b0=0 or 1; A is the radical of a drug and is such as to meet the pharmacological tests reported in the description, C...
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JP2002541186A |
Bacterial infections may be treated using a high dosage regimen of amoxycillin. Preferably, the dosage is provided by a bilayer tablet.
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JP2002338578A |
To provide a β-lactam compound excellent in storage stability.This β-lactam compound is a hydrate crystal of tazobactam obtained by reacting a β-lactam compound with cresol and is excellent in shelf life. The hydrate crystal is produc...
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JP2002538215A |
The present invention relates to novel biologically active compounds from fungi of the species Ganoderma pfeifferi DSM 13239, processes for their preparation, and their use. From the fruit body and mycelium of the species Ganoderma pfeif...
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JP2002316991A |
To provide the penicillin and cephalosporin causing no enzyme inhibition.The objective penicillin and cephalosporin includes phenylacetic acid or phenoxyacetic acid in an amount of ≤100 ppm.
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JP2002535335A |
Compounds are provided having formulae (I) and (II) wherein n is 0 or 1 and when n=1, R is a 5 or 6 membered heterocyclic ring, hydroxy, halogen, oxo, carbamoyl, alkoxy, or disubstituted amino, when n=0, R is an ester, cyano or amide gro...
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JP2002531571A |
[Chemical 1]
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JP3306473B1 |
The present invention provides anhydrous crystals of β-lactam compound represented by the formula: The β-lactam compound of the invention is produced by heating an aqueous solution of a salt of the β-lactam compound and adjusting the ...
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JP3302369B2 |
Intermediates in the production of cephalosporins of formula wherein either alpha ) R denote hydrogen or a silyl group; R denotes a group of formula -OR, wherein R denotes hydrogen or alkyl; and R and R together denote a bond; or beta ) ...
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JP2002517422A |
This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligan...
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JP2002517398A |
A novel process for preparing a crystalline alkali metal salt of amoxycillin is dislcosed.
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JP2002517465A |
This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligan...
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JP2002516330A |
The present invention relates to penem antibacterial agents in which the releaseable liphophilic aromatic side-chain, tethered to the carbapenem nucleus via a methylene linker, necessary for anti-MRSA activity replaces the non-releaseabl...
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JP3274854B2 |
To obtain a new compound of a penem compound having carboxyl group protected with a specific ester-forming group, having high bioavailability at the time of oral administration, and useful as an antimicrobial material. This new compound ...
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JP3274855B2 |
To obtain a new compound of a penem compound having a carboxyl group protected by a specific ester-formable group capable of being easily hydrolyzed in vivo, having high bioavailability at the time of oral administration, and useful as a...
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JP3274856B2 |
To obtain a penem compound exhibiting excellent in vivo availableness and useful as an oral antibiotic. This compound is represented by formula I [R is a group of formula II or III; R1 is H or a 1-6C alkyl or R1 forms an o-phenylene toge...
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JP2002507189A |
The present invention provides substituted amino bicyclic-beta-lactam penam derivatives and substituted amino bicyclic-beta-lactam cepham derivatives and their diastereoisomers of formula I, as well as compositions, methods of making, an...
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JP3242677B2 |
PURPOSE: To obtain a new β-lactam compound having excellent antimicrobial activity against imipenem-resistant Pseudomonas aeruginosa. CONSTITUTION: The objective compound of formula I {(j) is 0 or 1; R1 is H, OH-protecting group or form...
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JP2001526291A |
Applicants have developed a process for purifying an ampicillin pro-drug ester, e.g., bacampicillin, or an acid addition salt thereof of formula I.The process comprises a step wherein a crude solution of the pro-drug ester is subjected t...
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JP3236261B2 |
To efficiently obtain the subject compound useful as an intermediate for synthesizing medicines, etc., in a high yield without using an organic solvent having the problems of safety and environmental pollution by reacting a specified ami...
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JP3234917B2 |
PURPOSE: To produce in high yield and high purity 2-exomethylenepenam deriv. by reducing allenyl β-lactam compd. expressed by the specific formula by electrolytic reduction. CONSTITUTION: Allenyl β-lactam compd. expressed by the formul...
