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JPH07196662A |
PURPOSE: To obtain a bicyclic compound useful for treating human and animal infectious diseases, having antimicrobial action by reacting plural compounds shown by specific formulas, respectively. CONSTITUTION: This compound of formula I ...
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JPH07196659A |
PURPOSE: To obtain a carbapenem derivative useful as an antimicrobial agent, having excellent resistance to β-lactase and renal dehydropeptidase and strongly antimicrobial activity, shown by a specific formula, containing a methyl group...
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JPH07196661A |
PURPOSE: To obtain a thiocarbapenem derivative useful as an antimicrobial agent, having excellent resistance to β-lactase and renal dehydropeptidase and strongly antimicrobial activity, shown by a specific formula, containing a methyl g...
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JPH0764846B2 |
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JPH0759581B2 |
NEW MATERIAL:A compound expressed by formula I [both of R<1> and R<2> are H or either one of R<1> and R<2> is H and other is lower alkyl, carboxyl or alkoxycarbonyl, or (substituted)imino wherein R<1> and R<2> are linked together; when b...
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JPH0759552B2 |
Process for preparing a compound with the formula wherein R<2> is a (1-4C) alkyl group optionally substituted by one or more hydroxy groups (optionally protected) or halogen atoms or is a precursor for such a group, and R<6> and R<7> are...
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JPH07157484A |
PURPOSE: To obtain a carbapenem derivative useful as a medicine, having excellent antimicrobial activity. CONSTITUTION: A compound of formula I (R1 is H or a lower alkyl; R2 is H, a negative charge or an ester residue; R3 is H or a lower...
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JPH07157483A |
PURPOSE: To obtain a new carbapenem compound useful as a medicine having antimicrobial action. CONSTITUTION: A compound of formula I (R1 is carboxy; R2 is a hydroxy (lower)alkyl; R3 is H or a lower alkyl; R4 is H or an imino-protecting g...
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JPH0755950B2 |
Carbapenems of the formula are useful antibacterial agents. r
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JPH0747588B2 |
Carbapenems having the formula: where X is O or S(O)0-2; are useful antibacterial agents, especially with respect to activity against methicillin resistant Staphylococcus aureus (MRSA).
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JPH07133277A |
PURPOSE: To obtain a new compound having excellent antimicrobial activity, especially on a multidrug resistant bacterium MRSA, a resistant Pseudomonas aeruginos, etc., as an antimicrobial agent. CONSTITUTION: A compound of formula I [R1 ...
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JPH0745499B2 |
NEW MATERIAL:The compound of formula I {R<1> is lower alkyl, cycloalkyl, aralkyl, aryl, heteroaryl, group of formula II [m is 0-2, n is 0-3; R<2> is H, (substituted) lower alkyl or alkanoyl], etc., substituted with carbamoyloxy or carbam...
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JPH0745500B2 |
1-Methylcarbapenem derivatives of the formula: wherein R<1> is hydrogen atom or a hydroxy-protecting group, R<2> is hydrogen atom or an ester residue, R<3> is hydrogen atom or a lower alkyl group, or salts thereof, which have excellent a...
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JPH0742290B2 |
A process for 5-aroylation of 1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole-1-carboxylic esters and nitriles by reacting a pyrrolo pyrrole with an aroyl morpholide and an inorganic acid chloride in an inert aprotic solvent; followed by treatment...
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JPH07109278A |
PURPOSE: To provide the novel compound useful as an antibacterial agent and comprising practically easily handleable and stable crystals. CONSTITUTION: Crystalline (1R,5S,6S)-2-[(4R)-2-oxo-4-pyrrolidinylthio]-6-[(1R)-1- hydroxyethyl]-1-m...
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JPH07109279A |
PURPOSE: To provide the crystalline compound excellent in storage stability and useful as an antibacterial agent for oral administration CONSTITUTION: Crystalline (1R,5R,6S)-2-[(4S)-2-oxo-1-methyl-4- pyrrolidinylthio]-6-[(1R)-1-hydroxyet...
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JPH0733381B2 |
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JPH0730078B2 |
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JPH0730077B2 |
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JPH07502257A |
The present invention provides a compound of the formula (I) (I) wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4alkyl; n is zero or an integer 1 to 4; and P is a benzene ring substituted by groups R3...
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JPH0717644B2 |
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JPH0751092A |
PURPOSE: To obtain an optically active pyrrolidine derivative having oxo- or thioxo-group at the 2-position in an industrially advantageous way, by hydrolyz ing or alcholyzing one of the optically active enantiomers of a specific pyrroli...
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JPH0713058B2 |
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JPH0710868B2 |
Carbapenem derivatives useful as antibacterial agents have the formulawherein:X represents a hydrogen atom or a methyl group: andY represents a group of the formula:in which:Z represents an oxygen atom or two hydrogen atoms;R' represents...
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JPH0710834B2 |
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JPH078868B2 |
Carbapenems having the formula: are useful antibacterial agents. M
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JPH075597B2 |
Carbapenem intermediates having the formula: where Z is M is a removable protecting group for carboxy and P min is a removable protecting group for hydroxy, are useful intermediates for preparing antibacterial agents, especially with res...