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JP3233407B2 |
PCT No. PCT/JP94/01855 Sec. 371 Date Mar. 21, 1995 Sec. 102(e) Date Mar. 21, 1995 PCT Filed Nov. 2, 1994 PCT Pub. No. WO95/12601 PCT Pub. Date May 11, 1995Crystalline sodium 2 alpha -methyl-2 beta -(1,2,3-triazol-1-yl) -methylpenam-3 alp...
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JP3224261B2 |
PURPOSE: To easily obtain in high yield the title compound in high purity by reaction of an allenyl β-lactam compound with a metallic reducing agent. CONSTITUTION: The objective compound can be obtained by reaction at -20 to 100°C of (...
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JP2001510194A |
A compound spiroÄ1-azabicycloÄ2.2.2Üoctane-3,2'-(3'H)-furoÄ2,3-bÜp
yridineÜ or an enantiomer thereof, and pharmaceutically acceptable salts thereof, processes for preparing them, composition containing them, and their use in therap...
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JP2001509776A |
Novel 3-(substituted)-3-methyl-4-thia-1-azabicyclo[3.2.0]heptane-2
-carboxylate, 4,4-dioxides which are of value for use in combination with beta -lactam antibiotics to increase the effectiveness of the antibiotics.
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JP3181903B2 |
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JP2001122801A |
To develop a medicine in order to correct disadvantages of an established therapy for sepsis and adult respiratory distress syndrome(ARDS). A therapeutic and a prophylactic methods for the sepsis and ARDS using a certain kind of chemokin...
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JP3148236B2 |
PCT No. PCT/JP91/01100 Sec. 371 Date Feb. 19, 1993 Sec. 102(e) Date Feb. 19, 1993 PCT Filed Aug. 16, 1991 PCT Pub. No. WO92/03444 PCT Pub. Date Mar. 5, 1992Antibiotic penem compounds are represented by the following formula: (I) wherein ...
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JP3148235B2 |
PCT No. PCT/JP91/01099 Sec. 371 Date Feb. 19, 1993 Sec. 102(e) Date Feb. 19, 1993 PCT Filed Aug. 16, 1991 PCT Pub. No. WO92/03443 PCT Pub. Date Mar. 5, 1992.Antibiotic penem compounds are represented by the following formula: wherein R r...
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JP3148234B2 |
Novel antibacterial penem esters are methyl (5R,6S)-6-Ä(R)-1-hydroxyethylÜ-2-Ä(R)-2-tetrahydrofurylÜ
-penem-3-carbo xylates having at the 3-position an ester group of the formula -COOR in which R represents -CH2OCO-Y or -CH2-Z in whi...
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JP2001058994A |
To obtain an amoxicillin preparation which is stabilized, namely controls decomposition at a low pH and maintains antimicrobial activity by using an inclusion complex of amoxicillin with a cyclodextrin (derivative). An inclusion complex ...
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JP2000344783A |
To obtain a new compound useful as an intermediate for producing either of a free base or a tosylate salt of sultamicillin under a mild condition in good yield.This new compound is 1,1-dioxopenicillanoyloxymethyl 6-[D-α-(benzylideneamin...
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JP3115593B2 |
beta -Lactam derivatives are synthesized by an enzymatic reaction of the parent amino beta -lactam with the corresponding acylating agent, the concentration of the acylating agent plus the concentration of beta -lactam derivative in the ...
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JP2000516215A |
Disclosed is a process for the synthesis of beta -lactam antibacterials using soluble side chain esters in the presence of enzyme acylase. Also disclosed are novel esters useful as reactants in said process.
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JP2000514042A |
Catechol derivatives of general formula (I)in which R1 denotes O-acyl and R2 represents amino acid residues in the 3- and/or 4-position function as siderophores and/or as biological chelating agents for iron in gram-negative bacteria. Co...
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JP2000514054A |
(57) [Summary] The present invention relates to a compound of formula (I) (in the formula, R).1, R2, R3, R4And R5Is defined herein, the functional groups may be protected if desired) and a method for producing salts thereof, obtained by ...
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