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JPH075598B2 |
Disclosed are Carbapenem antibacterial agents of the formula and intermediates for making them. a
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JPH075607B2 |
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JPH0717977A |
PURPOSE: To provide the novel compound providing powerful antibacterial activity, highly resistant to β-lactamase-inhibitory activity and nephrodehydropeptidase, thus useful as an antibacterial agent. CONSTITUTION: The compound of formu...
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JPH07500354A |
A compound of formula (I) in which R<1> is carboxy, COO<-> or protected carboxy, R<2> is hydroxy(lower)alkyl or protected hydroxy(lower)alkyl, R<3> is hydrogen or lower alkyl, and R<4> is substituted lower alkyl or substituted lower alke...
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JPH072856A |
PURPOSE: To obtain a new derivative, composed of a 1-methylcarbapenem derivative, having strong antimicrobial activity, stable to dehydropeptidase I and a high recovery ratio in urine and effective in treating, etc., microbism due to a w...
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JPH072857A |
PURPOSE: To obtain a new compound (salt), composed of a 1- phosphorandiylmethyl-3-thiocarbonylalkyl-2-oxoazetidine derivative and useful as an intermediate, etc., for producing carbapenem derivatives having antimicrobial action. CONSTITU...
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JPH06104657B2 |
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JPH06102649B2 |
A new process involving novel intermediates for the synthesis of antibiotics comprises: 1. acylation of a dianion followed by reduction to introduce an arylhydroxymethyl or alkylhydroxymethyl group; alternatively, alkylation followed by ...
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JPH0699434B2 |
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JPH06336483A |
PURPOSE: To obtain a new compound excellent in antimicrobial property to resistant bacteria, exhibiting excellent stability to β-lactamase and renal dehydropeptidase and useful as a antimicrobial agent. CONSTITUTION: A compound of formu...
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JPH06321948A |
PURPOSE: To provide a new compound having anti-microbial activity and useful for treatment of bacterial infections. CONSTITUTION: This is a compound of formula I (Z is O, S, sulfoxide, solfone; ring Z is a substituted ring of 4-6 members...
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JPH0684376B2 |
Carbapenems having the formula: are useful antibacterial agents. M
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JPH06293765A |
PURPOSE: To obtain the subject compound useful as a practical synthetic intermediate for a carbapenem derivative having excellent antibacterial activity. CONSTITUTION: A compound of formula I [R1 is H or OH-protecting group; R2 is 1-6C a...
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JPH06293766A |
PURPOSE: To obtain a new compound effective against various kinds of pathogenic bacteria and useful as an antibacterial agent. CONSTITUTION: A 3-pyrazolidinylthio-1-azabicyclo[3.2.0]hept-2-ene-2-carboxyl
ic acid compound of formula I [R1...
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JPH06263761A |
PURPOSE: To obtain a new 3-pyrrolidinylthio-1-azabicyclo [3.2.0.]hept-2-ene-2- carboxylic acid compound useful as an antimicrobial agent. CONSTITUTION: A compound of formula I [R1 is a (protected) carboxyl group; R2 is a (protected) hydr...
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JPH0670059B2 |
Compounds of formula I I wherein, R1 represents hydrogen or methyl, R2 represents hydrogen or lower alkyl, lower alkenyl, lower alkynyl or cycloalkyl each of which may be unsubstituted or mono- or poly-substituted by amino, mono- or di(l...
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JPH06239830A |
PURPOSE: To obtain new optically active diols useful as intermediates for producing carbapenem-based antibiotic substances, etc. CONSTITUTION: These optically active diols are expressed by formula I (Ar is phenylene, naphthylene, bipheny...
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JPH06234676A |
PURPOSE: To enable efficient and inexpensive removal of silyl groups by reaction of a specific silyl ether compound with an acidic ammonium fluoride in an organic solvent whereby an alcohol of high optical purity is obtained. CONSTITUTIO...
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JPH0660182B2 |
A process for 5-aroylation of 1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole-1-carboxylic esters and nitriles by reacting a pyrrolo pyrrole with an aroyl morpholide and an inorganic acid chloride in an inert aprotic solvent; followed by treatment...
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JPH06220058A |
PURPOSE: To obtain the subject compound useful as an antimicrobial agent by reacting specific two compounds in the presence of a metal salt. CONSTITUTION: A compound of formula I [R1 is H or carboxyl-protecting group; R2 and R3 are H, lo...
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JPH06211860A |
PURPOSE: To provide novel compounds with a broad spectrum of antibacterial activity including both Gram positive and negative, anaerobic and aerobic bacteria exhibiting good stability to beta-lactamases. CONSTITUTION: By reacting a compo...
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JPH06211859A |
PURPOSE: To obtain a new compound having excellent antibacterial action on sensitive and resistant strains of bath Gram-positive bacteria and Gram-negative bacteria, exhibiting excellent stability to β-lactamase and DHP-1 and useful as ...
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JPH06206881A |
PURPOSE: To obtain a new compound, capable of manifesting excellent stability to β-lactamase and renal dehydropeptidase I and useful as an antimicrobial agent having strong antimicrobial activity against sensitive and resistant Gram- po...
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